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protein-coding   GIFtS: 71
GCID: GC07P139476

Thromboxane A Synthase 1 (Platelet)

(Previous names: thromboxane A synthase 1 (platelet, cytochrome P450, subfamily...)
  See TBXAS1-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Thromboxane A Synthase 1 (Platelet)1 2     Polypeptide 11
CYP52 3 5     Subfamily A1
Cytochrome P450 5A12 3     Thromboxane A Synthase 1 (Platelet, Cytochrome P450, Subfamily V)1
CYP5A12 3     THAS2
TXS2 3     TS2
TXA Synthase2 3     TXAS2
EC 8     Cytochrome P450, Family 5, Subfamily A, Polypeptide 12
BDPLT142 5     Platelet, Cytochrome P450, Subfamily V2
GHOSAL2 5     Thromboxane A Synthase 1 (Platelet, Cytochrome P450, Family 5, Subfamily
Cytochrome P4501     Thromboxane-A Synthase2
Family 51     

External Ids:    HGNC: 116091   Entrez Gene: 69162   Ensembl: ENSG000000593777   OMIM: 2741805   UniProtKB: P245573   

Export aliases for TBXAS1 gene to outside databases

Previous GC identifers: GC07P137799 GC07P138808 GC07P138936 GC07P138982 GC07P139124 GC07P133772

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TBXAS1 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of
sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the
conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation.
The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and
stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Aug 2008)

GeneCards Summary for TBXAS1 Gene:
TBXAS1 (thromboxane A synthase 1 (platelet)) is a protein-coding gene. Diseases associated with TBXAS1 include ghosal hematodiaphyseal syndrome, and thromboxane synthase deficiency. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F22.

Gene Wiki entry for TBXAS1 (Thromboxane-A synthase) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TBXAS1 gene promoter:
         STAT1   RP58   GATA-3   C/EBPalpha   GATA-1   GATA-2   FOXO1a   Sox9   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TBXAS1 promoter sequence
   Search Chromatin IP Primers for TBXAS1

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBXAS1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34-q35   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34-q35

TBXAS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBXAS1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P139476:  view genomic region     (about GC identifiers)

139,476,850 bp from pter      End:
139,720,125 bp from pter
243,276 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 138,807,008-139,048,964     
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TBXAS1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: THAS_HUMAN, P24557 (See protein sequence)
Recommended Name: Thromboxane-A synthase  
Size: 533 amino acids; 60518 Da
Cofactor: Heme group
Subunit: Monomer
Caution: It is uncertain whether Met-1 is the initiator. An alternative upstream Met is found in primates, but not
in other mammals
Sequence caution: Sequence=AAC01761.1; Type=Erroneous gene model prediction; Sequence=AAC01761.1; Type=Erroneous
initiation; Sequence=AAF99269.1; Type=Erroneous initiation; Sequence=AAF99270.1; Type=Erroneous initiation;
Sequence=AAF99271.1; Type=Erroneous initiation; Sequence=AAF99272.1; Type=Erroneous initiation;
Sequence=AAF99273.1; Type=Erroneous initiation; Sequence=AAF99274.1; Type=Erroneous initiation;
Sequence=AAF99275.1; Type=Erroneous initiation; Sequence=AAF99276.1; Type=Erroneous initiation;
Sequence=AAF99277.1; Type=Erroneous initiation; Sequence=AAF99278.1; Type=Erroneous initiation;
Sequence=AAF99279.1; Type=Erroneous initiation; Sequence=AAH41157.1; Type=Erroneous initiation;
Secondary accessions: E7ESB5 O14987 Q16844 Q8IUN1 Q96CN2 Q9GZW4 Q9HD77 Q9HD78 Q9HD79 Q9HD80
Q9HD81 Q9HD82 Q9HD83 Q9HD84
Alternative splicing: 2 isoforms:  P24557-1   P24557-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TBXAS1: NX_P24557

Explore proteomics data for TBXAS1 at MOPED

Selected DME Specific Peptides for TBXAS1 (P24557) (see all 6)

See TBXAS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (5 alternative transcripts): 
NP_001052.2  NP_001124438.1  NP_001159725.1  NP_001159726.1  NP_112246.2  

ENSEMBL proteins: 
 ENSP00000388736   ENSP00000388612   ENSP00000338087   ENSP00000402536   ENSP00000415892  
 ENSP00000391567   ENSP00000411274   ENSP00000411326   ENSP00000412710   ENSP00000263552  
 ENSP00000389414   ENSP00000392361   ENSP00000392702   ENSP00000444626  
Reactome Protein details: P24557

TBXAS1 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Proteins for TBXAS1
OriGene Protein Over-expression Lysate for TBXAS1
OriGene MassSpec for TBXAS1
OriGene Custom Protein Services for TBXAS1
GenScript Custom Purified and Recombinant Proteins Services for TBXAS1
Novus Biologicals TBXAS1 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

Search eBioscience for Proteins for TBXAS1 

Search GeneTex for Proteins for TBXAS1 

antibodies-online proteins for TBXAS1 (2 products) 

antibodies-online peptides for TBXAS1

TBXAS1 Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of TBXAS1
Browse R&D Systems for Antibodies
OriGene Antibodies for TBXAS1
OriGene Custom Antibody Services for TBXAS1
Novus Biologicals TBXAS1 Antibodies
Abcam antibodies for TBXAS1
Browse Antibodies at Cloud-Clone Corp.
ThermoFisher Antibodies for TBXAS1
antibodies-online antibodies for TBXAS1 (53 products) 

TBXAS1 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for TBXAS1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for TBXAS1
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.
Search eBioscience for ELISAs for TBXAS1 
antibodies-online kits for TBXAS1 (9 products) 

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:
CYP: Cytochrome P450s

IUPHAR Guide to PHARMACOLOGY protein family classification: CYP5A1
CYP5, CYP7 and CYP8 families

3 InterPro protein domains:
 IPR001128 Cyt_P450
 IPR017972 Cyt_P450_CS
 IPR002401 Cyt_P450_E_grp-I

Graphical View of Domain Structure for InterPro Entry P24557

ProtoNet protein and cluster: P24557

3 Blocks protein domains:
IPB002401 E-class P450 group I signature
IPB002402 Group II E-class P450 signature
IPB008072 CYP3A P450 family signature

UniProtKB/Swiss-Prot: THAS_HUMAN, P24557
Similarity: Belongs to the cytochrome P450 family

Find genes that share domains with TBXAS1           About GenesLikeMe

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: THAS_HUMAN, P24557
Catalytic activity: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate =

     Genatlas biochemistry entry for TBXAS1:
thromboxane synthase,cytochrome p450 superfamily

     Enzyme Number (IUBMB): EC 2

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004497monooxygenase activity IEA--
GO:0004796thromboxane-A synthase activity IEA--
GO:0005506iron ion binding IEA--
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA--
GO:0020037heme binding IEA--
Find genes that share ontologies with TBXAS1           About GenesLikeMe

     4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tbxas1):
 hematopoietic system  homeostasis/metabolism  immune system  no phenotypic analysis 

Find genes that share phenotypes with TBXAS1           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for TBXAS1: Tbxas1tm1Swl Tbxas1tm1Okun

   genOway: Develop your customized and physiologically relevant rodent model for TBXAS1

    Search Taconic Biosciences for animal models for TBXAS1 

miRTarBase miRNAs that target TBXAS1:
hsa-mir-335-5p (MIRT017567)

Block miRNA regulation of human, mouse, rat TBXAS1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate TBXAS1 (see all 10):
hsa-miR-301b hsa-miR-519c-3p hsa-miR-301a hsa-miR-519a hsa-miR-3666 hsa-miR-519b-3p hsa-miR-454 hsa-miR-4295
SwitchGear 3'UTR luciferase reporter plasmidTBXAS1 3' UTR sequence
Inhib. RNA
OriGene RNAi products in human, mouse, rat for TBXAS1
Predesigned siRNA for gene silencing in human, mouse, rat TBXAS1

Gene Editing
DNA2.0 Custom Protein Engineering Service for TBXAS1

OriGene clones in human, mouse for TBXAS1 (see all 31)
OriGene ORF clones in mouse, rat for TBXAS1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 5): TBXAS1 (NM_030984)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBXAS1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBXAS1

Cell Line
GenScript Custom overexpressing Cell Line Services for TBXAS1
ESI BIO PureStem Progenitor for TBXAS1: 
PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
In Situ Assay

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBXAS1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot
THAS_HUMAN, P24557: Endoplasmic reticulum membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

endoplasmic reticulum5
plasma membrane2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005789endoplasmic reticulum membrane TAS--
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with TBXAS1           About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for TBXAS1 About   (see all 9)  
See pathways by source

SuperPathContained pathways About
1Arachidonic acid metabolism
Arachidonic acid metabolism0.41
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)0.00
Arachidonic acid metabolism0.40
C20 prostanoid biosynthesis0.00
HETE and HPETE biosynthesis and metabolism0.33
Metabolism of lipids and lipoproteins0.37
Metabolic pathways0.38
3Biological oxidations
Biological oxidations0.56
Phenytoin Pathway, Pharmacokinetics0.00
4Cytochrome P450 - arranged by substrate type
Cytochrome P450 - arranged by substrate type0.75
Phase 1 - Functionalization of compounds0.75
5Prostaglandin Synthesis and Regulation
Prostaglandin Synthesis and Regulation

Find genes that share SuperPaths with TBXAS1           About GenesLikeMe

Pathways by source                                   See SuperPaths
Show all pathways

2 GeneGo (Thomson Reuters) Pathways for TBXAS1
    HETE and HPETE biosynthesis and metabolism
Prostaglandin 2 biosynthesis and metabolism FM

3 BioSystems Pathways for TBXAS1
    Eicosanoid Synthesis
Prostaglandin Synthesis and Regulation
C20 prostanoid biosynthesis

2 Reactome Pathways for TBXAS1
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

3 PharmGKB Pathways for TBXAS1
    Celecoxib Pathway, Pharmacodynamics
Phenytoin Pathway, Pharmacokinetics
Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

2 Kegg Pathways  (Kegg details for TBXAS1):
    Arachidonic acid metabolism
Metabolic pathways

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBXAS1

    GeneGlobe Interaction Network for TBXAS1

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

Selected Interacting proteins for TBXAS1 (P245572, 3 ENSP000002635524) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
InteractantInteraction Details
GeneCardExternal ID(s)
YWHAZP631043I2D: score=1 
HPGDSENSP000002952564STRING: ENSP00000295256
PTGDSENSP000003606874STRING: ENSP00000360687
PTGESENSP000003423854STRING: ENSP00000342385
PTGES2ENSP000003453414STRING: ENSP00000345341
About this table

Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006690icosanoid metabolic process TAS--
GO:0006805xenobiotic metabolic process TAS--
GO:0019369arachidonic acid metabolic process TAS--
GO:0019371cyclooxygenase pathway TAS--
GO:0030644cellular chloride ion homeostasis ----

Find genes that share ontologies with TBXAS1           About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore
   Enzo Life Sciences drugs & compounds for TBXAS1
  Browse compounds at ApexBio 

Browse Tocris compounds for TBXAS1 (THAS)

4 HMDB Compounds for TBXAS1    About this table
CompoundSynonyms CAS #PubMed Ids
Heme(protoporphyrinato)iron (see all 19)14875-96-8--
Prostaglandin H2Prostaglandin-H2 (see all 27)42935-17-1--
ThromboxaneThromboxane A2 66719-58-2--
Thromboxane A2(1S-(1alpha,3alpha,3R*),4beta(Z),5alpha)-7-(3-(3-hydroxy-1-octenyl)-2,6-dioxabicyclo(3.1.1)hept-4-yl)-5-Heptenoate (see all 25)57576-52-0--

2 DrugBank Compounds for TBXAS1    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Ridogrel-- 110140-89-1targetinhibitor8376914 11856082 8313547 10848666 10592235 11270983
Dazoxiben-- --targetinhibitor17139284 11752352 17016423 10592235

Selected Novoseek inferred chemical compound relationships for TBXAS1 gene (see all 22)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
thromboxane 89.8 50 16250911 (3), 8325653 (2), 16134166 (2), 7925341 (2) (see all 38)
thromboxane a2 89.8 79 8325653 (2), 11006279 (2), 19403042 (2), 8306107 (2) (see all 38)
prostaglandin-h2 89 20 11006279 (3), 18590695 (3), 16297851 (2), 16134166 (1) (see all 11)
pgh2 85.7 15 11297515 (4), 7700866 (2), 7488650 (1), 8964509 (1) (see all 8)
12-hydroxy-5,8,10-heptadecatrienoic acid 85.6 3 12859980 (2)
prostacyclin 70.5 21 11006279 (1), 12154203 (1), 18590695 (1), 19748489 (1) (see all 13)
pgd2 61 1 10359019 (1)
txb2 59.4 2 8444174 (1), 10359019 (1)
arachidonic acid 58.9 10 9063093 (1), 7488650 (1), 8444174 (1), 18264100 (1) (see all 7)
clotrimazole 43.9 2 11297515 (1), 9873013 (1)

Find genes that share compounds with TBXAS1           About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for TBXAS1 gene (5 alternative transcripts): 
NM_001061.4  NM_001130966.2  NM_001166253.1  NM_001166254.1  NM_030984.3  

Unigene Cluster for TBXAS1:

Thromboxane A synthase 1 (platelet)
Hs.520757  [show with all ESTs]
Unigene Representative Sequence: NM_001130966
Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
ENST00000493340 ENST00000462053 ENST00000473948 ENST00000425687 ENST00000474763
ENST00000481440 ENST00000438104 ENST00000336425 ENST00000448866 ENST00000422328
ENST00000492560 ENST00000455353 ENST00000458722 ENST00000411653 ENST00000476637
ENST00000462275(uc011kqu.2) ENST00000414041 ENST00000469630
Block miRNA regulation of human, mouse, rat TBXAS1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate TBXAS1 (see all 10):
hsa-miR-301b hsa-miR-519c-3p hsa-miR-301a hsa-miR-519a hsa-miR-3666 hsa-miR-519b-3p hsa-miR-454 hsa-miR-4295
SwitchGear 3'UTR luciferase reporter plasmidTBXAS1 3' UTR sequence
Inhib. RNA
OriGene RNAi products in human, mouse, rat for TBXAS1
Predesigned siRNA for gene silencing in human, mouse, rat TBXAS1
OriGene clones in human, mouse for TBXAS1 (see all 31)
OriGene ORF clones in mouse, rat for TBXAS1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 5): TBXAS1 (NM_030984)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBXAS1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBXAS1
OriGene qPCR primer pairs and template standards for TBXAS1
OriGene qSTAR qPCR primer pairs in human, mouse for TBXAS1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBXAS1
  QuantiTect SYBR Green Assays in human, mouse, rat TBXAS1
  QuantiFast Probe-based Assays in human, mouse, rat TBXAS1

Additional mRNA sequence: 

AK223466.1 AK296069.1 AK301049.1 AK301164.1 AK303440.1 BC014117.2 BC041157.1 M74055.1 
M80646.1 M80647.1 NR_029394.1 S60133.1 

15 DOTS entries:

DT.97782814  DT.99992833  DT.455401  DT.121056733  DT.100022756  DT.121643591  DT.100780064  DT.95284796 
DT.91644383  DT.100017058  DT.100710582  DT.40244924  DT.101967262  DT.40231588  DT.95282732 

Selected AceView cDNA sequences (see all 135):

CB117531 AL551161 CB121763 AA907907 BG326666 CA437040 BM673654 CD368493 
BC014117 BG255550 BM672386 CD367977 AU099213 AW615299 BC041157 CR625096 
BQ030101 BU616000 AI872272 BQ027613 BQ101037 AU076426 BQ710761 AI738743 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for TBXAS1 (see all 7)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1:                                      -     -                             -                       -                                 
SP2:                                      -     -                             -                       -                 -               
SP3:                                      -                                                                                             
SP4:                                            -                                                                                       
SP5:                                      -     -     -                                                                                 

ECgene alternative splicing isoforms for TBXAS1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TBXAS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
TBXAS1 Expression
About this image

TBXAS1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 Brain (Nervous System)    fully expand to see all 4 entries
         Cerebral Cortex
 Paraxial Mesoderm (Gastrulation Derivatives)
         PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
 Neural Crest (Gastrulation Derivatives)
         PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
 Bone (Muscoskeletal System)
         Bone Marrow
 Spleen (Hematopoietic System)
TBXAS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TBXAS1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.520757

UniProtKB/Swiss-Prot: THAS_HUMAN, P24557
Tissue specificity: Platelets, lung, kidney, spleen, macrophages and lung fibroblasts

    Custom PCR Arrays for TBXAS1
OriGene qPCR primer pairs and template standards for TBXAS1
OriGene qSTAR qPCR primer pairs in human, mouse for TBXAS1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBXAS1
QuantiTect SYBR Green Assays in human, mouse, rat TBXAS1
QuantiFast Probe-based Assays in human, mouse, rat TBXAS1
In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBXAS1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TBXAS1 gene from Selected species (see all 17)    About this table
Organism Taxonomic
Gene Description Human
(Mus musculus)
Mammalia Tbxas11 , 5 thromboxane A synthase 1, platelet1, 5 82.86(n)1
  6 (17.85 cM)5
213911  NM_011539.31  NP_035669.31 
(Gallus gallus)
Aves TBXAS11 thromboxane A synthase 1 (platelet) 64.89(n)
  418101  XM_416334.4  XP_416334.4 
(Anolis carolinensis)
Reptilia TBXAS16
thromboxane A synthase 1 (platelet)
1 ↔ 1
African clawed frog
(Xenopus laevis)
Amphibia BC059313.12   -- 74.44(n)    BC059313.1 
(Danio rerio)
Actinopterygii wufk19d082 Danio rerio clone RK064A2E01 thromboxane A synthase more 73.62(n)    AY398422.1 
fruit fly
(Drosophila melanogaster)
Insecta Cyp9c13
cytochrome P4503
(best of 14)3
  2 60D103
366611  NM_137156.21  NP_611000.21 
(Caenorhabditis elegans)
Secernentea T10B9.73 cytochrome P450 29(a)
(best of 7)
  II(9783728-9787263)   --
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP711A11 CYP711A1 45.8(n)
  817157  NM_128175.3  NP_565617.2 
(Oryza sativa)
Liliopsida Os01g07015001 Os01g0701500 45.76(n)
  4326929  NM_001050524.2  NP_001043989.2 

ENSEMBL Gene Tree for TBXAS1 (if available)
TreeFam Gene Tree for TBXAS1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for TBXAS1 gene
CYP4F222  CYP4F32  CYP4F22  CYP4F112  CYP3A432  CYP3A42  CYP4A222  CYP3A72  
CYP4V22  CYP4B12  CYP3A52  CYP4A112  CYP4Z12  CYP4F122  CYP4X12  
7 SIMAP similar genes for TBXAS1 using alignment to 12 protein entries:     THAS_HUMAN (see all proteins):
thromboxane synthase    CYP3A5    CYP3A43    CYP3A43/CYP3A4    CYP3A4    CYP3A7

Find genes that share paralogs with TBXAS1           About GenesLikeMe

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Selected SNPs for TBXAS1 (see all 5274)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
Chr 7 posSequence#AA
Ghosal hematodiaphyseal dysplasia (GHDD)4--see VAR_0443892 G W mis40--------
A breast cancer sample4--see VAR_0362942 R W mis40--------
Ghosal hematodiaphyseal dysplasia (GHDD)4--see VAR_0443902 L P mis40--------
Ghosal hematodiaphyseal dysplasia (GHDD)4--see VAR_0443882 R Q mis40--------
Ghosal hematodiaphyseal dysplasia (GHDD)4--see VAR_0443862 L P mis40--------
Cpathogenic1142973741(+) CTATCT/CTGGTC 11 /P /L mis11Minor allele frequency- C:0.00NA 4552
Cpathogenic1143078122(+) CACACG/AGGAGG 11 /Q /R mis11Minor allele frequency- A:0.00EU 1323
Cpathogenic1143080140(+) GCCTCA/G/TGGGTG 10 G W mis1 int11EU 1305
Cpathogenic1143080159(+) GCTGCC/TTGAGG 10 P L mis1 int10--------
C--133803236(+) TAGAT-/GATAG 
2 -- int10--------

HapMap Linkage Disequilibrium report for TBXAS1 (139476850 - 139720125 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for TBXAS1 (see all 13):    About this table    
Variant IDTypeSubtypePubMed ID
esv2735236CNV Deletion23290073
esv2676633CNV Deletion23128226
esv2735212CNV Deletion23290073
esv2735234CNV Deletion23290073
esv2671572CNV Deletion23128226
esv2735235CNV Deletion23290073
nsv365428CNV Loss16902084
nsv464733CNV Loss19166990
nsv831156CNV Loss17160897
nsv889244CNV Loss21882294

The Human Cytochrome P450 Allele Nomenclature Database: TBXAS1 
Human Gene Mutation Database (HGMD): TBXAS1
Locus Specific Mutation Databases (LSDB): TBXAS1

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing TBXAS1
DNA2.0 Custom Variant and Variant Library Synthesis for TBXAS1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 274180   
OMIM disorders: 231095  614158  
UniProtKB/Swiss-Prot: THAS_HUMAN, P24557
  • Ghosal hematodiaphyseal dysplasia (GHDD) [MIM:231095]: Rare autosomal recessive disorder characterized by
    increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia.
    Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated
    slowly or not at all. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Note=Thromboxane synthetase deficiency has been detected in some patients with a bleeding disorder due to
    platelet dysfunction

  • 3 diseases for TBXAS1:    
    About MalaCards
    ghosal hematodiaphyseal syndrome    thromboxane synthase deficiency    aregenerative anemia

    1 inferred disease relationship from the University of Copenhagen DISEASES database for TBXAS1:

    Find genes that share disorders with TBXAS1           About GenesLikeMe

    9 Novoseek inferred disease relationships for TBXAS1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroleukemia 33.4 1 1633871 (1)
    coagulopathy 13.1 1 8325653 (1)
    renal disease 0.28 1 7878751 (1)
    cardiovascular diseases 0 2 8325653 (1), 8964509 (1)
    adenocarcinoma 0 1 16357168 (1)
    metastasis 0 4 16357168 (1), 16627914 (1), 17603559 (1)
    tumors 0 13 16627914 (3), 16357168 (2), 16709411 (1), 17603559 (1) (see all 5)
    prostate cancer 0 1 14742249 (1)
    cancer 0 3 16709411 (3)

    Genetic Association Database (GAD): TBXAS1
    Human Genome Epidemiology (HuGE) Navigator: TBXAS1 (20 documents)

    Export disorders for TBXAS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TBXAS1 gene, integrated from 10 sources (see all 139) (see top 10):
    (articles sorted by number of sources associating them with TBXAS1)

    1. Molecular cloning of human platelet thromboxane A synthase. (PubMed id 1714723)1, 2, 3, 9 Yokoyama C.... Tanabe T. (Biochem. Biophys. Res. Commun. 1991)
    2. Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum. (PubMed id 8366093)1, 2, 9 Ruan K.H.... Kulmacz R.J. (J. Biol. Chem. 1993)
    3. Association of polymorphisms in thromboxane A2 receptor and thromboxane A synthase 1 with cerebral infarction in a Korean population. (PubMed id 19403042)1, 4, 9 Park S.A....Shin H.D. (BMB Rep 2009)
    4. Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome). (PubMed id 18264100)1, 2, 9 Genevieve D.... Cormier-Daire V. (Nat. Genet. 2008)
    5. Genomic structure and polymorphism of the human thromboxane synthase-encoding gene. (PubMed id 8964509)1, 3, 9 Baek S.J....Shen R.F. (Gene 1996)
    6. Characterization of the human gene (TBXAS1) encoding thromboxane synthase. (PubMed id 7925341)1, 2, 9 Miyata A....Tanabe T. (Eur. J. Biochem. 1994)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. [Association of the Pro1770Leu polymorphism in CYP5A1 gene with myocardial infarction in Uigur population of Xinjiang]. (PubMed id 20931532)1, 4 Wang B.Z....Yu Z.X. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2010)
    10. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    11. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    12. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    13. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. (PubMed id 19046748)1, 4 Lemaitre R.N....Psaty B.M. (Atherosclerosis 2009)
    14. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (amp 2009)
    15. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    16. The effect of an exon 12 polymorphism of the human thromboxane synthase (CYP5A1) gene in stroke patients. (PubMed id 19114962)1, 4 Kimouli M....Spandidos D.A. (Med. Sci. Monit. 2009)
    17. Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival. (PubMed id 19276290)1, 4 Abraham J.E....Pharoah P.D. (Clin. Cancer Res. 2009)
    18. Candidate gene polymorphisms for ischemic stroke. (PubMed id 19729601)1, 4 Matarin M....Meschia J.F. ( a journal of cerebral circulation 2009)
    19. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (amp 2008)
    20. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    21. Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population. (PubMed id 12721789)1, 2 Saito S....Nakamura Y. (J. Hum. Genet. 2003)
    22. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    23. Identification of genetic variants in the human thromboxane synthase gene (CYP5A1). (PubMed id 11465543)1, 2 Chevalier D.... Broly F. (Mutat. Res. 2001)
    24. Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PubMed id 10391209)1, 2 Cargill M....Lander E.S. (Nat. Genet. 1999)
    25. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. (PubMed id 10391210)1, 2 Halushka M.K.... Chakravarti A. (Nat. Genet. 1999)
    26. Primary structure of human thromboxane synthase determined from the cDNA sequence. (PubMed id 1730669)1, 2 Ohashi K.... Wang L.-H. (J. Biol. Chem. 1992)
    27. Isolation of partial complementary DNA encoding human thromboxane synthase. (PubMed id 2043115)1, 2 Wang L.-H.... Wu K.K. (Biochem. Biophys. Res. Commun. 1991)
    28. Immunoaffinity purification of human thromboxane synthase. (PubMed id 2195994)1, 2 Nuesing R.... Ullrich V. (Arch. Biochem. Biophys. 1990)
    29. Severe bleeding associated with defective thromboxane synthetase. (PubMed id 6101498)1, 2 Mestel F.... Wagner H.P. (Lancet 1980)
    30. Substrate binding is the rate-limiting step in thromboxane synthase catalysis. (PubMed id 11297515)1, 9 Wang L.H....Hsu P.Y. (J. Biol. Chem. 2001)
    31. Prognostic and functional significance of thromboxane synthase gene overexpression in invasive bladder cancer. (PubMed id 16357168)1, 9 Moussa O....Watson D.K. (Cancer Res. 2005)
    32. Nrf2 regulates thromboxane synthase gene expression in human lung cells. (PubMed id 14565864)1, 9 Yaekashiwa M. and Wang L.H. (DNA Cell Biol. 2003)
    33. Mapping of the human thromboxane synthase gene (TBXAS1) to chromosome 7q34-q35 by two-color fluorescence in situ hybridization. (PubMed id 8325653)1, 9 Chase M.B....Shen R.F. (Genomics 1993)
    34. Characterization of the complete genomic structure of human thromboxane synthase gene and functional analysis of its promoter. (PubMed id 8900410)1, 9 Tazawa R....Wang L.H. (Arch. Biochem. Biophys. 1996)
    35. Alternate splicing of human thromboxane synthase mRNA. (PubMed id 7986068)1, 9 Wang L.H....Wu K.K. (Arch. Biochem. Biophys. 1994)
    36. Characterization of the prostaglandin biosynthetic pathway in non-small cell lung cancer: a comparison with small cell lung cancer and correlation with angiogenesis, angiogenic factors and metastases. (PubMed id 15870920)1, 9 Yoshimoto A....Nakao S. (Oncol. Rep. 2005)
    37. Cloning and characterization of the human thromboxane synthase gene promoter. (PubMed id 8198598)1, 9 Lee K.D....Shen R.F. (Biochem. Biophys. Res. Commun. 1994)
    38. Genome-wide meta-analysis identifies new susceptibility loci for migraine. (PubMed id 23793025)1 Anttila V.... . (Nat. Genet. 2013)
    39. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    40. Association of thromboxane A1 synthase (TBXAS1) gene polymorphism with acute urticaria induced by nonsteroidal anti-inflammatory drugs. (PubMed id 23763970)1 Vidal C....Carracedo A. (J. Allergy Clin. Immunol. 2013)
    41. Reduced methylation of the thromboxane synthase gene is correlated with its increased vascular expression in preeclampsia. (PubMed id 22493072)1 Mousa A.A....Walsh S.W. (Hypertension 2012)
    42. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    43. Upregulation of thromboxane synthase mediates visfatin-induced interleukin-8 expression and angiogenic activity in endothelial cells. (PubMed id 22293189)1 Kim S.R....Bae M.K. (Biochem. Biophys. Res. Commun. 2012)
    44. Functional analysis of human thromboxane synthase polymorphic variants. (PubMed id 22735388)1 Chen C.Y....Wang L.H. (Pharmacogenet. Genomics 2012)
    45. Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. (PubMed id 23007406)1 Yang J.J....Relling M.V. (Blood 2012)
    46. Polymorphisms in the platelet-specific collagen receptor GP6 are associated with risk of nonfatal myocardial infarction in Caucasians. (PubMed id 20227257)1 Shaffer J.R....Donahue R.P. (Nutr Metab Cardiovasc Dis 2011)
    47. Association analysis of thromboxane A synthase 1 gene polymorphisms with aspirin intolerance in asthmatic patients. (PubMed id 21449675)1 Oh S.H....Park C.S. (Pharmacogenomics 2011)
    48. Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer. (PubMed id 21388528)1 Cathcart M.C....Pidgeon G.P. (Mol. Cancer 2011)
    49. Thromboxane synthase expression and thromboxane A2 production in the atherosclerotic lesion. (PubMed id 20383787)1 Gabrielsen A....Hansson G.K. (J. Mol. Med. 2010)
    50. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    51. Thromboxane synthase suppression induces lung cancer cell apoptosis via inhibiting NF-I_B. (PubMed id 20647010)1 Leung K.C....Chen G.G. (Exp. Cell Res. 2010)
    52. [Association of Rs10487667 genetic polymorphism of thromboxane synthase with myocardial infarction in Uigur population of Xinjiang]. (PubMed id 21215134)1 Wang B.Z....Yu Z.X. (Zhonghua Yu Fang Yi Xue Za Zhi 2010)
    53. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    54. Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men. (PubMed id 19141999)4 Giedraitis V....Glaser A. (Dement Geriatr Cogn Disord 2009)
    55. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    56. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    57. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)
    58. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
    59. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    60. The human plasma proteome: a nonredundant list developed by combination of four separate sources. (PubMed id 14718574)1 Anderson N.L....Lobley A. (amp 2004)
    61. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1 Nelson D.R....Nebert D.W. (Pharmacogenetics 2004)
    62. Analysis of Cox-2 and thromboxane synthase expression in pituitary adenomas and carcinomas. (PubMed id 15067173)1 Onguru O....Lloyd R.V. (Endocr. Pathol. 2004)
    63. Thromboxane synthase: structure and function of protein and gene. (PubMed id 12432933)1 Wang L.H. and Kulmacz R.J. (amp 2002)
    64. Transcriptional control of the human thromboxane synthase gene in vivo and in vitro. (PubMed id 11956185)1 Yaekashiwa M. and Wang L.H. (J. Biol. Chem. 2002)
    65. Efficacy and safety of oral ridogrel in the treatment of ulcerative colitis: two multicentre, randomized, double-blind studies. (PubMed id 11856082)7 Tytgat G.N....Hanauer S.B. (amp 2002)
    66. TTD: Therapeutic Target Database. (PubMed id 11752352)7 Chen X....Chen Y.Z. (Nucleic Acids Res. 2002)
    67. Gene transfer of thromboxane A(2) synthase and prostaglandin I(2) synthase antithetically altered tumor angiogenesis and tumor growth. (PubMed id 11782360)1 Pradono P....Nukiwa T. (Cancer Res. 2002)
    68. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    69. Coupling between cyclooxygenase, terminal prostanoid synthase, and phospholipase A2. (PubMed id 11418589)1 Ueno N....Kudo I. (J. Biol. Chem. 2001)
    70. Identification and characterization of the potential promoter regions of 1031 kinds of human genes. (PubMed id 11337467)1 Suzuki Y....Sugano S. (Genome Res. 2001)
    71. Ridogrel, a dual thromboxane synthase inhibitor and receptor antagonist: anti-inflammatory profile in inflammatory bowel disease. (PubMed id 10848666)7 Carty E....Rampton D.S. (amp 2000)
    72. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (Nucleic Acids Res. 2000)
    73. Endothelin-1 releases endothelium-derived endoperoxides and thromboxane A2 in porcine coronary arteries with regenerated endothelium. (PubMed id 11270983)7 Park S.J....Vanhoutte P.M. (Zhongguo Yao Li Xue Bao 1999)
    74. Molecular genetics of the human cytochrome P450 monooxygenase superfamily. (PubMed id 9890157)1 Smith G....Wolf C.R. ( the fate of foreign compounds in biological systems 1998)
    75. Toward a complete human genome sequence. (PubMed id 9847074)1 Sulston J.E. and Waterston R. (Genome Res. 1998)
    76. Thromboxanes: synthase and receptors. (PubMed id 9678486)1 Shen R.F. and Tai H.H. (J. Biomed. Sci. 1998)
    77. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
    78. Randomized trial of ridogrel, a combined thromboxane A2 synthase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial infarction. The Ridogrel Versus Aspirin Patency Trial (RAPT). (PubMed id 8313547)7 (Circulation 1994)
    79. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)
    80. The effect of a combined administration of ridogrel and ketanserin in patients with intermittent claudication. (PubMed id 8376914)7 De Cree J....Verhaegen H. (Int Angiol 1993)
    81. Thromboxane A2 synthesis in human erythroleukemia cells. (PubMed id 1930241)1 Jones D.A....Malcolm K.C. (Biochem. Biophys. Res. Commun. 1991)
    82. Comparison of the construction of a 3-D model for human thromboxane synthase using P450cam and BM-3 as templates: implications for the substrate binding pocket. (PubMed id 7700866)9 Ruan K.H....Wu K.K. (Protein Eng. 1994)
    83. Differential expression of thromboxane A synthase and prostaglandin H synthase in megakaryocytic cell line. (PubMed id 7488650)9 Matijevic-Aleksic N....Wu K.K. (Biochim. Biophys. Acta 1995)
    84. Expression of thromboxane synthase, TBXAS1 and the thromboxane A2 receptor, TBXA2R, in human breast cancer. (PubMed id 16250911)9 Watkins G....Jiang W.G. (Int Semin Surg Oncol 2005)
    85. Differential expression of thromboxane synthase in prostate carcinoma: role in tumor cell motility. (PubMed id 14742249)9 Nie D....Honn K.V. (Am. J. Pathol. 2004)
    86. Expression, purification, and spectroscopic characterization of human thromboxane synthase. (PubMed id 9873013)9 Hsu P.Y....Wang L.H. (J. Biol. Chem. 1999)
    87. Selective eicosanoid formation during HL-60 macrophage differentiation. Regulation of thromboxane synthase. (PubMed id 8444174)9 NA1sing R....Ullrich V. (Eur. J. Biochem. 1993)
    88. Thromboxane synthase has the same pattern of expression as platelet specific glycoproteins during human megakaryocyte differentiation. (PubMed id 10823275)9 Vitrat N....Debili N. (Thromb. Haemost. 2000)
    89. Thromboxane synthase expression in renal transplant patients with rejection. (PubMed id 7878751)9 Ramos E.L....Wilcox C.S. (Transplantation 1995)
    90. Inhibition of thromboxane synthase induces lung cancer cell death via increasing the nuclear p27. (PubMed id 19576211)9 Leung K.C....Chen G.G. (Exp. Cell Res. 2009)
    91. Inhibition of thromboxane synthase activity modulates bladder cancer cell responses to chemotherapeutic agents. (PubMed id 17603559)9 Moussa O....Watson D.K. (Oncogene 2008)
    92. Protein engineering of thromboxane synthase: conversion of membrane-bound to soluble form. (PubMed id 12859980)9 Hsu P.Y. and Wang L.H. (Arch. Biochem. Biophys. 2003)
    93. Multiple factors regulating the expression of human thromboxane synthase gene. (PubMed id 8920981)9 Lee K.D....Shen R.F. (Biochem. J. 1996)
    94. Identification of thromboxane A2 synthase active site residues by molecular modeling-guided site-directed mutagenesis. (PubMed id 8702713)9 Wang L.H....Kulmacz R.J. (J. Biol. Chem. 1996)
    95. Structural characterization and topology of the second potential membrane anchor region in the thromboxane A2 synthase amino-terminal domain. (PubMed id 9454571)9 Ruan K.H....Gao X. (Biochemistry 1998)
    96. Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases. (PubMed id 17459323)9 Yeh H.C....Wang L.H. (Arch. Biochem. Biophys. 2007)
    97. Upregulation of thromboxane synthase in human colorectal carcinoma and the cancer cell proliferation by thromboxane A2. (PubMed id 16709411)9 Sakai H....Takeguchi N. (FEBS Lett. 2006)
    98. Solution structure of a common substrate mimetic of cyclooxygenase-downstream synthases bound to an engineered thromboxane A2 synthase using a high-resolution NMR technique. (PubMed id 16297851)9 Ruan K.H....Wang L.H. (Arch. Biochem. Biophys. 2005)
    99. Identification of thromboxane synthase amino acid residues involved in heme-propionate binding. (PubMed id 11097184)9 Hsu P.Y....Wang L.H. (Arch. Biochem. Biophys. 2000)
    100. Identification of the substrate interaction site in the N-terminal membrane anchor segment of thromboxane A2 synthase by determination of its substrate analog conformational changes using high resolution NMR technique. (PubMed id 11006279)9 So S.P....Ruan K.H. (J. Biol. Chem. 2000)
    101. Expression of cyclo-oxygenase-2 and downstream enzymes in diabetic fibrovascular epiretinal membranes. (PubMed id 18952655)9 El-Asrar A.M....Geboes K. (Br J Ophthalmol 2008)
    102. Cyclooxygenase-2 and thromboxane synthase in non-endocrine and endocrine tumors: a review. (PubMed id 16627914)9 Onguru O....Lloyd R.V. (Endocr. Pathol. 2005)
    103. Thromboxane synthase (TBXAS1) polymorphisms in African-American and Caucasian populations: evidence for selective pressure. (PubMed id 16134166)9 Ulrich C.M....Bigler J. (Hum. Mutat. 2005)
    104. Characterization of the secondary structure and membrane interaction of the putative membrane anchor domains of prostaglandin I2 synthase and cytochrome P450 2C1. (PubMed id 9521818)9 Lin Y....Ruan K.H. (Arch. Biochem. Biophys. 1998)
    105. Expression of thromboxane synthase in kidney tissues from patients with IgA nephropathy. (PubMed id 9105763)9 Endoh M....Kurokawa K. (Clin. Nephrol. 1997)
    106. The porcine thromboxane synthase-encoding cDNA: sequence, mRNA expression and enzyme production in Sf9 insect cells. (PubMed id 8144035)9 Shen R.F....Lee K.D. (Gene 1994)
    107. Molecular cloning and expression of murine thromboxane synthase. (PubMed id 7688225)9 Zhang L....Shen R.F. (Biochem. Biophys. Res. Commun. 1993)
    108. Induction of thromboxane synthase and prostaglandin endoperoxide synthase mRNAs in human erythroleukemia cells by phorbol ester. (PubMed id 1633871)9 Ihara H....Tanabe T. (FEBS Lett. 1992)
    109. Characterization of the prostaglandin H2 mimic: binding to the purified human thromboxane A2 receptor in solution. (PubMed id 18590695)9 Ruan K.H....Wu J. (Arch. Biochem. Biophys. 2008)
    110. Enhanced cell-surface stability of rescued DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) by pharmacological chaperones. (PubMed id 18052931)9 Varga K....Collawn J.F. (Biochem. J. 2008)
    111. Activation of the thromboxane A2 pathway in human prostate cancer correlates with tumor Gleason score and pathologic stage. (PubMed id 16522350)9 Dassesse T....Waltregny D. (Eur. Urol. 2006)
    112. Resonance Raman investigation of the interaction of thromboxane synthase with substrate analogues. (PubMed id 12614148)9 Chen Z....Schelvis J.P. (Biochemistry 2003)
    113. Differential regulation of prostaglandin E2 and thromboxane A2 production in human monocytes: implications for the use of cyclooxygenase inhibitors. (PubMed id 10903770)9 Penglis P.S....James M.J. (J. Immunol. 2000)
    114. Non-monooxygenase cytochromes P450 as potential human autoantigens in anticonvulsant hypersensitivity reactions. (PubMed id 9682267)9 Leeder J.S....Gaedigk A. (Pharmacogenetics 1998)
    115. Expression of prostacyclin and thromboxane synthases in placenta and placental bed after pre-eclamptic pregnancies. (PubMed id 8916205)9 Wetzka B....Smith S.K. (Placenta 1996)
    116. Characterization of the structure and membrane interaction of NH2-terminal domain of thromboxane A2 synthase. (PubMed id 8063711)9 Ruan K.H....Wu K.K. (J. Biol. Chem. 1994)
    117. ZD1542, a potent thromboxane A2 synthase inhibitor and receptor antagonist in vitro. (PubMed id 8306107)9 Brownlie R.P....Wayne M.G. (Br. J. Pharmacol. 1993)
    118. Role of prostaglandins in pregnancy-induced hypertension. (PubMed id 1899531)9 Satoh K....Sakamoto H. (Am. J. Kidney Dis. 1991)
    119. Differentiation-associated expression of prostaglandin H and thromboxane A synthases in monocytoid leukemia cell lines. (PubMed id 1742485)9 Sanduja S.K....Wu K.K. (Blood 1991)
    120. Estradiol selectively stimulates endothelial prostacyclin production through estrogen receptor-{alpha}. (PubMed id 20110403)9 Sobrino A....Hermenegildo C. (J. Mol. Endocrinol. 2010)
    121. Cyclic stretch induces cyclooxygenase-2 gene expression in vascular endothelial cells via activation of nuclear factor kappa-beta. (PubMed id 19748489)9 Zhao H....Rade J.J. (Biochem. Biophys. Res. Commun. 2009)
    122. Effect of pharmaceutical interventions targeting thromboxane receptors and thromboxane synthase in cardiovascular and renal diseases. (PubMed id 19715412)9 Sakariassen K.S....Sorensen A.S. (Future Cardiol 2009)
    123. Effects of the flavonoid biochanin A on gene expression in primary human hepatocytes and human intestinal cells. (PubMed id 17340576)9 Moon Y.J....Morris M.E. (amp 2007)
    124. Double-label expression studies of prostacyclin synthase, thromboxane synthase and COX isoforms in normal aortic endothelium. (PubMed id 17189713)9 Kawka D.W....Riendeau D. (Biochim. Biophys. Acta 2007)
    125. Molecular analysis integrating different pathways associated with androgen-independent progression in LuCaP 23.1 xenograft. (PubMed id 15489889)9 Rocchi P....Martin P.M. (Oncogene 2004)
    126. Nuclear factor-erythroid 2 (NF-E2) expression in normal and malignant megakaryocytopoiesis. (PubMed id 12200693)9 Catani L....Baccarani M. (Leukemia 2002)
    127. Elevated expression of the genes encoding TNF-alpha and thromboxane synthase in leucocytes from patients with systemic sclerosis. (PubMed id 12154203)9 Young V....Palmer C.N. (Rheumatology (Oxford) 2002)
    128. Intraluminal pressure modulates eicosanoid enzyme expression in vascular endothelium of intact human conduit vessels at physiological levels of shear stress. (PubMed id 11791027)9 Doroudi R....Jern S. (J. Hypertens. 2002)
    129. Effects of shear stress on eicosanoid gene expression and metabolite production in vascular endothelium as studied in a novel biomechanical perfusion model. (PubMed id 10694510)9 Doroudi R....Jern S. (Biochem. Biophys. Res. Commun. 2000)
    130. Generation of thromboxane A2 from highly purified human sinus mast cells after immunological stimulation. (PubMed id 10359019)9 Mita H....Akiyama K. (Prostaglandins Leukot. Essent. Fatty Acids 1999)

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    Entrez Gene: 6916 HGNC: 11609 AceView: TBXAS1 Ensembl:ENSG00000059377 euGenes: HUgn6916
    ECgene: TBXAS1 Kegg: 6916 H-InvDB: TBXAS1

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