Aliases for TBXAS1 Gene
External Ids for TBXAS1 Gene
Previous GeneCards Identifiers for TBXAS1 Gene
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
GeneCards Summary for TBXAS1 Gene
TBXAS1 (Thromboxane A Synthase 1 (Platelet)) is a Protein Coding gene. Diseases associated with TBXAS1 include ghosal hematodiaphyseal syndrome and thromboxane synthase deficiency. Among its related pathways are Platelet Aggregation Inhibitor Pathway, Pharmacodynamics and Platelet activation. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F12.