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Aliases for TBXA2R Gene

Aliases for TBXA2R Gene

  • Thromboxane A2 Receptor 2 3
  • Prostanoid TP Receptor 3 4
  • TXA2-R 3 4
  • BDPLT13 3

External Ids for TBXA2R Gene

Previous GeneCards Identifiers for TBXA2R Gene

  • GC19M003687
  • GC19M003664
  • GC19M003534
  • GC19M003545
  • GC19M003359

Summaries for TBXA2R Gene

Entrez Gene Summary for TBXA2R Gene

  • This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

GeneCards Summary for TBXA2R Gene

TBXA2R (Thromboxane A2 Receptor) is a Protein Coding gene. Diseases associated with TBXA2R include bleeding disorder, platelet-type, 13 and bleeding diathesis due to thromboxane synthesis deficiency. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include G-protein coupled receptor activity and thromboxane receptor activity. An important paralog of this gene is PTGER2.

UniProtKB/Swiss-Prot for TBXA2R Gene

  • Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.

Tocris Summary for TBXA2R Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for TBXA2R Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBXA2R Gene

Genomics for TBXA2R Gene

Regulatory Elements for TBXA2R Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TBXA2R Gene

Chromosome:
19
Start:
3,594,506 bp from pter
End:
3,606,851 bp from pter
Size:
12,346 bases
Orientation:
Minus strand

Genomic View for TBXA2R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBXA2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBXA2R Gene

Proteins for TBXA2R Gene

  • Protein details for TBXA2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21731-TA2R_HUMAN
    Recommended name:
    Thromboxane A2 receptor
    Protein Accession:
    P21731
    Secondary Accessions:
    • O75228
    • Q6DK52
    • Q9UCY1
    • Q9UCY2

    Protein attributes for TBXA2R Gene

    Size:
    343 amino acids
    Molecular mass:
    37431 Da
    Quaternary structure:
    • Interacts with RPGRIP1L. Interacts with PSMA3. Interacts with GNB2L1/RACK1; the interaction regulates TBXA2R cell surface expression.
    SequenceCaution:
    • Sequence=AAA58957.1; Type=Frameshift; Positions=329; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TBXA2R Gene

    Alternative splice isoforms for TBXA2R Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBXA2R Gene

Proteomics data for TBXA2R Gene at MOPED

Post-translational modifications for TBXA2R Gene

  • Glycosylation at Asn 4 and Asn 16
  • Modification sites at PhosphoSitePlus

Other Protein References for TBXA2R Gene

Antibody Products

No data available for DME Specific Peptides for TBXA2R Gene

Domains & Families for TBXA2R Gene

Gene Families for TBXA2R Gene

Protein Domains for TBXA2R Gene

Suggested Antigen Peptide Sequences for TBXA2R Gene

Graphical View of Domain Structure for InterPro Entry

P21731

UniProtKB/Swiss-Prot:

TA2R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TBXA2R: view

Function for TBXA2R Gene

Molecular function for TBXA2R Gene

GENATLAS Biochemistry:
thromboxane A2 receptor (platelet,placenta,lung,megakaryocyte), G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.

Gene Ontology (GO) - Molecular Function for TBXA2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004960 thromboxane receptor activity --
GO:0004961 thromboxane A2 receptor activity TAS 8119956
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0005515 protein binding IPI 17644091
genes like me logo Genes that share ontologies with TBXA2R: view
genes like me logo Genes that share phenotypes with TBXA2R: view

Animal Models for TBXA2R Gene

MGI Knock Outs for TBXA2R:

Animal Model Products

CRISPR Products

miRNA for TBXA2R Gene

miRTarBase miRNAs that target TBXA2R

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBXA2R

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TBXA2R Gene

Localization for TBXA2R Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBXA2R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBXA2R Gene COMPARTMENTS Subcellular localization image for TBXA2R gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TBXA2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1825698
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with TBXA2R: view

Pathways & Interactions for TBXA2R Gene

genes like me logo Genes that share pathways with TBXA2R: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for TBXA2R Gene

Other effect:

Gene Ontology (GO) - Biological Process for TBXA2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 1825698
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0007584 response to nutrient IEA --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with TBXA2R: view

Drugs & Compounds for TBXA2R Gene

(72) Drugs for TBXA2R Gene - From: NovoSeek, IUPHAR, DGIdb, Tocris, PharmGKB, ApexBio, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iloprost Approved, Investigational Pharma Full agonist, Agonist, agonist Others, Prostacyclin (PGI2) analog 73
Ridogrel Approved Pharma Target, antagonist 0
Aspirin Approved Pharma Channel blocker 971
Candesartan Approved Pharma Antagonist Angiotensin II receptor 1 (AT1) antagonist 144
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437

(38) Additional Compounds for TBXA2R Gene - From: NovoSeek, HMDB, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GR 32191
Antagonist
Thromboxane
  • Thromboxane A2
66719-58-2
Thromboxane A2
  • (1S-(1alpha,3alpha,3R*),4beta(Z),5alpha)-7-(3-(3-hydroxy-1-octenyl)-2,6-dioxabicyclo(3.1.1)hept-4-yl)-5-Heptenoate
  • (1S-(1alpha,3alpha,3R*),4beta(Z),5alpha)-7-(3-(3-hydroxy-1-octenyl)-2,6-dioxabicyclo(3.1.1)hept-4-yl)-5-Heptenoic acid
  • (5Z)-7-[(1S,3R,4S,5S)-3-[(1E,3S)-3-hydroxy-1-octenyl]-2,6-dioxabicyclo[3.1.1]hept-4-yl]-5-Heptenoate
  • (5Z)-7-[(1S,3R,4S,5S)-3-[(1E,3S)-3-hydroxy-1-octenyl]-2,6-dioxabicyclo[3.1.1]hept-4-yl]-5-Heptenoic acid
  • (5Z,13E)-(15S)-9,11-epoxy-15-hydroxythromba-5,13-dienoate
57576-52-0
AGN192093
Agonist
CTA<sub>2</sub>
Full agonist, Agonist
genes like me logo Genes that share compounds with TBXA2R: view

Drug Products

Transcripts for TBXA2R Gene

Unigene Clusters for TBXA2R Gene

Thromboxane A2 receptor:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBXA2R

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBXA2R Gene

No ASD Table

Relevant External Links for TBXA2R Gene

GeneLoc Exon Structure for
TBXA2R
ECgene alternative splicing isoforms for
TBXA2R

Expression for TBXA2R Gene

mRNA expression in normal human tissues for TBXA2R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TBXA2R Gene

This gene is overexpressed in Artery - Aorta (x8.3), Artery - Tibial (x7.9), and Artery - Coronary (x6.7).

Protein differential expression in normal tissues from HIPED for TBXA2R Gene

This gene is overexpressed in Platelet (61.8) and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TBXA2R Gene



SOURCE GeneReport for Unigene cluster for TBXA2R Gene Hs.442530

genes like me logo Genes that share expression patterns with TBXA2R: view

Protein tissue co-expression partners for TBXA2R Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TBXA2R Gene

Orthologs for TBXA2R Gene

This gene was present in the common ancestor of chordates.

Orthologs for TBXA2R Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TBXA2R 35
  • 82.65 (n)
  • 83.33 (a)
TBXA2R 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBXA2R 35
  • 86.51 (n)
  • 86.61 (a)
TBXA2R 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbxa2r 35
  • 77.61 (n)
  • 78.64 (a)
Tbxa2r 16
Tbxa2r 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TBXA2R 35
  • 97.92 (n)
  • 98.81 (a)
TBXA2R 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbxa2r 35
  • 78.12 (n)
  • 77.71 (a)
oppossum
(Monodelphis domestica)
Mammalia TBXA2R 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TBXA2R 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TBXA2R 35
  • 66.58 (n)
  • 56.52 (a)
TBXA2R 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17668 35
tbxa2r 35
  • 55.65 (n)
  • 57.44 (a)
zebrafish
(Danio rerio)
Actinopterygii ptger1c 36
  • 34 (a)
ManyToMany
Species with no ortholog for TBXA2R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBXA2R Gene

ENSEMBL:
Gene Tree for TBXA2R (if available)
TreeFam:
Gene Tree for TBXA2R (if available)

Paralogs for TBXA2R Gene

Paralogs for TBXA2R Gene

(6) SIMAP similar genes for TBXA2R Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TBXA2R: view

Variants for TBXA2R Gene

Sequence variations from dbSNP and Humsavar for TBXA2R Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs4523 -- 3,595,796(-) GTGTA(C/T)ATCCT synonymous-codon, reference
rs5742 -- 3,602,629(-) ccgag(C/T)agctg intron-variant, utr-variant-5-prime
rs5743 - 3,600,433(+) TCCTC(A/T)GCGGC missense, reference
rs5744 - 3,600,396(-) GCTGG(A/T)GACCG missense, reference
rs5745 -- 3,600,392(-) GTGAC(C/G/T)GGTAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TBXA2R Gene

Variant ID Type Subtype PubMed ID
nsv910722 CNV Loss 21882294
nsv910723 CNV Loss 21882294
dgv3651n71 CNV Loss 21882294
nsv470114 CNV Loss 18288195
dgv3652n71 CNV Loss 21882294
dgv3655n71 CNV Loss 21882294
dgv3656n71 CNV Loss 21882294
dgv3657n71 CNV Loss 21882294
nsv833713 CNV Loss 17160897
dgv3658n71 CNV Loss 21882294
nsv910752 CNV Loss 21882294
dgv3659n71 CNV Loss 21882294
dgv3660n71 CNV Loss 21882294
dgv3661n71 CNV Loss 21882294
nsv910762 CNV Loss 21882294
nsv910763 CNV Loss 21882294
nsv910764 CNV Loss 21882294
esv2717950 CNV Deletion 23290073
esv2717952 CNV Deletion 23290073
esv2717953 CNV Deletion 23290073

Variation tolerance for TBXA2R Gene

Residual Variation Intolerance Score: 83.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBXA2R Gene

HapMap Linkage Disequilibrium report
TBXA2R
Human Gene Mutation Database (HGMD)
TBXA2R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBXA2R Gene

Disorders for TBXA2R Gene

MalaCards: The human disease database

(5) MalaCards diseases for TBXA2R Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
bleeding disorder, platelet-type, 13
  • bleeding disorder, platelet-type, 13, susceptibility to
bleeding diathesis due to thromboxane synthesis deficiency
allergic rhinitis
  • seasonal allergic rhinitis
stroke, ischemic
  • ischemic stroke
asthma
  • asthma, protection against
- elite association

UniProtKB/Swiss-Prot

TA2R_HUMAN
  • Bleeding disorder, platelet-type 13 (BDPLT13) [MIM:614009]: A disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding. {ECO:0000269 PubMed:7929844}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Genatlas disease for TBXA2R Gene

bleeding diathesis with platelet unresponsiveness to thromboxane A2

Relevant External Links for TBXA2R

Genetic Association Database (GAD)
TBXA2R
Human Genome Epidemiology (HuGE) Navigator
TBXA2R
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TBXA2R
genes like me logo Genes that share disorders with TBXA2R: view

Publications for TBXA2R Gene

  1. [Inactivated factor VII exercises a powerful antithrombotic activity in an experimental model of recurrent arterial thrombosis]. (PMID: 8697470) Ragni M. … Chiariello M. (Cardiologia 1996) 23 25 26 67
  2. On the bioisosteric potential of diazines: diazine analogues of the combined thromboxane A2 receptor antagonist and synthetase inhibitor Ridogrel. (PMID: 8831771) Heinisch G. … Weissenberger H. (J. Med. Chem. 1996) 23 25 26 67
  3. 6,6-Disubstituted Hex-5-enoic acid derivatives as combined thromboxane A2 receptor antagonists and synthetase inhibitors. (PMID: 8289199) Soyka R. … Weisenberger H. (J. Med. Chem. 1994) 23 25 26 67
  4. Cloning and expression of cDNA for a human thromboxane A2 receptor. (PMID: 1825698) Hirata M. … Narumiya S. (Nature 1991) 2 23 67
  5. A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis. (PMID: 19828703) Mumford A.D. … Watson S.P. (Blood 2010) 23 67

Products for TBXA2R Gene

Sources for TBXA2R Gene

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