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TBXA2R Gene

protein-coding   GIFtS: 69
GCID: GC19M003594

Thromboxane A2 Receptor

  See TBXA2R-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thromboxane A2 Receptor1 2
Prostanoid TP Receptor2 3
TXA2-R2 3
BDPLT132 5

External Ids:    HGNC: 116081   Entrez Gene: 69152   Ensembl: ENSG000000066387   OMIM: 1880705   UniProtKB: P217313   

Export aliases for TBXA2R gene to outside databases

Previous GC identifers: GC19M003687 GC19M003664 GC19M003534 GC19M003545 GC19M003359


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TBXA2R Gene:
This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to
induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder.
Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct
2009)

GeneCards Summary for TBXA2R Gene:
TBXA2R (thromboxane A2 receptor) is a protein-coding gene. Diseases associated with TBXA2R include bleeding disorder, platelet-type, 13, and dowling-degos disease 1. GO annotations related to this gene include thromboxane A2 receptor activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is PTGER1.

UniProtKB/Swiss-Prot: TA2R_HUMAN, P21731
Function: Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this
receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the
kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase
C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase

summary for TBXA2R Gene:
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2,
prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which
the other prostaglandins are synthesized. Prostanoid receptors are a family of nine G-protein-coupled
receptors that have distinct tissue distributions and actions. TP receptors can be coupled to both Galphaq
and Galphai. They are expressed abundantly in highly vascular tissues such as the kidney and heart, and
immune-related organs such as the thymus and spleen. They mediate smooth muscle contraction and platelet
aggregation.

Gene Wiki entry for TBXA2R (Thromboxane receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the TBXA2R gene promoter:
         LCR-F1   PPAR-alpha   HEN1   CREB   PPAR-gamma1   deltaCREB   PPAR-gamma2   Meis-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBXA2R promoter sequence
   Search Chromatin IP Primers for TBXA2R

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBXA2R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

TBXA2R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBXA2R gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M003594:  view genomic region     (about GC identifiers)

Start:
3,594,504 bp from pter      End:
3,606,838 bp from pter
Size:
12,335 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TA2R_HUMAN, P21731 (See protein sequence)
Recommended Name: Thromboxane A2 receptor  
Size: 343 amino acids; 37431 Da
Subunit: Interacts with RPGRIP1L. Interacts with PSMA3. Interacts with GNB2L1/RACK1; the interaction regulates
TBXA2R cell surface expression
Sequence caution: Sequence=AAA58957.1; Type=Frameshift; Positions=329;
1 PDB 3D structure from and Proteopedia for TBXA2R:
1LBN (3D)    
Secondary accessions: O75228 Q6DK52 Q9UCY1 Q9UCY2
Alternative splicing: 2 isoforms:  P21731-3   P21731-2   (Ref.2 (AAA58957) sequence differs from that shown due to frameshifts in positions 330 and 386)

Explore the universe of human proteins at neXtProt for TBXA2R: NX_P21731

Explore proteomics data for TBXA2R at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn4, Asn16
  • Modification sites at PhosphoSitePlus

  • See TBXA2R Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001051.1  NP_963998.2  

    ENSEMBL proteins: 
     ENSP00000364336   ENSP00000468145   ENSP00000393333  
    Reactome Protein details: P21731

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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PTGR: GPCR / Class A : Prostanoid receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: TP receptor
    Prostanoid receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR008365 Prostanoid_rcpt
     IPR001105 Thbox_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P21731

    ProtoNet protein and cluster: P21731

    1 Blocks protein domain: IPB001105 Thromboxane receptor signature

    UniProtKB/Swiss-Prot: TA2R_HUMAN, P21731
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with TBXA2R           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TA2R_HUMAN, P21731
    Function: Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this
    receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the
    kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase
    C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase

         Genatlas biochemistry entry for TBXA2R:
    thromboxane A2 receptor (platelet,placenta,lung,megakaryocyte), G protein coupled receptor superfamily

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004960thromboxane receptor activity ----
    GO:0004961thromboxane A2 receptor activity TAS8119956
    GO:0005085guanyl-nucleotide exchange factor activity TAS--
    GO:0005515protein binding IPI17644091
         
    Find genes that share ontologies with TBXA2R           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tbxa2r):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     reproductive system  respiratory system 

    Find genes that share phenotypes with TBXA2R           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TBXA2R: Tbxa2rtm1Cof Tbxa2rtm1Sna

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBXA2R
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TBXA2R

    miRNA
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    miRTarBase miRNAs that target TBXA2R:
    hsa-mir-124-3p (MIRT022135)

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    hsa-miR-31 hsa-miR-182 hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmidTBXA2R 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBXA2R


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TA2R_HUMAN, P21731: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS1825698
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with TBXA2R           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TBXA2R About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Eicosanoid ligand-binding receptors
    Eicosanoid ligand-binding receptors0.31
    Prostanoid ligand receptors0.00
    Small Ligand GPCRs0.31
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5ADP signalling through P2Y purinoceptor 12
    Signal amplification0.79
    Thromboxane signalling through TP receptor0.79


    Find genes that share SuperPaths with TBXA2R           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TBXA2R
        G12-G13 in Cellular Signaling

    1 GeneGo (Thomson Reuters) Pathway for TBXA2R
        Cell adhesion Integrin inside-out signaling

    2 BioSystems Pathways for TBXA2R
        GPCRs, Class A Rhodopsin-like
    Small Ligand GPCRs

    4 Reactome Pathways for TBXA2R
        Prostanoid ligand receptors
    G alpha (12/13) signalling events
    G alpha (q) signalling events
    Thromboxane signalling through TP receptor

    2 PharmGKB Pathways for TBXA2R
        Celecoxib Pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for TBXA2R):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including TBXA2R: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TBXA2R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TBXA2R (P217311, 2, 3 ENSP000003643364) via UniProtKB, MINT, STRING, and/or I2D (see all 155)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRDX4Q131621, 2, 3, ENSP000003686464EBI-2625082,EBI-2211957 MINT-4981021 MINT-4980999 MINT-4980980 MINT-4981047 I2D: score=1 STRING: ENSP00000368646
    NME2P223923, ENSP000003655724I2D: score=2 STRING: ENSP00000365572
    GNAQP501483, ENSP000002865484I2D: score=3 STRING: ENSP00000286548
    GPRASP1Q5JY773, ENSP000003551464I2D: score=2 STRING: ENSP00000355146
    GRK6P432503, ENSP000003772044I2D: score=2 STRING: ENSP00000377204
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    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0007186G-protein coupled receptor signaling pathway TAS1825698
    GO:0007204positive regulation of cytosolic calcium ion concentration IEA--
    GO:0007584response to nutrient IEA--
    GO:0007596blood coagulation TAS--

    Find genes that share ontologies with TBXA2R           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for TBXA2R
      Browse compounds at ApexBio 

    Compounds for TBXA2R available from Tocris Bioscience    About this table
    CompoundAction CAS #
    IloprostProstacyclin (PGI2) analog[78919-13-8]
    L-798,106 Potent and highly selective EP3 antagonist[244101-02-8]
    U 46619 Potent, stable thromboxane A2 (TP) receptor agonist [56985-40-1]
    Prostaglandin E2Major endogenous prostanoid[363-24-6]
    L-161,982 Selective EP4 receptor antagonist[147776-06-5]

    3 HMDB Compounds for TBXA2R    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ThromboxaneThromboxane A2 66719-58-2--
    Thromboxane A2(1S-(1alpha,3alpha,3R*),4beta(Z),5alpha)-7-(3-(3-hydroxy-1-octenyl)-2,6-dioxabicyclo(3.1.1)hept-4-yl)-5-Heptenoate (see all 25)57576-52-0--

    1 DrugBank Compound for TBXA2R    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ridogrel-- 110140-89-1targetantagonist10522750 8289199 9272380 8697470 8831771 11752352

    Selected IUPHAR Ligands for TBXA2R (TP receptor) (see all 38)    About this table
    LigandTypeActionAffinityPubmed IDs
    ifetroban
    AntagonistAntagonist8.4 - 108437108
    S-145
    AntagonistAntagonist9.61833018
    GR 32191
    AntagonistAntagonist8.3 - 9.42527074 8242228
    I-SAP
    AntagonistAntagonist9.331386885
    I-BOP
    AgonistAgonist8.94 - 9.321830308
    [125I]SAP
    AntagonistAntagonist7.7 - 9.31386885
    SQ-29548
    AntagonistAntagonist8.1 - 9.116604093 10634944 2975605
    KW-3635
    AntagonistAntagonist8.91434130
    [3H]S-145
    AntagonistAntagonist8.91825698
    ONO 3708
    AntagonistAntagonist7.4 - 8.93008368

    Selected Novoseek inferred chemical compound relationships for TBXA2R gene (see all 65)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thromboxane a2 96.8 378 8454607 (4), 8894620 (4), 9724809 (4), 8289199 (3) (see all 99)
    i-bop 90.7 2 18950617 (2)
    sq 29548 90 6 11145933 (1), 9283691 (1), 10455315 (1), 18158556 (1) (see all 6)
    thromboxane 86.9 35 1963845 (2), 16250911 (2), 1451271 (2), 8220898 (2) (see all 27)
    gr 32191 86.6 6 11824652 (2), 7545124 (1), 8562396 (1), 9288512 (1) (see all 5)
    ramatroban 85 8 9870646 (2), 15091003 (1), 16418339 (1), 9296280 (1) (see all 7)
    seratrodast 81.9 2 11471861 (1), 12153692 (1)
    ridogrel 80.3 3 8831771 (1), 8289199 (1), 8697470 (1)
    picotamide 79 7 1963845 (2), 9754941 (2), 8725994 (1), 9058495 (1) (see all 5)
    prostaglandin-h2 77.7 7 18590695 (1), 1830100 (1), 1847490 (1), 1312024 (1) (see all 7)

    1 PharmGKB related drug/compound annotation for TBXA2R gene    About this table
    Drug/compound PharmGKB Annotation
    aspirinCA  



    Find genes that share compounds with TBXA2R           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TBXA2R gene (2 alternative transcripts): 
    NM_001060.5  NM_201636.2  

    Unigene Cluster for TBXA2R:

    Thromboxane A2 receptor
    Hs.442530  [show with all ESTs]
    Unigene Representative Sequence: NM_001060
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375190(uc002lyg.2) ENST00000589966 ENST00000411851(uc021umv.1)
    ENST00000587717
    miRNA
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    hsa-miR-31 hsa-miR-182 hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmidTBXA2R 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TBXA2R
      QuantiFast Probe-based Assays in human, mouse, rat TBXA2R

    Additional mRNA sequence: 

    AY429110.1 BC028027.1 BC074749.2 BC074750.2 BC121148.1 BC121149.2 U11271.1 U27325.1 

    2 DOTS entries:

    DT.409369  DT.100739466 

    Selected AceView cDNA sequences (see all 27):

    AY429110 NM_201636 BC028027 BC074750 BX101625 BC074749 NM_001060 AI521224 
    AI763284 AW027365 BV183824 U11271 BV199033 BV183823 BV199034 BM990145 
    U27325 BV183822 BV199029 BV199030 AW270991 BV199032 R82830 BX279611 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TBXA2R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCACCACA
    TBXA2R Expression
    About this image


    TBXA2R expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Heart (Cardiovascular System)
             Atrioventricular Node
    TBXA2R Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TBXA2R Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.442530
        Pathway & Disease-focused RT2 Profiler PCR Array including TBXA2R: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TBXA2R gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbxa2r1 , 5 thromboxane A2 receptor1, 5 77.61(n)1
    78.64(a)1
      10 (39.72 cM)5
    213901  NM_009325.41  NP_033351.11 
     813287325 
    chicken
    (Gallus gallus)
    Aves TBXA2R1 thromboxane A2 receptor 66.58(n)
    56.52(a)
      100857635  XM_003642841.2  XP_003642889.2 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.176682 Transcribed sequence with weak similarity to protein spP21731 (H.sapiens) TA2R_HUMAN Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor) less 70.8(n)    AL867786.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ptger1c6
    prostaglandin E receptor 1c (subtype EP1)
    34(a)
    many ↔ many
    3(53166628-53177685) ENSDARG00000078602


    ENSEMBL Gene Tree for TBXA2R (if available)
    TreeFam Gene Tree for TBXA2R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TBXA2R gene
    PTGER12  PTGDR2  PTGER42  PTGER32  PTGFR2  PTGER22  PTGIR2  
    6 SIMAP similar genes for TBXA2R using alignment to 5 protein entries:     TA2R_HUMAN (see all proteins):
    PTGFR    EP3-I    EP3-VI    EP3f    PTGER3    PTGER4

    Find genes that share paralogs with TBXA2R           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TBXA2R (see all 539)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs343770971,2,,4
    CBleeding disorder, platelet-type 13 (BDPLT13)4 other13524996(-) CACGCG/TCTCCT 4 R L mis12Minor allele frequency- T:0.00NA 4
    rs3684642591,2
    C--3364692(+) TTTTT-/TAT   
      TTTTTA
    ATTTT
    2 -- int10--------
    rs129809481,2
    C,F,A--3364693(+) tttttA/Tttttt 2 -- int15Minor allele frequency- T:0.42NS 184
    rs1511342281,2
    C--3364693(+) TTTTT-/ATT   
       TTTTA
    TTTTT
    2 -- int10--------
    rs352303571,2
    C,F--3369796(-) GGGAA-/ACCAAG 2 -- int16Minor allele frequency- A:0.33NS NA 176
    rs1509515221,2
    --3518575(+) TGGCAC/TTACAG 2 -- ds50010--------
    rs344648791,2
    C,F--3518583(-) GCGGGC/TGCCTG 2 -- ds50015Minor allele frequency- T:0.01NS 190
    rs72557141,2
    C--3518611(+) tttttG/Ttttgt 2 -- ds50010--------
    rs356112591,2
    C,F--3518638(-) TCAAA-/AAAC/ 
    AAACAAAC
    AAACA
    2 -- ds50015NS 190
    rs1864061291,2
    --3518639(+) TGTTTG/TTTGAG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for TBXA2R (3594504 - 3606838 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TBXA2R (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717952CNV Deletion23290073
    esv2717950CNV Deletion23290073
    esv2717953CNV Deletion23290073
    nsv910763CNV Loss21882294
    nsv833713CNV Loss17160897
    nsv910752CNV Loss21882294
    dgv3652n71CNV Loss21882294
    nsv910723CNV Loss21882294
    dgv3660n71CNV Loss21882294
    nsv910764CNV Loss21882294

    Human Gene Mutation Database (HGMD): TBXA2R
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TBXA2R
    DNA2.0 Custom Variant and Variant Library Synthesis for TBXA2R

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 188070   
    OMIM disorders: 614009  
    UniProtKB/Swiss-Prot: TA2R_HUMAN, P21731
  • Bleeding disorder, platelet-type 13 (BDPLT13) [MIM:614009]: A disorder characterized by reduced platelet
    aggregation and a tendency to mild mucocutaneous bleeding. Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry

  • 7 diseases for TBXA2R:    
    About MalaCards
    bleeding disorder, platelet-type, 13    dowling-degos disease 1    dowling-degos disease    degos disease
    gilles de la tourette syndrome    atopy    essential hypertension

    1 disease from the University of Copenhagen DISEASES database for TBXA2R:
    Asthma

    Find genes that share disorders with TBXA2R           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TBXA2R gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroleukemia 48.7 1 8594318 (1)
    asthma 36.6 13 12897758 (1), 15898979 (1), 9324703 (1), 8950952 (1) (see all 12)
    rhinitis allergic perennial 30.1 2 9870646 (2)
    astrocytoma 24.8 5 1534919 (2), 10482287 (1), 7620818 (1), 8632356 (1)
    restenosis 23.9 2 1833088 (1), 7586303 (1)
    allergic rhinitis 17 1 16418339 (1)
    atopy 10.8 2 12897758 (1), 18031559 (1)
    coagulopathy 2.45 2 9184416 (1), 7929844 (1)
    tumors 0.491 1 8894620 (1)
    cardiovascular diseases 0 1 7974982 (1)

    Genatlas disease: TBXA2R
    bleeding diathesis with platelet unresponsiveness to thromboxane A2

    Genetic Association Database (GAD): TBXA2R
    Human Genome Epidemiology (HuGE) Navigator: TBXA2R (18 documents)

    Export disorders for TBXA2R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TBXA2R gene, integrated from 10 sources (see all 326):
    (articles sorted by number of sources associating them with TBXA2R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of cDNA for a human thromboxane A2 receptor. (PubMed id 1825698)1, 2, 3, 9 Hirata M.... Narumiya S. (Nature 1991)
    2. Association of polymorphisms in thromboxane A2 receptor and thromboxane A synthase 1 with cerebral infarction in a Korean population. (PubMed id 19403042)1, 4, 9 Park S.A....Shin H.D. (BMB Rep 2009)
    3. Cloning and pharmacologic characterization of a thromboxane A2 receptor from K562 (human chronic myelogenous leukemia) cells. (PubMed id 7965765)1, 2, 9 D'Angelo D.D.... Dorn G.W. II (J. Pharmacol. Exp. Ther. 1994)
    4. TBXA2R gene polymorphism and responsiveness to leukotriene receptor antagonist in children with asthma. (PubMed id 18031559)1, 4, 9 Kim J.H....Hong S.J. (Clin. Exp. Allergy 2008)
    5. Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma. (PubMed id 15898979)1, 4, 9 Kim S.H....Shin H.D. (Clin. Exp. Allergy 2005)
    6. Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation. (PubMed id 8613548)1, 2, 9 Hirata T.... Narumiya S. (J. Clin. Invest. 1996)
    7. Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder. (PubMed id 7929844)1, 2, 9 Hirata T.... Narumiya S. (J. Clin. Invest. 1994)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Replication of genetic association studies in asthma and related phenotypes. (PubMed id 20395963)1, 4 Undarmaa S....Suzuki Y. (J. Hum. Genet. 2010)
    10. Thromboxane A2-induced signal transduction is negatively regulated by KIAA1005 that directly interacts with thromboxane A2 receptor. (PubMed id 19464661)1, 2 Tokue S.... Nakahata N. (Prostaglandins Other Lipid Mediat. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6915 HGNC: 11608 AceView: TBXA2R Ensembl:ENSG00000006638 euGenes: HUgn6915
    ECgene: TBXA2R Kegg: 6915 H-InvDB: TBXA2R

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TBXA2R Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tbxa2r/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TBXA2R gene:
    Search GeneIP for patents involving TBXA2R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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