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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TBXA2R Gene

protein-coding   GIFtS: 67
GCID: GC19M003594

Thromboxane A2 Receptor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Thromboxane A2 Receptor1 2
Prostanoid TP Receptor2 3
TXA2-R2 3
BDPLT132

External Ids:    HGNC: 116081   Entrez Gene: 69152   Ensembl: ENSG000000066387   OMIM: 1880705   UniProtKB: P217313   

Export aliases for TBXA2R gene to outside databases

Previous GC identifers: GC19M003687 GC19M003664 GC19M003534 GC19M003545 GC19M003359


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TBXA2R Gene:
This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to
induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder.
Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct
2009)

GeneCards Summary for TBXA2R Gene: 
TBXA2R (thromboxane A2 receptor) is a protein-coding gene. Diseases associated with TBXA2R include gilles de la tourette syndrome, and rhinitis, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Eicosanoid ligand-binding receptors. GO annotations related to this gene include thromboxane A2 receptor activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is PTGER1.

UniProtKB/Swiss-Prot: TA2R_HUMAN, P21731
Function: Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this
receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the
kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase
C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase

summary for TBXA2R Gene:
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2,
prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which
the other prostaglandins are synthesized. Prostanoid receptors are a family of nine G-protein-coupled
receptors that have distinct tissue distributions and actions. TP receptors can be coupled to both Galphaq
and Galphai. They are expressed abundantly in highly vascular tissues such as the kidney and heart, and
immune-related organs such as the thymus and spleen. They mediate smooth muscle contraction and platelet
aggregation.

Gene Wiki entry for TBXA2R (Thromboxane receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TBXA2R gene promoter:
         LCR-F1   PPAR-alpha   HEN1   CREB   PPAR-gamma1   deltaCREB   PPAR-gamma2   Meis-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBXA2R promoter sequence
   Search SABiosciences Chromatin IP Primers for TBXA2R

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBXA2R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

TBXA2R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBXA2R gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M003594:  view genomic region     (about GC identifiers)

Start:
3,594,504 bp from pter      End:
3,606,838 bp from pter
Size:
12,335 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TA2R_HUMAN, P21731 (See protein sequence)
Recommended Name: Thromboxane A2 receptor  
Size: 343 amino acids; 37431 Da
Subunit: Interacts with RPGRIP1L. Interacts with PSMA3. Interacts with GNB2L1/RACK1; the interaction regulates
TBXA2R cell surface expression
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAA58957.1; Type=Frameshift; Positions=329;
1 PDB 3D structure from and Proteopedia for TBXA2R:
1LBN (3D)    
Secondary accessions: O75228 Q6DK52 Q9UCY1 Q9UCY2
Alternative splicing: 2 isoforms:  P21731-3   P21731-2   (Ref.2 (AAA58957) sequence differs from that shown due to frameshifts in positions 330 and 386)

Explore the universe of human proteins at neXtProt for TBXA2R: NX_P21731

Explore proteomics data for TBXA2R at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P21731

  • TBXA2R Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TBXA2R Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001051.1  NP_963998.2  

    ENSEMBL proteins: 
     ENSP00000364336   ENSP00000468145   ENSP00000393333  
    Reactome Protein details: P21731
    Human Recombinant Protein Products for TBXA2R: 
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    Novus Biologicals TBXA2R Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS1825698
    GO:0016021integral to membrane ----

    TBXA2R for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PTGR: GPCR / Class A : Prostanoid receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: TP receptor 
    Prostanoid receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR008365 Prostanoid_rcpt
     IPR001105 Thbox_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P21731

    ProtoNet protein and cluster: P21731

    1 Blocks protein domain: IPB001105 Thromboxane receptor signature

    UniProtKB/Swiss-Prot: TA2R_HUMAN, P21731
    Similarity: Belongs to the G-protein coupled receptor 1 family


    TBXA2R for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TA2R_HUMAN, P21731
    Function: Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this
    receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the
    kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase
    C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase

         Genatlas biochemistry entry for TBXA2R:
    thromboxane A2 receptor (platelet,placenta,lung,megakaryocyte), G protein coupled receptor superfamily

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004960thromboxane receptor activity ----
    GO:0004961thromboxane A2 receptor activity TAS8119956
    GO:0005085guanyl-nucleotide exchange factor activity TAS--
    GO:0005515protein binding IPI17644091
         
    TBXA2R for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tbxa2r):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     reproductive system  respiratory system 

    TBXA2R for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TBXA2R: Tbxa2rtm1Cof Tbxa2rtm1Sna

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TBXA2R 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TBXA2R 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TBXA2R 

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate TBXA2R:
    hsa-miR-31 hsa-miR-182 hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmidTBXA2R 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBXA2R


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TBXA2R About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    2Prostanoid ligand receptors
    Prostanoid ligand receptors0.60
    Small Ligand GPCRs0.40
    Eicosanoid ligand-binding receptors0.60
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    4G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5Thromboxane signalling through TP receptor
    Signal amplification0.78
    Thromboxane signalling through TP receptor0.78

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TBXA2R
        Cell adhesion Integrin inside-out signaling

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TBXA2R
        G12-G13 in Cellular Signaling

    1 GeneGo (Thomson Reuters) Pathway for TBXA2R
        Cell adhesion Integrin inside-out signaling

    2 BioSystems Pathways for TBXA2R
        GPCRs, Class A Rhodopsin-like
    Small Ligand GPCRs

    5/14        Reactome Pathways for TBXA2R (see all 14)
        GPCR downstream signaling
    Hemostasis
    Eicosanoid ligand-binding receptors
    G alpha (12/13) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK

    2 PharmGKB Pathways for TBXA2R
        Celecoxib Pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for TBXA2R):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction


    TBXA2R for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TBXA2R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/154 Interacting proteins for TBXA2R (P217312, 3 ENSP000003643364) via UniProtKB, MINT, STRING, and/or I2D (see all 154)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRDX4Q131622, 3, ENSP000003686464MINT-4981021 MINT-4980999 MINT-4980980 MINT-4981047 I2D: score=1 STRING: ENSP00000368646
    GNAQP501483, ENSP000002865484I2D: score=3 STRING: ENSP00000286548
    GPRASP1Q5JY773, ENSP000003551464I2D: score=2 STRING: ENSP00000355146
    GRK6P432503, ENSP000003772044I2D: score=2 STRING: ENSP00000377204
    NME2P223923, ENSP000003655724I2D: score=2 STRING: ENSP00000365572
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0007186G-protein coupled receptor signaling pathway TAS1825698
    GO:0007204elevation of cytosolic calcium ion concentration IEA--
    GO:0007584response to nutrient IEA--
    GO:0007596blood coagulation TAS--

    TBXA2R for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TBXA2R for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for TBXA2R

    Compounds for TBXA2R available from Tocris Bioscience    About this table
    CompoundAction CAS #
    IloprostProstacyclin (PGI2) analog[78919-13-8]
    L-798,106 Potent and highly selective EP3 antagonist[244101-02-8]
    U 46619 Potent, stable thromboxane A2 (TP) receptor agonist [56985-40-1]
    Prostaglandin E2Major endogenous prostanoid[363-24-6]
    L-161,982 Selective EP4 receptor antagonist[147776-06-5]

    3 HMDB Compounds for TBXA2R    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ThromboxaneThromboxane A2 66719-58-2--
    Thromboxane A2(1S-(1alpha,3alpha,3R*),4beta(Z),5alpha)-7-(3-(3-hydroxy-1-octenyl)-2,6-dioxabicyclo(3.1.1)hept-4-yl)-5-Heptenoate (see all 25)57576-52-0--

    1 DrugBank Compound for TBXA2R    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ridogrel-- 110140-89-1targetantagonist10522750 8289199 9272380 8697470 8831771 11752352

    10/38 IUPHAR Ligands for TBXA2R (TP receptor) (see all 38)    About this table 
    LigandTypeActionAffinityPubmed IDs
    ifetroban
    AntagonistAntagonist8.4 - 108437108
    S-145
    AntagonistAntagonist9.61833018
    GR 32191
    AntagonistAntagonist8.3 - 9.42527074 8242228
    I-SAP
    AntagonistAntagonist9.331386885
    I-BOP
    AgonistAgonist8.94 - 9.321830308
    [125I]SAP
    AntagonistAntagonist7.7 - 9.31386885
    SQ-29548
    AntagonistAntagonist8.1 - 9.116604093 10634944 2975605
    KW-3635
    AntagonistAntagonist8.91434130
    [3H]S-145
    AntagonistAntagonist8.91825698
    ONO 3708
    AntagonistAntagonist7.4 - 8.93008368

    10/65 Novoseek inferred chemical compound relationships for TBXA2R gene (see all 65)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thromboxane a2 96.8 378 8454607 (4), 8894620 (4), 9724809 (4), 8289199 (3) (see all 99)
    i-bop 90.7 2 18950617 (2)
    sq 29548 90 6 11145933 (1), 9283691 (1), 10455315 (1), 18158556 (1) (see all 6)
    thromboxane 86.9 35 1963845 (2), 16250911 (2), 1451271 (2), 8220898 (2) (see all 27)
    gr 32191 86.6 6 11824652 (2), 7545124 (1), 8562396 (1), 9288512 (1) (see all 5)
    ramatroban 85 8 9870646 (2), 15091003 (1), 16418339 (1), 9296280 (1) (see all 7)
    seratrodast 81.9 2 11471861 (1), 12153692 (1)
    ridogrel 80.3 3 8831771 (1), 8289199 (1), 8697470 (1)
    picotamide 79 7 1963845 (2), 9754941 (2), 8725994 (1), 9058495 (1) (see all 5)
    prostaglandin-h2 77.7 7 18590695 (1), 1830100 (1), 1847490 (1), 1312024 (1) (see all 7)

    1 PharmGKB related drug/compound annotation for TBXA2R gene    About this table
    Drug/compound PharmGKB Annotation
    aspirinCA  

    Search CenterWatch for drugs/clinical trials and news about TBXA2R / TA2R

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for TBXA2R gene (2 alternative transcripts): 
    NM_001060.5  NM_201636.2  

    Unigene Cluster for TBXA2R:

    Thromboxane A2 receptor
    Hs.442530  [show with all ESTs]
    Unigene Representative Sequence: NM_001060
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375190(uc002lyg.2) ENST00000589966 ENST00000411851(uc021umv.1)
    ENST00000587717
    miRNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBXA2R
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBXA2R
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBXA2R
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    Additional mRNA sequence: 

    AY429110.1 BC028027.1 BC074749.2 BC074750.2 BC121148.1 BC121149.2 U11271.1 U27325.1 

    2 DOTS entries:

    DT.409369  DT.100739466 

    24/27 AceView cDNA sequences (see all 27):

    BC074749 BX101625 NM_001060 BC028027 NM_201636 AY429110 BC074750 AI521224 
    BV199032 BV199029 AW027365 BV183824 BM990145 BV183823 BV199030 AI763284 
    AW270991 BV199034 U27325 BV183822 BV199033 U11271 AA039960 BX279611 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TBXA2R expression in normal human tissues (normalized intensities)      TBXA2R embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCACCACA
    TBXA2R Expression
    About this image


    TBXA2R expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     Blood (Hematopoietic System)
             platelets   
     
     Brain (Nervous System)
             Human Brain Vascular Pericyte (HBVP)   

    See TBXA2R Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TBXA2R

    SOURCE GeneReport for Unigene cluster: Hs.442530
        SABiosciences Expression via Pathway-Focused PCR Array including TBXA2R: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TBXA2R gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbxa2r1 , 5 thromboxane A2 receptor1, 5 77.81(n)1
    78.64(a)1
      10 (39.72 cM)5
    213901  NM_009325.31  NP_033351.11 
     813287325 
    chicken
    (Gallus gallus)
    Aves LOC1008576351 thromboxane A2 receptor-like 68.75(n)
    59.52(a)
      100857635  XM_003642841.1  XP_003642889.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.176682 Transcribed sequence with weak similarity to protein more 70.8(n)    AL867786.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74976
    --
    17(a)
    1 → many
    3L(17626549-17630975)


    ENSEMBL Gene Tree for TBXA2R (if available)
    TreeFam Gene Tree for TBXA2R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TBXA2R gene
    PTGER12  PTGDR2  PTGER42  PTGFR2  PTGER32  PTGER22  PTGIR2  
    10 SIMAP similar genes for TBXA2R using alignment to 5 protein entries:     TA2R_HUMAN (see all proteins):
    PTGFR    EP3-I    EP3-III    EP3-IV    EP3-V    EP3-VI
    EP3e    EP3f    PTGER3    PTGER4

    TBXA2R for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/539 SNPs in TBXA2R are shown (see all 539)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs343770971,2,4
    CBleeding disorder, platelet-type 13 (BDPLT13)4 other13524996(-) CACGCG/TCTCCT 4 R L mis12Minor allele frequency- T:0.00NA 4
    rs3684642591,2
    C--3364692(+) TTTTT-/TAT   
      TTTTTA
    ATTTT
    2 -- int10--------
    rs129809481,2
    C,F,A--3364693(+) tttttA/Tttttt 2 -- int15Minor allele frequency- T:0.42NS 184
    rs1511342281,2
    C--3364693(+) TTTTT-/ATT   
       TTTTA
    TTTTT
    2 -- int10--------
    rs352303571,2
    C,F--3369796(-) GGGAA-/ACCAAG 2 -- int16Minor allele frequency- A:0.33NS NA 176
    rs1509515221,2
    --3518575(+) TGGCAC/TTACAG 2 -- ds50010--------
    rs344648791,2
    C,F--3518583(-) GCGGGC/TGCCTG 2 -- ds50015Minor allele frequency- T:0.01NS 190
    rs72557141,2
    C--3518611(+) tttttG/Ttttgt 2 -- ds50010--------
    rs356112591,2
    C,F--3518638(-) TCAAA-/AAAC/ 
    AAACAAAC
    AAACA
    2 -- ds50015NS 190
    rs1864061291,2
    --3518639(+) TGTTTG/TTTGAG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for TBXA2R (3594504 - 3606838 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for TBXA2R (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2717952CNV Deletion23290073
    esv2717950CNV Deletion23290073
    esv2717953CNV Deletion23290073
    nsv910763CNV Loss21882294
    nsv833713CNV Loss17160897
    nsv910752CNV Loss21882294
    dgv3652n71CNV Loss21882294
    nsv910723CNV Loss21882294
    dgv3660n71CNV Loss21882294
    nsv910764CNV Loss21882294


    Human Gene Mutation Database (HGMD): TBXA2R
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 188070    OMIM disorders: --

    UniProtKB/Swiss-Prot: TA2R_HUMAN, P21731
  • Bleeding disorder, platelet-type 13 (BDPLT13) [MIM:614009]: A disorder characterized by reduced platelet
    aggregation and a tendency to mild mucocutaneous bleeding. Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry

  • 20/35 diseases for TBXA2R (see all 35):    About MalaCards
    gilles de la tourette syndrome    rhinitis    atopy    t cell deficiency
    allergic rhinitis    congestive heart failure    otitis media    thrombocytosis
    cerebral infarction    urticaria    essential hypertension    rabies
    astrocytoma    hypertension    thromboembolism    asthma
    atopic dermatitis    blindness    thrombosis    dermatitis

    1 disease from the University of Copenhagen DISEASES database for TBXA2R:
    Asthma

    TBXA2R for disorders           About GeneDecksing

    10/21 Novoseek inferred disease relationships for TBXA2R gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroleukemia 48.7 1 8594318 (1)
    asthma 36.6 13 12897758 (1), 15898979 (1), 9324703 (1), 8950952 (1) (see all 12)
    rhinitis allergic perennial 30.1 2 9870646 (2)
    astrocytoma 24.8 5 1534919 (2), 10482287 (1), 7620818 (1), 8632356 (1)
    restenosis 23.9 2 1833088 (1), 7586303 (1)
    allergic rhinitis 17 1 16418339 (1)
    atopy 10.8 2 12897758 (1), 18031559 (1)
    coagulopathy 2.45 2 9184416 (1), 7929844 (1)
    tumors 0.491 1 8894620 (1)
    cardiovascular diseases 0 1 7974982 (1)

    Genatlas disease: TBXA2R
    bleeding diathesis with platelet unresponsiveness to thromboxane A2

    Genetic Association Database (GAD): TBXA2R
    Human Genome Epidemiology (HuGE) Navigator: TBXA2R (18 documents)

    Export disorders for TBXA2R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TBXA2R gene, integrated from 9 sources (see all 312):
    (articles sorted by number of sources associating them with TBXA2R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of cDNA for a human thromboxane A2 receptor. (PubMed id 1825698)1, 2, 3, 9 Hirata M.... Narumiya S. (1991)
    2. Association of polymorphisms in thromboxane A2 receptor and thromboxane A synthase 1 with cerebral infarction in a Korean population. (PubMed id 19403042)1, 4, 9 Park S.A....Shin H.D. (2009)
    3. Cloning and pharmacologic characterization of a thromboxane A2 receptor from K562 (human chronic myelogenous leukemia) cells. (PubMed id 7965765)1, 2, 9 D'Angelo D.D.... Dorn G.W. II (1994)
    4. TBXA2R gene polymorphism and responsiveness to leukotriene receptor antagonist in children with asthma. (PubMed id 18031559)1, 4, 9 Kim J.H....Hong S.J. (2008)
    5. Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma. (PubMed id 15898979)1, 4, 9 Kim S.H....Shin H.D. (2005)
    6. Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation. (PubMed id 8613548)1, 2, 9 Hirata T.... Narumiya S. (1996)
    7. Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder. (PubMed id 7929844)1, 2, 9 Hirata T.... Narumiya S. (1994)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Replication of genetic association studies in asthma and related phenotypes. (PubMed id 20395963)1, 4 Undarmaa S....Suzuki Y. (2010)
    10. Thromboxane A2-induced signal transduction is negatively regulated by KIAA1005 that directly interacts with thromboxane A2 receptor. (PubMed id 19464661)1, 2 Tokue S.... Nakahata N. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6915 HGNC: 11608 AceView: TBXA2R Ensembl:ENSG00000006638 euGenes: HUgn6915
    ECgene: TBXA2R Kegg: 6915 H-InvDB: TBXA2R

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TBXA2R Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tbxa2r/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TBXA2R gene:
    Search GeneIP for patents involving TBXA2R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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