TBXA2R Gene
protein-coding GIFtS: 67
GCID: GC19M003594
|
|
thromboxane A2 receptor
| |
Aliases
for TBXA2R gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Thromboxane A2 Receptor1 2 | | Prostanoid TP Receptor2 3 | | TXA2-R2 3 | | BDPLT132 |
Export aliases for TBXA2R gene to outside databasesPrevious GC identifers: GC19M003687 GC19M003664 GC19M003534 GC19M003545 GC19M003359 |
Summaries
for TBXA2R gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TBXA2R:
This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 toinduce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multipletranscript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2009)
UniProtKB/Swiss-Prot: TA2R_HUMAN, P21731Function: Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of thisreceptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In thekidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C.Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase
 summary
for TBXA2R: Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2,
prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which
the other prostaglandins are synthesized. Prostanoid receptors are a family of nine G-protein-coupled
receptors that have distinct tissue distributions and actions. TP receptors can be coupled to both Galphaq
and Galphai. They are expressed abundantly in highly vascular tissues such as the kidney and heart, and
immune-related organs such as the thymus and spleen. They mediate smooth muscle contraction and platelet
aggregation.
Gene Wiki entry for TBXA2R (Thromboxane receptor)
|
Genomic Views
for TBXA2R gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TBXA2R gene promoter:
LCR-F1 PPAR-alpha HEN1 CREB PPAR-gamma1 deltaCREB PPAR-gamma2 Meis-1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for TBXA2R
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBXA2R |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3TBXA2R Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M003594: view genomic region
(about GC identifiers)
Start:
|
3,594,504 bp from pter |
End:
|
3,606,838 bp from pter |
Size:
|
12,335 bases |
Orientation:
|
minus strand |
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Proteins
for TBXA2R gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TA2R_HUMAN, P21731 (See
protein sequence)Recommended Name: Thromboxane A2 receptor Size: 343 amino acids; 37431 Da
Subunit: Interacts with RPGRIP1L. Interacts with PSMA3. Interacts with GNB2L1/RACK1; the interaction regulates TBXA2Rcell surface expression
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAA58957.1; Type=Frameshift; Positions=329;
1 PDB 3D structure from  and Proteopedia  for TBXA2R:1LBN (3D)
Secondary accessions: O75228 Q6DK52 Q9UCY1 Q9UCY2Alternative splicing: 2 isoforms: P21731-3 P21731-2 (Ref.2 (AAA58957) sequence differs from that shown due to frameshifts in positions 330 and 386)Explore the universe of human proteins at neXtProt for TBXA2R: NX_P21731
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P21731
TBXA2R Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001051.1 NP_963998.2
ENSEMBL proteins: ENSP00000364336 ENSP00000468145 ENSP00000393333 Reactome Protein details: P21731
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TBXA2R for ontologies About GeneDecksing
TBXA2R Antibody Products:
Assay Products for TBXA2R: |
Protein
Domains /
Families
for TBXA2R gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TBXA2R for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P21731ProtoNet protein and cluster: P21731 1 Blocks protein family: IPB001105 Thromboxane receptor signature
UniProtKB/Swiss-Prot: TA2R_HUMAN, P21731Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for TBXA2R gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TA2R_HUMAN, P21731Function: Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of thisreceptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In thekidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C.Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase Genatlas biochemistry entry for TBXA2R:thromboxane A2 receptor (platelet,placenta,lung,megakaryocyte), G protein coupled receptor superfamily
Clone
Products: |  | EMD Millipore Clones for the Expression of TBXA2R | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBXA2R (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBXA2R (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TBXA2R (NM_001060) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBXA2R | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBXA2R |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBXA2R |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
TBXA2R for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for TBXA2R: Tbxa2rtm1Cof Tbxa2rtm1Sna
7 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Tbxa2r):
TBXA2R for phenotypes About GeneDecksing
|
Pathways & Interactions
for TBXA2R gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Prostanoid ligand receptors | | | 3 | Signaling by GPCR | | | 4 | Cell adhesion_Integrin inside-out signaling | | | 5 | Platelet activation, signaling and aggregation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for TBXA2R
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TBXA2R
1  GeneGo (Thomson Reuters) Pathway for TBXA2R
2  BioSystems Pathways for TBXA2R
5/14 
Reactome Pathways for TBXA2R (see all 14)
2  PharmGKB Pathways for TBXA2R
2 
Kegg Pathways (Kegg details for TBXA2R):
TBXA2R for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TBXA2R
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/155 Interacting proteins for TBXA2R (P217312, 3 ENSP000003643364) via UniProtKB, MINT, STRING, and/or I2D (see all 155)About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table
TBXA2R for ontologies About GeneDecksing
|
Drugs & Compounds
for TBXA2R gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TBXA2R for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for TBXA2R |
Compounds for TBXA2R available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| BAY-u 3405 | Dual TP/DP2 (CRTH2) receptor antagonist | [116649-85-5] | | U 46619 | Potent, stable thromboxane A2 (TP) receptor agonist | [56985-40-1] | | ICI 192,605 | Potent thromboxane A2/TP receptor antagonist | [117621-64-4] | | AA 2414 | Thromboxane A2 (TP) receptor antagonist | [112665-43-7] |
3 HMDB Compounds for TBXA2R About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Calcium | Ca (see all 2) | 7440-70-2 | -- | | Thromboxane | Thromboxane A2 | 66719-58-2 | -- | | Thromboxane A2 | (1S-(1alpha,3alpha,3R*),4beta(Z),5alpha)-7-(3-(3-hydroxy-1-octenyl)-2,6-dioxabicyclo(3.1.1)hept-4-yl)-5-Heptenoate (see all 25) | 57576-52-0 | -- |
1 DrugBank Compound for TBXA2R About this table
10/65 Novoseek chemical compound relationships for TBXA2R gene (see all 65) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| thromboxane a2 |
96.8 |
378 |
8454607 (4), 8894620 (4), 9724809 (4), 8289199 (3) (see all 99) |
| i-bop |
90.7 |
2 |
18950617 (2) |
| sq 29548 |
90 |
6 |
11145933 (1), 9283691 (1), 10455315 (1), 18158556 (1) (see all 6) |
| thromboxane |
86.9 |
35 |
1963845 (2), 16250911 (2), 1451271 (2), 8220898 (2) (see all 27) |
| gr 32191 |
86.6 |
6 |
11824652 (2), 7545124 (1), 8562396 (1), 9288512 (1) (see all 5) |
| ramatroban |
85 |
8 |
9870646 (2), 15091003 (1), 16418339 (1), 9296280 (1) (see all 7) |
| seratrodast |
81.9 |
2 |
11471861 (1), 12153692 (1) |
| ridogrel |
80.3 |
3 |
8831771 (1), 8289199 (1), 8697470 (1) |
| picotamide |
79 |
7 |
1963845 (2), 9754941 (2), 8725994 (1), 9058495 (1) (see all 5) |
| prostaglandin-h2 |
77.7 |
7 |
18590695 (1), 1830100 (1), 1847490 (1), 1312024 (1) (see all 7) |
Search CenterWatch for drugs/clinical trials and news about TBXA2R / TA2R
|
Transcripts
for TBXA2R gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TBXA2R gene (2 alternative transcripts): NM_001060.5 NM_201636.2 Unigene Cluster for TBXA2R: Thromboxane A2 receptor Hs.442530 [show with all ESTs]Unigene Representative Sequence: NM_0010604 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000375190(uc002lyg.2) ENST00000589966 ENST00000411851(uc021umv.1)
ENST00000587717
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBXA2R (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBXA2R (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TBXA2R (NM_001060) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBXA2R | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBXA2R |
Additional cDNA sequence: AY429110.1 BC028027.1 BC074749.2 BC074750.2 BC121148.1 BC121149.2 U11271.1 U27325.1 2 DOTS entries: DT.409369 DT.100739466 24/27 AceView cDNA sequences (see all 27): BX101625 BC074750 NM_001060 NM_201636 AI521224 AY429110 BC074749 BC028027 BV199033 BV199030 BV183824 BV199029 BV199034 BM990145 U11271 BV183823 AW027365 AW270991 BV199032 U27325 BV183822 AI763284 BX279611 R82830
GeneLoc Exon Structure
|
Expression
for TBXA2R gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TBXA2R expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACCACCACA
About this image
See TBXA2R Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TBXA2R
SOURCE GeneReport for Unigene cluster: Hs.442530
SABiosciences Expression via Pathway-Focused PCR Array including TBXA2R:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBXA2R
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TBXA2R | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBXA2R | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBXA2R | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBXA2R |
Orthologs
for TBXA2R gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TBXA2R gene from 3/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC1008576351 |
thromboxane A2 receptor-like |
68.75(n)
59.52(a) |
|
100857635 XM_003642841.1 XP_003642889.1 |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.176682 |
Transcribed sequence with weak similarity to protein more |
70.8(n) |
|
AL867786.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG74976 |
-- |
16(a) |
possible ortholog |
3L(17626549-17630975) |
ENSEMBL Gene Tree for TBXA2R (if available)
TreeFam Gene Tree for TBXA2R (if available) |
Paralogs
for TBXA2R gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TBXA2R gene
- PTGDR2 PTGER12 PTGER42 PTGER32 PTGFR2 PTGER22 PTGIR2
10 SIMAP similar genes for TBXA2R using alignment to 5 protein entries: TA2R_HUMAN (see all proteins):PTGFR EP3-I EP3-III EP3-IV EP3-V EP3-VI
EP3e EP3f PTGER3 PTGER4
TBXA2R for paralogs About GeneDecksing
|
Genomic Variants
for TBXA2R gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TBXA2R (3594504 - 3606838 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TBXA2R
3 CNVs: 30067 30070 5073
Human Gene Mutation Database (HGMD): TBXA2R
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBXA2R |
|
Disorders
/ Diseases
for TBXA2R gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TBXA2R for disorders About GeneDecksing
OMIM gene information: 188070
OMIM disorders: --
UniProtKB/Swiss-Prot: TA2R_HUMAN, P21731
Defects in TBXA2R are the cause of susceptibility to bleeding disorder platelet-type 13 (BDPLT13)[MIM:614009]. BDPLT13 is a disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneousbleeding
20/40  diseases for TBXA2R (see all 40): About MalaCardsbleeding disorder gilles de la tourette syndrome allergic rhinitis congestive heart failure
otitis media tourette syndrome essential hypertension rhinitis
pulmonary function bronchial asthma atopic dermatitis epithelial ovarian cancer
atopy thrombocytosis cerebral infarction pulmonary hypertension
hypertension urticaria asthma dermatitis
1 disease from the University of Copenhagen DISEASES database for TBXA2R:Asthma 10/21 Novoseek disease relationships for TBXA2R gene (see all 21) About this table
Genatlas disease: TBXA2R bleeding diathesis with platelet unresponsiveness to thromboxane A2
Genetic Association Database (GAD): TBXA2R
Human Genome Epidemiology (HuGE) Navigator: TBXA2R (18 documents)
Export disorders for TBXA2R gene to outside databases
|
Publications
for TBXA2R gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TBXA2R gene, integrated from 9 sources (see all 305):
(articles sorted by number of sources associating them with TBXA2R) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and expression of cDNA for a human thromboxane A2 receptor. (PubMed id 1825698)1, 2, 3, 9 Hirata M.... Narumiya S. (1991)
- Cloning and pharmacologic characterization of a thromboxane A2 receptor from K562 (human chronic myelogenous leukemia) cells. (PubMed id 7965765)1, 2, 9 D'Angelo D.D.... Dorn G.W. II (1994)
- Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma. (PubMed id 15898979)1, 4, 9 Kim S.H....Shin H.D. (2005)
- Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation. (PubMed id 8613548)1, 2, 9 Hirata T.... Narumiya S. (1996)
- Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder. (PubMed id 7929844)1, 2, 9 Hirata T.... Narumiya S. (1994)
- Thromboxane A2-induced signal transduction is negatively regulated by KIAA1005 that directly interacts with thromboxane A2 receptor. (PubMed id 19464661)1, 2 Tokue S.... Nakahata N. (2009)
- RACK1 regulates the cell surface expression of the G protein-coupled receptor for thromboxane A(2). (PubMed id 18088317)1, 2 Parent A....Parent J.L. (2008)
- Low expression of cell-surface thromboxane A2 receptor beta-isoform through the negative regulation of its membrane traffic by proteasomes. (PubMed id 17499743)1, 2 Sasaki M....Nakahata N. (2007)
- IL-5 and thromboxane A2 receptor gene polymorphisms are associated with decreased pulmonary function in Korean children with atopic asthma. (PubMed id 15805995)1, 4 Hong S.J....Hong T.J. (2005)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
|
External Searches for TBXA2R gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TBXA2R gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBXA2R gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TBXA2R gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TBXA2R | Pharmacogenomics, SNPs, Pathways | | NIEHS-SNPs | http://egp.gs.washington.edu/data/tbxa2r/ |
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About This Section
| Patent Information for TBXA2R gene:
Search GeneIP for patents involving TBXA2R
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TBXA2R gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for TBXA2R | | OriGene shRNA RFP for TBXA2R | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TBXA2R | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBXA2R | | | OriGene Protein Over-expression Lysate for TBXA2R | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TBXA2R | | OriGene 3'-UTR Clone for TBXA2R | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBXA2R | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBXA2R | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TBXA2R | | OriGene Custom Protein Services for TBXA2R | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TBXA2R | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBXA2R | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBXA2R | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBXA2R | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBXA2R | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBXA2R |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBXA2R |
|  |  |  | | | | ThermoFisher Antibodies for TBXA2R |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBXA2R |
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