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Aliases for TBXA2R Gene

Aliases for TBXA2R Gene

  • Thromboxane A2 Receptor 2 3 5
  • Prostanoid TP Receptor 3 4
  • TXA2-R 3 4
  • BDPLT13 3

External Ids for TBXA2R Gene

Previous GeneCards Identifiers for TBXA2R Gene

  • GC19M003687
  • GC19M003664
  • GC19M003534
  • GC19M003545
  • GC19M003359

Summaries for TBXA2R Gene

Entrez Gene Summary for TBXA2R Gene

  • This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

GeneCards Summary for TBXA2R Gene

TBXA2R (Thromboxane A2 Receptor) is a Protein Coding gene. Diseases associated with TBXA2R include Bleeding Disorder, Platelet-Type, 13 and Stroke, Ischemic. Among its related pathways are Peptide ligand-binding receptors and Platelet activation, signaling and aggregation. GO annotations related to this gene include G-protein coupled receptor activity and thromboxane receptor activity. An important paralog of this gene is PTGFR.

UniProtKB/Swiss-Prot for TBXA2R Gene

  • Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.

Tocris Summary for TBXA2R Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for TBXA2R Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBXA2R Gene

Genomics for TBXA2R Gene

Regulatory Elements for TBXA2R Gene

Enhancers for TBXA2R Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TBXA2R on UCSC Golden Path with GeneCards custom track

Promoters for TBXA2R Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TBXA2R Gene

Chromosome:
19
Start:
3,594,506 bp from pter
End:
3,606,851 bp from pter
Size:
12,346 bases
Orientation:
Minus strand

Genomic View for TBXA2R Gene

Genes around TBXA2R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBXA2R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBXA2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBXA2R Gene

Proteins for TBXA2R Gene

  • Protein details for TBXA2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21731-TA2R_HUMAN
    Recommended name:
    Thromboxane A2 receptor
    Protein Accession:
    P21731
    Secondary Accessions:
    • O75228
    • Q6DK52
    • Q9UCY1
    • Q9UCY2

    Protein attributes for TBXA2R Gene

    Size:
    343 amino acids
    Molecular mass:
    37431 Da
    Quaternary structure:
    • Interacts with RPGRIP1L. Interacts with PSMA3. Interacts with RACK1; the interaction regulates TBXA2R cell surface expression.
    SequenceCaution:
    • Sequence=AAA58957.1; Type=Frameshift; Positions=329; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TBXA2R Gene

    Alternative splice isoforms for TBXA2R Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBXA2R Gene

Post-translational modifications for TBXA2R Gene

  • Glycosylation at Asn 4 and Asn 16
  • Modification sites at PhosphoSitePlus

Other Protein References for TBXA2R Gene

No data available for DME Specific Peptides for TBXA2R Gene

Domains & Families for TBXA2R Gene

Gene Families for TBXA2R Gene

Protein Domains for TBXA2R Gene

Suggested Antigen Peptide Sequences for TBXA2R Gene

Graphical View of Domain Structure for InterPro Entry

P21731

UniProtKB/Swiss-Prot:

TA2R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TBXA2R: view

Function for TBXA2R Gene

Molecular function for TBXA2R Gene

GENATLAS Biochemistry:
thromboxane A2 receptor (platelet,placenta,lung,megakaryocyte), G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.

Gene Ontology (GO) - Molecular Function for TBXA2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004960 thromboxane receptor activity IEA --
GO:0004961 thromboxane A2 receptor activity TAS 8119956
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0005515 protein binding IEA,IPI 17644091
genes like me logo Genes that share ontologies with TBXA2R: view
genes like me logo Genes that share phenotypes with TBXA2R: view

Human Phenotype Ontology for TBXA2R Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TBXA2R Gene

MGI Knock Outs for TBXA2R:

Animal Model Products

CRISPR Products

miRNA for TBXA2R Gene

miRTarBase miRNAs that target TBXA2R

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for TBXA2R (Thromboxane A2 R/TBXA2R)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TBXA2R Gene

Localization for TBXA2R Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBXA2R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBXA2R Gene COMPARTMENTS Subcellular localization image for TBXA2R gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TBXA2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 1825698
genes like me logo Genes that share ontologies with TBXA2R: view

Pathways & Interactions for TBXA2R Gene

genes like me logo Genes that share pathways with TBXA2R: view

SIGNOR curated interactions for TBXA2R Gene

Other effect:

Gene Ontology (GO) - Biological Process for TBXA2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA,IBA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 1825698
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA,IBA --
GO:0007584 response to nutrient IEA --
genes like me logo Genes that share ontologies with TBXA2R: view

Drugs & Compounds for TBXA2R Gene

(76) Drugs for TBXA2R Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iloprost Approved, Investigational Pharma Full agonist, Agonist, agonist Others, Prostacyclin (PGI2) analog 77
Ridogrel Approved Pharma Target, antagonist 0
Aspirin Approved, Vet_approved Pharma Channel blocker 1074
Alprostadil Approved, Investigational Pharma Prostaglandin. Vasodilator and antiplatelet agent in vivo 69
AH23848 Pharma Antagonist 0

(34) Additional Compounds for TBXA2R Gene - From: Novoseek, HMDB, and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GR 32191
Antagonist
Thromboxane
  • Thromboxane A2
66719-58-2
Thromboxane A2
  • (1S-(1alpha,3alpha,3R*),4beta(Z),5alpha)-7-(3-(3-hydroxy-1-octenyl)-2,6-dioxabicyclo(3.1.1)hept-4-yl)-5-Heptenoate
  • (1S-(1alpha,3alpha,3R*),4beta(Z),5alpha)-7-(3-(3-hydroxy-1-octenyl)-2,6-dioxabicyclo(3.1.1)hept-4-yl)-5-Heptenoic acid
  • (5Z)-7-[(1S,3R,4S,5S)-3-[(1E,3S)-3-hydroxy-1-octenyl]-2,6-dioxabicyclo[3.1.1]hept-4-yl]-5-Heptenoate
  • (5Z)-7-[(1S,3R,4S,5S)-3-[(1E,3S)-3-hydroxy-1-octenyl]-2,6-dioxabicyclo[3.1.1]hept-4-yl]-5-Heptenoic acid
  • (5Z,13E)-(15S)-9,11-epoxy-15-hydroxythromba-5,13-dienoate
57576-52-0
AGN192093
Agonist
CTA<sub>2</sub>
Full agonist, Agonist

(5) Tocris Compounds for TBXA2R Gene

Compound Action Cas Number
Alprostadil Prostaglandin. Vasodilator and antiplatelet agent in vivo 745-65-3
Iloprost Prostacyclin (PGI2) analog 78919-13-8
L-798,106 Potent and highly selective EP3 antagonist 244101-02-8
Prostaglandin E2 Major endogenous prostanoid 363-24-6
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist 56985-40-1

(1) ApexBio Compounds for TBXA2R Gene

Compound Action Cas Number
Ozagrel HCl 78712-43-3
genes like me logo Genes that share compounds with TBXA2R: view

Drug Products

Transcripts for TBXA2R Gene

Unigene Clusters for TBXA2R Gene

Thromboxane A2 receptor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for TBXA2R (Thromboxane A2 R/TBXA2R)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBXA2R Gene

No ASD Table

Relevant External Links for TBXA2R Gene

GeneLoc Exon Structure for
TBXA2R
ECgene alternative splicing isoforms for
TBXA2R

Expression for TBXA2R Gene

mRNA expression in normal human tissues for TBXA2R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TBXA2R Gene

This gene is overexpressed in Artery - Aorta (x8.3), Artery - Tibial (x7.9), and Artery - Coronary (x6.7).

Protein differential expression in normal tissues from HIPED for TBXA2R Gene

This gene is overexpressed in Platelet (61.8) and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TBXA2R Gene



Protein tissue co-expression partners for TBXA2R Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TBXA2R Gene:

TBXA2R

SOURCE GeneReport for Unigene cluster for TBXA2R Gene:

Hs.442530
genes like me logo Genes that share expression patterns with TBXA2R: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TBXA2R Gene

Orthologs for TBXA2R Gene

This gene was present in the common ancestor of chordates.

Orthologs for TBXA2R Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TBXA2R 34
  • 82.65 (n)
  • 83.33 (a)
TBXA2R 35
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBXA2R 34
  • 86.51 (n)
  • 86.61 (a)
TBXA2R 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbxa2r 34
  • 77.61 (n)
  • 78.64 (a)
Tbxa2r 16
Tbxa2r 35
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TBXA2R 34
  • 97.92 (n)
  • 98.81 (a)
TBXA2R 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbxa2r 34
  • 78.12 (n)
  • 77.71 (a)
oppossum
(Monodelphis domestica)
Mammalia TBXA2R 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TBXA2R 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TBXA2R 34
  • 66.58 (n)
  • 56.52 (a)
TBXA2R 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17668 34
tbxa2r 34
  • 55.65 (n)
  • 57.44 (a)
zebrafish
(Danio rerio)
Actinopterygii ptger1c 35
  • 34 (a)
ManyToMany
Species where no ortholog for TBXA2R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBXA2R Gene

ENSEMBL:
Gene Tree for TBXA2R (if available)
TreeFam:
Gene Tree for TBXA2R (if available)

Paralogs for TBXA2R Gene

Paralogs for TBXA2R Gene

(6) SIMAP similar genes for TBXA2R Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TBXA2R: view

Variants for TBXA2R Gene

Sequence variations from dbSNP and Humsavar for TBXA2R Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs34377097 Bleeding disorder, platelet-type 13 (BDPLT13) 3,600,456(-) CACGC(G/T)CTCCT reference, missense
rs5743 - 3,600,433(+) TCCTC(A/T)GCGGC reference, missense
rs5744 - 3,600,396(-) GCTGG(A/T)GACCG reference, missense
rs5746 - 3,600,354(-) CTTCG(A/T)GTGGC reference, missense
rs5749 - 3,600,157(-) CGGCC(A/G/T)CGCTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TBXA2R Gene

Variant ID Type Subtype PubMed ID
esv2717950 CNV deletion 23290073
esv2717952 CNV deletion 23290073
esv2717953 CNV deletion 23290073
nsv470114 CNV loss 18288195
nsv833713 CNV loss 17160897
nsv953948 CNV deletion 24416366

Variation tolerance for TBXA2R Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBXA2R Gene

Human Gene Mutation Database (HGMD)
TBXA2R
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TBXA2R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBXA2R Gene

Disorders for TBXA2R Gene

MalaCards: The human disease database

(2) MalaCards diseases for TBXA2R Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bleeding disorder, platelet-type, 13
  • bleeding disorder, platelet-type, 13, susceptibility to
stroke, ischemic
  • ischemic stroke
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TA2R_HUMAN
  • Bleeding disorder, platelet-type 13 (BDPLT13) [MIM:614009]: A disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding. {ECO:0000269 PubMed:7929844}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Genatlas disease for TBXA2R Gene

bleeding diathesis with platelet unresponsiveness to thromboxane A2

Relevant External Links for TBXA2R

Genetic Association Database (GAD)
TBXA2R
Human Genome Epidemiology (HuGE) Navigator
TBXA2R
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TBXA2R
genes like me logo Genes that share disorders with TBXA2R: view

Publications for TBXA2R Gene

  1. Cloning and expression of cDNA for a human thromboxane A2 receptor. (PMID: 1825698) Hirata M. … Narumiya S. (Nature 1991) 2 3 4 22 65
  2. Association of polymorphisms in thromboxane A2 receptor and thromboxane A synthase 1 with cerebral infarction in a Korean population. (PMID: 19403042) Park S.A. … Shin H.D. (BMB Rep 2009) 3 22 46 65
  3. Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma. (PMID: 15898979) Kim S.H. … Shin H.D. (Clin. Exp. Allergy 2005) 3 22 46 65
  4. Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation. (PMID: 8613548) Hirata T. … Narumiya S. (J. Clin. Invest. 1996) 3 4 22 65
  5. Cloning and pharmacologic characterization of a thromboxane A2 receptor from K562 (human chronic myelogenous leukemia) cells. (PMID: 7965765) D'Angelo D.D. … Dorn G.W. II (J. Pharmacol. Exp. Ther. 1994) 3 4 22 65

Products for TBXA2R Gene

Sources for TBXA2R Gene

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