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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TBX6 Gene

protein-coding   GIFtS: 53
GCID: GC16M030097

T-box 6
 Explore 5 diseases affiliated with
TBX6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TBX6    

Aliases
for TBX6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
T-Box 61 2
T-Box Protein 62 3
T-Box Transcription Factor TBX62

External Ids:    HGNC: 116051   Entrez Gene: 69112   Ensembl: ENSG000001499227   OMIM: 6024275   UniProtKB: O959473   

Export aliases for TBX6 gene to outside databases

Previous GC identifers: GC16P029057 GC16M030419 GC16M030095 GC16M030134 GC16M030004 GC16M027758


Summaries
for TBX6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TBX6:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the
T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout
studies in mice indicate that this gene is important for specification of paraxial mesoderm structures. (provided by
RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: TBX6_HUMAN, O95947
Function: T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells:
neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural
development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch
signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By
similarity)




Genomic Views
for TBX6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TBX6 gene promoter:
         Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TBX6 promoter sequence
   Search SABiosciences Chromatin IP Primers for TBX6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBX6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

TBX6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBX6 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M030097:  view genomic region     (about GC identifiers)

Start:
 30,097,114 bp from pter      End:
 30,103,208 bp from pter
Size:
 6,095 bases      Orientation:
 minus strand

Proteins
for TBX6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TBX6_HUMAN, O95947 (See protein sequence)
Recommended Name: T-box transcription factor TBX6  
Size: 436 amino acids; 47045 Da
Subunit: Forms a dimeric complex with DNA (in vitro)
Subcellular location: Nucleus (Potential)
Developmental stage: Expressed during gastrulation and during a second phase in some adult tissues
Secondary accessions: Q8TAS4

Explore the universe of human proteins at neXtProt for TBX6: NX_O95947

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95947

    • TBX6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004599.2  
    ENSEMBL proteins: 
     ENSP00000378650   ENSP00000460425   ENSP00000461223   ENSP00000279386  

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    OriGene Protein Over-expression Lysate (see all 2): TBX6
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    Novus Biologicals TBX6 Proteins
    Novus Biologicals TBX6 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TBX6

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    TBX6 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TBX6

    Protein Domains /
    Families
    for TBX6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TBX6 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001699 TF_T-box
     IPR008967 p53-like_TF_DNA-bd
     IPR002070 TF_Brachyury
     IPR018186 TF_T-box_CS

    Graphical View of Domain Structure for InterPro Entry O95947

    ProtoNet protein and cluster: O95947

    2 Blocks protein families:
    IPB001699 Transcription factor
    IPB002070 Brachyury protein family signature


    UniProtKB/Swiss-Prot: TBX6_HUMAN, O95947
    Similarity: Contains 1 T-box DNA-binding domain


    Function
    for TBX6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TBX6_HUMAN, O95947
    Function: T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells:
    neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural
    development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch
    signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By
    similarity)

         Genatlas biochemistry entry for TBX6:
    murine T-box gene Tbx6 (T,brachyury) homolog,expressed during gastrulation and in some adult tissues,including
    testis,involved in paraxial mesoderm formation and somitogenesis

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TBX6
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate TBX6 (see all 15):
    hsa-miR-588 hsa-miR-4271 hsa-miR-3611 hsa-miR-548s hsa-miR-551b* hsa-miR-3179 hsa-miR-378b hsa-miR-422a
    SwitchGear 3'UTR luciferase reporter plasmid: TBX6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TBX6 (see all 7)
    OriGene shRNA RFP: TBX6
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for TBX6

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001085RNA polymerase II transcription factor binding ISS--
    GO:0001102RNA polymerase II activating transcription factor binding ISS--
    GO:0001191RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription ISS--
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--


    TBX6 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for TBX6: Tbx6tm1Pa Tbx6/Ppp4cTbx6/tm1.2Htn
         11 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Tbx6):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size 
     limbs/digits/tail  mortality/aging  nervous system  renal/urinary system  reproductive system 
     skeleton 

    TBX6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TBX6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Neural Crest Differentiation
    		Neural Crest Differentiation1.00


    1 BioSystems Pathway for TBX6 
        Neural Crest Differentiation


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TBX6

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001707mesoderm formation IEA--
    GO:0001708cell fate specification IEA--
    GO:0006351transcription, DNA-dependent ----
    GO:0007498mesoderm development TAS9933572


    TBX6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TBX6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TBX6
    Search CenterWatch for drugs/clinical trials and news about TBX6 

    Transcripts
    for TBX6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TBX6 gene (2 alternative transcripts): 
    NM_004608.3  NM_080758.1  

    Unigene Cluster for TBX6:

    T-box 6
    Hs.198301  [show with all ESTs]
    Unigene Representative Sequence: AK022330
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395224(uc010veh.2) ENST00000567664 ENST00000553607(uc002dwk.1)
    ENST00000279386

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TBX6
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate TBX6 (see all 15):
    hsa-miR-588 hsa-miR-4271 hsa-miR-3611 hsa-miR-548s hsa-miR-551b* hsa-miR-3179 hsa-miR-378b hsa-miR-422a
    SwitchGear 3'UTR luciferase reporter plasmid: TBX6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TBX6 (see all 7)
    OriGene shRNA RFP: TBX6
    OriGene siRNA: TBX6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBX6
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBX6 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TBX6 (NM_004608)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBX6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBX6 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TBX6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBX6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBX6

    Additional cDNA sequence: 

    AJ007989.1 AK022330.1 BC026031.1 

    3 DOTS entries:

    DT.75152813  DT.97780366  DT.100008765 

    24/27 AceView cDNA sequences (see all 27):

    BM904343 NM_080758 BC026031 AL525988 BQ574382 BM974461 CA313998 BQ882771 
    BX349928 AJ007989 BX475585 AL525945 CA430905 AK022330 CA502854 BX327658 
    AU122082 BM013006 BU687718 CB852962 NM_004608 BU151254 BM818041 AU147761 

    GeneLoc Exon Structure


    Expression
    for TBX6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TBX6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTCAGGAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TBX6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Primitive StreakPosterior Primitive StreakPosterior Primitive Streak CellsEarly Embryo
    EpiblastEpiblastIntraembryonic Epiblast CellsEarly Embryo
    Primitive StreakPrimitive StreakPrimitive Streak CellsEarly Embryo
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    Early mesoderm cells (Generation of human ...)
    Definitive endoderm-like cells (Generation and expan...)
    Mesoderm precursors (Generation of skelet...)
    Lateral plate mesoderm (Generation of human ...)

    See TBX6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TBX6

    SOURCE GeneReport for Unigene cluster: Hs.198301

    UniProtKB/Swiss-Prot: TBX6_HUMAN, O95947
    Tissue specificity: Expressed in fetal tail bud, posterior spinal tissue, intervertebral disk and testis. Also
    expressed in adult testis, kidney, lung, muscle and thymus

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    In Situ
    Assay Products:     
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    Orthologs
    for TBX6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TBX6 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia TBX66
    		 --
    		 42(a)
    		 1 ↔ 1
    		 GL343279.1(356983-365052)
    zebrafish
    (Danio rerio)    		 Actinopterygii tbx66
    		 T-box gene 6
    		 15(a)
    		 1 ↔ 1
    		 12(4593057-4603583)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Doc23
    Doc31    		 transcription factor3
    Dorsocross31    		 57(a)
    (best of 3)3
    49.66(n)1
    47.2(a)1    		   66F13
    390361  NM_140023.21  NP_648280.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea tbx-76
    		 Putative T-box protein 7
    		 27(a)
    		 1 → many
    		 III(6024910-6028483)


    ENSEMBL Gene Tree for TBX6 (if available)
    TreeFam Gene Tree for TBX6 (if available) 

    Paralogs
    for TBX6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TBX6 gene
    TBX12  TBX222  TBX192  T2  EOMES2  TBX22  TBX212  TBX32  
    TBX202  TBX52  TBX102  TBX42  TBR12  TBX152  TBX182  
    15 SIMAP similar genes for TBX6 using alignment to 2 protein entries:     TBX6_HUMAN (see all proteins):
    MGA    TBX5    T    TBX19    TBX20    TBX4
    DKFZp762H2012    TBX18    EOMES    TBX10    TBX15    TBX2
    TBR1    TBX1    TBX22

    TBX6 for paralogs           About GeneDecksing



    Genomic Variants
    for TBX6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/139 NCBI SNPs in TBX6 are shown (see all 139)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs351755831,2
    		C--27758651(-) CCCCTC/GTGGCT 1 -- ut310--------
    rs1133395331,2
    		F--27759348(+) CCCATC/TGCCAT 1 -- int11Minor allele frequency- T:0.50CSA 4
    rs796278131,2
    		F,--27759773(+) ATCCTC/GTTCTG 1 -- int11Minor allele frequency- G:0.04WA 118
    rs620577541,2
    		--27760839(+) CTTTAG/TAATGG 1 -- int12Minor allele frequency- T:0.04NA WA 120
    rs1130270371,2
    		--27761060(+) CAGCAC/TGGTGC 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs129274921,2
    		H--27761606(+) TGTGCA/CCCAGT 2 G syn1 ese35Minor allele frequency- C:0.00NS EA NA 420
    rs129258381,2
    		H--27761617(+) GGCAGG/AAGAGT 2 /P /S mis1 ese35Minor allele frequency- A:0.00NS EA NA 398
    rs129258391,2
    		C,F,H--27761619(+) CAGGAG/AAGTCG 2 /S /F mis1 ese37Minor allele frequency- A:0.01NS EA 854
    rs129259441,2
    		C--27761636(+) ATGTAG/AACACG 2 /V syn1 ese31Minor allele frequency- A:0.00NA 2
    rs129276391,2
    		C--27761639(+) TAGACA/CCGGTC 2 R syn1 ese30--------

    HapMap Linkage Disequilibrium report for TBX6 (30097114 - 30103208 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for TBX6
         3 CNVs: 4940 35383 4001
    Human Gene Mutation Database (HGMD): TBX6

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBX6
    DNA2.0 Custom Variant and Variant Library Synthesis for TBX6

    Disorders / Diseases
    for TBX6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TBX6 for disorders           About GeneDecksing

    OMIM gene information: 602427    OMIM disorders: --

    5 diseases for TBX6:    About MalaCards
    klippel-feil syndrome    spondylocostal dysostosis    dysostosis    scoliosis
    pharyngitis

    2 diseases from the University of Copenhagen DISEASES database for TBX6:
    Klippel-Feil syndrome     Spondylocostal dysostosis
    Human Genome Epidemiology (HuGE) Navigator: TBX6 (2 documents)

    Export disorders for TBX6 gene to outside databases

    Publications
    for TBX6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TBX6 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with TBX6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human TBX6 gene: cloning and assignment to chromosome 16p11.2. (PubMed id 9933572)1, 2, 3 Papapetrou C....Edwards Y.H. (1999)
    2. Identification, mapping and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19. (PubMed id 9888994)1, 2, 3 Yi C.-H.... Brook J.D. (1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The association analysis of TBX6 polymorphism with su sceptibility to congenital scoliosis in a Chinese Han population. (PubMed id 20228709)1 Fei Q....Qiu G. (2010)
    5. A Missense T(Brachyury) Mutation Contributes to Vertebral Malformations. (PubMed id 18466071)1 Ghebranious N....Giampietro P.F. (2008)
    6. Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors. (PubMed id 17584735)1 Farin H.F....Kispert A. (2007)
    7. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Multiple signaling pathways control Tbx6 expression during Xenopus myogenesis. (PubMed id 15188053)9 Fang P.F....Ding X.Y. (2004)

    External Searches for TBX6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing TBX6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6911 HGNC: 11605 AceView: TBX6 Ensembl:ENSG00000149922 euGenes: HUgn6911
    ECgene: TBX6 H-InvDB: TBX6

    Other Databases showing TBX6 gene

    (According to HUGE)
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    Specialized Databases showing TBX6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TBX6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TBX6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for TBX6 gene:
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