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TBX6 Gene

protein-coding   GIFtS: 53
GCID: GC16M030097

T-Box 6

  See TBX6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
T-Box 61 2
T-Box Protein 62 3
SCDO52 5
T-Box Transcription Factor TBX62

External Ids:    HGNC: 116051   Entrez Gene: 69112   Ensembl: ENSG000001499227   OMIM: 6024275   UniProtKB: O959473   

Export aliases for TBX6 gene to outside databases

Previous GC identifers: GC16P029057 GC16M030419 GC16M030095 GC16M030134 GC16M030004 GC16M027758


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TBX6 Gene:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the
T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout
studies in mice indicate that this gene is important for specification of paraxial mesoderm structures. (provided
by RefSeq, Aug 2008)

GeneCards Summary for TBX6 Gene:
TBX6 (T-box 6) is a protein-coding gene. Diseases associated with TBX6 include classic mayer-rokitansky-k??ster-hauser syndrome, and murcs association. GO annotations related to this gene include RNA polymerase II transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TBX1.

UniProtKB/Swiss-Prot: TBX6_HUMAN, O95947
Function: T-box transcription factor that plays an essential role in the determination of the fate of axial stem
cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural
development. Seems to play also an essential role in left/right axis determination and acts through effects on
Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TBX6 gene promoter:
         Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBX6 promoter sequence
   Search Chromatin IP Primers for TBX6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBX6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

TBX6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBX6 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M030097:  view genomic region     (about GC identifiers)

Start:
30,097,114 bp from pter      End:
30,103,208 bp from pter
Size:
6,095 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TBX6_HUMAN, O95947 (See protein sequence)
Recommended Name: T-box transcription factor TBX6  
Size: 436 amino acids; 47045 Da
Subunit: Forms a dimeric complex with DNA (in vitro)
Developmental stage: Expressed during gastrulation and during a second phase in some adult tissues
Secondary accessions: Q8TAS4

Explore the universe of human proteins at neXtProt for TBX6: NX_O95947

Explore proteomics data for TBX6 at MOPED


See TBX6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_004599.2  
ENSEMBL proteins: 
 ENSP00000378650   ENSP00000460425   ENSP00000461223   ENSP00000279386  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
TBX: T-boxes

4 InterPro protein domains:
 IPR001699 TF_T-box
 IPR008967 p53-like_TF_DNA-bd
 IPR002070 TF_Brachyury
 IPR018186 TF_T-box_CS

Graphical View of Domain Structure for InterPro Entry O95947

ProtoNet protein and cluster: O95947

2 Blocks protein domains:
IPB001699 Transcription factor
IPB002070 Brachyury protein family signature


UniProtKB/Swiss-Prot: TBX6_HUMAN, O95947
Similarity: Contains 1 T-box DNA-binding domain


Find genes that share domains with TBX6           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TBX6_HUMAN, O95947
Function: T-box transcription factor that plays an essential role in the determination of the fate of axial stem
cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural
development. Seems to play also an essential role in left/right axis determination and acts through effects on
Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia
(By similarity)

     Genatlas biochemistry entry for TBX6:
murine T-box gene Tbx6 (T,brachyury) homolog,expressed during gastrulation and in some adult tissues,including
testis,involved in paraxial mesoderm formation and somitogenesis

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001085RNA polymerase II transcription factor binding ISS--
GO:0001102RNA polymerase II activating transcription factor binding ISS--
GO:0001191RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription ISS--
GO:0003677DNA binding IEA--
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
     
Find genes that share ontologies with TBX6           About GenesLikeMe


Phenotypes:
     11 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Tbx6):
 cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size/body 
 limbs/digits/tail  mortality/aging  nervous system  renal/urinary system  reproductive system 
 skeleton 

Find genes that share phenotypes with TBX6           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for TBX6: Tbx6tm1Pa Tbx6/Ppp4cTbx6/tm1.2Htn

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBX6
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miRNA
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Selected qRT-PCR Assays for microRNAs that regulate TBX6 (see all 15):
hsa-miR-588 hsa-miR-4271 hsa-miR-3611 hsa-miR-548s hsa-miR-551b* hsa-miR-3179 hsa-miR-378b hsa-miR-422a
SwitchGear 3'UTR luciferase reporter plasmidTBX6 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat TBX6

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBX6

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBX6


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TBX6_HUMAN, O95947: Nucleus (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2
cytoskeleton1
extracellular1
mitochondrion1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

Find genes that share ontologies with TBX6           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TBX6 About    
See pathways by source

SuperPathContained pathways About
1Neural Crest Differentiation
Neural Crest Differentiation


1 BioSystems Pathway for TBX6
    Neural Crest Differentiation


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBX6
Interactions:

    GeneGlobe Interaction Network for TBX6

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

Selected Interacting proteins for TBX6 (ENSP000002793864) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
InteractantInteraction Details
GeneCardExternal ID(s)
ARCENSP000003490224STRING: ENSP00000349022
NUPL2ENSP000002587424STRING: ENSP00000258742
DHHENSP000002669914STRING: ENSP00000266991
IHHENSP000002957314STRING: ENSP00000295731
SHHENSP000002972614STRING: ENSP00000297261
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Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
GO:0001707mesoderm formation IEA--
GO:0001708cell fate specification IEA--
GO:0006351transcription, DNA-templated ----
GO:0006355regulation of transcription, DNA-templated ----

Find genes that share ontologies with TBX6           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TBX6



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TBX6 gene (2 alternative transcripts): 
NM_004608.3  NM_080758.1  

Unigene Cluster for TBX6:

T-box 6
Hs.198301  [show with all ESTs]
Unigene Representative Sequence: AK022330
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000395224(uc010veh.2) ENST00000567664 ENST00000553607(uc002dwk.1)
ENST00000279386
miRNA
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Selected qRT-PCR Assays for microRNAs that regulate TBX6 (see all 15):
hsa-miR-588 hsa-miR-4271 hsa-miR-3611 hsa-miR-548s hsa-miR-551b* hsa-miR-3179 hsa-miR-378b hsa-miR-422a
SwitchGear 3'UTR luciferase reporter plasmidTBX6 3' UTR sequence
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat TBX6
Clone
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OriGene ORF clones in mouse, rat for TBX6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TBX6 (NM_004608)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBX6
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBX6
Primer
Products:
    
OriGene qPCR primer pairs and template standards for TBX6
OriGene qSTAR qPCR primer pairs in human, mouse for TBX6
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBX6
  QuantiTect SYBR Green Assays in human, mouse, rat TBX6
  QuantiFast Probe-based Assays in human, mouse, rat TBX6

Additional mRNA sequence: 

AJ007989.1 AK022330.1 BC026031.1 

3 DOTS entries:

DT.75152813  DT.97780366  DT.100008765 

Selected AceView cDNA sequences (see all 27):

BC026031 BM904343 BM974461 AL525988 NM_080758 CA313998 BQ574382 BQ882771 
AJ007989 AK022330 BX475585 AL525945 BM013006 CA502854 NM_004608 BU687718 
CA430905 AU122082 BX349928 CB852962 BX327658 BU151254 BX340973 BM818041 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TBX6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTCAGGAAAA
TBX6 Expression
About this image


TBX6 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 6) fully expand
 
 Primitive Streak (Early Embryonic Tissues)    fully expand to see all 3 entries
         Primitive Streak Cells Posterior Primitive Streak
         Mesendoderm-like cells
 
 Epiblast (Early Embryo)    fully expand to see all 2 entries
         Primitive Streak Cells Posterior Primitive Streak
 
 NULL (Uncategorized)    fully expand to see all 2 entries
         Definitive endoderm-like cells
 
 Mesoderm (Gastrulation Derivatives)
         Early mesoderm cells
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Muscle Progenitor Cells Mandibular Arch Muscles
TBX6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TBX6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.198301

UniProtKB/Swiss-Prot: TBX6_HUMAN, O95947
Tissue specificity: Expressed in fetal tail bud, posterior spinal tissue, intervertebral disk and testis. Also
expressed in adult testis, kidney, lung, muscle and thymus

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBX6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TBX6 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tbx61 , 5 T-box 61, 5 85.02(n)1
87.84(a)1
  7 (69.25 cM)5
213891  NM_011538.21  NP_035668.21 
 1267814835 
chicken
(Gallus gallus)
Aves TBX66
Gallus gallus T-box 6 (TBX6), mRNA.
33(a)
1 ↔ 1
15(8240402-8251321)
lizard
(Anolis carolinensis)
Reptilia TBX66
T-box 6
49(a)
1 ↔ 1
GL343279.1(356983-365052)
zebrafish
(Danio rerio)
Actinopterygii tbx66
T-box gene 6
21(a)
1 ↔ 1
12(4593057-4603583) ENSDARG00000011785
fruit fly
(Drosophila melanogaster)
Insecta Doc23 transcription factor 57(a)
(best of 3)
  66F1   --


ENSEMBL Gene Tree for TBX6 (if available)
TreeFam Gene Tree for TBX6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TBX6 gene
TBX12  TBX222  TBX192  T2  TBX22  TBX202  TBX32  TBX52  
TBX152  TBX102  TBX42  TBX182  
15 SIMAP similar genes for TBX6 using alignment to 2 protein entries:     TBX6_HUMAN (see all proteins):
MGA    TBX5    T    TBX18    TBX19    TBX20
TBX4    DKFZp762H2012    EOMES    TBX10    TBX15    TBX2
TBR1    TBX1    TBX22

Find genes that share paralogs with TBX6           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TBX6 (see all 220)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs359332191,2
C--30098192(-) ATCAC-/CATCATCA 1 -- int11Minor allele frequency- CAT:0.00NA 2
rs2012285321,2
C--30098204(-) CACCAC/TCATCA 1 -- int10--------
rs1442567741,2
--30996021(+) TTTTTA/GGATAA 1 -- ds50010--------
rs1164763881,2
C,F--30996037(+) TTGAGA/GAAAAA 1 -- ds50011Minor allele frequency- G:0.04WA 118
rs1501599611,2
C--30996062(+) AATAA-/AAGAAGAA 1 -- ds50010--------
rs1901641671,2
--30996075(+) AAATGA/GTTTTT 1 -- ds50010--------
rs1473650011,2
--30996111(+) ATGCAC/TAGGGT 1 -- ds50010--------
rs1394457241,2
--30996142(+) TGGACA/GTCAGG 1 -- ds50010--------
rs1499663691,2
--30996211(+) TGCCCA/GGGGCC 1 -- ds50010--------
rs1450726601,2
--30996301(+) GCATAC/TACACA 1 -- ds50010--------

HapMap Linkage Disequilibrium report for TBX6 (30097114 - 30103208 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for TBX6:    About this table    
Variant IDTypeSubtypePubMed ID
nsv833187CNV Loss17160897
dgv2668n71CNV Loss21882294
nsv905720CNV Loss21882294
dgv846e1CNV Complex17122850

Human Gene Mutation Database (HGMD): TBX6
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TBX6
DNA2.0 Custom Variant and Variant Library Synthesis for TBX6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 602427   
OMIM disorders: 122600  
5 diseases for TBX6:    
About MalaCards
classic mayer-rokitansky-k??ster-hauser syndrome    murcs association    spondylocostal dysostosis 5, autosomal dominant    spondylocostal dysostosis
klippel-feil syndrome

2 diseases from the University of Copenhagen DISEASES database for TBX6:
Klippel-Feil syndrome     Spondylocostal dysostosis

Find genes that share disorders with TBX6           About GenesLikeMe

Genetic Association Database (GAD): TBX6
Human Genome Epidemiology (HuGE) Navigator: TBX6 (2 documents)

Export disorders for TBX6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TBX6 gene, integrated from 10 sources (see all 25):
(articles sorted by number of sources associating them with TBX6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human TBX6 gene: cloning and assignment to chromosome 16p11.2. (PubMed id 9933572)1, 2, 3 Papapetrou C.... Edwards Y.H. (Genomics 1999)
  2. Identification, mapping and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19. (PubMed id 9888994)1, 2, 3 Yi C.-H.... Brook J.D. (Genomics 1999)
  3. The association analysis of TBX6 polymorphism with susceptibility to congenital scoliosis in a Chinese Han population. (PubMed id 20228709)1, 4 Fei Q....Qiu G. (Spine 2010)
  4. A missense T (Brachyury) mutation contributes to vertebral malformations. (PubMed id 18466071)1, 4 Ghebranious N....Giampietro P.F. (J. Bone Miner. Res. 2008)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Autosomal dominant spondylocostal dysostosis is caused by mutation in TBX6. (PubMed id 23335591)1 Sparrow D.B....Dunwoodie S.L. (Hum. Mol. Genet. 2013)
  7. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
  8. Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors. (PubMed id 17584735)1 Farin H.F....Kispert A. (J. Biol. Chem. 2007)
  9. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
  10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6911 HGNC: 11605 AceView: TBX6 Ensembl:ENSG00000149922 euGenes: HUgn6911
ECgene: TBX6 H-InvDB: TBX6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TBX6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TBX6 gene:
Search GeneIP for patents involving TBX6

GeneCards and IP:
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