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TBX5 Gene

protein-coding GIFtS: 65

GC12M113254

T-box 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: HOS)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
HOS ^²

Descriptions
T-box 5 ^²
T-box protein 5 ^³
T-box transcription factor TBX5 ^²

External Ids
HGNC: 11604¹
Entrez Gene: 6910²
UniProtKB: Q99593³
Ensembl: ENSG00000089225⁷

Search outside databases for aliases for TBX5 gene

Previous GC identifers: GC12M113701 GC12M114312 GC12M114574 GC12M113203

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for TBX5:

This gene is a member of a phylogenetically conserved family of genes that share a common

DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation

of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar

mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development

and specification of limb identity. Mutations in this gene have been associated with Holt-Oram

syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript

variants encoding different isoforms have been described for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: TBX5_HUMAN, Q99593

Function: Involved in the transcriptional regulation of genes required for mesoderm

differentiation. Probably plays a role in limb pattern formation

Gene Wiki entry for TBX5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TBX5 gene

Entrez Gene cytogenetic band: 12q24.1 Ensembl cytogenetic band: 12q24.21 HGNC cytogenetic band: 12q24.1

TBX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M113254: (about GC identifiers)

Start:	113,276,118 bp from pter
End:	113,330,630 bp from pter
Size:	54,513 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_009775.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TBX5_HUMAN, Q99593 (See protein sequence)

Recommended Name: T-box transcription factor TBX5

Size: 518 amino acids; 57711 Da

Subcellular location: Nucleus (Potential)

Secondary accessions: O15301 Q9Y4I2

Alternative splicing: 2 isoforms: Q99593-1 Q99593-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_000183.2 NP_542448.1 NP_542449.1 NP_852259.1

ENSEMBL proteins:

ENSP00000309913 ENSP00000384152 ENSP00000337723 ENSP00000327158 ENSP00000376342 ENSP00000386124

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TBX5)
	Human Recombinant Proteins from Abnova (TBX5)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	12237100 12499378 14519429
GO:0005737	cytoplasm	IDA	14519429

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Antibodies for TBX5:

	Invitrogen Antibodies for TBX5
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TBX5
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (TBX5), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TBX5)
	Novus Biologicals Antibody for TBX5

Assays for TBX5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q99593

ProtoNet protein and cluster: Q99593

2 Blocks protein families:

IPB001699 Transcription factor

IPB002070 Brachyury protein family signature

UniProtKB/Swiss-Prot: TBX5_HUMAN, Q99593

Similarity: Contains 1 T-box DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TBX5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TBX5)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_000192

Applied Biosystems Silencer® siRNAs for TBX5

Sigma-Aldrich siRNA for TBX5

Sigma-Aldrich shRNA Panels and shRNA for TBX5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TBX5
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000192
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000192
untagged cDNA clones in CMV expression vector (see all 4): NM_000192

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000192

UniProtKB/Swiss-Prot: TBX5_HUMAN, Q99593

Function: Involved in the transcriptional regulation of genes required for mesoderm

differentiation. Probably plays a role in limb pattern formation

Genatlas biochemistry entry for TBX5:

murine T-box gene Tbx5 (T,brachyury)homolog,putative transcription factor,likely expressed in

developing limb bud and heart in mice,involved in developmental regulation,pairing with

TBX3,homolog to Drosophila optomotor-blind gene (omb),involved in optic lobe and wing development

8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tbx5):

	embryogenesis	homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal
limbs/digits/tail	normal	skeleton

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IDA	11431700 12499378 16332960
GO:0003702	RNA polymerase II transcription factor activity	IDA	12845333
GO:0008134	transcription factor binding	IPI	11431700
GO:0043565	sequence-specific DNA binding	IDA	11431700 12499378

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for TBX5 (Your Favorite Gene powered by Ingenuity)

Factors Promoting Cardiogenesis in Vertebrates

GeneDecks TBX5 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for TBX5

5/36 Interacting proteins for TBX5 (Q99593¹ ENSP00000309913³) via UniProtKB, MINT, and/or STRING (see all 36 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NKX2-5	P52952¹, ENSP00000327758³	EBI-304423, EBI-936601 STRING (score=.999)
Gata4 Gata4 (xeno)	Q08369¹	EBI-297043, EBI-297008
Nkx2-5 Nkx2-5 (xeno)	P42582¹	EBI-297043, EBI-297021
Wwtr1 Wwtr1 (xeno)	Q9EPK5¹	EBI-297043, EBI-1211920
GATA4	ENSP00000334458³	STRING (score=.995)

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5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006917	induction of apoptosis	IDA	12237100
GO:0007267	cell-cell signaling	IDA	11161571
GO:0007275	multicellular organismal development	IEA	--
GO:0007507	heart development	NAS	12845333
GO:0010552	positive regulation of specific transcription from RNA polymerase II promoter	IMP	11431700

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TBX5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TBX5)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TBX5)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_000192

Sigma-Aldrich siRNA for TBX5

Sigma-Aldrich shRNA Panels and shRNA for TBX5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000192 NM_080717 NM_080718 NM_181486

REFSEQ mRNAs for TBX5 gene (4 alternative transcripts):

NM_000192.3 NM_080717.2 NM_080718.1 NM_181486.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000192 NM_080717 NM_080718 NM_181486

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000192
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000192
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_000192

Additional cDNA sequence:

AB051068.1 AF086146.1 AF221714.1 AK290611.1 AK300251.1 BC011028.1 BC027942.1 U80987.1

U89353.1

4 DOTS entries:

DT.303668 DT.205719 DT.91647764 DT.92052463

24/38 AceView cDNA sequences (see all 38 ):

NM_080717 AF221714 U80987 NM_181486 AB051068 NM_000192 U89353 NM_080718

CB988702 AA909517 BF105934 BX378377 AA247888 AI822068 BX089920 BM792230

BI769267 AF086146 BU681707 CB960757 BC011028 AA909518 AL691742 AA906435

highest scoring ESTs for TBX5:

AA247888 AA909517 AB051068 AF221714 BC011028 U80987 Y09445 AA358451 AA906435 AA909518

Unigene Cluster for TBX5:

T-box 5

Hs.381715 [show with all ESTs]

Unigene Representative Sequence: NM_000192

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TBX5

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10
SP1:					-																		-
SP2:																							-
SP3:					-		-		-														-
SP4:

About this scheme

ECgene alternative splicing isoforms for TBX5

6 Ensembl transcripts including schematic representations:

ENST00000310346 ENST00000405440 ENST00000349716 ENST00000317232 ENST00000392559 ENST00000408924

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TBX5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TBX5

¹ / ² / ³

12 probe-sets matching TBX5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
77296_at²^{, 3}	U95-D	1	1.00	1.00	0.89	1.11	AI143430	0.60	1.00	0.82	1
33558_at²^{, 3}	U95-A	1	1.00	1.00	0.94	1.31	Y09445	0.80	1.00	0.91	1
380_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.48	Y09445	0.80	1.00	0.91	1
49443_at²^{, 3}	U95-C	1	1.00	1.00	0.91	1.18	AA909517	0.80	1.00	0.91	1
145_s_at²^{, 3}	U95-A	1	1.00	1.00	0.75	0.97	U80987	0.80	1.00	0.91	1
211886_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U80987	0.80	1.00	0.91	1
240715_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW269421	0.60	1.00	0.82	1
207155_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000192	0.60	1.00	0.82	1
211886_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
240715_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1563018_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207155_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks TBX5 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAATGAAACC

SOURCE GeneReport for Unigene cluster: Hs.381715
Expression variation in blood from EXPOLDB for TBX5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for TBX5 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TBX5¹	--	T-box 5	90.54(n) 96.53(a)	491447 XM_548568.2 XP_548568.2
chimpanzee (Pan troglodytes)	TBX5¹	--	T-box 5	99.23(n) 99.81(a)	452276 XM_509400.2 XP_509400.2
cow (Bos taurus)	TBX5¹	--	T-box 5	91.25(n) 97.68(a)	532970 XM_612208.2 XP_612208.2
rat (Rattus norvegicus)	Tbx5¹	--	T-box 5	87.04(n) 95.94(a)	304514 NM_001009964.1 NP_001009964.1
mouse (Mus musculus)	Tbx5^{1, 5}	5 (65.00 cM)⁵	T-box 5^{1, 5}	87.13(n)¹ 96.14(a)¹	21388¹ NM_011537.2¹ NP_035667.1¹ AF140427⁵ AI413447⁵ (see all 11)

About this table Species with no ortholog for TBX5

ENSEMBL Gene Tree for TBX5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for TBX5 gene

TBX4² MGA²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/414 NCBI SNPs in TBX5 are shown (see all 414 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 181)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs883079^1,2	A,C,F,H,O	113277623(-)	`CCCACA/GGACAA`	3	--	ut3¹ ese³		11		MN EU EA WA NA	2196
	rs6489956^1,2	A,C,F,H	113276619(+)	`TGTGTC/TGGCAT`	3	--	ut3¹		7		EU EA WA NA	554
	rs2113436^1,2	A,C,F,H	113326379(-)	`CACCTC/TCTCCG`	4	--	int¹ ng3¹		8		EU EA WA	808
	rs3782467^1,2	A,C,F,H	113327309(+)	`GCAAGC/GGGCCA`	4	--	int¹ ng3¹		5		EA EU WA	1904
	rs1895596^1,2	C,F,O	113275911(-)	`TATCCC/TTGGAA`	3	--	ng5¹		4		MN NA	326
	rs12426660^1,2	C,F,H	113277336(+)	`CAGGGA/GCAGAC`	3	--	ut3¹ ese³		7		EU EA WA NA	558
	rs7316919^1,2	C,F,H	113275838(+)	`TAAATA/CGGTTG`	3	--	ng5¹		8		EA NA EU WA	620
	rs3741694^1,2	C,F,H	113288310(+)	`GGAAAA/GGGTAA`	4	L/P	mis¹ int¹ trp³		9		EU EA WA MN	894
--	rs11067101^1,2	C,F,H	113328586(+)	`AACGCG/AGTCGG`	3	--	int¹ ng3¹		12		EU EA WA NA	1038
--	rs10850326^1,2	A,C	113277680(+)	`CTCTCC/TCTTTC`	3	--	ut3¹ trp³		0	--	--	--	--

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HapMap Linkage Disequilibrium images for TBX5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 601620 disorders: 142900

UniProtKB/Swiss-Prot: TBX5_HUMAN, Q99593

Defects in TBX5 are the cause of Holt-Oram syndrome (HOS) [MIM:142900]. HOS is a

developmental disorder affecting the heart and upper limbs. It is characterized by thumb anomaly

and atrial septal defects

10/17 Novoseek disease relationships for TBX5 gene (see all 17 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
holt-oram syndrome	98.64	72	10373308 (3), 8988165 (3), 17534187 (3), 16792966 (3) (see all 46)
holt oram syndrome	91.53	2	10745699 (1), 12668595 (1)
ulnar-mammary syndrome	86.71	3	12005433 (1), 16892408 (1), 12668595 (1)
limb malformation	86.62	4	12789647 (2), 12436037 (1), 16917909 (1)
okihiro syndrome	78.50	1	12843316 (1)
heart defects congenital	76.50	14	16258075 (1), 10373308 (1), 12736217 (1), 15221798 (1) (see all 13)
congenital heart disease	69.07	16	15639924 (4), 15096952 (2), 17668378 (1), 15221798 (1) (see all 8)
septal defect	63.47	5	12845333 (3), 10373308 (1)
digeorge syndrome	56.15	3	12005433 (1), 12668595 (1), 15548583 (1)
atrioventricular septal defect	53.54	2	10373308 (1), 15221798 (1)

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GeneTests: TBX5

TBX5-Related Holt-Oram Syndrome

Human Gene Mutation Database: TBX5
Genetic Association Database: TBX5
Human Genome Epidemiology Navigator: TBX5 (6 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/120 PubMed articles for TBX5 gene (see all 120 ):

Mutations in human TBX5 cause limb and cardiac malformation in Holt- Oram syndrome. (PubMed id 8988165)^{1, 2, 3, 4} Basson C.T....Seidman C.E. (1997)
Different TBX5 interactions in heart and limb defined by Holt-Oram syndrome mutations. (PubMed id 10077612)^{1, 3, 4, 6} Basson C.T.... Seidman C.E. (1999)
TBX5 genetic testing validates strict clinical criteria for Holt-Oram syndrome. (PubMed id 16183809)^{1, 3, 6} McDermott D.A....Basson C.T. (2005)
Three novel TBX5 mutations in Chinese patients with Holt-Oram syndrome. (PubMed id 10842287)^{1, 3, 4} Yang J.... Zhou X. (2000)
Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family. (PubMed id 8988164)^{1, 3, 4} Li Q.Y.... Brook J.D. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The mutation spectrum in Holt-Oram syndrome. (PubMed id 11183182)^{3, 4} Cross S.J.... Gardiner C.A. (2000)
Holt-Oram syndrome is a genetically heterogeneous disease with one locus mapping to human chromosome 12q. (PubMed id 8054982)^{2, 3} Terrett J.A....Brook J.D. (1994)
Functional analysis of TBX5 missense mutations associated with Holt-Oram syndrome. (PubMed id 12499378)^{1, 3} Fan C....Wang Q. (2003)
Identification of the TBX5 transactivating domain and the nuclear localization signal. (PubMed id 15087119)^{1, 3} Zaragoza M.V....Huang T. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 6910	HGNC: 11604	AceView: TBX5	Ensembl:ENSG00000089225	euGenes: HUgn6910
ECgene: TBX5	H-InvDB: TBX5

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GeneReviews	http://www.genetests.org/query?gene=TBX5

Licensable Technologies for TBX5
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for TBX5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TBX5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TBX5		Antibodies for TBX5
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TBX5		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TBX5)
	Antibodies (TBX5)
	Chimera RNAi (TBX5)
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	Recombinant Proteins (TBX5)
	Antibodies (TBX5)

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Antibodies for TBX5

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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TBX5 Gene at Home site.
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TBX5 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for TBX5

Summaries
for TBX5

Genomic Location
for TBX5

Proteins
for TBX5

Protein Domains/
Families
for TBX5

Gene Function
for TBX5

Pathways & Interactions
for TBX5

Drugs & Compounds
for TBX5

Transcripts
for TBX5

Expression
for TBX5

Orthologs
for TBX5

Paralogs
for TBX5

SNPs/Variants
for TBX5

Disorders & Mutations
for TBX5

Medical News
for TBX5

Publications
for TBX5

Search for TBX5

Genome Databases showing TBX5

Other Databases showing TBX5

Specialized Databases showing TBX5

Licensable Technologies
for TBX5

Services
for TBX5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TBX5 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor TBX5

Summariesfor TBX5

Genomic Locationfor TBX5

Proteinsfor TBX5

Protein Domains/Familiesfor TBX5

Gene Functionfor TBX5

Pathways & Interactionsfor TBX5

Drugs & Compoundsfor TBX5

Transcriptsfor TBX5

Expression for TBX5

Orthologsfor TBX5

Paralogsfor TBX5

SNPs/Variantsfor TBX5

Disorders & Mutationsfor TBX5

Medical Newsfor TBX5

Publicationsfor TBX5

Search for TBX5

Genome Databases showing TBX5

Other Databases showing TBX5

Specialized Databases showing TBX5

Licensable Technologiesfor TBX5

Servicesfor TBX5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TBX5

Summaries
for TBX5

Genomic Location
for TBX5

Proteins
for TBX5

Protein Domains/
Families
for TBX5

Gene Function
for TBX5

Pathways & Interactions
for TBX5

Drugs & Compounds
for TBX5

Transcripts
for TBX5

Expression
for TBX5

Orthologs
for TBX5

Paralogs
for TBX5

SNPs/Variants
for TBX5

Disorders & Mutations
for TBX5

Medical News
for TBX5

Publications
for TBX5

Licensable Technologies
for TBX5

Services
for TBX5