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TBX3 Gene

protein-coding GIFtS: 65

GC12M113570

T-box 3
(Previous name: ulnar mammary syndrome )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: UMS)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
TBX3-ISO ^¹, ²
UMS ^²
XHL ^¹, ²

Descriptions
T-box 3 ^²
T-box 3 protein ^²
T-box protein 3 ^³
T-box transcription factor TBX3 ^²
bladder cancer related protein XHL ^²
ulnar mammary syndrome ^¹

External Ids
HGNC: 11602¹
Entrez Gene: 6926²
UniProtKB: O15119³
Ensembl: ENSG00000135111⁷

Search outside databases for aliases for TBX3 gene

Previous GC identifers: GC12M114019 GC12M114628 GC12M114890 GC12M113520

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TBX3:

This gene is a member of a phylogenetically conserved family of genes that share a common

DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation

of developmental processes. This protein is a transcriptional repressor and is thought to play a

role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause

ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development.

Alternative splicing of this gene results in three transcript variants encoding different

isoforms; however, the full length nature of one variant has not been determined. [provided by

RefSeq]

UniProtKB/Swiss-Prot: TBX3_HUMAN, O15119

Function: Transcriptional repressor involved in developmental processes. Probably plays a role in

limb pattern formation

Gene Wiki entry for TBX3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TBX3 gene

Entrez Gene cytogenetic band: 12q24.1 Ensembl cytogenetic band: 12q24.21 HGNC cytogenetic band: 12q24.1

TBX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M113570: (about GC identifiers)

Start:	113,592,442 bp from pter
End:	113,606,352 bp from pter
Size:	13,911 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_009775.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TBX3_HUMAN, O15119 (See protein sequence)

Recommended Name: T-box transcription factor TBX3

Size: 743 amino acids; 79389 Da

Subcellular location: Nucleus (Potential)

PDB structures from and Proteopedia :

1H6F (3D)

Secondary accessions: Q8TB20 Q9UKF8

Alternative splicing: 4 isoforms: O15119-1 O15119-2 O15119-3 O15119-4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_005987.3 NP_057653.3

ENSEMBL proteins:

ENSP00000257566 ENSP00000257567 ENSP00000354397

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Tbx3)
	Human Recombinant Proteins from Abnova (TBX3)

OriGene Purified Recombinant Human Protein: TBX3

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	11689487
GO:0005730	NOT nucleolus	IDA	18029348
GO:0005737	cytoplasm	IDA	18029348

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Antibodies for TBX3:

	Invitrogen Antibodies for TBX3
	Millipore Mono- and Polyclonal Antibodies for the study of TBX3
	Sigma-Aldrich Antibodies for TBX3
	R&D Systems Antibodies for TBX3
	Antibodies from Abcam (Tbx3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TBX3)
	Novus Biologicals Antibodies for TBX3

Assays for TBX3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O15119

ProtoNet protein and cluster: O15119

1 Blocks protein family: IPB001699 Transcription factor

UniProtKB/Swiss-Prot: TBX3_HUMAN, O15119

Similarity: Contains 1 T-box DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TBX3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TBX3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_016569

Applied Biosystems Silencer® siRNAs for TBX3

Sigma-Aldrich siRNA for TBX3

Sigma-Aldrich shRNA for TBX3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TBX3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005996
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005996
untagged cDNA clones in CMV expression vector (see all 2): NM_005996

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_016569

UniProtKB/Swiss-Prot: TBX3_HUMAN, O15119

Function: Transcriptional repressor involved in developmental processes. Probably plays a role in

limb pattern formation

Genatlas biochemistry entry for TBX3:

murine T-box gene Tbx3 (T,brachyury)homolog,putative transcription factor,pairing with TBX5,homolog

to Drosophila optomotor-blind gene (omb),involved in optic lobe and wing development,involved in

developmental regulation,expressed in anterior and posterior mouse limb buds,widely expressed in

adults

10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tbx3):

	embryogenesis	endocrine/exocrine gland	growth/size	homeostasis/metabolism
lethality-prenatal/perinatal	limbs/digits/tail	liver/biliary system	reproductive system	skeleton

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0003702	RNA polymerase II transcription factor activity	TAS	9207801
GO:0016565	general transcriptional repressor activity	IDA	11689487
GO:0043565	sequence-specific DNA binding	IDA	11689487

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for TBX3

5/14 Interacting proteins for TBX3 (ENSP00000257566³) via UniProtKB, MINT, and/or STRING (see all 14 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BMP4	ENSP00000245451³	STRING (score=.911)
RBM19	ENSP00000261741³	STRING (score=.892)
HDAC1	ENSP00000362649³	STRING (score=.881)
CTNNB1	ENSP00000344456³	STRING (score=.856)
HDAC9	ENSP00000262069³	STRING (score=.845)

About this table

5/20 Gene Ontology (GO) biological process terms (links to tree view) (see all 20 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	IMP	9207801
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	9207801
GO:0006916	anti-apoptosis	IDA	12032820
GO:0007275	multicellular organismal development	IEA	--
GO:0007569	cell aging	IDA	11689487 11748239

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TBX3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TBX3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TBX3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_016569

Sigma-Aldrich siRNA for TBX3

Sigma-Aldrich shRNA for TBX3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005996 NM_016569

REFSEQ mRNAs for TBX3 gene (2 alternative transcripts):

NM_005996.3 NM_016569.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005996 NM_016569

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005996
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005996
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_005996

Additional cDNA sequence:

AF002228.1 AF074999.1 AF140240.1 AF170708.2 AF216750.1 AK054604.1 AK075457.1 AK130978.1

AK304639.1 AY034105.1 BC025258.1 CR618062.1

11 DOTS entries:

DT.216500 DT.91980610 DT.105635 DT.121181995 DT.40126465 DT.40127993 DT.121181998 DT.75153637

DT.92436721 DT.121181994 DT.95268862

24/263 AceView cDNA sequences (see all 263 ):

AI200223 AI200118 BU688119 AI347976 BM997578 AI499622 NM_016569 AV702518

AI823662 AF002228 BF002728 BQ188072 AI220883 AI762596 BG055137 BQ948902

BM771638 BV177985 CB048970 AI004151 BQ015077 AI374773 AI183433 AI347688

highest scoring ESTs for TBX3:

AF002228 AF170708 AI659386 AI806338 AI888845 AK054604 AW136159 BC025258 BE735102 BM012034

Unigene Cluster for TBX3:

T-box 3

Hs.714737 [show with all ESTs]

Unigene Representative Sequence: NM_016569

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for TBX3

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b
SP1:
SP2:					-

About this scheme

ECgene alternative splicing isoforms for TBX3

3 Ensembl transcripts including schematic representations:

ENST00000257566 ENST00000349155 ENST00000361100

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TBX3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TBX3

¹ / ² / ³

10 probe-sets matching TBX3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
49375_at²^{, 3}	U95-B	1	1.00	1.00	0.99	1.27	AI806338	0.80	1.00	0.91	1
78725_at²^{, 3}	U95-E	1	1.00	1.00	0.41	0.75	U69556	0.80	1.00	0.91	1
222917_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	U69556	0.80	1.00	0.91	1
219682_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_016569	0.60	1.00	0.82	1
225544_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI806338	0.80	1.00	0.91	1
229576_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	N29712	0.60	1.00	0.82	1
222917_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
219682_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225544_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
229576_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks TBX3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAGGTATATT

SOURCE GeneReport for Unigene cluster: Hs.714737
UniProtKB/Swiss-Prot: TBX3_HUMAN, O15119
Tissue specificity: Widely expressed

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TBX3 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TBX3¹	--	T-box 3	90.79(n) 92.49(a)	477494 XM_534692.2 XP_534692.2
chimpanzee (Pan troglodytes)	TBX3¹	--	T-box 3	99.55(n) 99.73(a)	740308 XM_001154426.1 XP_001154426.1
rat (Rattus norvegicus)	Tbx3¹	--	T-box 3	87(n) 94.6(a)	353305 NM_181638.1 NP_853669.1
mouse (Mus musculus)	Tbx3^{1, 5}	5 (65.00 cM)⁵	T-box 3^{1, 5}	86.51(n)¹ 94.45(a)¹	21386¹ NM_011535.2¹ NP_035665.2¹ AA543734⁵ AF429310⁵ (see all 20)
chicken (Gallus gallus)	TBX3¹	--	T-box 3	77.07(n) 82.8(a)	374202 XM_001234534.1 XP_001234535.1

About this table Species with no ortholog for TBX3

ENSEMBL Gene Tree for TBX3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TBX3 gene

TBX2² TBX6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/102 NCBI SNPs in TBX3 are shown (see all 102 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 66)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3741698^1,2	A,C,F,H	113593606(+)	`TGTCCC/GGATTT`	2	--	ut3¹		13		EA EU WA NA	2448
	rs3759173^1,2	A,C,F,H	113607258(+)	`GAACAC/AGCGCC`	2	--	ng3¹		9		EA EU WA	2322
	rs1061657^1,2	A,C,F,H	113592519(-)	`TGATGA/GGTTCT`	2	--	ut3¹		5		MN EU EA WA	596
	rs8853^1,2	A,C,F	113593290(-)	`ACCCAA/GGGGAG`	2	--	ut3¹ ese³ trp³		1		MN	184
	rs1061651^1,2	A,C,F	113592744(-)	`GAGGGA/GGGAGG`	2	--	ut3¹ ese³ trp³		1		MN	184
	rs2242442^1,2	C,F,H	113605572(+)	`GAGGGG/AAAGTG`	2	--	ut5¹ trp³		5		EA EU WA	1686
	rs3759174^1,2	A,C	113608121(+)	`CACCCC/GCGCAA`	2	--	ng3¹		0	--	--	--	--
	rs9805019^1,2	C	113605639(+)	`ATAGTC/TGCGCG`	2	--	ut5¹ ese³		0	--	--	--	--
	rs3741695^1,2	C	113593282(+)	`ATCCCC/TCCCTC`	2	--	ut3¹ trp³		0	--	--	--	--
	rs3741697^1,2	F	113593458(+)	`ACACAG/CATTTT`	2	--	ut3¹		1		EA	1464

About this table

HapMap Linkage Disequilibrium images for TBX3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601621 disorders: 181450

UniProtKB/Swiss-Prot: TBX3_HUMAN, O15119

Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS) [MIM:181450]. UMS is

characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of

nipples and apocrine glands

6 Novoseek disease relationships for TBX3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ulnar-mammary syndrome	98.90	23	9207801 (2), 12668170 (2), 11689487 (2), 16896345 (2) (see all 17)
holt-oram syndrome	84.94	1	9611267 (1)
digeorge syndrome	60.81	1	12668595 (1)
hypoplasia	41.46	1	16955224 (1)
breast cancer	9.65	16	18245468 (5), 15289316 (4), 16049973 (2)
cancer	6.73	6	16049973 (2), 18534921 (1), 19052953 (1), 18829543 (1) (see all 5)

About this table

Human Gene Mutation Database: TBX3
Human Genome Epidemiology Navigator: TBX3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/50 PubMed articles for TBX3 gene (see all 50 ):

The spectrum of mutations in TBX3: genotype/phenotype relationship in ulnar-mammary syndrome. (PubMed id 10330342)^{1, 3, 4} Bamshad M.... Jorde L.B. (1999)
Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome. (PubMed id 9207801)^{1, 3, 4} Bamshad M.... Jorde L.B. (1997)
Structure of the DNA-bound T-box domain of human TBX3, a transcription factor responsible for ulnar-mammary syndrome. (PubMed id 12005433)^{1, 3, 4} Coll M.... Muller C.W. (2002)
Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome. (PubMed id 10468588)^{1, 3, 4} He M.-L.... Rao Y. (1999)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family. (PubMed id 8988164)^{2, 3} Li Q.Y.... Brook J.D. (1997)
TBX3 and its isoform TBX3+2a are functionally distinctive in inhibition of senescence and are overexpressed in a subset of breast cancer cell lines. (PubMed id 15289316)^{1, 3} Fan W....Huang T. (2004)
TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases. (PubMed id 18245468)^{1, 3} Yarosh W....Huang T. (2008)
A dominant repression domain in Tbx3 mediates transcriptional repression and cell immortalization: relevance to mutations in Tbx3 that cause ulnar-mammary syndrome. (PubMed id 11689487)^{1, 3} Carlson H....Hurlin P.J. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6926	HGNC: 11602	AceView: TBX3	Ensembl:ENSG00000135111	euGenes: HUgn6926
ECgene: TBX3	H-InvDB: TBX3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TBX3	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=TBX3

Licensable Technologies for TBX3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TBX3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TBX3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TBX3		Antibodies for TBX3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TBX3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TBX3)
	Antibodies (TBX3)
	Chimera RNAi (TBX3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Tbx3)
	Antibodies (Tbx3)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for TBX3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TBX3

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TBX3 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for TBX3

Summaries
for TBX3

Genomic Location
for TBX3

Proteins
for TBX3

Protein Domains/
Families
for TBX3

Gene Function
for TBX3

Pathways & Interactions
for TBX3

Drugs & Compounds
for TBX3

Transcripts
for TBX3

Expression
for TBX3

Orthologs
for TBX3

Paralogs
for TBX3

SNPs/Variants
for TBX3

Disorders & Mutations
for TBX3

Medical News
for TBX3

Publications
for TBX3

Search for TBX3

Genome Databases showing TBX3

Other Databases showing TBX3

Specialized Databases showing TBX3

Licensable Technologies
for TBX3

Services
for TBX3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TBX3 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor TBX3

Summariesfor TBX3

Genomic Locationfor TBX3

Proteinsfor TBX3

Protein Domains/Familiesfor TBX3

Gene Functionfor TBX3

Pathways & Interactionsfor TBX3

Drugs & Compoundsfor TBX3

Transcriptsfor TBX3

Expression for TBX3

Orthologsfor TBX3

Paralogsfor TBX3

SNPs/Variantsfor TBX3

Disorders & Mutationsfor TBX3

Medical Newsfor TBX3

Publicationsfor TBX3

Search for TBX3

Genome Databases showing TBX3

Other Databases showing TBX3

Specialized Databases showing TBX3

Licensable Technologiesfor TBX3

Servicesfor TBX3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TBX3

Summaries
for TBX3

Genomic Location
for TBX3

Proteins
for TBX3

Protein Domains/
Families
for TBX3

Gene Function
for TBX3

Pathways & Interactions
for TBX3

Drugs & Compounds
for TBX3

Transcripts
for TBX3

Expression
for TBX3

Orthologs
for TBX3

Paralogs
for TBX3

SNPs/Variants
for TBX3

Disorders & Mutations
for TBX3

Medical News
for TBX3

Publications
for TBX3

Licensable Technologies
for TBX3

Services
for TBX3