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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TBX22 Gene

protein-coding   GIFtS: 53
GCID: GC0XP079270

T-Box 22

(Previous name: cleft palate and/or ankyloglossia)
(Previous symbols: CPX, CLPA)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
T-Box 221 2     ABERS2
CPX1 2 5     TBXX2
CLPA1 2     dJ795G23.12
T-Box Protein 222 3     T-Box Transcription Factor TBX222
Cleft Palate And/Or Ankyloglossia1     TBOX223

External Ids:    HGNC: 116001   Entrez Gene: 509452   Ensembl: ENSG000001221457   OMIM: 3003075   UniProtKB: Q9Y4583   

Export aliases for TBX22 gene to outside databases

Previous GC identifers: GC0XP074823 GC0XP076231 GC0XP077311 GC0XP078033 GC0XP079083 GC0XP072851


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TBX22 Gene:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the
T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations
in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it
is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TBX22 Gene: 
TBX22 (T-box 22) is a protein-coding gene. Diseases associated with TBX22 include cleft palate, and cleft palate x-linked. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TBX1.

UniProtKB/Swiss-Prot: TBX22_HUMAN, Q9Y458
Function: Probable transcriptional regulator involved in developmental processes. This is major determinant
crucial to palatogenesis

Gene Wiki entry for TBX22 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011651.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TBX22 gene promoter:
         C/EBPbeta   SRY   POU2F1   GATA-3   POU2F1a   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBX22 promoter sequence
   Search SABiosciences Chromatin IP Primers for TBX22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBX22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.1   Ensembl cytogenetic band:  Xq21.1   HGNC cytogenetic band: Xq21.1

TBX22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBX22 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP079270:  view genomic region     (about GC identifiers)

Start:
79,270,255 bp from pter      End:
79,287,268 bp from pter
Size:
17,014 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TBX22_HUMAN, Q9Y458 (See protein sequence)
Recommended Name: T-box transcription factor TBX22  
Size: 520 amino acids; 57910 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q5JZ06 Q96LC0 Q9HBF1
Alternative splicing: 2 isoforms:  Q9Y458-1   Q9Y458-2   

Explore the universe of human proteins at neXtProt for TBX22: NX_Q9Y458

Explore proteomics data for TBX22 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y458

  • TBX22 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TBX22 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001103348.1  NP_001103349.1  NP_058650.1  

    ENSEMBL proteins: 
     ENSP00000362393   ENSP00000362390   ENSP00000362388   ENSP00000396394  

    Human Recombinant Protein Products for TBX22: 
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    OriGene Protein Over-expression Lysate for TBX22
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    Novus Biologicals TBX22 Proteins
    Novus Biologicals TBX22 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TBX22 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--

    TBX22 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for TBX22


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TBX: T-boxes

    3 InterPro protein domains:
     IPR001699 TF_T-box
     IPR008967 p53-like_TF_DNA-bd
     IPR018186 TF_T-box_CS

    Graphical View of Domain Structure for InterPro Entry Q9Y458

    ProtoNet protein and cluster: Q9Y458

    1 Blocks protein domain: IPB001699 Transcription factor

    UniProtKB/Swiss-Prot: TBX22_HUMAN, Q9Y458
    Similarity: Contains 1 T-box DNA-binding domain


    TBX22 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBX22_HUMAN, Q9Y458
    Function: Probable transcriptional regulator involved in developmental processes. This is major determinant
    crucial to palatogenesis

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA17846996
    GO:0003700sequence-specific DNA binding transcription factor activity TAS11024289
         
    TBX22 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tbx22):
     cellular  craniofacial  digestive/alimentary  mortality/aging  normal 
     respiratory system  skeleton 

    TBX22 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tbx22tm1.1Sta for TBX22

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TBX22 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TBX22

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    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate TBX22:
    hsa-miR-3671 hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidTBX22 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of TBX22 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBX22


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBX22

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA17846996
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent TAS11024289
    GO:0007275multicellular organismal development TAS11024289
    GO:0045892negative regulation of transcription, DNA-dependent IDA17846996

    TBX22 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TBX22

    Search CenterWatch for drugs/clinical trials and news about TBX22

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TBX22 gene (3 alternative transcripts): 
    NM_001109878.1  NM_001109879.1  NM_016954.2  

    Unigene Cluster for TBX22:

    T-box 22
    Hs.374253  [show with all ESTs]
    Unigene Representative Sequence: NM_001109878
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373296 ENST00000476373 ENST00000373294(uc004edj.1) ENST00000373291
    ENST00000442340(uc010nmg.1 uc004edi.1)
    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate TBX22:
    hsa-miR-3671 hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidTBX22 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TBX22
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBX22
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    OriGene ORF clones in mouse, rat for TBX22
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    GenScript: all cDNA clones in your preferred vector (see all 3): TBX22 (NM_016954)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBX22
    Sirion Biotech Customized lentivirus for stable overexpression of TBX22 
                         Customized lentivirus expression plasmids for stable overexpression of TBX22 
    Primer
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    OriGene qPCR primer pairs and template standards for TBX22
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBX22
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBX22

    Additional mRNA sequence: 

    AF251684.1 AK097514.1 AY035371.1 BC014194.2 

    3 DOTS entries:

    DT.75148119  DT.95365125  DT.305015 

    11 AceView cDNA sequences:

    BX115071 NM_016954 BC014194 AY035371 AW104387 AF251684 AI018657 AK097514 
    BF025868 AA952933 BF376476 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TBX22    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                          -                                             
    SP2:                          -                                             
    SP3:                                                                        


    ECgene alternative splicing isoforms for TBX22

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TBX22 expression in normal human tissues (normalized intensities)      TBX22 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAACAAATA
    TBX22 Expression
    About this image


    TBX22 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Nose (Sensory Organs)    fully expand to see all 6 entries
             sensory organ/nose/nasal cavity   
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 3 entries
             Branchial Arch 1
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Pharynx
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Maxillary Process
     
     Neural Crest (Sensory Organs)
             sensory organ/nose/process   

    See TBX22 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TBX22

    SOURCE GeneReport for Unigene cluster: Hs.374253

    UniProtKB/Swiss-Prot: TBX22_HUMAN, Q9Y458
    Tissue specificity: Seems to be expressed at a low level

        SABiosciences Custom PCR Arrays for TBX22
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBX22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TBX22 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbx221 , 5 T-box 221, 5 81.4(n)1
    73.06(a)1
      X (47.59 cM)5
    2455721  NM_181319.41  NP_851836.21 
     1076679645 
    chicken
    (Gallus gallus)
    Aves TBX221 T-box 22 68.03(n)
    68.65(a)
      373895  NM_204106.1  NP_989437.1 
    lizard
    (Anolis carolinensis)
    Reptilia TBX226
    Uncharacterized protein
    68(a)
    1 ↔ 1
    GL343528.1(60476-72975)
    zebrafish
    (Danio rerio)
    Actinopterygii tbx226
    T-box 22
    45(a)
    1 ↔ 1
    14(9562996-9572702)


    ENSEMBL Gene Tree for TBX22 (if available)
    TreeFam Gene Tree for TBX22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TBX22 gene
    TBX12  TBX192  T2  EOMES2  TBX22  TBX62  TBX212  TBX202  
    TBX32  TBX52  TBX152  TBR12  TBX102  TBX42  TBX182  
    8 SIMAP similar genes for TBX22 using alignment to 1 protein entry:     TBX22_HUMAN:
    TBX18    TBX4    TBX15    TBX2    TBX10    TBX20
    TBX1    TBX6

    TBX22 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/379 SNPs in TBX22 are shown (see all 379)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0153844
    Cleft palate with or without ankyloglossia, X-linked (CPX)4--see VAR_0153842 T M mis40--------
    VAR_0360674
    A colorectal cancer sample4--see VAR_0360672 A T mis40--------
    VAR_0218314
    Cleft palate with or without ankyloglossia, X-linked (CPX)4--see VAR_0218312 M V mis40--------
    VAR_0218294
    Cleft palate with or without ankyloglossia, X-linked (CPX)4--see VAR_0218292 L P mis40--------
    VAR_0360664
    A colorectal cancer sample4--see VAR_0360662 V A mis40--------
    VAR_0360684
    A colorectal cancer sample4--see VAR_0360682 D N mis40--------
    VAR_0153834
    Cleft palate with or without ankyloglossia, X-linked (CPX)4--see VAR_0153832 G C mis40--------
    VAR_0218324
    Cleft palate with or without ankyloglossia, X-linked (CPX)4--see VAR_0218322 P L mis40--------
    rs289351771,2,4
    CCleft palate with or without ankyloglossia, X-linked (CPX)4 pathogenic179254134(+) ACCAAA/TACCAA 6 N Y mis1 ese30--------
    rs1048949451,2
    Cpathogenic179249709(+) AGAGCG/TAGCCG 5 E * stg1 ut510--------

    HapMap Linkage Disequilibrium report for TBX22 (79270255 - 79287268 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TBX22:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv521266CNV Gain19592680


    Human Gene Mutation Database (HGMD): TBX22

    Locus Specific Mutation Databases (LSDB): TBX22
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TBX22
    DNA2.0 Custom Variant and Variant Library Synthesis for TBX22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300307   
    OMIM disorders: 303400  
    UniProtKB/Swiss-Prot: TBX22_HUMAN, Q9Y458
  • Cleft palate with or without ankyloglossia, X-linked (CPX) [MIM:303400]: A congenital mouth abnormality
    characterized by fissure of the soft and/or hard palate, due to faulty fusion. Some patients also manifest
    ankyloglossia, a condition in which movements of the tongue are restricted. Complete ankyloglossia is due to
    fusion between the tongue and the floor of the mouth. Partial ankyloglossia is due to a short lingual frenum or
    one which is attached too near the tip of the tongue. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 7 diseases for TBX22:    About MalaCards
    cleft palate    cleft palate x-linked    abruzzo erickson syndrome    pterygium
    cleft lip +/- cleft palate    cleft lip    alcoholism

    2 diseases from the University of Copenhagen DISEASES database for TBX22:
    Cleft palate     Cleft lip

    TBX22 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TBX22 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ankyloglossia 96 4 12412015 (2), 19816249 (1), 17868388 (1)
    cleft palate 81.6 8 12412015 (3), 19816249 (3), 17868388 (2)

    Genetic Association Database (GAD): TBX22
    Human Genome Epidemiology (HuGE) Navigator: TBX22 (5 documents)

    Export disorders for TBX22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TBX22 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with TBX22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TBX22 mutations are a frequent cause of cleft palate. (PubMed id 14729838)1, 2, 3 Marcano A.C.B....Stanier P. (2004)
    2. The T-box transcription factor gene TBX22 is mutated in X-linked cleft palate and ankyloglossia. (PubMed id 11559848)1, 2, 3 Braybrook C.... Stanier P. (2001)
    3. TBX22 mutations are a frequent cause of non-syndromic cleft palate in the Thai population. (PubMed id 17868388)1, 4, 9 Suphapeetiporn K....Shotelersuk V. (2007)
    4. Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia phenotype observed in CPX patients. (PubMed id 12374769)1, 2, 9 Braybrook C....Lindsay S. (2002)
    5. Genetic variants in COL2A1, COL11A2, and IRF6 contrib ute risk to nonsyndromic cleft palate. (PubMed id 20672350)1, 4 Nikopensius T....Metspalu A. (2010)
    6. MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. (PubMed id 20572854)1, 4 JagomAogi T....Metspalu A. (2010)
    7. A functional haplotype variant in the TBX22 promoter is associated with cleft palate and ankyloglossia. (PubMed id 19648124)1, 4 Pauws E....Stanier P. (2009)
    8. PAX9 and TGFB3 are linked to susceptibility to nonsyndromic cleft lip with or without cleft palate in the Japanese: population-based and family-based candidate gene analyses. (PubMed id 16247549)1, 4 Ichikawa E....Yoshiura K. (2006)
    9. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50945 HGNC: 11600 AceView: TBX22 Ensembl:ENSG00000122145 euGenes: HUgn50945
    ECgene: TBX22 H-InvDB: TBX22

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TBX22 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TBX22 gene:
    Search GeneIP for patents involving TBX22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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