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Aliases for TBX21 Gene

Aliases for TBX21 Gene

  • T-Box 21 2 3
  • TBET 3 4 6
  • T-Cell-Specific T-Box Transcription Factor T-Bet 3 4
  • Transcription Factor TBLYM 3 4
  • T-Box Protein 21 3 4
  • TBLYM 3 4
  • T-Box Transcription Factor TBX21 3
  • T-Box Expressed In T Cells 3
  • T-PET 3
  • T-Bet 3

External Ids for TBX21 Gene

Previous GeneCards Identifiers for TBX21 Gene

  • GC17P045516
  • GC17P048291
  • GC17P046152
  • GC17P046285
  • GC17P043166
  • GC17P045810
  • GC17P041179

Summaries for TBX21 Gene

Entrez Gene Summary for TBX21 Gene

  • This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for TBX21 Gene

TBX21 (T-Box 21) is a Protein Coding gene. Diseases associated with TBX21 include asthma, aspirin-induced and angioimmunoblastic t-cell lymphoma. Among its related pathways are Glucocorticoid receptor regulatory network and IL12-mediated signaling events. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is MGA.

UniProtKB/Swiss-Prot for TBX21 Gene

  • Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs

Gene Wiki entry for TBX21 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBX21 Gene

Genomics for TBX21 Gene

Regulatory Elements for TBX21 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TBX21 Gene

Start:
47,733,244 bp from pter
End:
47,746,119 bp from pter
Size:
12,876 bases
Orientation:
Plus strand

Genomic View for TBX21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBX21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBX21 Gene

Proteins for TBX21 Gene

  • Protein details for TBX21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL17-TBX21_HUMAN
    Recommended name:
    T-box transcription factor TBX21
    Protein Accession:
    Q9UL17
    Secondary Accessions:

    Protein attributes for TBX21 Gene

    Size:
    535 amino acids
    Molecular mass:
    58328 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TBX21 Gene

Proteomics data for TBX21 Gene at MOPED

Post-translational modifications for TBX21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBX21 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TBX21 (TBX21)

No data available for DME Specific Peptides for TBX21 Gene

Domains for TBX21 Gene

Gene Families for TBX21 Gene

HGNC:

Protein Domains for TBX21 Gene

Suggested Antigen Peptide Sequences for TBX21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UL17

UniProtKB/Swiss-Prot:

TBX21_HUMAN :
  • Q9UL17
Domain:
  • Contains 1 T-box DNA-binding domain.
genes like me logo Genes that share domains with TBX21: view

Function for TBX21 Gene

Molecular function for TBX21 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs

Gene Ontology (GO) - Molecular Function for TBX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 10761931
GO:0005515 protein binding --
GO:0044212 transcription regulatory region DNA binding IDA 19805038
genes like me logo Genes that share ontologies with TBX21: view
genes like me logo Genes that share phenotypes with TBX21: view

Animal Models for TBX21 Gene

MGI Knock Outs for TBX21:

Animal Model Products

miRNA for TBX21 Gene

miRTarBase miRNAs that target TBX21
Targeting motifs for TBX21 Gene
HOMER Transcription Factor Regulatory Elements motif TBX21
  • Consensus sequence: AGGTGTGAAM Submotif: canonical Cell Type: CD8 GeoId: GSE33802

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for TBX21 Gene

Localization for TBX21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBX21 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBX21 Gene COMPARTMENTS Subcellular localization image for TBX21 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TBX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with TBX21: view

Pathways for TBX21 Gene

genes like me logo Genes that share pathways with TBX21: view

Pathways by source for TBX21 Gene

1 GeneGo (Thomson Reuters) pathway for TBX21 Gene
1 R&D Systems pathway for TBX21 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for TBX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 10761931
GO:0007275 multicellular organismal development TAS 10761931
GO:0009615 response to virus IEP 20583921
GO:0030217 T cell differentiation IEA --
genes like me logo Genes that share ontologies with TBX21: view

Transcripts for TBX21 Gene

mRNA/cDNA for TBX21 Gene

(9) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TBX21 Gene

T-box 21:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBX21

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBX21 Gene

No ASD Table

Relevant External Links for TBX21 Gene

GeneLoc Exon Structure for
TBX21
ECgene alternative splicing isoforms for
TBX21

Expression for TBX21 Gene

mRNA expression in normal human tissues for TBX21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TBX21 Gene

This gene is overexpressed in Whole Blood (26.5) and Spleen (6.4).

Protein differential expression in normal tissues for TBX21 Gene

This gene is overexpressed in NK cells (22.8), Peripheral blood mononuclear cells (15.3), Brain (15.0), and CD8 Tcells (11.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TBX21 Gene

SOURCE GeneReport for Unigene cluster for TBX21 Gene Hs.272409

mRNA Expression by UniProt/SwissProt for TBX21 Gene

Q9UL17-TBX21_HUMAN
Tissue specificity: T-cell specific
genes like me logo Genes that share expressions with TBX21: view

Expression partners for TBX21 Gene

In Situ Assay Products

Orthologs for TBX21 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBX21 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TBX21 35
  • 89.97 (n)
  • 90.6 (a)
TBX21 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBX21 35
  • 90.97 (n)
  • 93.27 (a)
TBX21 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbx21 35
  • 86.35 (n)
  • 87.74 (a)
Tbx21 16
Tbx21 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TBX21 35
  • 99.75 (n)
  • 100 (a)
TBX21 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbx21 35
  • 85.98 (n)
  • 87.69 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TBX21 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBX21 36
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tbx21 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tbx-8 37
  • 41 (a)
tbx-9 37
  • 37 (a)
tbx-11 36
  • 26 (a)
ManyToMany
tbx-30 36
  • 19 (a)
ManyToMany
tbx-34 36
  • 20 (a)
ManyToMany
tbx-35 36
  • 19 (a)
ManyToMany
tbx-37 36
  • 27 (a)
ManyToMany
tbx-38 36
  • 24 (a)
ManyToMany
tbx-39 36
  • 14 (a)
ManyToMany
tbx-40 36
  • 15 (a)
ManyToMany
tbx-42 36
  • 19 (a)
ManyToMany
tbx-43 36
  • 25 (a)
ManyToMany
tbx-8 36
  • 26 (a)
ManyToMany
tbx-9 36
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7001 36
  • 15 (a)
OneToMany
Species with no ortholog for TBX21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TBX21 Gene

ENSEMBL:
Gene Tree for TBX21 (if available)
TreeFam:
Gene Tree for TBX21 (if available)

Paralogs for TBX21 Gene

Paralogs for TBX21 Gene

Selected SIMAP similar genes for TBX21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TBX21: view

Variants for TBX21 Gene

Sequence variations from dbSNP and Humsavar for TBX21 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2074190 -- 47,733,844(-) TCCAG(C/T)CCCGC reference, synonymous-codon
rs2158079 -- 47,741,184(-) TCACC(A/G)TCACA intron-variant
rs2240017 - 47,733,553(-) TAGCG(C/G)TGCTG reference, missense
rs3922359 -- 47,732,792(-) tactg(C/T)gtgcc upstream-variant-2KB
rs4794067 -- 47,731,462(+) AATGG(C/T)GGGTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TBX21 Gene

Variant ID Type Subtype PubMed ID
nsv908571 CNV Loss 21882294
nsv2071 CNV Loss 18451855
nsv507841 CNV Insertion 20534489

Relevant External Links for TBX21 Gene

HapMap Linkage Disequilibrium report
TBX21
Human Gene Mutation Database (HGMD)
TBX21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBX21 Gene

Disorders for TBX21 Gene

(1) OMIM Diseases for TBX21 Gene (604895)

UniProtKB/Swiss-Prot

TBX21_HUMAN
  • Asthma, with nasal polyps and aspirin intolerance (ANPAI) [MIM:208550]: A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for TBX21 Gene

(1) Novoseek inferred disease relationships for TBX21 Gene

Disease -log(P) Hits PubMed IDs
asthma 36.8 14

Relevant External Links for TBX21

Genetic Association Database (GAD)
TBX21
Human Genome Epidemiology (HuGE) Navigator
TBX21
genes like me logo Genes that share disorders with TBX21: view

No data available for Genatlas for TBX21 Gene

Publications for TBX21 Gene

  1. Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. (PMID: 15806396) Akahoshi M. … Shirakawa T. (Hum. Genet. 2005) 3 4 23 48
  2. Association analysis of hepatitis virus B infection with haplotypes of the TBX21 gene promoter region in the Chinese population. (PMID: 17378728) Cao B. … Xu C. (Clin. Chem. Lab. Med. 2007) 3 23 48
  3. T cell-specific T-box transcription factor haplotype is associated with allergic asthma in children. (PMID: 17949803) Munthe-Kaas M.C. … Undlien D. (J. Allergy Clin. Immunol. 2008) 3 23 48
  4. Association of TBX21 polymorphisms in a Korean population with rheumatoid arthritis. (PMID: 19287198) Chae S.C. … Chung H.T. (Exp. Mol. Med. 2009) 3 23 48
  5. Association analysis of novel TBX21 variants with asthma phenotypes. (PMID: 12938094) Chung H.T. … Shin H.D. (Hum. Mutat. 2003) 3 23 48

Products for TBX21 Gene

Sources for TBX21 Gene

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