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TBX21 Gene

protein-coding   GIFtS: 62
GCID: GC17P045810

T-Box 21

  See TBX21-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
T-Box 211 2     T-Cell-Specific T-Box Transcription Factor T-Bet2 3
TBET2 3 5     T-PET2
Transcription Factor TBLYM2 3     T-bet2
TBLYM2 3     T-Box Expressed In T Cells2
T-Box Protein 212 3     T-Box Transcription Factor TBX212

External Ids:    HGNC: 115991   Entrez Gene: 300092   Ensembl: ENSG000000738617   OMIM: 6048955   UniProtKB: Q9UL173   

Export aliases for TBX21 gene to outside databases

Previous GC identifers: GC17P045516 GC17P048291 GC17P046152 GC17P046285 GC17P043166 GC17P041179


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TBX21 Gene:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the
T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene
is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific
transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG).
Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting
a role for this gene in initiating Th1 lineage development from naive Th precursor cells. (provided by RefSeq,
Jul 2008)

GeneCards Summary for TBX21 Gene:
TBX21 (T-box 21) is a protein-coding gene. Diseases associated with TBX21 include angioimmunoblastic t-cell lymphoma, and asthma, aspirin-induced. GO annotations related to this gene include transcription regulatory region DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is EOMES.

UniProtKB/Swiss-Prot: TBX21_HUMAN, Q9UL17
Function: Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1
lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the
opposing TH2 programs

Gene Wiki entry for TBX21 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TBX21 gene promoter:
         c-Fos   STAT1   AP-1   ATF-2   STAT1beta   c-Jun   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBX21 promoter sequence
   Search Chromatin IP Primers for TBX21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBX21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.2

TBX21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBX21 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P045810:  view genomic region     (about GC identifiers)

Start:
45,810,610 bp from pter      End:
45,823,485 bp from pter
Size:
12,876 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TBX21_HUMAN, Q9UL17 (See protein sequence)
Recommended Name: T-box transcription factor TBX21  
Size: 535 amino acids; 58328 Da

Explore the universe of human proteins at neXtProt for TBX21: NX_Q9UL17

Explore proteomics data for TBX21 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TBX21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037483.1  
    ENSEMBL proteins: 
     ENSP00000177694  

    TBX21 Human Recombinant Protein Products:

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    Novus Biologicals TBX21 Proteins
    Novus Biologicals TBX21 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for TBX21

     
    Search eBioscience for Proteins for TBX21 

    TBX21 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TBX21
    R&D Systems Antibodies for TBX21 (T-bet/TBX21)
    Cell Signaling Technology (CST) Antibodies for TBX21 
    OriGene Antibodies for TBX21
    OriGene Custom Antibody Services for TBX21
    Novus Biologicals TBX21 Antibodies
    Search for Antibodies for TBX21 at Abcam
    Cloud-Clone Corp. Antibodies for TBX21
    ThermoFisher Antibodies for TBX21
    LSBio Antibodies in human, mouse, rat for TBX21

    TBX21 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TBX21
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    Search eBioscience for ELISAs for TBX21 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TBX: T-boxes

    3 InterPro protein domains:
     IPR001699 TF_T-box
     IPR008967 p53-like_TF_DNA-bd
     IPR018186 TF_T-box_CS

    Graphical View of Domain Structure for InterPro Entry Q9UL17

    ProtoNet protein and cluster: Q9UL17

    1 Blocks protein domain: IPB001699 Transcription factor

    UniProtKB/Swiss-Prot: TBX21_HUMAN, Q9UL17
    Similarity: Contains 1 T-box DNA-binding domain


    Find genes that share domains with TBX21           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBX21_HUMAN, Q9UL17
    Function: Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1
    lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the
    opposing TH2 programs

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS10761931
    GO:0005515protein binding ----
    GO:0044212transcription regulatory region DNA binding IDA19805038
         
    Find genes that share ontologies with TBX21           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TBX21:
     Decreased influenza A/WSN/33 r 

         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tbx21):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  nervous system  respiratory system  tumorigenesis 

    Find genes that share phenotypes with TBX21           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TBX21: Tbx21tm1Glm Tbx21tm1Srnr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBX21
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TBX21

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TBX21
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TBX21

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  AGGTGTGAAM 

    miRNA
    Products:
        
    miRTarBase miRNAs that target TBX21:
    hsa-mir-29b-3p (MIRT007033)

    Block miRNA regulation of human, mouse, rat TBX21 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TBX21 (see all 12):
    hsa-miR-526b hsa-miR-3065-3p hsa-miR-29a hsa-miR-29c hsa-miR-766 hsa-miR-20b* hsa-miR-519e* hsa-miR-1248
    SwitchGear 3'UTR luciferase reporter plasmidTBX21 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TBX21
    Predesigned siRNA for gene silencing in human, mouse, rat TBX21

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TBX21

    Clone
    Products:
         
    OriGene clones in human, mouse for TBX21 (see all 8)
    OriGene ORF clones in mouse, rat for TBX21
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TBX21 (NM_013351)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBX21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBX21

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TBX21
    Browse ESI BIO Cell Lines and PureStem Progenitors for TBX21 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBX21


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TBX21_HUMAN, Q9UL17: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular2
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0043025neuronal cell body IEA--

    Find genes that share ontologies with TBX21           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TBX21 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Th1 Differentiation
    IL27-mediated signaling events0.38
    Th1 Differentiation0.38
    2IL12-mediated signaling events
    Immune response IL 12 induced IFN gamma production0.33
    IL12-mediated signaling events0.33
    3Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes0.38
    4Leishmaniasis
    Inflammatory bowel disease (IBD)0.34
    5Lymphocyte Signaling
    Lymphocyte Signaling


    Find genes that share SuperPaths with TBX21           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TBX21
        Th1 Differentiation


    1 Cell Signaling Technology (CST) Pathway for TBX21
        Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for TBX21
        Immune response IL-12-induced IFN-gamma production

    5 BioSystems Pathways for TBX21
        IL27-mediated signaling events
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    IL12-mediated signaling events
    IL12 signaling mediated by STAT4
    Glucocorticoid receptor regulatory network


    1 Kegg Pathway  (Kegg details for TBX21):
        Inflammatory bowel disease (IBD)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TBX21 (see all 6): 
              Innate & Adaptive Immune Responses in human mouse rat
              Th17 Response in human mouse rat
              Th1/Th2 Response in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TBX21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TBX21 (Q9UL173 ENSP000001776944) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GATA3P237713, ENSP000003686324I2D: score=3 STRING: ENSP00000368632
    CREBBPQ927933, ENSP000002623674I2D: score=1 STRING: ENSP00000262367
    HOXC11O432483, ENSP000002430824I2D: score=1 STRING: ENSP00000243082
    SMARCA4P515323, ENSP000003507204I2D: score=1 STRING: ENSP00000350720
    TECP426803, ENSP000003709124I2D: score=1 STRING: ENSP00000370912
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated TAS10761931
    GO:0007275multicellular organismal development TAS10761931
    GO:0009615response to virus IEP--
    GO:0030217T cell differentiation IEA--

    Find genes that share ontologies with TBX21           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TBX21



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TBX21 gene: 
    NM_013351.1  

    Unigene Cluster for TBX21:

    T-box 21
    Hs.272409  [show with all ESTs]
    Unigene Representative Sequence: NM_013351
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000177694(uc002ilv.1) ENST00000581328
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TBX21 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TBX21 (see all 12):
    hsa-miR-526b hsa-miR-3065-3p hsa-miR-29a hsa-miR-29c hsa-miR-766 hsa-miR-20b* hsa-miR-519e* hsa-miR-1248
    SwitchGear 3'UTR luciferase reporter plasmidTBX21 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TBX21
    Predesigned siRNA for gene silencing in human, mouse, rat TBX21
    Clone
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    GenScript: all cDNA clones in your preferred vector: TBX21 (NM_013351)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBX21
    Primer
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    OriGene qPCR primer pairs and template standards for TBX21
    OriGene qSTAR qPCR primer pairs in human, mouse for TBX21
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBX21
      QuantiTect SYBR Green Assays in human, mouse, rat TBX21
      QuantiFast Probe-based Assays in human, mouse, rat TBX21

    Additional mRNA sequence: 

    AF093098.1 AF241243.2 AK223634.1 BC039739.2 

    1 DOTS entry:

    DT.70103303 

    9 AceView cDNA sequences:

    BC039739 AI439037 NM_013351 AI439019 AF093098 AF241243 AI762808 BX112288 
    AA465449 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TBX21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCAGGAG
    TBX21 Expression
    About this image


    TBX21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
    TBX21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TBX21 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.272409

    UniProtKB/Swiss-Prot: TBX21_HUMAN, Q9UL17
    Tissue specificity: T-cell specific

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TBX21 (see all 6): 
              Innate & Adaptive Immune Responses in human mouse rat
              Th17 Response in human mouse rat
              Th1/Th2 Response in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TBX21
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    QuantiTect SYBR Green Assays in human, mouse, rat TBX21
    QuantiFast Probe-based Assays in human, mouse, rat TBX21
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBX21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TBX21 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbx211 , 5 T-box 211, 5 86.35(n)1
    87.74(a)1
      11 (60.95 cM)5
    577651  NM_019507.21  NP_062380.21 
     970980715 
    lizard
    (Anolis carolinensis)
    Reptilia TBX216
    T-box 21
    55(a)
    1 ↔ 1
    6(74470000-74477010)
    zebrafish
    (Danio rerio)
    Actinopterygii tbx216
    T-box 21
    41(a)
    1 ↔ 1
    12(30297350-30318978) ENSDARG00000004473
    worm
    (Caenorhabditis elegans)
    Secernentea tbx-83 Brachyury 41(a)
    (best of 2)
      III(10419228-10421240)   --


    ENSEMBL Gene Tree for TBX21 (if available)
    TreeFam Gene Tree for TBX21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TBX21 gene
    EOMES2  TBR12  MGA2  
    4 SIMAP similar genes for TBX21 using alignment to 1 protein entry:     TBX21_HUMAN:
    TBR1    EOMES    T    TBX19

    Find genes that share paralogs with TBX21           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TBX21 (see all 320)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs620740581,2
    C--41181056(+) GTGTGG/TGTGTG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1435558431,2
    --45811921(+) GTCTG-/GTGTGTGTGTGTGTGTGTGT
    GTGTGTGTGTGTGTGTGTGTGT
    GTGTG
    1 -- int10--------
    rs563661021,2
    C--45816847(+) GGCCTG/-GGCGC 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1179251311,2
    C,F--46823629(+) AGGTAC/AGGAGA 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs47940671,2
    C,F,A,H--46823640(+) AATGGT/CGGGTA 1 -- us2k128Minor allele frequency- C:0.21NA NS EA WA CSA 2910
    rs1402374421,2
    --46823654(+) TGTTGA/GGGAGG 1 -- us2k10--------
    rs760053811,2
    C,F--46823696(+) TATCCG/CGTCTC 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1846409741,2
    --46824035(+) AAATAC/TTCCAT 1 -- us2k10--------
    rs744623331,2
    F--46824067(+) AAAGTA/GCACAT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs172509321,2
    C,F--46824119(+) GTGCAT/CGTGTG 1 -- us2k16Minor allele frequency- C:0.14NA WA 246

    HapMap Linkage Disequilibrium report for TBX21 (45810610 - 45823485 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TBX21:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv507841CNV Insertion20534489
    nsv2071CNV Loss18451855
    nsv908571CNV Loss21882294

    Human Gene Mutation Database (HGMD): TBX21
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TBX21
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604895   
    OMIM disorders: 208550  
    UniProtKB/Swiss-Prot: TBX21_HUMAN, Q9UL17
  • Asthma, with nasal polyps and aspirin intolerance (ANPAI) [MIM:208550]: A condition consisting of asthma,
    aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus
    mucosa, leading to protrusion of edematous polyps into the nasal cavities. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry

  • 11 diseases for TBX21:    
    About MalaCards
    angioimmunoblastic t-cell lymphoma    asthma, aspirin-induced    asthma and nasal polyps    chronic inflammatory demyelinating polyradiculoneuropathy
    genital herpes    allergic asthma    hypersensitivity reaction type ii disease    polyradiculoneuropathy
    hairy cell leukemia    aplastic anemia    asthma

    3 diseases from the University of Copenhagen DISEASES database for TBX21:
    Asthma     Hypersensitivity reaction type II disease     Multiple sclerosis

    Find genes that share disorders with TBX21           About GenesLikeMe

    1 Novoseek inferred disease relationship for TBX21 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 36.8 18 19362357 (5), 12938094 (4), 15806396 (3), 17949803 (2)

    Genetic Association Database (GAD): TBX21
    Human Genome Epidemiology (HuGE) Navigator: TBX21 (23 documents)

    Export disorders for TBX21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TBX21 gene, integrated from 10 sources (see all 132):
    (articles sorted by number of sources associating them with TBX21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. (PubMed id 15806396)1, 2, 4, 9 Akahoshi M....Shirakawa T. (Hum. Genet. 2005)
    2. TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants. (PubMed id 19362357)1, 4, 9 Suttner K....Kabesch M. (J. Allergy Clin. Immunol. 2009)
    3. Association of TBX21 polymorphisms in a Korean population with rheumatoid arthritis. (PubMed id 19287198)1, 4, 9 Chae S.C....Chung H.T. (amp 2009)
    4. Association analysis of novel TBX21 variants with asthma phenotypes. (PubMed id 12938094)1, 4, 9 Chung H.T....Shin H.D. (Hum. Mutat. 2003)
    5. Association analysis of hepatitis virus B infection with haplotypes of the TBX21 gene promoter region in the Chinese population. (PubMed id 17378728)1, 4, 9 Cao B....Xu C. (Clin. Chem. Lab. Med. 2007)
    6. Association of TBX21 gene haplotypes in a Chinese population with systemic lupus erythematosus. (PubMed id 20429676)1, 4, 9 You Y....Deng G. (Scand. J. Rheumatol. 2010)
    7. T cell-specific T-box transcription factor haplotype is associated with allergic asthma in children. (PubMed id 17949803)1, 4, 9 Munthe-Kaas M.C....Undlien D. (J. Allergy Clin. Immunol. 2008)
    8. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    9. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    10. Association of TBX21 T-1993C polymorphism with viral persistence but not disease progression in hepatitis B virus carriers. (PubMed id 19473434)1, 4 Chen S....Deng G. (Hepatol. Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 30009 HGNC: 11599 AceView: TBX21 Ensembl:ENSG00000073861 euGenes: HUgn30009
    ECgene: TBX21 Kegg: 30009 H-InvDB: TBX21

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TBX21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TBX21 gene:
    Search GeneIP for patents involving TBX21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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