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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TBX21 Gene

protein-coding   GIFtS: 60
GCID: GC17P045810

T-box 21

 Explore 41 diseases affiliated with
TBX21 via our new
 Human Malady Compendium 
Biological research products
for TBX21
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
T-Box 211 2     T-Box Protein 212 3
TBLYM1 2 3     T-Cell-Specific T-Box Transcription Factor T-Bet2 3
TBET2 3 5     T-PET2
T-Bet1     T-Box Expressed In T Cells2
Transcription Factor TBLYM2 3     T-Box Transcription Factor TBX212

External Ids:    HGNC: 115991   Entrez Gene: 300092   Ensembl: ENSG000000738617   OMIM: 6048955   UniProtKB: Q9UL173   

Export aliases for TBX21 gene to outside databases

Previous GC identifers: GC17P045516 GC17P048291 GC17P046152 GC17P046285 GC17P043166 GC17P041179


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TBX21:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the
T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is
the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific
transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of
the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this
gene in initiating Th1 lineage development from naive Th precursor cells. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TBX21_HUMAN, Q9UL17
Function: Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1
lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the
opposing TH2 programs

Gene Wiki entry for TBX21


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TBX21 gene promoter:
         c-Fos   STAT1   AP-1   ATF-2   STAT1beta   c-Jun   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBX21 promoter sequence
   Search SABiosciences Chromatin IP Primers for TBX21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBX21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.2

TBX21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBX21 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P045810:  view genomic region     (about GC identifiers)

Start:
45,810,610 bp from pter      End:
45,823,485 bp from pter
Size:
12,876 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TBX21_HUMAN, Q9UL17 (See protein sequence)
Recommended Name: T-box transcription factor TBX21  
Size: 535 amino acids; 58328 Da
Subcellular location: Nucleus

Explore the universe of human proteins at neXtProt for TBX21: NX_Q9UL17

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UL17

  • TBX21 Protein expression data from MOPED and PaxDb:    About this image 
    TBX21 Protein Expression
    REFSEQ proteins: NP_037483.1  
    ENSEMBL proteins: 
     ENSP00000177694  

    Human Recombinant Protein Products for TBX21: 
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    Novus Biologicals TBX21 Proteins
    Novus Biologicals TBX21 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TBX21

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--
    GO:0043025neuronal cell body IEA--

    TBX21 for ontologies           About GeneDecksing



    TBX21 Antibody Products: 
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TBX21


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TBX21 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001699 TF_T-box
     IPR008967 p53-like_TF_DNA-bd
     IPR018186 TF_T-box_CS

    Graphical View of Domain Structure for InterPro Entry Q9UL17

    ProtoNet protein and cluster: Q9UL17

    1 Blocks protein family: IPB001699 Transcription factor

    UniProtKB/Swiss-Prot: TBX21_HUMAN, Q9UL17
    Similarity: Contains 1 T-box DNA-binding domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBX21_HUMAN, Q9UL17
    Function: Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1
    lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the
    opposing TH2 programs

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS10761931
    GO:0005515protein binding ----
    GO:0044212transcription regulatory region DNA binding IDA19805038
         
    TBX21 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TBX21:
     Decreased influenza A/WSN/33 r 

         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tbx21):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  nervous system  respiratory system  tumorigenesis 

    TBX21 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for TBX21: Tbx21tm1Glm Tbx21tm1Srnr
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TBX21 

    miRNA
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    OriGene 3'-UTR Clone: TBX21
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TBX21
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate TBX21 (see all 12):
    hsa-miR-526b hsa-miR-3065-3p hsa-miR-29a hsa-miR-29c hsa-miR-766 hsa-miR-20b* hsa-miR-519e* hsa-miR-1248
    SwitchGear 3'UTR luciferase reporter plasmidTBX21 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TBX21 (see all 7)
    OriGene shRNA RFP: TBX21
    OriGene siRNA: TBX21
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBX21
    Sirion Biotech Custom design and validation of potent shRNA sequences against TBX21 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of TBX21 
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    Clone
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    GenScript: all cDNA clones in your preferred vector: TBX21 (NM_013351)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBX21 

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    Sirion Biotech Customized inducible overexpressing cell line services for TBX21

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBX21


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune response IL-12-induced IFN-gamma production
    Immune response IL-12-induced IFN-gamma production1.00
    IL12-mediated signaling events0.33
    Immune response_IL-12-induced IFN-gamma production0.88
    2IL27-mediated signaling events
    IL27-mediated signaling events1.00
    Th1 Differentiation0.38
    3Lymphocyte Signaling
    Lymphocyte Signaling1.00
    4Glucocorticoid receptor regulatory network
    Glucocorticoid receptor regulatory network1.00
    5IL12 signaling mediated by STAT4
    IL12 signaling mediated by STAT41.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TBX21
        Immune response IL-12-induced IFN-gamma production

    1 R&D Systems Pathway for TBX21
        Th1 Differentiation


    1 Cell Signaling Technology (CST) Pathway for TBX21
        Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for TBX21
        Immune response IL-12-induced IFN-gamma production

    5 BioSystems Pathways for TBX21 
        Glucocorticoid receptor regulatory network
    IL12-mediated signaling events
    IL27-mediated signaling events
    IL12 signaling mediated by STAT4
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes



    TBX21 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TBX21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/28 Interacting proteins for TBX21 (Q9UL173 ENSP000001776944) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GATA3P237713, ENSP000003686324I2D: score=3 STRING: ENSP00000368632
    CREBBPQ927933, ENSP000002623674I2D: score=1 STRING: ENSP00000262367
    HOXC11O432483, ENSP000002430824I2D: score=1 STRING: ENSP00000243082
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    SP1P080473, ENSP000003293574I2D: score=1 STRING: ENSP00000329357
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent TAS10761931
    GO:0007275multicellular organismal development TAS10761931
    GO:0009615response to virus IEP--
    GO:0030217T cell differentiation IEA--

    TBX21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TBX21
    Search CenterWatch for drugs/clinical trials and news about TBX21 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TBX21 gene: 
    NM_013351.1  

    Unigene Cluster for TBX21:

    T-box 21
    Hs.272409  [show with all ESTs]
    Unigene Representative Sequence: NM_013351
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000177694(uc002ilv.1) ENST00000581328

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TBX21
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate TBX21 (see all 12):
    hsa-miR-526b hsa-miR-3065-3p hsa-miR-29a hsa-miR-29c hsa-miR-766 hsa-miR-20b* hsa-miR-519e* hsa-miR-1248
    SwitchGear 3'UTR luciferase reporter plasmidTBX21 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TBX21 (see all 7)
    OriGene shRNA RFP: TBX21
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    Sirion Biotech Custom design and validation of potent shRNA sequences against TBX21 
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBX21 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBX21 (see all 2)
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    GenScript: all cDNA clones in your preferred vector: TBX21 (NM_013351)
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    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBX21
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBX21
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBX21

    Additional cDNA sequence: 

    AF093098.1 AF241243.2 AK223634.1 BC039739.2 

    1 DOTS entry:

    DT.70103303 

    9 AceView cDNA sequences:

    AF241243 BC039739 AI439019 NM_013351 AF093098 AI439037 AI762808 AA465449 
    BX112288 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TBX21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAGCAGGAG
    TBX21 Expression
    About this image
    See TBX21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TBX21

    SOURCE GeneReport for Unigene cluster: Hs.272409

    UniProtKB/Swiss-Prot: TBX21_HUMAN, Q9UL17
    Tissue specificity: T-cell specific

        SABiosciences Expression via Pathway-Focused PCR Arrays including TBX21 (see all 6): 
              Innate & Adaptive Immune Responses in human mouse rat
              Th17 Response in human mouse rat
              Th1/Th2 Response in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBX21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TBX21 gene from 2/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia TBX216
    --
    55(a)
    1 ↔ 1
    6(74470000-74477010)
    zebrafish
    (Danio rerio)
    Actinopterygii tbx216
    T-box 21
    37(a)
    1 ↔ 1
    12(30297350-30318978)


    ENSEMBL Gene Tree for TBX21 (if available)
    TreeFam Gene Tree for TBX21 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TBX21 gene
    TBX12  TBX222  TBX192  T2  EOMES2  TBX22  TBX62  TBX32  
    TBX202  TBX52  TBX102  TBX42  TBX152  TBR12  TBX182  
    4 SIMAP similar genes for TBX21 using alignment to 1 protein entry:     TBX21_HUMAN:
    TBR1    EOMES    T    TBX19

    TBX21 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/260 NCBI SNPs in TBX21 are shown (see all 260    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs760053811,2
    --41177957(+) TATCCG/CGTCTC 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs744623331,2
    --41178328(+) AAAGTA/GCACAT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1129756211,2
    C--41178587(+) CAATTG/-TGGGG 1 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs116504511,2
    C,F,H--41178895(+) TTTCAG/AGNNNN 1 -- us2k118Minor allele frequency- A:0.09NS EA NA WA 2172
    rs39223591,2
    C,H--41179231(-) tactgT/Cgtgcc 1 -- us2k16Minor allele frequency- C:0.00NS EA NA 418
    rs1113480821,2
    C--41179333(+) CGAGTC/TCCACT 1 -- us2k12Minor allele frequency- T:0.08CSA WA 119
    rs172445441,2
    F--41179815(+) CCTGCC/TCATCC 1 -- ut511Minor allele frequency- T:0.04NA 120
    rs792928781,2
    C--41180321(+) CAACAA/CCCACC 2 N T mis10--------
    rs1116204791,2
    C--41180517(+) GACAGG/AGGAAT 1 -- int11Minor allele frequency- A:0.50NA 2
    rs620740581,2
    C--41181056(+) GTGTGG/TGTGTG 1 -- int11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for TBX21 (45810610 - 45823485 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TBX21: --
    Human Gene Mutation Database (HGMD): TBX21

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBX21
    DNA2.0 Custom Variant and Variant Library Synthesis for TBX21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TBX21 for disorders           About GeneDecksing

    OMIM gene information: 604895   
    OMIM disorders: 208550  
    UniProtKB/Swiss-Prot: TBX21_HUMAN, Q9UL17
  • Genetic variations in TBX21 are associated with susceptibility to asthma with nasal polyps and aspirin
  • intolerance (ANPAI) [MIM:208550]. A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal
    polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into
    the nasal cavities

    20/41 diseases for TBX21 (see all 41):    About MalaCards
    asthma, aspirin-induced    chronic inflammatory demyelinating polyradiculoneuropathy    hypersensitivity reaction type ii disease    graft versus host disease
    wiskott-aldrich syndrome    polyradiculoneuropathy    asthma and nasal polyps    genital herpes
    hairy cell leukemia    systemic lupus erythematosus    allergic rhinitis    aplastic anemia
    lupus erythematosus    asthma    herpes simplex    allergic asthma
    cutaneous t cell lymphoma    hepatitis a    rhinitis    bronchiolitis

    3 diseases from the University of Copenhagen DISEASES database for TBX21:
    Asthma     Hypersensitivity reaction type II disease     Multiple sclerosis

    1 Novoseek disease relationship for TBX21 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 36.8 18 19362357 (5), 12938094 (4), 15806396 (3), 17949803 (2)

    Genetic Association Database (GAD): TBX21
    Human Genome Epidemiology (HuGE) Navigator: TBX21 (23 documents)

    Export disorders for TBX21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TBX21 gene, integrated from 9 sources (see all 119):
    (articles sorted by number of sources associating them with TBX21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. (PubMed id 15806396)1, 2, 4, 9 Akahoshi M....Shirakawa T. (2005)
    2. Association analysis of novel TBX21 variants with asthma phenotypes. (PubMed id 12938094)1, 4, 9 Chung H.T....Shin H.D. (2003)
    3. T-bet polymorphisms are associated with asthma and airway hyperresponsiveness. (PubMed id 16179640)1, 4 Raby B.A....Weiss S.T. (2006)
    4. Association study of 15 novel single-nucleotide polymorphisms of the T-bet locus among Finnish asthma families. (PubMed id 15248849)1, 4 Ylikoski E....Lahesmaa R. (2004)
    5. TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids. (PubMed id 15604153)1, 4 Tantisira K.G....Weiss S.T. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. A novel transcription factor, T-bet, directs Th1 lineage commitment. (PubMed id 10761931)1, 2 Szabo S.J....Glimcher L.H. (2000)
    8. TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants. (PubMed id 19362357)1, 9 Suttner K....Kabesch M. (2009)
    9. Association of TBX21 polymorphisms in a Korean population with rheumatoid arthritis. (PubMed id 19287198)1, 9 Chae S.C....Chung H.T. (2009)
    10. Association analysis of hepatitis virus B infection with haplotypes of the TBX21 gene promoter region in the Chinese population. (PubMed id 17378728)1, 9 Cao B....Xu C. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 30009 HGNC: 11599 AceView: TBX21 Ensembl:ENSG00000073861 euGenes: HUgn30009
    ECgene: TBX21 H-InvDB: TBX21

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TBX21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TBX21 gene:
    Search GeneIP for patents involving TBX21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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