Aliases for TBX21 Gene
External Ids for TBX21 Gene
Previous GeneCards Identifiers for TBX21 Gene
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for TBX21 Gene
TBX21 (T-Box 21) is a Protein Coding gene. Diseases associated with TBX21 include Asthma, Aspirin-Induced and Genital Herpes. Among its related pathways are Glucocorticoid receptor regulatory network and Development and heterogeneity of the ILC family. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is EOMES.
UniProtKB/Swiss-Prot for TBX21 Gene
Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.