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Aliases for TBX21 Gene

Aliases for TBX21 Gene

  • T-Box 21 2 3 5
  • T-Cell-Specific T-Box Transcription Factor T-Bet 3 4
  • Transcription Factor TBLYM 3 4
  • T-Box Protein 21 3 4
  • TBLYM 3 4
  • TBET 3 4
  • T-Box Transcription Factor TBX21 3
  • T-Box Expressed In T Cells 3
  • T-PET 3
  • T-Bet 3

External Ids for TBX21 Gene

Previous GeneCards Identifiers for TBX21 Gene

  • GC17P045516
  • GC17P048291
  • GC17P046152
  • GC17P046285
  • GC17P043166
  • GC17P045810
  • GC17P041179

Summaries for TBX21 Gene

Entrez Gene Summary for TBX21 Gene

  • This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for TBX21 Gene

TBX21 (T-Box 21) is a Protein Coding gene. Diseases associated with TBX21 include Asthma, Aspirin-Induced and Genital Herpes. Among its related pathways are IL12-mediated signaling events and IL27-mediated signaling events. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is EOMES.

UniProtKB/Swiss-Prot for TBX21 Gene

  • Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.

Gene Wiki entry for TBX21 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBX21 Gene

Genomics for TBX21 Gene

Regulatory Elements for TBX21 Gene

Enhancers for TBX21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G047728 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20.7 -0.2 -210 8.4 HDGF WRNIP1 SIN3A GLIS2 ZNF143 TBX21 GLIS1 NBN STAT3 KDM1A TBKBP1 OSBPL7 TBX21 KPNB1 SCRN2 EFCAB13 MRPL10 SP2
GH17G047700 2 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -28.3 -28259 9.3 HDGF PKNOX1 ARNT FEZF1 ZNF2 CBX5 ZNF263 SP3 MCM3 SP5 TBKBP1 LRRC37A17P ENSG00000253347 OSBPL7 KPNB1 TBX21 LOC101927060 ENSG00000263412 EFCAB13 HOXB2
GH17G047719 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.2 -13.5 -13529 1.0 HDGF ZNF366 FOS ETV6 CBFB JUNB GATAD2B TBX21 IKZF1 HMBOX1 TBKBP1 TBX21
GH17G048001 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.8 +270.2 270157 4.4 HDGF ARNT ZNF133 SIN3A YBX1 FEZF1 ZBTB7B YY1 ZNF121 ZNF766 PRR15L SP2-AS1 PNPO HOXB4 ENSG00000266601 NFE2L1 SNX11 CBX1 COPZ2 TBKBP1
GH17G047737 0.6 FANTOM5 dbSUPER 8.1 +4.1 4112 0.1 MLLT1 TBX21 OSBPL7 MRPL10 PIR42414
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TBX21 on UCSC Golden Path with GeneCards custom track

Promoters for TBX21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000095207 256 601 SIN3A RAD21 GLIS2 SCRT2 HMG20B GATAD2B ZNF398 KLF16 GLIS1 NBN

Genomic Location for TBX21 Gene

Chromosome:
17
Start:
47,733,244 bp from pter
End:
47,746,122 bp from pter
Size:
12,879 bases
Orientation:
Plus strand

Genomic View for TBX21 Gene

Genes around TBX21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBX21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBX21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBX21 Gene

Proteins for TBX21 Gene

  • Protein details for TBX21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL17-TBX21_HUMAN
    Recommended name:
    T-box transcription factor TBX21
    Protein Accession:
    Q9UL17

    Protein attributes for TBX21 Gene

    Size:
    535 amino acids
    Molecular mass:
    58328 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TBX21 Gene

Post-translational modifications for TBX21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBX21 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TBX21 (TBX21)

No data available for DME Specific Peptides for TBX21 Gene

Domains & Families for TBX21 Gene

Gene Families for TBX21 Gene

Protein Domains for TBX21 Gene

Suggested Antigen Peptide Sequences for TBX21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TBX21: view

No data available for UniProtKB/Swiss-Prot for TBX21 Gene

Function for TBX21 Gene

Molecular function for TBX21 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.

Gene Ontology (GO) - Molecular Function for TBX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 10761931
GO:0044212 transcription regulatory region DNA binding IDA 19805038
genes like me logo Genes that share ontologies with TBX21: view
genes like me logo Genes that share phenotypes with TBX21: view

Human Phenotype Ontology for TBX21 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TBX21 Gene

MGI Knock Outs for TBX21:

Animal Model Products

CRISPR Products

miRNA for TBX21 Gene

miRTarBase miRNAs that target TBX21
Targeted motifs for TBX21 Gene
HOMER Transcription Factor Regulatory Elements motif TBX21
  • Consensus sequence: AGGTGTGAAM Submotif: canonical Cell Type: CD8 GEO ID: GSE33802

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for TBX21 Gene

Localization for TBX21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBX21 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBX21 gene
Compartment Confidence
nucleus 5
extracellular 3
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TBX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with TBX21: view

Pathways & Interactions for TBX21 Gene

genes like me logo Genes that share pathways with TBX21: view

Gene Ontology (GO) - Biological Process for TBX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 10761931
GO:0007275 multicellular organism development TAS 10761931
GO:0009615 response to virus IEP 20583921
GO:0030217 T cell differentiation IEA --
genes like me logo Genes that share ontologies with TBX21: view

No data available for SIGNOR curated interactions for TBX21 Gene

Drugs & Compounds for TBX21 Gene

(1) Drugs for TBX21 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
corticosteroids Pharma 0
genes like me logo Genes that share compounds with TBX21: view

Transcripts for TBX21 Gene

mRNA/cDNA for TBX21 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TBX21 Gene

T-box 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBX21 Gene

No ASD Table

Relevant External Links for TBX21 Gene

GeneLoc Exon Structure for
TBX21
ECgene alternative splicing isoforms for
TBX21

Expression for TBX21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TBX21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TBX21 Gene

This gene is overexpressed in Whole Blood (x26.5) and Spleen (x6.4).

Protein differential expression in normal tissues from HIPED for TBX21 Gene

This gene is overexpressed in NK cells (22.8), Peripheral blood mononuclear cells (15.3), Brain (15.0), and CD8 Tcells (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TBX21 Gene



Protein tissue co-expression partners for TBX21 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TBX21 Gene:

TBX21

SOURCE GeneReport for Unigene cluster for TBX21 Gene:

Hs.272409

mRNA Expression by UniProt/SwissProt for TBX21 Gene:

Q9UL17-TBX21_HUMAN
Tissue specificity: T-cell specific.

Evidence on tissue expression from TISSUES for TBX21 Gene

  • Blood(3.5)
  • Spleen(3.2)
  • Lymph node(2.8)
  • Lung(2.2)
  • Bone marrow(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TBX21 Gene

Germ Layers:
  • ectoderm
  • endoderm
Systems:
  • immune
  • respiratory
Organs:
Head and neck:
  • head
  • mouth
  • nose
  • pharynx
Thorax:
  • bronchus
  • lung
General:
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with TBX21: view

Primer Products

Orthologs for TBX21 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBX21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBX21 34 35
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia TBX21 34 35
  • 90.97 (n)
cow
(Bos Taurus)
Mammalia TBX21 34 35
  • 89.97 (n)
mouse
(Mus musculus)
Mammalia Tbx21 34 16 35
  • 86.35 (n)
rat
(Rattus norvegicus)
Mammalia Tbx21 34
  • 85.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TBX21 35
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 56 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia TBX21 35
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tbx21 35
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tbx-8 36 35
  • 41 (a)
tbx-9 36 35
  • 37 (a)
tbx-37 35
  • 27 (a)
ManyToMany
tbx-11 35
  • 26 (a)
ManyToMany
tbx-43 35
  • 25 (a)
ManyToMany
tbx-38 35
  • 24 (a)
ManyToMany
tbx-34 35
  • 20 (a)
ManyToMany
tbx-30 35
  • 19 (a)
ManyToMany
tbx-35 35
  • 19 (a)
ManyToMany
tbx-42 35
  • 19 (a)
ManyToMany
tbx-40 35
  • 15 (a)
ManyToMany
tbx-39 35
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7001 35
  • 15 (a)
OneToMany
Species where no ortholog for TBX21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TBX21 Gene

ENSEMBL:
Gene Tree for TBX21 (if available)
TreeFam:
Gene Tree for TBX21 (if available)

Paralogs for TBX21 Gene

Paralogs for TBX21 Gene

(4) SIMAP similar genes for TBX21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TBX21: view

Variants for TBX21 Gene

Sequence variations from dbSNP and Humsavar for TBX21 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000631219 -- 47,746,614(+) GTAAA(C/G)GGTTT downstream-variant-500B
rs1001075810 -- 47,746,326(+) TAAGG(C/T)ATCTT downstream-variant-500B
rs1001193365 -- 47,745,907(+) CACAG(G/T)GGGGA utr-variant-3-prime
rs1001312189 -- 47,735,783(+) CAGCT(A/C)GGGGC intron-variant
rs1001331350 -- 47,733,292(+) GACGA(-/G)GGGCG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TBX21 Gene

Variant ID Type Subtype PubMed ID
nsv1116224 CNV deletion 24896259
nsv2071 CNV deletion 18451855
nsv507841 OTHER sequence alteration 20534489

Variation tolerance for TBX21 Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBX21 Gene

Human Gene Mutation Database (HGMD)
TBX21
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TBX21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBX21 Gene

Disorders for TBX21 Gene

MalaCards: The human disease database

(9) MalaCards diseases for TBX21 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma, aspirin-induced
  • asthma and nasal polyps
genital herpes
  • genital herpes simplex
acute necrotizing encephalitis
  • encephalitis, acute necrotizing
heart sarcoma
  • cardiac sarcoma
polyradiculoneuropathy
- elite association - COSMIC cancer census association via MalaCards
Search TBX21 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TBX21_HUMAN
  • Asthma, with nasal polyps and aspirin intolerance (ANPAI) [MIM:208550]: A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities. {ECO:0000269 PubMed:15806396}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for TBX21

Genetic Association Database (GAD)
TBX21
Human Genome Epidemiology (HuGE) Navigator
TBX21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TBX21
genes like me logo Genes that share disorders with TBX21: view

No data available for Genatlas for TBX21 Gene

Publications for TBX21 Gene

  1. Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. (PMID: 15806396) Akahoshi M. … Shirakawa T. (Hum. Genet. 2005) 3 4 22 46 64
  2. Association of TBX21 gene haplotypes in a Chinese population with systemic lupus erythematosus. (PMID: 20429676) You Y. … Deng G. (Scand. J. Rheumatol. 2010) 3 22 46 64
  3. Association of TBX21 polymorphisms in a Korean population with rheumatoid arthritis. (PMID: 19287198) Chae S.C. … Chung H.T. (Exp. Mol. Med. 2009) 3 22 46 64
  4. TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants. (PMID: 19362357) Suttner K. … Kabesch M. (J. Allergy Clin. Immunol. 2009) 3 22 46 64
  5. T cell-specific T-box transcription factor haplotype is associated with allergic asthma in children. (PMID: 17949803) Munthe-Kaas M.C. … Undlien D. (J. Allergy Clin. Immunol. 2008) 3 22 46 64

Products for TBX21 Gene

Sources for TBX21 Gene

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