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TBX20 Gene

protein-coding   GIFtS: 52
GCID: GC07M035237

T-Box 20

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
T-Box 201 2
T-Box Protein 202 3
ASD42 5
T-Box Transcription Factor TBX202

External Ids:    HGNC: 115981   Entrez Gene: 570572   Ensembl: ENSG000001645327   OMIM: 6060615   UniProtKB: Q9UMR33   

Export aliases for TBX20 gene to outside databases

Previous GC identifers: GC07M034889 GC07M035013 GC07M035044


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TBX20 Gene:
This gene encodes a T-box family member. The T-box family members share a common DNA binding domain, termed the
T-box, and they are transcription factors involved in the regulation of developmental processes. This gene is
essential for heart development. Mutations in this gene are associated with diverse cardiac pathologies,
including defects in septation, valvulogenesis and cardiomyopathy. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2009)

GeneCards Summary for TBX20 Gene:
TBX20 (T-box 20) is a protein-coding gene. Diseases associated with TBX20 include acute stress disorder, and atrial septal defect 4. GO annotations related to this gene include RNA polymerase II transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TBX1.

UniProtKB/Swiss-Prot: TBX20_HUMAN, Q9UMR3
Function: Acts as a transcriptional activator and repressor required for cardiac development and may have key
roles in the maintenance of functional and structural phenotypes in adult heart (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the TBX20 gene promoter:
         SRF   AREB6   POU2F1   SRF (504 AA)   Nkx2-5   ATF6   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBX20 promoter sequence
   Search Chromatin IP Primers for TBX20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBX20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.3   Ensembl cytogenetic band:  7p14.2   HGNC cytogenetic band: 7p14.3

TBX20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBX20 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M035237:  view genomic region     (about GC identifiers)

Start:
35,242,042 bp from pter      End:
35,293,758 bp from pter
Size:
51,717 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 35,281,142-35,332,810     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TBX20_HUMAN, Q9UMR3 (See protein sequence)
Recommended Name: T-box transcription factor TBX20  
Size: 447 amino acids; 49232 Da
Sequence caution: Sequence=AAD21787.1; Type=Erroneous gene model prediction; Sequence=AAI20946.1; Type=Frameshift;
Positions=294; Sequence=AAI20946.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAI20947.1;
Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: A4D1Y6 Q000T4 Q0IJ70 Q0VAS1 Q9Y2N5

Explore the universe of human proteins at neXtProt for TBX20: NX_Q9UMR3

Explore proteomics data for TBX20 at MOPED


See TBX20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001071121.1  NP_001159692.1  

ENSEMBL proteins: 
 ENSP00000386170  

TBX20 Human Recombinant Protein Products:

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OriGene Purified Proteins for TBX20
OriGene Protein Over-expression Lysate for TBX20
OriGene MassSpec for TBX20
OriGene Custom Protein Services for TBX20
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Novus Biologicals TBX20 Protein
Novus Biologicals TBX20 Lysates
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Browse Sino Biological Cell Lysates
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Cloud-Clone Corp. Proteins for TBX20

TBX20 Antibody Products:

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R&D Systems Antibodies for TBX20
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OriGene Custom Antibody Services for TBX20
Novus Biologicals TBX20 Antibodies
Search for Antibodies for TBX20 at Abcam
Cloud-Clone Corp. Antibodies for TBX20
Search ThermoFisher Antibodies for TBX20
LSBio Antibodies in human, mouse, rat for TBX20

TBX20 Assay Products:

Browse Kits and Assays available from EMD Millipore
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Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for TBX20
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for TBX20
Cloud-Clone Corp. CLIAs for TBX20


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
TBX: T-boxes

3 InterPro protein domains:
 IPR001699 TF_T-box
 IPR008967 p53-like_TF_DNA-bd
 IPR018186 TF_T-box_CS

Graphical View of Domain Structure for InterPro Entry Q9UMR3

ProtoNet protein and cluster: Q9UMR3

1 Blocks protein domain: IPB001699 Transcription factor

UniProtKB/Swiss-Prot: TBX20_HUMAN, Q9UMR3
Similarity: Contains 1 T-box DNA-binding domain


TBX20 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TBX20_HUMAN, Q9UMR3
Function: Acts as a transcriptional activator and repressor required for cardiac development and may have key
roles in the maintenance of functional and structural phenotypes in adult heart (By similarity)

     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IDA19762328
GO:0001085RNA polymerase II transcription factor binding ISS--
GO:0001102RNA polymerase II activating transcription factor binding ISS--
GO:0001105RNA polymerase II transcription coactivator activity IDA19762328
GO:0003677DNA binding ----
     
TBX20 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for TBX20:
 Synthetic lethal with Ras 

     9 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Tbx20):
 cardiovascular system  cellular  embryogenesis  growth/size/body  homeostasis/metabolism 
 mortality/aging  muscle  no phenotypic analysis  normal 

TBX20 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Tbx20tm1.1Sev for TBX20

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBX20
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TBX20

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TBX20
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TBX20

Transcription Factor Targeting: 
Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                      Consensus sequence:  GGTGYTGACAGS 

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat TBX20 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate TBX20
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for TBX20
Predesigned siRNA for gene silencing in human, mouse, rat TBX20

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for TBX20

Clone
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OriGene clones in human, mouse for TBX20 (see all 14)
OriGene ORF clones in mouse, rat for TBX20
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): TBX20 (NM_001077653)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBX20
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBX20

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for TBX20
Browse ESI BIO Cell Lines and PureStem Progenitors for TBX20 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBX20


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TBX20_HUMAN, Q9UMR3: Nucleus (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2
endoplasmic reticulum1
extracellular1
mitochondrion1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus ISS--
GO:0005737cytoplasm ISS--

TBX20 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TBX20 About    
See pathways by source

SuperPathContained pathways About
1Heart Development
Heart Development
2Cardiac Progenitor Differentiation
Cardiac Progenitor Differentiation


2 BioSystems Pathways for TBX20
    Heart Development
Cardiac Progenitor Differentiation


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBX20
Interactions:

    Search GeneGlobe Interaction Network for TBX20

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

Selected Interacting proteins for TBX20 (Q9UMR33 ENSP000003861704) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
ZSCAN1Q8NBB43, ENSP000002823264I2D: score=1 STRING: ENSP00000282326
SMAD1Q157973I2D: score=1 
SMAD5Q997173I2D: score=1 
SMARCA4ENSP000003507204STRING: ENSP00000350720
SMARCA2ENSP000002657734STRING: ENSP00000265773
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Gene Ontology (GO): Selected biological process terms (see all 36):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
GO:0001569patterning of blood vessels IEA--
GO:0001706endoderm formation ISS--
GO:0001764neuron migration IEA--
GO:0001947heart looping ISS--

TBX20 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TBX20



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TBX20 gene (3 alternative transcripts): 
NM_001077653.2  NM_001166220.1  NM_020417.1  

Unigene Cluster for TBX20:

T-box 20
Hs.404167  [show with all ESTs]
Unigene Representative Sequence: DQ986374
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000408931(uc011kas.2) ENST00000492961
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat TBX20 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate TBX20
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for TBX20
Predesigned siRNA for gene silencing in human, mouse, rat TBX20
Clone
Products:
     
OriGene clones in human, mouse for TBX20 (see all 14)
OriGene ORF clones in mouse, rat for TBX20
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): TBX20 (NM_001077653)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBX20
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBX20
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for TBX20
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBX20
  QuantiTect SYBR Green Assays in human, mouse, rat TBX20
  QuantiFast Probe-based Assays in human, mouse, rat TBX20

Additional mRNA sequence: 

AJ237589.1 BC120945.1 BC120946.1 DQ986374.1 

1 DOTS entry:

DT.91906257 

3 AceView cDNA sequences:

AJ237589 NM_020417 BP872586 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TBX20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TBX20 Expression
About this image


TBX20 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 9) fully expand
 
 Heart (Cardiovascular System)    fully expand to see all 13 entries
         Cardiac Crescent Cells Cardiac Crescent
         Cardiovascular progenitor cells
 
 NULL (Uncategorized)    fully expand to see all 5 entries
         Cardiovascular progenitor cells
 
 Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
         Pre-endocardial Cells Cardiogenic Mesoderm
 
 Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
         Human embryonic stem cells (family)
 
 Eye (Sensory Organs)
         Retinal Pigmented Epithelium
TBX20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TBX20 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.404167
    Custom PCR Arrays for TBX20
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for TBX20
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBX20
QuantiTect SYBR Green Assays in human, mouse, rat TBX20
QuantiFast Probe-based Assays in human, mouse, rat TBX20
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBX20

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TBX20 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tbx201 , 5 T-box 201, 5 89.21(n)1
97.53(a)1
  9 (10.25 cM)5
572461  NM_194263.21  NP_919239.11 
 247208125 
chicken
(Gallus gallus)
Aves TBX201 T-box 20 82.5(n)
93.41(a)
  373943  NM_204144.1  NP_989475.1 
lizard
(Anolis carolinensis)
Reptilia TBX206
T-box 20
92(a)
1 ↔ 1
6(46249211-46307694)
African clawed frog
(Xenopus laevis)
Amphibia tbx20-A2 T-box 20 77.68(n)    AY154394.1 
zebrafish
(Danio rerio)
Actinopterygii tbx202 T-box 20 78.73(n)   57936  AF239664.1 
fruit fly
(Drosophila melanogaster)
Insecta org-13 transcription factor 64(a)
(best of 6)
    --
worm
(Caenorhabditis elegans)
Secernentea mab-93 transcription regulator 61(a)   II(516155-521443)   --


ENSEMBL Gene Tree for TBX20 (if available)
TreeFam Gene Tree for TBX20 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TBX20 gene
TBX12  TBX222  TBX192  T2  TBX22  TBX62  TBX32  TBX52  
TBX152  TBX102  TBX42  TBX182  
11 SIMAP similar genes for TBX20 using alignment to 11 protein entries:     TBX20_HUMAN (see all proteins):
TBX18    TBX2    TBX6    MGA    TBX5    T
TBX10    TBX15    TBX22    TBX4    TBX1

TBX20 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for TBX20
PGOHUM00000239491


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TBX20 (see all 1110)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0369954
Atrial septal defect 4 (ASD4)4--see VAR_0369952 I M mis40--------
rs1835743631,2
--35214289(+) ATAAAC/TTGACT 1 -- ds50010--------
rs1115030591,2
F--35214311(-) ACTGAC/TCATAA 1 -- ds50011Minor allele frequency- T:0.08NS 506
rs1124711341,2
C,F--35214417(-) TAAAAC/TGCTGT 1 -- ds50011Minor allele frequency- T:0.01NS 516
rs1145751141,2
C--35214519(+) CCCAAA/GAGCTG 1 -- ds50010--------
rs1127839061,2
F--35214546(-) ACCACG/AGACCA 1 -- ds50011Minor allele frequency- A:0.01NS 514
rs2012174621,2
C--35214737(+) ATGGCG/ATCATC 2 /T /M mis11Minor allele frequency- A:0.00EU 661
rs2007045611,2
C--35214759(+) ATGGCA/GTAGTC 2 R C mis10--------
rs25321221,2
--35214874(+) GATGGG/TGTCAG 2 T syn10--------
rs1811809951,2
--35215036(+) AGAGAC/TAAATT 2 L syn10--------

HapMap Linkage Disequilibrium report for TBX20 (35242042 - 35293758 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TBX20: --
Human Gene Mutation Database (HGMD): TBX20
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TBX20
DNA2.0 Custom Variant and Variant Library Synthesis for TBX20

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606061   
OMIM disorders: 611363  
UniProtKB/Swiss-Prot: TBX20_HUMAN, Q9UMR3
  • Atrial septal defect 4 (ASD4) [MIM:611363]: A congenital heart malformation characterized by incomplete
    closure of the wall between the atria resulting in blood flow from the left to the right atria. Patients show
    other heart abnormalities including defects in septation, chamber growth and valvulogenesis. The disease is not
    associated with defects in the cardiac conduction system or with non-cardiac abnormalities. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 14 diseases for TBX20:    
    About MalaCards
    acute stress disorder    atrial septal defect 4    isolated nonsyndromic congenital heart disease/defects    patent foramen ovale
    atrial septal defect 8    ventricular septal defect    congenital heart defect    fatty liver disease
    liver disease    retinitis    multiple myeloma    myeloma
    malaria    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for TBX20:
    Congenital heart defect     Acute stress disorder

    TBX20 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TBX20
    Human Genome Epidemiology (HuGE) Navigator: TBX20 (2 documents)

    Export disorders for TBX20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TBX20 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with TBX20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human TBX20 gene, a new member of the T-box gene family closely related to the Drosophila H15 gene. (PubMed id 10936053)1, 2, 3 Meins M.... Sowden J.C. (Genomics 2000)
    2. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. (PubMed id 21076409)1, 4 Sotoodehnia N....Arking D.E. (Nat. Genet. 2010)
    3. T-box transcription factor TBX20 mutations in Chinese patients with congenital heart disease. (PubMed id 18834961)1, 4 Liu C....Li Z. (Eur J Med Genet 2008)
    4. Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy. (PubMed id 17668378)1, 2 Kirk E.P.... Harvey R.P. (Am. J. Hum. Genet. 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    8. Genetic analysis of the TBX20 gene promoter region in patients with ventricular septal defects. (PubMed id 22465533)1 Qiao Y....Yan B. (Gene 2012)
    9. Characterization of the novel interaction between muskelin and TBX20, a critical cardiogenic transcription factor. (PubMed id 21586270)1 Debenedittis P....Jiao K. (Biochem. Biophys. Res. Commun. 2011)
    10. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PubMed id 21130836)4 Luciano M....Deary I.J. (Biol Psychol 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57057 HGNC: 11598 AceView: TBX20 Ensembl:ENSG00000164532 euGenes: HUgn57057
    ECgene: TBX20 H-InvDB: TBX20

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TBX20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TBX20 gene:
    Search GeneIP for patents involving TBX20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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