 |
 | Services
| |
 |
Aliases & Descriptions for TBX2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| T-box 2 2 | | T-box protein 2 3 |
|
| | Search outside databases for aliases for TBX2 genePrevious GC identifers: GC17P059241 GC17P061963 GC17P059819 GC17P059951 |
Summaries for TBX2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for TBX2: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. [provided by RefSeq] UniProtKB/Swiss-Prot: TBX2_HUMAN, Q13207Function: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formationGene Wiki entry for TBX2 |
Genomic Location for TBX2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the TBX2 gene 
Entrez Gene cytogenetic band: 17q23 Ensembl cytogenetic band: 17q23.2 HGNC cytogenetic band: 17q23TBX2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P056832:
(about GC identifiers)
Start:
|
56,832,039 bp from pter |
End:
|
56,841,609 bp from pter |
Size:
|
9,571 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010783.14
| Proteins for TBX2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TBX2_HUMAN, Q13207 (See
protein sequence)Recommended Name: T-box transcription factor TBX2 Size: 702 amino acids; 74068 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q16424 Q7Z647Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005985.3
ENSEMBL proteins: ENSP00000240328
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | | GO:0005667 | transcription factor complex |
IEA | -- | About this table
Antibodies for TBX2:  | Invitrogen Antibodies for TBX2 |  | Millipore Mono- and Polyclonal Antibodies for the study of TBX2 |  | Sigma-Aldrich Antibodies for TBX2 |  | R&D Systems Antibodies for TBX2 |  | Antibodies from Abcam (Tbx2), each with their AbpromiseSM |  | Monoclonal and Polyclonal Antibodies from Abnova (TBX2) |  | Novus Biologicals Antibodies for TBX2 |
Assays for TBX2: | Protein
Domains/ Families for TBX2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q13207
ProtoNet protein and cluster: Q13207 2 Blocks protein families: IPB001699 Transcription factor IPB002070 Brachyury protein family signature
UniProtKB/Swiss-Prot: TBX2_HUMAN, Q13207Similarity: Contains 1 T-box DNA-binding domain | Gene Function for TBX2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005994
Applied Biosystems Silencer® siRNAs for TBX2
Sigma-Aldrich siRNA for TBX2  Sigma-Aldrich shRNA for TBX2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005994                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005994                                  untagged cDNA clone in CMV expression vector: NM_005994 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005994
UniProtKB/Swiss-Prot: TBX2_HUMAN, Q13207Function: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formationGenatlas biochemistry entry for TBX2:murine T-box gene Tbx2 (T,brachyury) homolog,with homology to Drosophila,Trg,expressed in placenta,fetal and adult lung,kidney,adult ovary,prostate,spleen,testis,involved in developmental regulation6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tbx2):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for TBX2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for TBX2 
5/11 Interacting proteins for TBX2 (ENSP000002403283) via UniProtKB, MINT, and/or STRING (see all 11
)About this table
5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0003007 | heart morphogenesis |
IEA | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0007521 | muscle cell fate determination |
IEA | -- | | GO:0007569 | cell aging |
IDA | 11748239 | About this table
|
Drugs & Compounds for TBX2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for TBX2
|
Transcripts for TBX2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005994
Sigma-Aldrich siRNA for TBX2  Sigma-Aldrich shRNA for TBX2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005994 REFSEQ mRNAs for TBX2 gene: NM_005994.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005994               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005994                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005994                                  untagged cDNA clone in CMV expression vector: NM_005994  Additional cDNA sequence: AK001031.1 AK127429.1 AL832900.1 BC052566.1 BC070054.1 CR615365.1 CR620143.1 S81264.1 U28049.1 8 DOTS entries: DT.80101718 DT.100751985 DT.97846791 DT.99975646 DT.100771118 DT.100743454 DT.86855164 DT.95076973 24/118 AceView cDNA sequences (see all 118
):BM707637 BQ883284 BE670348 CR620143 AI200289 BM678321 BM985069 BM713401 BC052566 AI572360 CR615365 BE048856 NM_005994 AI656691 BM725621 BM925013 CA488028 BQ709839 AI632760 BM971063 AI628781 AW300325 AA909667 AI804773
highest scoring ESTs for TBX2:AW006595 U28049 AA099257 AA360001 AI202279 AI241297 AI244102 AI245020 AI968510 AK001031 Unigene Cluster for TBX2: T-box 2 Hs.531085 [show with all ESTs]Unigene Representative Sequence: AK127429
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TBX2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | |
| SP1: | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for TBX2
1 Ensembl transcript including schematic representation: ENST00000240328
|
Expression for TBX2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TBX2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TBX2
1 / 2 / 3 8 probe-sets matching TBX2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCAGCAGCAG
SOURCE GeneReport for Unigene cluster: Hs.531085
Expression variation in blood from EXPOLDB for TBX2 UniProtKB/Swiss-Prot: TBX2_HUMAN, Q13207Tissue specificity: Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary |
Orthologs for TBX2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TBX2 gene from 5/12 species (see all 12
)
About this table Species with no ortholog for TBX2
ENSEMBL Gene Tree for TBX2 | Paralogs for TBX2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for TBX2 gene
- TBX32 TBX62
|
SNPs/Variants for TBX2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for TBX2 (up to first 250kb)
|
Disorders & Mutations for TBX2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 600747
2 Novoseek disease relationships for TBX2 gene
About this table
Human Genome Epidemiology Navigator: TBX2 (3 documents)
|
Medical News for TBX2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for TBX2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/41 PubMed articles for TBX2 gene (see all 41
):- Cloning and mapping of a human gene (TBX2) sharing a highly conserved protein motif with the Drosophila omb gene. (PubMed id 8530034)1, 2, 3, 4 Campbell C.... Beatty B. (1995)
- Identification, characterization, and localization to chromosome 17q21-22 of the human TBX2 homolog, member of a conserved developmental gene family. (PubMed id 8597636)1, 3, 4 Law D.J.... Silver L.M. (1995)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- UV-mediated regulation of the anti-senescence factor Tbx2. (PubMed id 18025091)1, 3 Abrahams A....Prince S. (2008)
- Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas. (PubMed id 15781639)1, 3 Vance K.W....Goding C.R. (2005)
- A role for Tbx2 in the regulation of the alpha2(1) collagen gene in human fibroblasts. (PubMed id 17407139)1, 3 Teng H....Prince S. (2007)
- Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter. (PubMed id 9710594)1, 3 Carreira S....Goding C.R. (1998)
- Cell cycle regulation of the T-box transcription factor tbx2. (PubMed id 16730707)1, 3 Bilican B. and Goding C.R. (2006)
- Tbx3 represses E-cadherin expression and enhances melanoma invasiveness. (PubMed id 18829543)1, 3 Rodriguez M....Goding C.R. (2008)
- Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. (PubMed id 12023302)1, 3 Habets P.E....Christoffels V.M. (2002)
|
Search for TBX2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TBX2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TBX2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TBX2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for TBX2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for TBX2:

 | |
 | | | | |
|
 |  |  |
| | Recombinant Proteins (Tbx2) | | Antibodies (Tbx2) |
| | | Search Tocris compounds for TBX2 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|