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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TBX18 Gene

protein-coding   GIFtS: 50
GCID: GC06M085400

T-Box 18

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
T-Box 181 2
T-Box Protein 182 3
T-Box Transcription Factor TBX182

External Ids:    HGNC: 115951   Entrez Gene: 90962   Ensembl: ENSG000001128377   OMIM: 6046135   UniProtKB: O959353   

Export aliases for TBX18 gene to outside databases

Previous GC identifers: GC06U990171 GC06M085413 GC06M085393 GC06M085453 GC06M085500 GC06M082667 GC06M085398 GC06M085444


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TBX18 Gene:
This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial
role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is
divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the
vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing
transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription
factors of the T-box family or other transcription factors. (provided by RefSeq, Nov 2012)

GeneCards Summary for TBX18 Gene: 
TBX18 (T-box 18) is a protein-coding gene. Diseases associated with TBX18 include hydronephrosis, and campomelic dysplasia. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TBX1.

UniProtKB/Swiss-Prot: TBX18_HUMAN, O95935
Function: Probable transcriptional regulator involved in developmental processes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007299.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TBX18 gene promoter:
         AREB6   MEF-2A   Ik-2   FOXO4   aMEF-2   Nkx2-5   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TBX18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBX18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14-q15   Ensembl cytogenetic band:  6q14.3   HGNC cytogenetic band: 6q14.1-q15

TBX18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBX18 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M085400:  view genomic region     (about GC identifiers)

Start:
85,397,069 bp from pter      End:
85,474,237 bp from pter
Size:
77,169 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TBX18_HUMAN, O95935 (See protein sequence)
Recommended Name: T-box transcription factor TBX18  
Size: 607 amino acids; 64753 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: A2RU13 Q7Z6U4 Q9UJI6

Explore the universe of human proteins at neXtProt for TBX18: NX_O95935

Explore proteomics data for TBX18 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95935

  • TBX18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TBX18 Protein Expression
    REFSEQ proteins: NP_001073977.1  
    ENSEMBL proteins: 
     ENSP00000475873   ENSP00000358677   ENSP00000475498   ENSP00000476137  

    Human Recombinant Protein Products for TBX18: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TBX18
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TBX18
    GenScript Custom Purified and Recombinant Proteins Services for TBX18
    Novus Biologicals TBX18 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TBX18 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--

    TBX18 for ontologies           About GeneDecksing



    TBX18 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TBX18
    R&D Systems Antibodies for TBX18
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    Novus Biologicals TBX18 Antibodies
    Abcam antibodies for TBX18
    Cloud-Clone Corp. Antibodies for TBX18 
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    LSBio Antibodies in human, mouse, rat for TBX18 

    Assay Products for TBX18: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TBX18
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TBX18 
    Cloud-Clone Corp. CLIAs for TBX18


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TBX: T-boxes

    3 InterPro protein domains:
     IPR001699 TF_T-box
     IPR008967 p53-like_TF_DNA-bd
     IPR018186 TF_T-box_CS

    Graphical View of Domain Structure for InterPro Entry O95935

    ProtoNet protein and cluster: O95935

    1 Blocks protein domain: IPB001699 Transcription factor

    UniProtKB/Swiss-Prot: TBX18_HUMAN, O95935
    Similarity: Contains 1 T-box DNA-binding domain


    TBX18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBX18_HUMAN, O95935
    Function: Probable transcriptional regulator involved in developmental processes

         Genatlas biochemistry entry for TBX18:
    murine T-box gene Tbx18 (T,brachyury) homolog

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding ISS--
    GO:0001106RNA polymerase II transcription corepressor activity ISS--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity ISS--
         
    TBX18 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Tbx18):
     cardiovascular system  craniofacial  embryogenesis  growth/size  integument 
     mortality/aging  nervous system  no phenotypic analysis  renal/urinary system  skeleton 

    TBX18 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TBX18 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TBX18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TBX18 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TBX18 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TBX18
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TBX18 (see all 16):
    hsa-miR-21* hsa-miR-3163 hsa-miR-205 hsa-miR-3614-3p hsa-miR-944 hsa-miR-410 hsa-miR-421 hsa-miR-33a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TBX18
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBX18

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of TBX18

    Clone
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    OriGene ORF clones in mouse, rat for TBX18
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    GenScript: all cDNA clones in your preferred vector: TBX18 (NM_001080508)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBX18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBX18
    Sirion Biotech Customized lentivirus for stable overexpression of TBX18 
                         Customized lentivirus expression plasmids for stable overexpression of TBX18 

    Cell Line
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    Search LifeMap BioReagents cell lines for TBX18
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBX18


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TBX18 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Selected targets of Oct-3/4
    Selected targets of Oct-3/4

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TBX18
        Selected targets of Oct-3/4




    TBX18 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TBX18

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001756somitogenesis IEA--
    GO:0002053positive regulation of mesenchymal cell proliferation ----
    GO:0003163sinoatrial node development IEA--
    GO:0006355regulation of transcription, DNA-dependent ----

    TBX18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TBX18

    Search CenterWatch for drugs/clinical trials and news about TBX18

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TBX18 gene: 
    NM_001080508.2  

    Unigene Cluster for TBX18:

    T-box 18
    Hs.251830  [show with all ESTs]
    Unigene Representative Sequence: NM_001080508
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330469 ENST00000606784 ENST00000369663(uc010kbq.2 uc003pkl.1)
    ENST00000607343 ENST00000606521 ENST00000606325 ENST00000606621
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TBX18
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TBX18 (see all 16):
    hsa-miR-21* hsa-miR-3163 hsa-miR-205 hsa-miR-3614-3p hsa-miR-944 hsa-miR-410 hsa-miR-421 hsa-miR-33a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TBX18
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBX18
    Clone
    Products:
         
    OriGene clones in human, mouse for TBX18 (see all 7)
    OriGene ORF clones in mouse, rat for TBX18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TBX18 (NM_001080508)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBX18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBX18
    Sirion Biotech Customized lentivirus for stable overexpression of TBX18 
                         Customized lentivirus expression plasmids for stable overexpression of TBX18 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TBX18
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TBX18
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBX18
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBX18

    Additional mRNA sequence: 

    AJ010278.1 AK310179.1 BC040697.2 BC132715.1 BC157841.1 

    8 DOTS entries:

    DT.40238800  DT.308320  DT.91850592  DT.100707679  DT.121344141  DT.75114827  DT.121381838  DT.92047601 

    11 AceView cDNA sequences:

    AL703333 H88260 CB962166 BI492230 AI470177 BM453888 AW023646 CB963170 
    H88049 AA331457 H89010 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TBX18 expression in normal human tissues (normalized intensities)      TBX18 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGAAAGAA
    TBX18 Expression
    About this image


    TBX18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 6 entries
             Epicardial Progenitors Cells Epicardium
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             sensory organ/ear/inner ear   
     
     Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Septum Transversum Mesenchyme Cells Septum Transversum
             Septum Transversum
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             sensory organ/ear/inner ear   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Autopod

    See TBX18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TBX18

    SOURCE GeneReport for Unigene cluster: Hs.251830
        SABiosciences Custom PCR Arrays for TBX18
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBX18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBX18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TBX18 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbx181 , 5 T-box181, 5 88.36(n)1
    94.56(a)1
      9 (47.06 cM)5
    763651  NM_023814.41  NP_076303.31 
     877028005 
    chicken
    (Gallus gallus)
    Aves TBX181 T-box 18 80.09(n)
    87.78(a)
      395104  NM_204453.1  NP_989784.1 
    lizard
    (Anolis carolinensis)
    Reptilia TBX186
    T-box 18
    83(a)
    1 ↔ 1
    1(196863916-196906983)
    zebrafish
    (Danio rerio)
    Actinopterygii tbx182 T-box 18 73.67(n)   246223  AF448503.2 
    worm
    (Caenorhabditis elegans)
    Secernentea mab-91 Protein MAB-9 51.63(n)
    50(a)
      173441  NM_061349.5  NP_493750.1 


    ENSEMBL Gene Tree for TBX18 (if available)
    TreeFam Gene Tree for TBX18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TBX18 gene
    TBX12  TBX222  TBX192  T2  EOMES2  TBX22  TBX62  TBX212  
    TBX202  TBX32  TBX52  TBX152  TBR12  TBX102  TBX42  
    15 SIMAP similar genes for TBX18 using alignment to 2 protein entries:     TBX18_HUMAN (see all proteins):
    TBX15    TBX22    TBX4    TBR1    TBX2    DKFZp762H2012
    MGA    TBX20    TBX10    EOMES    T    TBX6
    TBX19    TBX5    TBX1

    TBX18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/632 SNPs in TBX18 are shown (see all 632)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs796188991,2
    Cuntested185457739(+) AAGATC/TGTCTC 2 N D mis11Minor allele frequency- T:0.01NA 180
    rs39205161,2
    C,F,A--85441903(+) AAAAAT/CGTTCT 1 -- ds50017Minor allele frequency- C:0.26NA WA EA 500
    rs787640251,2
    C,F--85441907(+) ATGTTC/TTAAAA 1 -- ds50011Minor allele frequency- T:0.12EA 120
    rs22069471,2
    C,F,A--85441982(+) AATAGA/GTGAAT 1 -- ds50013Minor allele frequency- G:0.13WA NA EA 358
    rs1481826581,2
    C--85442088(+) AAAATA/GTGGAT 1 -- ds50010--------
    rs16215301,2
    C,F,H--85442211(+) CACAAG/TTGTTT 1 -- ds500128Minor allele frequency- T:0.14NS EA NA WA CSA 2768
    rs1411518321,2
    C--85442523(+) TTTGTA/GAAGCC 1 -- ut310--------
    rs344315331,2
    C--85442539(+) TATAT-/TAATATA 1 -- ut310--------
    rs608657361,2
    C--85442555(+) TATAT-/AT/TC 
            
    CCAAA
    2 -- ut310--------
    rs1508971941,2
    --85442768(+) ATCCAC/TAGTCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TBX18 (85397069 - 85474237 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TBX18: --

    Human Gene Mutation Database (HGMD): TBX18
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TBX18
    DNA2.0 Custom Variant and Variant Library Synthesis for TBX18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604613    OMIM disorders: --

    3 diseases for TBX18:    About MalaCards
    hydronephrosis    campomelic dysplasia    renal agenesis

    1 disease from the University of Copenhagen DISEASES database for TBX18:
    Hydronephrosis

    TBX18 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TBX18

    Export disorders for TBX18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TBX18 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with TBX18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, mapping and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19. (PubMed id 9888994)1, 2, 3 Yi C.-H.... Brook J.D. (1999)
    2. Direct conversion of quiescent cardiomyocytes to pacem aker cells by expression of Tbx18. (PubMed id 23242162)1, 3 Kapoor N....Cho H.C. (2013)
    3. T-genes and limb bud development. (PubMed id 16688725)1, 3 King M....Morrow B.E. (2006)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. Transcriptional suppression of connexin43 by TBX18 un dermines cell-cell electrical coupling in postnatal cardiomyocytes. (PubMed id 21205823)1 Kapoor N....Cho H.C. (2011)
    6. Setting the pace: Tbx3 and Tbx18 in cardiac conduction system development. (PubMed id 19213963)1 McNally E.M. and Svensson E.C. (2009)
    7. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (2007)
    8. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)4 Seshadri S....Wolf P.A. (2007)
    9. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    10. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (2007)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9096 HGNC: 11595 AceView: TBX18.1 Ensembl:ENSG00000112837 euGenes: HUgn9096
    ECgene: TBX18 H-InvDB: TBX18

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TBX18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TBX18 gene:
    Search GeneIP for patents involving TBX18

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