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TBX18 Gene

protein-coding GIFtS: 50
GCID: GC06M085400

T-Box 18

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
T-Box 18¹ ²
T-Box Protein 18² ³
T-Box Transcription Factor TBX18²

External Ids:	HGNC: 11595¹	Entrez Gene: 9096²	Ensembl: ENSG00000112837⁷	OMIM: 604613⁵	UniProtKB: O95935³

Export aliases for TBX18 gene to outside databases

Previous GC identifers: GC06U990171 GC06M085413 GC06M085393 GC06M085453 GC06M085500 GC06M082667 GC06M085398 GC06M085444

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TBX18 Gene:

This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial

role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is

divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the

vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing

transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription

factors of the T-box family or other transcription factors. (provided by RefSeq, Nov 2012)

GeneCards Summary for TBX18 Gene:

TBX18 (T-box 18) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TBX1.

UniProtKB/Swiss-Prot: TBX18_HUMAN, O95935

Function: Probable transcriptional regulator involved in developmental processes

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000006.11 NT_025741.16 NC_018917.2

Regulatory elements:

Regulatory transcription factor binding sites in the TBX18 gene promoter:
AREB6 MEF-2A Ik-2 FOXO4 aMEF-2 Nkx2-5
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for TBX18

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBX18

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14-q15 Ensembl cytogenetic band: 6q14.3 HGNC cytogenetic band: 6q14.1-q15

TBX18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBX18 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M085400: view genomic region (about GC identifiers)

Start:	85,397,069 bp from pter	End:	85,474,237 bp from pter
Size:	77,169 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TBX18_HUMAN, O95935 (See protein sequence)

Recommended Name: T-box transcription factor TBX18

Size: 607 amino acids; 64753 Da

Secondary accessions: A2RU13 Q7Z6U4 Q9UJI6

Explore the universe of human proteins at neXtProt for TBX18: NX_O95935

Explore proteomics data for TBX18 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See TBX18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001073977.1

ENSEMBL proteins:

ENSP00000475873 ENSP00000358677 ENSP00000475498 ENSP00000476137

TBX18 Human Recombinant Protein Products:

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	antibodies-online proteins for TBX18 (3 products)
	antibodies-online peptides for TBX18

TBX18 Antibody Products:

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	Abcam antibodies for TBX18 (O95935, Q96SF7)
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	antibodies-online antibodies for TBX18 (45 products)

TBX18 Assay Products:

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	Cloud-Clone Corp. ELISAs for TBX18 Cloud-Clone Corp. CLIAs for TBX18
	Search eBioscience for ELISAs for TBX18
	antibodies-online kits for TBX18 (4 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

TBX: T-boxes

3 InterPro protein domains:

IPR001699 TF_T-box

IPR008967 p53-like_TF_DNA-bd

IPR018186 TF_T-box_CS

Graphical View of Domain Structure for InterPro Entry O95935

ProtoNet protein and cluster: O95935

1 Blocks protein domain: IPB001699 Transcription factor

UniProtKB/Swiss-Prot: TBX18_HUMAN, O95935

Similarity: Contains 1 T-box DNA-binding domain

Find genes that share domains with TBX18 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: TBX18_HUMAN, O95935

Function: Probable transcriptional regulator involved in developmental processes

Genatlas biochemistry entry for TBX18:

murine T-box gene Tbx18 (T,brachyury) homolog

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000976	transcription regulatory region sequence-specific DNA binding	ISS	--
GO:0001106	RNA polymerase II transcription corepressor activity	ISS	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	--	--
GO:0042803	protein homodimerization activity	ISS	--

Find genes that share ontologies with TBX18 About GenesLikeMe

Phenotypes:
12 MGI mutant phenotypes (inferred from 11 alleles) (MGI details for Tbx18):

cardiovascular system	craniofacial	embryogenesis	growth/size/body	integument
mortality/aging	muscle	nervous system	no phenotypic analysis	renal/urinary system
respiratory system	skeleton

Find genes that share phenotypes with TBX18 About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for TBX18

miRNA Products:		miRTarBase miRNAs that target TBX18: hsa-mir-1226-3p (MIRT036442)

		Block miRNA regulation of human, mouse, rat TBX18 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TBX18 (see all 16):
		hsa-miR-21* hsa-miR-3163 hsa-miR-205 hsa-miR-3614-3p hsa-miR-944 hsa-miR-410 hsa-miR-421 hsa-miR-33a*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TBX18
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBX18

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

TBX18_HUMAN, O95935: Nucleus (Potential)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	3
cytosol	2
cytoskeleton	1
extracellular	1
golgi apparatus	1
plasma membrane	1

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Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--

Find genes that share ontologies with TBX18 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for TBX18
Interactions:

GeneGlobe Interaction Network for TBX18

Gene Ontology (GO): Selected biological process terms (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	ISS	--
GO:0001756	somitogenesis	IEA	--
GO:0002053	positive regulation of mesenchymal cell proliferation	--	--
GO:0003163	sinoatrial node development	IEA	--
GO:0006355	regulation of transcription, DNA-templated	--	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for TBX18

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TBX18 gene:

NM_001080508.2

Unigene Cluster for TBX18:

T-box 18

Hs.251830 [show with all ESTs]

Unigene Representative Sequence: NM_001080508

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000330469 ENST00000606784 ENST00000369663(uc010kbq.2 uc003pkl.1)

ENST00000607343 ENST00000606521 ENST00000606325 ENST00000606621

miRNA Products:		Block miRNA regulation of human, mouse, rat TBX18 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TBX18 (see all 16):
		hsa-miR-21* hsa-miR-3163 hsa-miR-205 hsa-miR-3614-3p hsa-miR-944 hsa-miR-410 hsa-miR-421 hsa-miR-33a*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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		QuantiFast Probe-based Assays in human, mouse, rat TBX18

Additional mRNA sequence:

AJ010278.1 AK310179.1 BC040697.2 BC132715.1 BC157841.1

8 DOTS entries:

DT.40238800 DT.308320 DT.91850592 DT.100707679 DT.121344141 DT.75114827 DT.121381838 DT.92047601

11 AceView cDNA sequences:

H88260 AL703333 AI470177 BM453888 CB962166 BI492230 CB963170 AW023646

H88049 AA331457 H89010

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TBX18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCAGAAAGAA

About this image

TBX18 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 15) fully expand


Heart (Cardiovascular System) fully expand to see all 6 entries
Epicardial Progenitors Cells Epicardium

Lateral Plate Mesoderm (Gastrulation Derivatives)
Proepicardial Progenitor cells Proepicardium

Mesoderm (Gastrulation Derivatives) fully expand to see all 2 entries
Septum Transversum Mesenchyme Cells Septum Transversum
Septum Transversum

Limb (Muscoskeletal System) fully expand to see all 2 entries
Mesenchymal Condensate Cells Zeugopod
Autopod

Smooth Muscle (Muscoskeletal System) fully expand to see all 2 entries
Vascular Smooth Muscle Cells Coronary Vessels

TBX18 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TBX18 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.251830

Custom PCR Arrays for TBX18

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBX18

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TBX18 gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tbx18^{1 , 5}	T-box18^{1, 5}	88.36(n)¹ 94.56(a)¹		9 (47.06 cM)⁵ 76365¹ NM_023814.4¹ NP_076303.3¹ 87702800⁵
chicken (Gallus gallus)	Aves	TBX18¹	T-box 18	80.63(n) 88.79(a)		395104 NM_204453.1 NP_989784.1
lizard (Anolis carolinensis)	Reptilia	TBX18⁶	T-box 18	83(a)	1 ↔ 1	1(196863916-196906983)
tropical clawed frog (Xenopus tropicalis)	Amphibia	tbx18¹	T-box 18	74.38(n) 83.04(a)		100489044 XM_002933925.2 XP_002933971.1
zebrafish (Danio rerio)	Actinopterygii	tbx18²	T-box 18	73.67(n)		246223 AF448503.2
worm (Caenorhabditis elegans)	Secernentea	mls-1⁶	Protein MLS-1 (mls-1) mRNA, complete cds	46(a)	1 → many	III(7460341-7461931) WBGene00003376

ENSEMBL Gene Tree for TBX18 (if available)
TreeFam Gene Tree for TBX18 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for TBX18 gene

TBX1² TBX22² TBX19² T² TBX2² TBX6² TBX20² TBX3²

TBX5² TBX15² TBX10² TBX4²

15 SIMAP similar genes for TBX18 using alignment to 5 protein entries: TBX18_HUMAN (see all proteins):

TBX15 TBX22 TBX4 TBR1 TBX20 TBX10

MGA TBX2 DKFZp762H2012 T TBX6 EOMES

TBX1 TBX19 TBX5

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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79618899^1,2	C	untested¹	85457739(+)	`AAGATC/TGTCTC`	2	N D	mis¹		1		NA	180
rs3920516^1,2	C,F,A	--	85441903(+)	`AAAAAT/CGTTCT`	1	--	ds500¹		7		NA WA EA	500
rs78764025^1,2	C,F	--	85441907(+)	`ATGTTC/TTAAAA`	1	--	ds500¹		1		EA	120
rs2206947^1,2	C,F,A	--	85441982(+)	`AATAGA/GTGAAT`	1	--	ds500¹		3		WA NA EA	358
rs148182658^1,2	C	--	85442088(+)	`AAAATA/GTGGAT`	1	--	ds500¹		0	--	--	--	--
rs1621530^1,2	C,F,H	--	85442211(+)	`CACAAG/TTGTTT`	1	--	ds500¹		28		NS EA NA WA CSA	2768
rs141151832^1,2	C	--	85442523(+)	`TTTGTA/GAAGCC`	1	--	ut3¹		0	--	--	--	--
rs34431533^1,2	C	--	85442539(+)	`TATAT-/TAATATA`	1	--	ut3¹		0	--	--	--	--
rs60865736^1,2	C	--	85442555(+)	`TATAT-/AT/TC CCAAA`	2	--	ut3¹		0	--	--	--	--
rs150897194^1,2		--	85442768(+)	`ATCCAC/TAGTCT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TBX18 (85397069 - 85474237 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for TBX18: --
Human Gene Mutation Database (HGMD): TBX18

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TBX18

DNA2.0 Custom Variant and Variant Library Synthesis for TBX18

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604613 OMIM disorders: --

1 inferred disease relationship from the University of Copenhagen DISEASES database for TBX18:

Hydronephrosis

Find genes that share disorders with TBX18 About GenesLikeMe

Genetic Association Database (GAD): TBX18

Export disorders for TBX18 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TBX18 gene, integrated from 10 sources (see all 15):
(articles sorted by number of sources associating them with TBX18)

Utopia: connect your pdf to the dynamic
world of online information

Identification, mapping and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19. (PubMed id 9888994)^{1, 2, 3} Yi C.-H.... Brook J.D. (Genomics 1999)
Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18. (PubMed id 23242162)^{1, 3} Kapoor N....Cho H.C. (Nat. Biotechnol. 2013)
T-genes and limb bud development. (PubMed id 16688725)^{1, 3} King M....Morrow B.E. (Am. J. Med. Genet. A 2006)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (Nature 2003)
Transcriptional suppression of connexin43 by TBX18 undermines cell-cell electrical coupling in postnatal cardiomyocytes. (PubMed id 21205823)¹ Kapoor N....Cho H.C. (J. Biol. Chem. 2011)
Setting the pace: Tbx3 and Tbx18 in cardiac conduction system development. (PubMed id 19213963)¹ McNally E.M. and Svensson E.C. (Circ. Res. 2009)
Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)⁴ Kiel D.P....Karasik D. (BMC Med. Genet. 2007)
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)⁴ Seshadri S....Wolf P.A. (BMC Med. Genet. 2007)
A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)⁴ Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)⁴ Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9096	HGNC: 11595	AceView: TBX18.1	Ensembl:ENSG00000112837	euGenes: HUgn9096
ECgene: TBX18	H-InvDB: TBX18

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TBX18	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TBX18 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TBX18 gene:
Search GeneIP for patents involving TBX18

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015

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