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TBX18 Gene

protein-coding   GIFtS: 50
GCID: GC06M085400

T-Box 18

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
T-Box 181 2
T-Box Protein 182 3
T-Box Transcription Factor TBX182

External Ids:    HGNC: 115951   Entrez Gene: 90962   Ensembl: ENSG000001128377   OMIM: 6046135   UniProtKB: O959353   

Export aliases for TBX18 gene to outside databases

Previous GC identifers: GC06U990171 GC06M085413 GC06M085393 GC06M085453 GC06M085500 GC06M082667 GC06M085398 GC06M085444


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TBX18 Gene:
This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial
role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is
divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the
vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing
transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription
factors of the T-box family or other transcription factors. (provided by RefSeq, Nov 2012)

GeneCards Summary for TBX18 Gene:
TBX18 (T-box 18) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TBX1.

UniProtKB/Swiss-Prot: TBX18_HUMAN, O95935
Function: Probable transcriptional regulator involved in developmental processes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TBX18 gene promoter:
         AREB6   MEF-2A   Ik-2   FOXO4   aMEF-2   Nkx2-5   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TBX18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBX18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14-q15   Ensembl cytogenetic band:  6q14.3   HGNC cytogenetic band: 6q14.1-q15

TBX18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBX18 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M085400:  view genomic region     (about GC identifiers)

Start:
85,397,069 bp from pter      End:
85,474,237 bp from pter
Size:
77,169 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TBX18_HUMAN, O95935 (See protein sequence)
Recommended Name: T-box transcription factor TBX18  
Size: 607 amino acids; 64753 Da
Secondary accessions: A2RU13 Q7Z6U4 Q9UJI6

Explore the universe of human proteins at neXtProt for TBX18: NX_O95935

Explore proteomics data for TBX18 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TBX18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073977.1  
    ENSEMBL proteins: 
     ENSP00000475873   ENSP00000358677   ENSP00000475498   ENSP00000476137  

    TBX18 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TBX18

     
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    antibodies-online proteins for TBX18 (3 products) 

     
    antibodies-online peptides for TBX18

    TBX18 Antibody Products:

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    antibodies-online antibodies for TBX18 (45 products) 

    TBX18 Assay Products:

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    Cloud-Clone Corp. ELISAs for TBX18
    Cloud-Clone Corp. CLIAs for TBX18
    Search eBioscience for ELISAs for TBX18 
    antibodies-online kits for TBX18 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TBX: T-boxes

    3 InterPro protein domains:
     IPR001699 TF_T-box
     IPR008967 p53-like_TF_DNA-bd
     IPR018186 TF_T-box_CS

    Graphical View of Domain Structure for InterPro Entry O95935

    ProtoNet protein and cluster: O95935

    1 Blocks protein domain: IPB001699 Transcription factor

    UniProtKB/Swiss-Prot: TBX18_HUMAN, O95935
    Similarity: Contains 1 T-box DNA-binding domain


    Find genes that share domains with TBX18           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBX18_HUMAN, O95935
    Function: Probable transcriptional regulator involved in developmental processes

         Genatlas biochemistry entry for TBX18:
    murine T-box gene Tbx18 (T,brachyury) homolog

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding ISS--
    GO:0001106RNA polymerase II transcription corepressor activity ISS--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity ISS--
         
    Find genes that share ontologies with TBX18           About GenesLikeMe


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 11 alleles(MGI details for Tbx18):
     cardiovascular system  craniofacial  embryogenesis  growth/size/body  integument 
     mortality/aging  muscle  nervous system  no phenotypic analysis  renal/urinary system 
     respiratory system  skeleton 

    Find genes that share phenotypes with TBX18           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TBX18

    miRNA
    Products:
        
    miRTarBase miRNAs that target TBX18:
    hsa-mir-1226-3p (MIRT036442)

    Block miRNA regulation of human, mouse, rat TBX18 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TBX18 (see all 16):
    hsa-miR-21* hsa-miR-3163 hsa-miR-205 hsa-miR-3614-3p hsa-miR-944 hsa-miR-410 hsa-miR-421 hsa-miR-33a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBX18

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TBX18_HUMAN, O95935: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    cytoskeleton1
    extracellular1
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--

    Find genes that share ontologies with TBX18           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TBX18 About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of Oct 3 4
    Selected targets of Oct 3 4



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBX18
    Interactions:

        GeneGlobe Interaction Network for TBX18

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001756somitogenesis IEA--
    GO:0002053positive regulation of mesenchymal cell proliferation ----
    GO:0003163sinoatrial node development IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    Find genes that share ontologies with TBX18           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TBX18



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TBX18 gene: 
    NM_001080508.2  

    Unigene Cluster for TBX18:

    T-box 18
    Hs.251830  [show with all ESTs]
    Unigene Representative Sequence: NM_001080508
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330469 ENST00000606784 ENST00000369663(uc010kbq.2 uc003pkl.1)
    ENST00000607343 ENST00000606521 ENST00000606325 ENST00000606621
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TBX18 (see all 16):
    hsa-miR-21* hsa-miR-3163 hsa-miR-205 hsa-miR-3614-3p hsa-miR-944 hsa-miR-410 hsa-miR-421 hsa-miR-33a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector: TBX18 (NM_001080508)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBX18
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TBX18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBX18
      QuantiTect SYBR Green Assays in human, mouse, rat TBX18
      QuantiFast Probe-based Assays in human, mouse, rat TBX18

    Additional mRNA sequence: 

    AJ010278.1 AK310179.1 BC040697.2 BC132715.1 BC157841.1 

    8 DOTS entries:

    DT.40238800  DT.308320  DT.91850592  DT.100707679  DT.121344141  DT.75114827  DT.121381838  DT.92047601 

    11 AceView cDNA sequences:

    H88260 AL703333 AI470177 BM453888 CB962166 BI492230 CB963170 AW023646 
    H88049 AA331457 H89010 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TBX18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGAAAGAA
    TBX18 Expression
    About this image


    TBX18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 6 entries
             Epicardial Progenitors Cells Epicardium
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Proepicardial Progenitor cells Proepicardium
     
     Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Septum Transversum Mesenchyme Cells Septum Transversum
             Septum Transversum
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Autopod
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Vascular Smooth Muscle Cells Coronary Vessels
    TBX18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TBX18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.251830
        Custom PCR Arrays for TBX18
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBX18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TBX18 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbx181 , 5 T-box181, 5 88.36(n)1
    94.56(a)1
      9 (47.06 cM)5
    763651  NM_023814.41  NP_076303.31 
     877028005 
    chicken
    (Gallus gallus)
    Aves TBX181 T-box 18 80.63(n)
    88.79(a)
      395104  NM_204453.1  NP_989784.1 
    lizard
    (Anolis carolinensis)
    Reptilia TBX186
    T-box 18
    83(a)
    1 ↔ 1
    1(196863916-196906983)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tbx181 T-box 18 74.38(n)
    83.04(a)
      100489044  XM_002933925.2  XP_002933971.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tbx182 T-box 18 73.67(n)   246223  AF448503.2 
    worm
    (Caenorhabditis elegans)
    Secernentea mls-16
    Protein MLS-1 (mls-1) mRNA, complete cds
    46(a)
    1 → many
    III(7460341-7461931) WBGene00003376


    ENSEMBL Gene Tree for TBX18 (if available)
    TreeFam Gene Tree for TBX18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TBX18 gene
    TBX12  TBX222  TBX192  T2  TBX22  TBX62  TBX202  TBX32  
    TBX52  TBX152  TBX102  TBX42  
    15 SIMAP similar genes for TBX18 using alignment to 5 protein entries:     TBX18_HUMAN (see all proteins):
    TBX15    TBX22    TBX4    TBR1    TBX20    TBX10
    MGA    TBX2    DKFZp762H2012    T    TBX6    EOMES
    TBX1    TBX19    TBX5

    Find genes that share paralogs with TBX18           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TBX18 (see all 632)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs796188991,2
    Cuntested185457739(+) AAGATC/TGTCTC 2 N D mis11Minor allele frequency- T:0.01NA 180
    rs39205161,2
    C,F,A--85441903(+) AAAAAT/CGTTCT 1 -- ds50017Minor allele frequency- C:0.26NA WA EA 500
    rs787640251,2
    C,F--85441907(+) ATGTTC/TTAAAA 1 -- ds50011Minor allele frequency- T:0.12EA 120
    rs22069471,2
    C,F,A--85441982(+) AATAGA/GTGAAT 1 -- ds50013Minor allele frequency- G:0.13WA NA EA 358
    rs1481826581,2
    C--85442088(+) AAAATA/GTGGAT 1 -- ds50010--------
    rs16215301,2
    C,F,H--85442211(+) CACAAG/TTGTTT 1 -- ds500128Minor allele frequency- T:0.14NS EA NA WA CSA 2768
    rs1411518321,2
    C--85442523(+) TTTGTA/GAAGCC 1 -- ut310--------
    rs344315331,2
    C--85442539(+) TATAT-/TAATATA 1 -- ut310--------
    rs608657361,2
    C--85442555(+) TATAT-/AT/TC 
            
    CCAAA
    2 -- ut310--------
    rs1508971941,2
    --85442768(+) ATCCAC/TAGTCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TBX18 (85397069 - 85474237 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TBX18: --
    Human Gene Mutation Database (HGMD): TBX18
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TBX18
    DNA2.0 Custom Variant and Variant Library Synthesis for TBX18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604613    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for TBX18:
    Hydronephrosis

    Find genes that share disorders with TBX18           About GenesLikeMe

    Genetic Association Database (GAD): TBX18

    Export disorders for TBX18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TBX18 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with TBX18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, mapping and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19. (PubMed id 9888994)1, 2, 3 Yi C.-H.... Brook J.D. (Genomics 1999)
    2. Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18. (PubMed id 23242162)1, 3 Kapoor N....Cho H.C. (Nat. Biotechnol. 2013)
    3. T-genes and limb bud development. (PubMed id 16688725)1, 3 King M....Morrow B.E. (Am. J. Med. Genet. A 2006)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. Transcriptional suppression of connexin43 by TBX18 undermines cell-cell electrical coupling in postnatal cardiomyocytes. (PubMed id 21205823)1 Kapoor N....Cho H.C. (J. Biol. Chem. 2011)
    6. Setting the pace: Tbx3 and Tbx18 in cardiac conduction system development. (PubMed id 19213963)1 McNally E.M. and Svensson E.C. (Circ. Res. 2009)
    7. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)
    8. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)4 Seshadri S....Wolf P.A. (BMC Med. Genet. 2007)
    9. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    10. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9096 HGNC: 11595 AceView: TBX18.1 Ensembl:ENSG00000112837 euGenes: HUgn9096
    ECgene: TBX18 H-InvDB: TBX18

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TBX18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TBX18 gene:
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    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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