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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TBX10 Gene

protein-coding   GIFtS: 51
GCID: GC11M067398

T-Box 10

(Previous name: T-box 7)
(Previous symbol: TBX7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
T-Box 101 2     TBX132
TBX71 2 3     T-Box Transcription Factor TBX102
T-Box 71 2     T-Box-Containing Transcriptional Activator2
T-Box Protein 102 3     

External Ids:    HGNC: 115931   Entrez Gene: 3478532   Ensembl: ENSG000001678007   OMIM: 6046485   UniProtKB: O753333   

Export aliases for TBX10 gene to outside databases

Previous GC identifers: GC11M069922 GC11M069095 GC11M067648 GC11M067174 GC11M067157 GC11M063728


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TBX10 Gene:
This gene encodes a member of the T-box family of transcription factors. These transcription factors share a
DNA-binding domain called the T-box, and play a role in several developmental processes including early embryonic
cell fate and organogenesis. The encoded protein is a member of the T-box 1 subfamily. Mutations in this gene are
thought to be a cause of isolated cleft lip with or without cleft palate. (provided by RefSeq, Nov 2010)

GeneCards Summary for TBX10 Gene: 
TBX10 (T-box 10) is a protein-coding gene. Diseases associated with TBX10 include cleft lip, and cleft palate. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TBX1.

UniProtKB/Swiss-Prot: TBX10_HUMAN, O75333
Function: Probable transcriptional regulator involved in developmental processes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TBX10 gene promoter:
         E47   Meis-1b   GATA-1   CREB   HEN1   PPAR-gamma1   Hand1   Meis-1a   PPAR-gamma2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBX10 promoter sequence
   Search SABiosciences Chromatin IP Primers for TBX10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBX10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.2

TBX10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBX10 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M067398:  view genomic region     (about GC identifiers)

Start:
67,398,774 bp from pter      End:
67,407,031 bp from pter
Size:
8,258 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TBX10_HUMAN, O75333 (See protein sequence)
Recommended Name: T-box transcription factor TBX10  
Size: 385 amino acids; 42341 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAC23481.1; Type=Erroneous gene model prediction;
Secondary accessions: Q14D64 Q86XS3

Explore the universe of human proteins at neXtProt for TBX10: NX_O75333

Explore proteomics data for TBX10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75333

  • TBX10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TBX10 Protein Expression
    REFSEQ proteins: NP_005986.2  
    ENSEMBL proteins: 
     ENSP00000335191  

    Human Recombinant Protein Products for TBX10: 
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    Novus Biologicals TBX10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for TBX10 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TBX10 for ontologies           About GeneDecksing



    TBX10 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for TBX10 
    Cloud-Clone Corp. CLIAs for TBX10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TBX: T-boxes

    3 InterPro protein domains:
     IPR001699 TF_T-box
     IPR008967 p53-like_TF_DNA-bd
     IPR018186 TF_T-box_CS

    Graphical View of Domain Structure for InterPro Entry O75333

    ProtoNet protein and cluster: O75333

    1 Blocks protein domain: IPB001699 Transcription factor

    UniProtKB/Swiss-Prot: TBX10_HUMAN, O75333
    Similarity: Contains 1 T-box DNA-binding domain


    TBX10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBX10_HUMAN, O75333
    Function: Probable transcriptional regulator involved in developmental processes

         Genatlas biochemistry entry for TBX10:
    murine T-box gene Tbx10 (T,brachyury),expressed in brain,ovary,uterus,pituitary and fetal kidney,involved in
    developmental regulation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
         
    TBX10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TBX10:
     Increased HPV18 LCR reporter a 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tbx10):
     behavior/neurological  craniofacial  digestive/alimentary  growth/size  hearing/vestibular/ear 
     integument  mortality/aging  nervous system  normal  pigmentation 
     vision/eye 

    TBX10 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TBX10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TBX10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TBX10 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TBX10 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TBX10
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TBX10
    SwitchGear 3'UTR luciferase reporter plasmidTBX10 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of TBX10

    Clone
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    OriGene ORF clones in mouse, rat for TBX10
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    GenScript: all cDNA clones in your preferred vector: TBX10 (NM_005995)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBX10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBX10
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                         Customized lentivirus expression plasmids for stable overexpression of TBX10 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBX10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBX10

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9545502
    GO:0009653anatomical structure morphogenesis TAS9545502

    TBX10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TBX10

    Search CenterWatch for drugs/clinical trials and news about TBX10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TBX10 gene: 
    NM_005995.4  

    Unigene Cluster for TBX10:

    T-box 10
    Hs.454480  [show with all ESTs]
    Unigene Representative Sequence: AY229977
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000335385(uc001omp.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TBX10
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TBX10
    SwitchGear 3'UTR luciferase reporter plasmidTBX10 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TBX10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBX10
    Clone
    Products:
         
    OriGene clones in human, mouse for TBX10 (see all 7)
    OriGene ORF clones in mouse, rat for TBX10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TBX10 (NM_005995)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBX10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBX10
    Sirion Biotech Customized lentivirus for stable overexpression of TBX10 
                         Customized lentivirus expression plasmids for stable overexpression of TBX10 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TBX10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TBX10
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBX10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBX10

    Additional mRNA sequence: 

    AY229977.1 BC113485.1 BC113487.1 

    1 DOTS entry:

    DT.40235507 

    8 AceView cDNA sequences:

    AY229977 NM_005995 BX106997 BF507660 BE868561 AW401421 AI674138 AA552158 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TBX10 expression in normal human tissues (normalized intensities)      TBX10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTTCATCC
    TBX10 Expression
    About this image


    TBX10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Neural Tube (Nervous System)
             Metencephalon

    See TBX10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TBX10

    SOURCE GeneReport for Unigene cluster: Hs.454480
        SABiosciences Custom PCR Arrays for TBX10
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TBX10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TBX10
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBX10
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBX10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBX10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TBX10 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbx101 , 5 T-box 101, 5 83.46(n)1
    82.08(a)1
      19 (3.71 cM)5
    1095751  NM_001001320.11  NP_001001320.11 
     39927525 
    chicken
    (Gallus gallus)
    Aves TBX101 T-box 10 72.94(n)
    71.96(a)
      428814  XM_426372.2  XP_426372.2 
    lizard
    (Anolis carolinensis)
    Reptilia TBX106
    Uncharacterized protein
    73(a)
    1 ↔ 1
    1(93405876-93411919)
    fruit fly
    (Drosophila melanogaster)
    Insecta org-16
    optomotor-blind-related-gene-1
    22(a)
    1 → many
    X(8342266-8348327)


    ENSEMBL Gene Tree for TBX10 (if available)
    TreeFam Gene Tree for TBX10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TBX10 gene
    TBX12  TBX222  TBX192  T2  EOMES2  TBX22  TBX62  TBX212  
    TBX202  TBX32  TBX52  TBX152  TBX42  TBR12  TBX182  
    14 SIMAP similar genes for TBX10 using alignment to 1 protein entry:     TBX10_HUMAN:
    TBX1    MGA    TBX18    TBX4    T    TBX15
    TBX6    EOMES    TBR1    TBX20    TBX22    TBX5
    DKFZp762H2012    TBX2

    TBX10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/277 SNPs in TBX10 are shown (see all 277)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs605218701,2
    C,F--67399462(+) CAAGTT/GACCTA 1 -- int13Minor allele frequency- G:0.36WA CSA 122
    rs1390605341,2
    --67399481(+) CCTTCA/GCCTTT 1 -- int10--------
    rs15518841,2
    C,F,A--67399601(+) CACCCC/GCTGCC 1 -- int110Minor allele frequency- G:0.21NA CSA WA EA 373
    rs1130179381,2
    C,F--67399689(+) GGGTTC/TGCTGA 1 -- int13Minor allele frequency- T:0.19CSA WA 121
    rs25140211,2
    C,H--67399735(+) TGCCTC/TCCGCC 1 -- int114Minor allele frequency- T:0.02NA WA CSA EA 379
    rs777140401,2
    C,F--67399752(+) GTACAC/ACTTAG 1 -- int11Minor allele frequency- A:0.03EA 120
    rs2006731511,2
    C--67399799(+) TCCCTA/GTCTGT 2 D syn10--------
    rs1893170531,2
    C--67399869(+) GGGGCC/TGTGGG 2 Q R mis10--------
    rs1500903061,2
    C--67399903(+) AGAAT-/GGGGGG 1 -- int10--------
    rs112278691,2
    C,F--67399914(+) GAGGGG/TATCAA 1 -- int1 trp310Minor allele frequency- T:0.15NA WA CSA EA 372

    HapMap Linkage Disequilibrium report for TBX10 (67398774 - 67407031 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for TBX10 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422195CNV Duplication17116639
    dgv1197n71CNV Loss21882294
    nsv469963CNV Loss18288195
    dgv154n27CNV Loss19166990
    dgv1194n71CNV Loss21882294
    dgv1198n71CNV Loss21882294
    nsv897801CNV Loss21882294
    nsv897815CNV Loss21882294
    nsv468609CNV Loss19166990
    dgv1196n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): TBX10
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TBX10
    DNA2.0 Custom Variant and Variant Library Synthesis for TBX10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604648    OMIM disorders: --

    4 diseases for TBX10:    About MalaCards
    cleft lip    cleft palate    digeorge syndrome    blindness

    2 diseases from the University of Copenhagen DISEASES database for TBX10:
    Cleft lip     Cleft palate

    TBX10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TBX10
    Human Genome Epidemiology (HuGE) Navigator: TBX10 (6 documents)

    Export disorders for TBX10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TBX10 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with TBX10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TBX10, a member of the Tbx1-subfamily of conserved developmental genes, is located at human chromosome 11q13 and proximal mouse chromosome 19. (PubMed id 9545502)1, 2, 3 Law D.J.... Silver L.M. (1998)
    2. Association between genetic variants of reported cand idate genes or regions and risk of cleft lip with or without cleft palate in th e polish population. (PubMed id 20544801)1, 4 Mostowska A....Jagodzinski P.P. (2010)
    3. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    4. MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. (PubMed id 20572854)1, 4 JagomAogi T....Metspalu A. (2010)
    5. Genetic variants in COL2A1, COL11A2, and IRF6 contrib ute risk to nonsyndromic cleft palate. (PubMed id 20672350)1, 4 Nikopensius T....Metspalu A. (2010)
    6. PAX9 and TGFB3 are linked to susceptibility to nonsyndromic cleft lip with or without cleft palate in the Japanese: population-based and family-based candidate gene analyses. (PubMed id 16247549)1, 4 Ichikawa E....Yoshiura K. (2006)
    7. Medical Sequencing of Candidate Genes for Nonsyndromic Cleft Lip and Palate. (PubMed id 16327884)1, 4 Vieira A.R.... Murray J.C. (2005)
    8. The T-box gene Tbx10 exhibits a uniquely restricted expression pattern during mouse embryogenesis. (PubMed id 12915323)1, 2 Bush J.O.... Jiang R. (2003)
    9. Identification of a novel nuclear localization signal in Tbx1 that is deleted in DiGeorge syndrome patients harboring the 1223delC mutation. (PubMed id 15703190)1 Stoller J.Z. and Epstein J.A. (2005)
    10. T-box genes in vertebrate development. (PubMed id 16285859)1 Naiche L.A....Papaioannou V.E. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 347853 HGNC: 11593 AceView: TBX10 Ensembl:ENSG00000167800 euGenes: HUgn347853
    ECgene: TBX10 H-InvDB: TBX10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TBX10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TBX10 gene:
    Search GeneIP for patents involving TBX10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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