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TBX10 Gene

protein-coding   GIFtS: 50
GCID: GC11M067398

T-Box 10

(Previous name: T-box 7)
(Previous symbol: TBX7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
T-Box 101 2     TBX132
TBX71 2 3     T-Box Transcription Factor TBX102
T-Box 71 2     T-Box-Containing Transcriptional Activator2
T-Box Protein 102 3     

External Ids:    HGNC: 115931   Entrez Gene: 3478532   Ensembl: ENSG000001678007   OMIM: 6046485   UniProtKB: O753333   

Export aliases for TBX10 gene to outside databases

Previous GC identifers: GC11M069922 GC11M069095 GC11M067648 GC11M067174 GC11M067157 GC11M063728


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TBX10 Gene:
This gene encodes a member of the T-box family of transcription factors. These transcription factors share a
DNA-binding domain called the T-box, and play a role in several developmental processes including early embryonic
cell fate and organogenesis. The encoded protein is a member of the T-box 1 subfamily. Mutations in this gene are
thought to be a cause of isolated cleft lip with or without cleft palate. (provided by RefSeq, Nov 2010)

GeneCards Summary for TBX10 Gene:
TBX10 (T-box 10) is a protein-coding gene. Diseases associated with TBX10 include cleft lip, and cleft palate. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TBX1.

UniProtKB/Swiss-Prot: TBX10_HUMAN, O75333
Function: Probable transcriptional regulator involved in developmental processes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TBX10 gene promoter:
         E47   Meis-1b   GATA-1   CREB   HEN1   PPAR-gamma1   Hand1   Meis-1a   PPAR-gamma2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBX10 promoter sequence
   Search Chromatin IP Primers for TBX10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBX10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.2

TBX10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBX10 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M067398:  view genomic region     (about GC identifiers)

Start:
67,398,774 bp from pter      End:
67,407,031 bp from pter
Size:
8,258 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TBX10_HUMAN, O75333 (See protein sequence)
Recommended Name: T-box transcription factor TBX10  
Size: 385 amino acids; 42341 Da
Sequence caution: Sequence=AAC23481.1; Type=Erroneous gene model prediction;
Secondary accessions: Q14D64 Q86XS3

Explore the universe of human proteins at neXtProt for TBX10: NX_O75333

Explore proteomics data for TBX10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TBX10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005986.2  
    ENSEMBL proteins: 
     ENSP00000335191  

    TBX10 Human Recombinant Protein Products:

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    Novus Biologicals TBX10 Lysate
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    Cloud-Clone Corp. Proteins for TBX10

    TBX10 Antibody Products:

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    Abcam antibodies for TBX10
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    LSBio Antibodies in human, mouse, rat for TBX10

    TBX10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TBX10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TBX10
    Cloud-Clone Corp. CLIAs for TBX10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TBX: T-boxes

    3 InterPro protein domains:
     IPR001699 TF_T-box
     IPR008967 p53-like_TF_DNA-bd
     IPR018186 TF_T-box_CS

    Graphical View of Domain Structure for InterPro Entry O75333

    ProtoNet protein and cluster: O75333

    1 Blocks protein domain: IPB001699 Transcription factor

    UniProtKB/Swiss-Prot: TBX10_HUMAN, O75333
    Similarity: Contains 1 T-box DNA-binding domain


    TBX10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBX10_HUMAN, O75333
    Function: Probable transcriptional regulator involved in developmental processes

         Genatlas biochemistry entry for TBX10:
    murine T-box gene Tbx10 (T,brachyury),expressed in brain,ovary,uterus,pituitary and fetal kidney,involved in
    developmental regulation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
         
    TBX10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TBX10:
     Increased HPV18 LCR reporter a 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tbx10):
     behavior/neurological  craniofacial  digestive/alimentary  growth/size/body  hearing/vestibular/ear 
     integument  mortality/aging  nervous system  normal  pigmentation 
     vision/eye 

    TBX10 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBX10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TBX10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TBX10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TBX10

    miRNA
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    Block miRNA regulation of human, mouse, rat TBX10 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidTBX10 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TBX10
    Predesigned siRNA for gene silencing in human, mouse, rat TBX10

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for TBX10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TBX10 (NM_005995)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBX10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBX10

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TBX10
    Browse ESI BIO Cell Lines and PureStem Progenitors for TBX10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBX10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TBX10_HUMAN, O75333: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    extracellular2
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TBX10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBX10
    Interactions:

        Search GeneGlobe Interaction Network for TBX10

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9545502
    GO:0009653anatomical structure morphogenesis TAS9545502

    TBX10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TBX10



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TBX10 gene: 
    NM_005995.4  

    Unigene Cluster for TBX10:

    T-box 10
    Hs.454480  [show with all ESTs]
    Unigene Representative Sequence: AY229977
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000335385(uc001omp.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TBX10 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TBX10
    SwitchGear 3'UTR luciferase reporter plasmidTBX10 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TBX10
    Predesigned siRNA for gene silencing in human, mouse, rat TBX10
    Clone
    Products:
         
    OriGene clones in human, mouse for TBX10 (see all 6)
    OriGene ORF clones in mouse, rat for TBX10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TBX10 (NM_005995)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBX10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBX10
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TBX10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBX10
      QuantiTect SYBR Green Assays in human, mouse, rat TBX10
      QuantiFast Probe-based Assays in human, mouse, rat TBX10

    Additional mRNA sequence: 

    AY229977.1 BC113485.1 BC113487.1 

    1 DOTS entry:

    DT.40235507 

    8 AceView cDNA sequences:

    AY229977 NM_005995 BX106997 BF507660 BE868561 AW401421 AA552158 AI674138 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TBX10 expression in normal human tissues (normalized intensities)      TBX10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTTCATCC
    TBX10 Expression
    About this image


    TBX10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)
             Metencephalon
    TBX10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TBX10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.454480
        Custom PCR Arrays for TBX10
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TBX10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBX10
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    QuantiFast Probe-based Assays in human, mouse, rat TBX10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBX10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TBX10 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbx101 , 5 T-box 101, 5 83.46(n)1
    82.08(a)1
      19 (3.71 cM)5
    1095751  NM_001001320.11  NP_001001320.11 
     39927525 
    chicken
    (Gallus gallus)
    Aves TBX101 T-box 10 82.47(n)
    84.9(a)
      428814  XM_426372.3  XP_426372.3 
    lizard
    (Anolis carolinensis)
    Reptilia TBX106
    T-box 10
    73(a)
    1 ↔ 1
    1(93405876-93411919)
    zebrafish
    (Danio rerio)
    Actinopterygii ntla6
    no tail a
    26(a)
    many ↔ many
    19(30633857-30637909) ENSDARG00000009905
    fruit fly
    (Drosophila melanogaster)
    Insecta org-16
    optomotor-blind-related-gene-1
    23(a)
    1 → many
    X(8342266-8348327)
    worm
    (Caenorhabditis elegans)
    Secernentea tbx-76
    Protein TBX-7 (tbx-7) mRNA, complete cds
    33(a)
    1 → many
    III(6024959-6028532) WBGene00006544


    ENSEMBL Gene Tree for TBX10 (if available)
    TreeFam Gene Tree for TBX10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TBX10 gene
    TBX12  TBX222  TBX192  T2  TBX22  TBX62  TBX202  TBX32  
    TBX52  TBX152  TBX42  TBX182  
    14 SIMAP similar genes for TBX10 using alignment to 1 protein entry:     TBX10_HUMAN:
    TBX18    TBX1    MGA    TBX4    T    TBX15
    TBX6    EOMES    TBR1    TBX20    TBX22    TBX5
    DKFZp762H2012    TBX2

    TBX10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TBX10 (see all 277)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs605218701,2
    C,F--67399462(+) CAAGTT/GACCTA 1 -- int13Minor allele frequency- G:0.36WA CSA 122
    rs1390605341,2
    --67399481(+) CCTTCA/GCCTTT 1 -- int10--------
    rs15518841,2
    C,F,A--67399601(+) CACCCC/GCTGCC 1 -- int110Minor allele frequency- G:0.21NA CSA WA EA 373
    rs1130179381,2
    C,F--67399689(+) GGGTTC/TGCTGA 1 -- int13Minor allele frequency- T:0.19CSA WA 121
    rs25140211,2
    C,H--67399735(+) TGCCTC/TCCGCC 1 -- int114Minor allele frequency- T:0.02NA WA CSA EA 379
    rs777140401,2
    C,F--67399752(+) GTACAC/ACTTAG 1 -- int11Minor allele frequency- A:0.03EA 120
    rs2006731511,2
    C--67399799(+) TCCCTA/GTCTGT 2 D syn10--------
    rs1893170531,2
    C--67399869(+) GGGGCC/TGTGGG 2 Q R mis10--------
    rs1500903061,2
    C--67399903(+) AGAAT-/GGGGGG 1 -- int10--------
    rs112278691,2
    C,F--67399914(+) GAGGGG/TATCAA 1 -- int1 trp310Minor allele frequency- T:0.15NA WA CSA EA 372

    HapMap Linkage Disequilibrium report for TBX10 (67398774 - 67407031 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TBX10 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422195CNV Duplication17116639
    dgv1197n71CNV Loss21882294
    nsv469963CNV Loss18288195
    dgv154n27CNV Loss19166990
    dgv1194n71CNV Loss21882294
    dgv1198n71CNV Loss21882294
    nsv897801CNV Loss21882294
    nsv897815CNV Loss21882294
    nsv468609CNV Loss19166990
    dgv1196n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): TBX10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TBX10
    DNA2.0 Custom Variant and Variant Library Synthesis for TBX10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604648    OMIM disorders: --

    4 diseases for TBX10:    About MalaCards
    cleft lip    cleft palate    digeorge syndrome    blindness

    2 diseases from the University of Copenhagen DISEASES database for TBX10:
    Cleft lip     Cleft palate

    TBX10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TBX10
    Human Genome Epidemiology (HuGE) Navigator: TBX10 (6 documents)

    Export disorders for TBX10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TBX10 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with TBX10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TBX10, a member of the Tbx1-subfamily of conserved developmental genes, is located at human chromosome 11q13 and proximal mouse chromosome 19. (PubMed id 9545502)1, 2, 3 Law D.J.... Silver L.M. (Mamm. Genome 1998)
    2. Association between genetic variants of reported candidate genes or regions and risk of cleft lip with or without cleft palate in the polish population. (PubMed id 20544801)1, 4 Mostowska A....Jagodzinski P.P. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010)
    3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    4. MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. (PubMed id 20572854)1, 4 JagomAogi T....Metspalu A. (Eur. J. Oral Sci. 2010)
    5. Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. (PubMed id 20672350)1, 4 Nikopensius T....Metspalu A. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010)
    6. PAX9 and TGFB3 are linked to susceptibility to nonsyndromic cleft lip with or without cleft palate in the Japanese: population-based and family-based candidate gene analyses. (PubMed id 16247549)1, 4 Ichikawa E....Yoshiura K. (J. Hum. Genet. 2006)
    7. Medical Sequencing of Candidate Genes for Nonsyndromic Cleft Lip and Palate. (PubMed id 16327884)1, 4 Vieira A.R.... Murray J.C. (PLoS Genet. 2005)
    8. The T-box gene Tbx10 exhibits a uniquely restricted expression pattern during mouse embryogenesis. (PubMed id 12915323)1, 2 Bush J.O.... Jiang R. (Gene Expr. Patterns 2003)
    9. Identification of a novel nuclear localization signal in Tbx1 that is deleted in DiGeorge syndrome patients harboring the 1223delC mutation. (PubMed id 15703190)1 Stoller J.Z. and Epstein J.A. (Hum. Mol. Genet. 2005)
    10. T-box genes in vertebrate development. (PubMed id 16285859)1 Naiche L.A....Papaioannou V.E. (Annu. Rev. Genet. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 347853 HGNC: 11593 AceView: TBX10 Ensembl:ENSG00000167800 euGenes: HUgn347853
    ECgene: TBX10 H-InvDB: TBX10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TBX10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TBX10 gene:
    Search GeneIP for patents involving TBX10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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