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Aliases for TBRG4 Gene

Aliases for TBRG4 Gene

  • Transforming Growth Factor Beta Regulator 4 2 3 4 5
  • Cell Cycle Progression Restoration Protein 2 3 4
  • FAST Kinase Domain-Containing Protein 4 3 4
  • Cell Cycle Progression Protein 2 3 4
  • FAST Kinase Domains 4 2 3
  • FASTKD4 3 4
  • CPR2 3 4
  • Cell Cycle Progression 2 Protein 2
  • Protein TBRG4 3
  • H_TD2522F11.8 3
  • KIAA0948 4

External Ids for TBRG4 Gene

Previous GeneCards Identifiers for TBRG4 Gene

  • GC07M044878
  • GC07M044910
  • GC07M045103
  • GC07M045023
  • GC07M045139

Summaries for TBRG4 Gene

GeneCards Summary for TBRG4 Gene

TBRG4 (Transforming Growth Factor Beta Regulator 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is FASTKD3.

UniProtKB/Swiss-Prot for TBRG4 Gene

  • May play a role in cell cycle progression.

Gene Wiki entry for TBRG4 Gene

Additional gene information for TBRG4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBRG4 Gene

Genomics for TBRG4 Gene

GeneHancer (GH) Regulatory Elements for TBRG4 Gene

Promoters and enhancers for TBRG4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I045108 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 565.7 +1.1 1112 4 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 TBRG4 SNHG15 NACAD CCM2 RAMP3 SNORA5B GC07P045063
GH07I044845 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.5 +264.5 264463 4.2 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC GLIS1 H2AFV LINC01952 CICP20 DDX56 SNORA5C POLM SNORA5B ENSG00000228434 SPDYE1 TMED4
GH07I044795 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.4 +314.6 314606 4.1 CLOCK ZFP64 DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC PPIA GC07P044796 GC07P044797 LOC105375259 SEPT7P2 SNORA5C POLM DDX56 SNORA5B ENSG00000228434
GH07I044121 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 18.9 +989.0 989007 3.4 HDGF PKNOX1 CLOCK MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF213 POLD2 POLM TMED4 SPDYE1 SNORA5B ENSG00000228434 DDX56 SNORA5C TBRG4 TUBG1P
GH07I045087 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14 +23.1 23085 2.4 HDAC1 PKNOX1 ATF1 KLF17 ZNF76 BMI1 ZBTB40 RFX5 GLIS2 EGR1 NACAD TBRG4 ADCY1 PIR44785 SNORA5A GC07M045154 GC07M045141 GC07M045104 GC07P045063
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TBRG4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TBRG4 gene promoter:

Genomic Locations for TBRG4 Gene

Genomic Locations for TBRG4 Gene
chr7:45,100,100-45,112,047
(GRCh38/hg38)
Size:
11,948 bases
Orientation:
Minus strand
chr7:45,139,699-45,151,646
(GRCh37/hg19)

Genomic View for TBRG4 Gene

Genes around TBRG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBRG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBRG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBRG4 Gene

Proteins for TBRG4 Gene

  • Protein details for TBRG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969Z0-TBRG4_HUMAN
    Recommended name:
    Protein TBRG4
    Protein Accession:
    Q969Z0
    Secondary Accessions:
    • A4D2L2
    • A4D2L3
    • D3DVL5
    • D3DVL6
    • O14710
    • Q53GI8
    • Q8NDM4
    • Q9BUC6
    • Q9Y2F6

    Protein attributes for TBRG4 Gene

    Size:
    631 amino acids
    Molecular mass:
    70738 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB69312.1; Type=Frameshift; Positions=211, 479, 498, 576; Evidence={ECO:0000305}; Sequence=BAA76792.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TBRG4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBRG4 Gene

Post-translational modifications for TBRG4 Gene

No data available for DME Specific Peptides for TBRG4 Gene

Domains & Families for TBRG4 Gene

Gene Families for TBRG4 Gene

Protein Domains for TBRG4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TBRG4 Gene

Graphical View of Domain Structure for InterPro Entry

Q969Z0

UniProtKB/Swiss-Prot:

TBRG4_HUMAN :
  • Belongs to the FAST kinase family.
Family:
  • Belongs to the FAST kinase family.
genes like me logo Genes that share domains with TBRG4: view

Function for TBRG4 Gene

Molecular function for TBRG4 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cell cycle progression.

Phenotypes From GWAS Catalog for TBRG4 Gene

Gene Ontology (GO) - Molecular Function for TBRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0004672 protein kinase activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TBRG4: view
genes like me logo Genes that share phenotypes with TBRG4: view

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBRG4 Gene

Localization for TBRG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBRG4 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBRG4 gene
Compartment Confidence
mitochondrion 5
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TBRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 20869947
GO:0005759 mitochondrial matrix IDA 28335001
genes like me logo Genes that share ontologies with TBRG4: view

Pathways & Interactions for TBRG4 Gene

SuperPathways for TBRG4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TBRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007050 cell cycle arrest TAS 9383053
GO:0008284 positive regulation of cell proliferation TAS 9383053
GO:0016071 mRNA metabolic process IMP 28335001
GO:0044528 regulation of mitochondrial mRNA stability IMP 28335001
genes like me logo Genes that share ontologies with TBRG4: view

No data available for Pathways by source and SIGNOR curated interactions for TBRG4 Gene

Drugs & Compounds for TBRG4 Gene

No Compound Related Data Available

Transcripts for TBRG4 Gene

Unigene Clusters for TBRG4 Gene

Transforming growth factor beta regulator 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBRG4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: -
SP5: - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - - -
SP7: - - - - - -
SP8:
SP9: - - - - - - -
SP10: -
SP11: - -
SP12: -
SP13: - - - - - - -
SP14: - -
SP15: - - - - - - -
SP16: - - - - -
SP17: - - - -
SP18: - -
SP19: - - - -
SP20: -
SP21:
SP22:
SP23: -

ExUns: 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c · 13d · 13e ^ 14a · 14b ^ 15 ^ 16a · 16b
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7:
SP8: - - -
SP9:
SP10: - - - - - -
SP11: -
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: -
SP20:
SP21: -
SP22: - -
SP23:

Relevant External Links for TBRG4 Gene

GeneLoc Exon Structure for
TBRG4
ECgene alternative splicing isoforms for
TBRG4

Expression for TBRG4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TBRG4 Gene

Protein differential expression in normal tissues from HIPED for TBRG4 Gene

This gene is overexpressed in Bone (33.8) and Nasal epithelium (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TBRG4 Gene



Protein tissue co-expression partners for TBRG4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TBRG4 Gene:

TBRG4

SOURCE GeneReport for Unigene cluster for TBRG4 Gene:

Hs.231411

mRNA Expression by UniProt/SwissProt for TBRG4 Gene:

Q969Z0-TBRG4_HUMAN
Tissue specificity: Ubiquitously expressed (PubMed:12759187). Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in smooth muscle (PubMed:20869947).

Evidence on tissue expression from TISSUES for TBRG4 Gene

  • Nervous system(4.9)
  • Lung(4.5)
  • Kidney(4.4)
  • Skin(2.9)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with TBRG4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TBRG4 Gene

Orthologs for TBRG4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBRG4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBRG4 33 34
  • 99.58 (n)
cow
(Bos Taurus)
Mammalia TBRG4 33 34
  • 81.19 (n)
rat
(Rattus norvegicus)
Mammalia Tbrg4 33
  • 80.1 (n)
dog
(Canis familiaris)
Mammalia LOC482691 33
  • 79.65 (n)
TBRG4 34
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbrg4 33 16 34
  • 79.09 (n)
oppossum
(Monodelphis domestica)
Mammalia TBRG4 34
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TBRG4 34
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves TBRG4 33 34
  • 60.53 (n)
lizard
(Anolis carolinensis)
Reptilia TBRG4 34
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tbrg4 33
  • 59.12 (n)
Str.7079 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68528 33
zebrafish
(Danio rerio)
Actinopterygii tbrg4 33 34
  • 53.23 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9270 33
fruit fly
(Drosophila melanogaster)
Insecta CG13850 34
  • 19 (a)
OneToOne
Species where no ortholog for TBRG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBRG4 Gene

ENSEMBL:
Gene Tree for TBRG4 (if available)
TreeFam:
Gene Tree for TBRG4 (if available)

Paralogs for TBRG4 Gene

Paralogs for TBRG4 Gene

genes like me logo Genes that share paralogs with TBRG4: view

Variants for TBRG4 Gene

Sequence variations from dbSNP and Humsavar for TBRG4 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000178664 -- 45,100,719(-) C/G intron_variant
rs1000194664 -- 45,099,606(-) G/A downstream_transcript_variant
rs1000204655 -- 45,100,494(-) C/T intron_variant
rs1000253966 -- 45,105,067(-) A/G intron_variant
rs1000539115 -- 45,111,860(-) T/C upstream_transcript_variant

Variation tolerance for TBRG4 Gene

Residual Variation Intolerance Score: 15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.47; 77.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TBRG4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TBRG4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TBRG4 Gene

Disorders for TBRG4 Gene

Additional Disease Information for TBRG4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TBRG4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBRG4 Gene

Publications for TBRG4 Gene

  1. Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells. (PMID: 9383053) Edwards MC … Elledge SJ (Genetics 1997) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. (PMID: 20869947) Simarro M … Anderson P (Biochemical and biophysical research communications 2010) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TBRG4 Gene

  • Addgene plasmids for TBRG4

Sources for TBRG4 Gene

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