Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TBRG4 Gene

Aliases for TBRG4 Gene

  • Transforming Growth Factor Beta Regulator 4 2 3 4
  • Cell Cycle Progression Restoration Protein 2 3 4
  • FAST Kinase Domain-Containing Protein 4 3 4
  • Cell Cycle Progression Protein 2 3 4
  • FAST Kinase Domains 4 2 3
  • FASTKD4 3 4
  • CPR2 3 4
  • Cell Cycle Progression 2 Protein 2
  • Protein TBRG4 3
  • H_TD2522F11.8 3
  • KIAA0948 4

External Ids for TBRG4 Gene

Previous GeneCards Identifiers for TBRG4 Gene

  • GC07M044878
  • GC07M044910
  • GC07M045103
  • GC07M045023
  • GC07M045139

Summaries for TBRG4 Gene

GeneCards Summary for TBRG4 Gene

TBRG4 (Transforming Growth Factor Beta Regulator 4) is a Protein Coding gene. GO annotations related to this gene include protein kinase activity. An important paralog of this gene is FASTKD1.

UniProtKB/Swiss-Prot for TBRG4 Gene

  • May play a role in cell cycle progression.

Gene Wiki entry for TBRG4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBRG4 Gene

Genomics for TBRG4 Gene

Regulatory Elements for TBRG4 Gene

Genomic Location for TBRG4 Gene

Start:
45,100,100 bp from pter
End:
45,112,047 bp from pter
Size:
11,948 bases
Orientation:
Minus strand

Genomic View for TBRG4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBRG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBRG4 Gene

Proteins for TBRG4 Gene

  • Protein details for TBRG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969Z0-TBRG4_HUMAN
    Recommended name:
    Protein TBRG4
    Protein Accession:
    Q969Z0
    Secondary Accessions:
    • A4D2L2
    • A4D2L3
    • D3DVL5
    • D3DVL6
    • O14710
    • Q53GI8
    • Q8NDM4
    • Q9BUC6
    • Q9Y2F6

    Protein attributes for TBRG4 Gene

    Size:
    631 amino acids
    Molecular mass:
    70738 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB69312.1; Type=Frameshift; Positions=211, 479, 498, 576; Evidence={ECO:0000305}; Sequence=BAA76792.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TBRG4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBRG4 Gene

Proteomics data for TBRG4 Gene at MOPED

Post-translational modifications for TBRG4 Gene

  • Ubiquitination at Lys70
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TBRG4 Gene

Domains for TBRG4 Gene

Protein Domains for TBRG4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TBRG4 Gene

Graphical View of Domain Structure for InterPro Entry

Q969Z0

UniProtKB/Swiss-Prot:

TBRG4_HUMAN :
  • Q969Z0
Domain:
  • Contains 1 RAP domain.
Family:
  • Belongs to the FAST kinase family.
genes like me logo Genes that share domains with TBRG4: view

No data available for Gene Families for TBRG4 Gene

Function for TBRG4 Gene

Molecular function for TBRG4 Gene

UniProtKB/Swiss-Prot Function: May play a role in cell cycle progression.

Gene Ontology (GO) - Molecular Function for TBRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TBRG4: view

Animal Model Products

CRISPR Products

miRNA for TBRG4 Gene

miRTarBase miRNAs that target TBRG4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBRG4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TBRG4 Gene

Localization for TBRG4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBRG4 Gene COMPARTMENTS Subcellular localization image for TBRG4 gene
Compartment Confidence
mitochondrion 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TBRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with TBRG4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TBRG4 Gene

Pathways for TBRG4 Gene

SuperPathways for TBRG4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TBRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007050 cell cycle arrest TAS 9383053
GO:0008284 positive regulation of cell proliferation TAS 9383053
GO:0045333 cellular respiration ISS 20869947
genes like me logo Genes that share ontologies with TBRG4: view

No data available for Pathways by source for TBRG4 Gene

Transcripts for TBRG4 Gene

Unigene Clusters for TBRG4 Gene

Transforming growth factor beta regulator 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBRG4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBRG4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: -
SP5: - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - - -
SP7: - - - - - -
SP8:
SP9: - - - - - - -
SP10: -
SP11: - -
SP12: -
SP13: - - - - - - -
SP14: - -
SP15: - - - - - - -
SP16: - - - - -
SP17: - - - -
SP18: - -
SP19: - - - -
SP20: -
SP21:
SP22:
SP23: -

ExUns: 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c · 13d · 13e ^ 14a · 14b ^ 15 ^ 16a · 16b
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7:
SP8: - - -
SP9:
SP10: - - - - - -
SP11: -
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: -
SP20:
SP21: -
SP22: - -
SP23:

Relevant External Links for TBRG4 Gene

GeneLoc Exon Structure for
TBRG4
ECgene alternative splicing isoforms for
TBRG4

Expression for TBRG4 Gene

mRNA expression in normal human tissues for TBRG4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TBRG4 Gene

SOURCE GeneReport for Unigene cluster for TBRG4 Gene Hs.231411

mRNA Expression by UniProt/SwissProt for TBRG4 Gene

Q969Z0-TBRG4_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with TBRG4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TBRG4 Gene

Orthologs for TBRG4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBRG4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBRG4 35
  • 99.58 (n)
  • 99.69 (a)
TBRG4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TBRG4 35
  • 81.19 (n)
  • 77.97 (a)
TBRG4 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC482691 35
  • 79.65 (n)
  • 75.99 (a)
TBRG4 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbrg4 35
  • 79.09 (n)
  • 75.96 (a)
Tbrg4 16
Tbrg4 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TBRG4 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TBRG4 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbrg4 35
  • 80.1 (n)
  • 76.91 (a)
chicken
(Gallus gallus)
Aves TBRG4 35
  • 60.53 (n)
  • 51.04 (a)
TBRG4 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBRG4 36
  • 48 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68528 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7079 35
tbrg4 35
  • 59.12 (n)
  • 48.01 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9270 35
zebrafish
(Danio rerio)
Actinopterygii tbrg4 35
  • 53.23 (n)
  • 45.47 (a)
tbrg4 36
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13850 36
  • 19 (a)
OneToOne
Species with no ortholog for TBRG4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBRG4 Gene

ENSEMBL:
Gene Tree for TBRG4 (if available)
TreeFam:
Gene Tree for TBRG4 (if available)

Paralogs for TBRG4 Gene

Paralogs for TBRG4 Gene

genes like me logo Genes that share paralogs with TBRG4: view

Variants for TBRG4 Gene

Sequence variations from dbSNP and Humsavar for TBRG4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4553 -- 45,100,293(-) CCTCT(C/T)CGCCG utr-variant-3-prime
rs1042969 -- 45,101,900(-) TGCAG(A/G)AGACG missense, reference
rs1042984 -- 45,101,315(-) TTGCT(A/G)GGTCG synonymous-codon, reference
rs1043013 -- 45,100,264(-) GCCAA(A/G)AAGGG utr-variant-3-prime
rs1043019 -- 45,100,195(-) CCACT(C/T)TGAGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TBRG4 Gene

Variant ID Type Subtype PubMed ID
nsv888001 CNV Loss 21882294

Relevant External Links for TBRG4 Gene

HapMap Linkage Disequilibrium report
TBRG4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBRG4 Gene

Disorders for TBRG4 Gene

Relevant External Links for TBRG4

Genetic Association Database (GAD)
TBRG4
Human Genome Epidemiology (HuGE) Navigator
TBRG4
genes like me logo Genes that share disorders with TBRG4: view

No data available for UniProtKB/Swiss-Prot for TBRG4 Gene

Publications for TBRG4 Gene

  1. Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells. (PMID: 9383053) Edwards M.C. … Elledge S.J. (Genetics 1997) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4

Products for TBRG4 Gene

Sources for TBRG4 Gene

Back to Top

Content