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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TBRG1 Gene

protein-coding   GIFtS: 47
GCID: GC11P124492

Transforming Growth Factor Beta Regulator 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transforming Growth Factor Beta Regulator 11 2
Nuclear Interactor Of ARF And Mdm21 2 3
NIAM2 3 5
TB-52

External Ids:    HGNC: 295511   Entrez Gene: 848972   Ensembl: ENSG000001541447   OMIM: 6106145   UniProtKB: Q3YBR23   
ORGUL members:         
NONCODE14:n406427      

Export aliases for TBRG1 gene to outside databases

Previous GC identifers: GC11P126493 GC11P126006 GC11P124526 GC11P124030 GC11P123997 GC11P120435


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TBRG1 Gene: 
TBRG1 (transforming growth factor beta regulator 1) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with TBRG1 include weill-marchesani syndrome, and tracheal stenosis, and among its related super-pathways are Rac1 Pathway and Ras Pathway. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: TBRG1_HUMAN, Q3YBR2
Function: Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to
restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into
the nucleoplasm. Involved in maintaining chromosomal stability

Gene Wiki entry for TBRG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TBRG1 gene promoter:
         E2F-4   E2F-3a   ISGF-3   E2F-5   p53   E2F-2   Evi-1   AREB6   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBRG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TBRG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBRG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24.2

TBRG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBRG1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P124492:  view genomic region     (about GC identifiers)

Start:
124,492,732 bp from pter      End:
124,505,822 bp from pter
Size:
13,091 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TBRG1_HUMAN, Q3YBR2 (See protein sequence)
Recommended Name: Transforming growth factor beta regulator 1  
Size: 411 amino acids; 44946 Da
Subunit: Interacts with CDKN2A and MDM2
Subcellular location: Nucleus
Sequence caution: Sequence=BAB84966.1; Type=Frameshift; Positions=229;
1 PDB 3D structure from and Proteopedia for TBRG1:
2WZO (3D)    
Secondary accessions: Q53GJ5 Q66ZJ6 Q69YS7 Q8TCS4 Q8TEI4 Q96SV0
Alternative splicing: 3 isoforms:  Q3YBR2-1   Q3YBR2-2   Q3YBR2-3   

Explore the universe of human proteins at neXtProt for TBRG1: NX_Q3YBR2

Explore proteomics data for TBRG1 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated; mediated by MDM2 and leading to its subsequent proteasomal degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q3YBR2

  • TBRG1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TBRG1 Protein Expression
    REFSEQ proteins: NP_116200.2  
    ENSEMBL proteins: 
     ENSP00000436238   ENSP00000435448   ENSP00000284290   ENSP00000409016   ENSP00000395145  
     ENSP00000436599   ENSP00000364144  

    Human Recombinant Protein Products for TBRG1: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17110379

    TBRG1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR003889 FYrich_C
     IPR003888 FYrich_N

    Graphical View of Domain Structure for InterPro Entry Q3YBR2

    ProtoNet protein and cluster: Q3YBR2

    UniProtKB/Swiss-Prot: TBRG1_HUMAN, Q3YBR2
    Similarity: Belongs to the TBRG1 family
    Similarity: Contains 1 FYR C-terminal domain
    Similarity: Contains 1 FYR N-terminal domain


    TBRG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBRG1_HUMAN, Q3YBR2
    Function: Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to
    restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into
    the nucleoplasm. Involved in maintaining chromosomal stability

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17110379
         
    TBRG1 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidTBRG1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TBRG1 About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51

    5/54 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TBRG1 (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TBRG1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TBRG1 (Q3YBR23 ENSP000004090164) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CDKN2AENSP000003551534STRING: ENSP00000355153
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IMP17110379
    GO:0007050cell cycle arrest IMP17110379
    GO:0008285negative regulation of cell proliferation IMP17110379
    GO:0032066nucleolus to nucleoplasm transport IDA17110379
    GO:0050821protein stabilization IMP17110379

    TBRG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TBRG1

    Search CenterWatch for drugs/clinical trials and news about TBRG1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TBRG1 gene: 
    NM_032811.2  

    Unigene Cluster for TBRG1:

    Transforming growth factor beta regulator 1
    Hs.436410  [show with all ESTs]
    Unigene Representative Sequence: NM_032811
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000473629 ENST00000530731 ENST00000531667 ENST00000284290(uc001qak.4 uc001qaj.4 uc009zbf.3 uc001qal.4 uc009zbh.3)
    ENST00000441174 ENST00000452080 ENST00000529543 ENST00000438907 ENST00000491010
    ENST00000531033 ENST00000375005
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    hsa-miR-185* hsa-miR-4251 hsa-miR-539 hsa-miR-188-5p hsa-miR-15a hsa-miR-888* hsa-miR-141* hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidTBRG1 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBRG1
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    Additional mRNA sequence: 

    AK027527.1 AK027766.1 AK057749.1 AK074140.1 AK074594.1 AK222936.1 AL713631.1 AL831881.1 
    AY696294.1 BC018452.1 BC032312.1 BC041043.1 BC064392.1 BC073160.1 BC107428.1 BC109269.2 
    DQ144542.1 NR_016021.1 

    20 DOTS entries:

    DT.100823605  DT.100823606  DT.100802387  DT.415670  DT.100037797  DT.65286898  DT.101983949  DT.95265897 
    DT.111748  DT.40131997  DT.409069  DT.95268947  DT.120747890  DT.100823609  DT.120747892  DT.95268949 
    DT.120747909  DT.86847505  DT.91645747  DT.92416461 

    24/346 AceView cDNA sequences (see all 346):

    BX104008 AI092468 AI393016 AA487234 CD367661 AA731369 BG286461 AI419873 
    BU178940 CA449371 BM712831 BQ574735 CR625770 AI767415 AA296570 AI288633 
    CR616019 AI246283 AI435960 AW592577 CR620586 CR620045 AA425697 AI804107 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TBRG1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b
    SP1:                    -           -     -     -     -     -     -     -     -                                                   
    SP2:                                                                    -     -                                                   
    SP3:                                                              -     -     -                                                   
    SP4:                                                              -                                                               
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for TBRG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TBRG1 expression in normal human tissues (normalized intensities)      TBRG1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGGTCCTG
    TBRG1 Expression
    About this image


    TBRG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             visceral organ/oral region/upper jaw   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Rostral Skull Membranous Bones
             skeleton/cranium/chondrocranium   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Meckel's Cartilage
             skeleton/cranium/chondrocranium   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             pbmc   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             skeleton/cranium/chondrocranium   

    See TBRG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TBRG1

    SOURCE GeneReport for Unigene cluster: Hs.436410

    UniProtKB/Swiss-Prot: TBRG1_HUMAN, Q3YBR2
    Tissue specificity: Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and
    liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas,
    chronic lymphocytic leukemia and diffuse large B-cell lymphoma

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBRG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TBRG1 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbrg11 , 5 transforming growth factor beta regulated gene 11, 5 87.77(n)1
    85.22(a)1
      9 (20.79 cM)5
    213761  NM_025289.31  NP_079565.21 
     376491825 
    lizard
    (Anolis carolinensis)
    Reptilia TBRG16
    Uncharacterized protein
    57(a)
    1 ↔ 1
    GL343279.1(488926-490351)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.73422 Xenopus laevis transcribed sequence with weak similarity more 75.38(n)    CA982487.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tbrg11 transforming growth factor beta regulator 1 65.75(n)
    65.24(a)
      573117  NM_001114446.1  NP_001107918.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG311111 CG31111 47.15(n)
    36.5(a)
      318595  NM_170195.3  NP_733074.1 


    ENSEMBL Gene Tree for TBRG1 (if available)
    TreeFam Gene Tree for TBRG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/309 SNPs in TBRG1 are shown (see all 309)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs776240211,2
    C,F--124490971(+) ACACAA/GGACTT 2 -- us2k12Minor allele frequency- G:0.06WA EA 238
    rs1481965291,2
    --124491065(+) TTGCAG/TTTCCC 2 -- us2k10--------
    rs1136179851,2
    C--124491113(+) CATGCC/TCCCCT 2 -- us2k10--------
    rs602607551,2
    C,F--124491116(+) GCCCCC/ACTTTG 2 -- us2k12Minor allele frequency- A:0.05WA 120
    rs1503835481,2
    --124491173(+) CAGATA/GTATCT 2 -- us2k10--------
    rs1875792101,2
    --124491200(+) CCTATC/GTCCTC 2 -- us2k10--------
    rs1902626421,2
    --124491225(+) TGCTGC/TCAAAT 2 -- us2k10--------
    rs760783731,2
    C,F--124491311(+) TTAAAT/CTAAGG 2 -- us2k12Minor allele frequency- C:0.03WA NA 238
    rs1820282811,2
    --124491415(+) GCACAA/CATATC 2 -- us2k10--------
    rs1857149321,2
    --124491482(+) TGGAAC/TTGACC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TBRG1 (124492732 - 124505822 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TBRG1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TBRG1
    DNA2.0 Custom Variant and Variant Library Synthesis for TBRG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610614    OMIM disorders: --

    9 diseases for TBRG1:    About MalaCards
    weill-marchesani syndrome    tracheal stenosis    diffuse large b-cell lymphoma    b-cell lymphomas
    chronic lymphocytic leukemia    adenocarcinoma    leukemia    pancreatitis
    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for TBRG1:
    Weill-Marchesani syndrome     Tracheal stenosis

    TBRG1 for disorders           About GeneDecksing


    Export disorders for TBRG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TBRG1 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with TBRG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability. (PubMed id 17110379)1, 2, 3 Tompkins V.S.... Quelle D.E. (2007)
    2. The structure of the FYR domain of transforming growt h factor beta regulator 1. (PubMed id 20506279)1, 2 GarcA-a-Alai M.M....Bycroft M. (2010)
    3. Identification of novel ARF binding proteins by two-hybrid screening. (PubMed id 16582619)1, 2 Tompkins V.... Quelle D.E. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta. (PubMed id 7654366)1, 3 Babalola G.O. and Schultz R.M. (1995)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    8. Generation and characterization of monoclonal antibodies to NIAM: a nuclear interactor of ARF and Mdm2. (PubMed id 18582208)1 Hagen J....Quelle D.E. (2008)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84897 HGNC: 29551 AceView: TBRG1 Ensembl:ENSG00000154144 euGenes: HUgn84897
    ECgene: TBRG1 H-InvDB: TBRG1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TBRG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TBRG1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TBRG1 gene:
    Search GeneIP for patents involving TBRG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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