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Aliases for TBRG1 Gene

Aliases for TBRG1 Gene

  • Transforming Growth Factor Beta Regulator 1 2 3
  • NIAM 3 4 6
  • Nuclear Interactor Of ARF And MDM2 2 3
  • Nuclear Interactor Of ARF And Mdm2 4
  • TB-5 3

External Ids for TBRG1 Gene

Summaries for TBRG1 Gene

GeneCards Summary for TBRG1 Gene

TBRG1 (Transforming Growth Factor Beta Regulator 1) is a Protein Coding gene. Diseases associated with TBRG1 include weill-marchesani syndrome and tracheal stenosis. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway.

UniProtKB/Swiss-Prot for TBRG1 Gene

  • Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.

Gene Wiki entry for TBRG1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBRG1 Gene

Genomics for TBRG1 Gene

Genomic Location for TBRG1 Gene

Start:
124,622,836 bp from pter
End:
124,635,926 bp from pter
Size:
13,091 bases
Orientation:
Plus strand

Genomic View for TBRG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBRG1 Gene

Regulatory Elements for TBRG1 Gene

Proteins for TBRG1 Gene

  • Protein details for TBRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3YBR2-TBRG1_HUMAN
    Recommended name:
    Transforming growth factor beta regulator 1
    Protein Accession:
    Q3YBR2
    Secondary Accessions:
    • Q53GJ5
    • Q66ZJ6
    • Q69YS7
    • Q8TCS4
    • Q8TEI4
    • Q96SV0

    Protein attributes for TBRG1 Gene

    Size:
    411 amino acids
    Molecular mass:
    44946 Da
    Quaternary structure:
    • Interacts with CDKN2A and MDM2.
    SequenceCaution:
    • Sequence=BAB84966.1; Type=Frameshift; Positions=229; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TBRG1 Gene

    Alternative splice isoforms for TBRG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBRG1 Gene

Proteomics data for TBRG1 Gene at MOPED

Post-translational modifications for TBRG1 Gene

  • Ubiquitinated; mediated by MDM2 and leading to its subsequent proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBRG1 Gene

No data available for DME Specific Peptides for TBRG1 Gene

Domains for TBRG1 Gene

Protein Domains for TBRG1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TBRG1_HUMAN
Domain:
  • Contains 1 FYR C-terminal domain.:
    • Q3YBR2
  • Contains 1 FYR N-terminal domain.:
    • Q3YBR2
Family:
  • Belongs to the TBRG1 family.:
    • Q3YBR2
genes like me logo Genes that share domains with TBRG1: view

No data available for Gene Families for TBRG1 Gene

Function for TBRG1 Gene

Molecular function for TBRG1 Gene

UniProtKB/Swiss-Prot Function: Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.

Gene Ontology (GO) - Molecular Function for TBRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17110379
genes like me logo Genes that share ontologies with TBRG1: view

miRNA for TBRG1 Gene

miRTarBase miRNAs that target TBRG1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TBRG1 Gene

Localization for TBRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBRG1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBRG1 Gene COMPARTMENTS Subcellular localization image for TBRG1 gene
Compartment Confidence
nucleus 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for TBRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with TBRG1: view

Pathways for TBRG1 Gene

genes like me logo Genes that share pathways with TBRG1: view

Pathways by source for TBRG1 Gene

Gene Ontology (GO) - Biological Process for TBRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IMP 17110379
GO:0007050 cell cycle arrest IMP 17110379
GO:0008285 negative regulation of cell proliferation IMP 17110379
GO:0032066 nucleolus to nucleoplasm transport IDA 17110379
GO:0050821 protein stabilization IMP 17110379
genes like me logo Genes that share ontologies with TBRG1: view

Transcripts for TBRG1 Gene

Unigene Clusters for TBRG1 Gene

Transforming growth factor beta regulator 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBRG1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: - - - - - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5:
SP6: -
SP7: - - - - - - - - - -
SP8:

Relevant External Links for TBRG1 Gene

GeneLoc Exon Structure for
TBRG1
ECgene alternative splicing isoforms for
TBRG1

Expression for TBRG1 Gene

mRNA expression in normal human tissues for TBRG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TBRG1 Gene

SOURCE GeneReport for Unigene cluster for TBRG1 Gene Hs.436410

mRNA Expression by UniProt/SwissProt for TBRG1 Gene

Q3YBR2-TBRG1_HUMAN
Tissue specificity: Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B-cell lymphoma.
genes like me logo Genes that share expressions with TBRG1: view

Orthologs for TBRG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBRG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBRG1 36
  • 99.59 (n)
  • 99.27 (a)
TBRG1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TBRG1 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBRG1 36
  • 91.89 (n)
  • 89.78 (a)
TBRG1 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbrg1 36
  • 87.77 (n)
  • 85.22 (a)
Tbrg1 16
Tbrg1 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TBRG1 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 78 (a)
OneToMany
-- 37
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tbrg1 36
  • 87.93 (n)
  • 84.73 (a)
lizard
(Anolis carolinensis)
Reptilia TBRG1 37
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7342 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7289 36
tbrg1 36
  • 63.07 (n)
  • 59.05 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9934 36
zebrafish
(Danio rerio)
Actinopterygii tbrg1 36
  • 65.95 (n)
  • 66.26 (a)
tbrg1 37
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31111 36
  • 49.37 (n)
  • 41.87 (a)
CG31111 37
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 43 (a)
OneToOne
Species with no ortholog for TBRG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBRG1 Gene

ENSEMBL:
Gene Tree for TBRG1 (if available)
TreeFam:
Gene Tree for TBRG1 (if available)

Paralogs for TBRG1 Gene

No data available for Paralogs for TBRG1 Gene

Variants for TBRG1 Gene

Sequence variations from dbSNP and Humsavar for TBRG1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs9723 -- 124,624,049(+) CAAAA(A/G)CACTT intron-variant
rs14348 -- 124,625,466(+) CAAGA(C/G)ATAAG intron-variant
rs529083 -- 124,622,895(+) GGGAG(G/T)CGCCG utr-variant-5-prime, nc-transcript-variant
rs678132 -- 124,623,303(+) CTGTT(A/C)CCCCT intron-variant
rs679079 -- 124,623,515(+) TCGTT(A/G)TTACT intron-variant

Relevant External Links for TBRG1 Gene

HapMap Linkage Disequilibrium report
TBRG1

No data available for Structural Variations from Database of Genomic Variants (DGV) for TBRG1 Gene

Disorders for TBRG1 Gene

(2) University of Copenhagen DISEASES for TBRG1 Gene

genes like me logo Genes that share disorders with TBRG1: view

No data available for UniProtKB/Swiss-Prot for TBRG1 Gene

Publications for TBRG1 Gene

  1. A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability. (PMID: 17110379) Tompkins V.S. … Quelle D.E. (J. Biol. Chem. 2007) 2 3 4
  2. The structure of the FYR domain of transforming growth factor beta regulator 1. (PMID: 20506279) Garcia-Alai M.M. … Bycroft M. (Protein Sci. 2010) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta. (PMID: 7654366) Babalola G.O. … Schultz R.M. (Mol. Reprod. Dev. 1995) 2 3

Products for TBRG1 Gene

Sources for TBRG1 Gene

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