Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TBRG1 Gene

Aliases for TBRG1 Gene

  • Transforming Growth Factor Beta Regulator 1 2 3 5
  • Nuclear Interactor Of ARF And MDM2 2 3
  • NIAM 3 4
  • Nuclear Interactor Of ARF And Mdm2 4
  • TB-5 3

External Ids for TBRG1 Gene

Previous GeneCards Identifiers for TBRG1 Gene

  • GC11P126493
  • GC11P126006
  • GC11P124526
  • GC11P124030
  • GC11P123997
  • GC11P124492
  • GC11P120435

Summaries for TBRG1 Gene

GeneCards Summary for TBRG1 Gene

TBRG1 (Transforming Growth Factor Beta Regulator 1) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling.

UniProtKB/Swiss-Prot for TBRG1 Gene

  • Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.

Gene Wiki entry for TBRG1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBRG1 Gene

Genomics for TBRG1 Gene

Regulatory Elements for TBRG1 Gene

Promoters for TBRG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TBRG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TBRG1 Gene

Chromosome:
11
Start:
124,622,599 bp from pter
End:
124,635,926 bp from pter
Size:
13,328 bases
Orientation:
Plus strand

Genomic View for TBRG1 Gene

Genes around TBRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBRG1 Gene

Proteins for TBRG1 Gene

  • Protein details for TBRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3YBR2-TBRG1_HUMAN
    Recommended name:
    Transforming growth factor beta regulator 1
    Protein Accession:
    Q3YBR2
    Secondary Accessions:
    • Q53GJ5
    • Q66ZJ6
    • Q69YS7
    • Q8TCS4
    • Q8TEI4
    • Q96SV0

    Protein attributes for TBRG1 Gene

    Size:
    411 amino acids
    Molecular mass:
    44946 Da
    Quaternary structure:
    • Interacts with CDKN2A and MDM2.
    SequenceCaution:
    • Sequence=BAB84966.1; Type=Frameshift; Positions=229; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TBRG1 Gene

    Alternative splice isoforms for TBRG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBRG1 Gene

Proteomics data for TBRG1 Gene at MOPED

Post-translational modifications for TBRG1 Gene

  • Ubiquitinated; mediated by MDM2 and leading to its subsequent proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBRG1 Gene

Antibody Products

No data available for DME Specific Peptides for TBRG1 Gene

Domains & Families for TBRG1 Gene

Protein Domains for TBRG1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q3YBR2

UniProtKB/Swiss-Prot:

TBRG1_HUMAN :
  • Contains 1 FYR C-terminal domain.
  • Belongs to the TBRG1 family.
Domain:
  • Contains 1 FYR C-terminal domain.
  • Contains 1 FYR N-terminal domain.
Family:
  • Belongs to the TBRG1 family.
genes like me logo Genes that share domains with TBRG1: view

No data available for Gene Families for TBRG1 Gene

Function for TBRG1 Gene

Molecular function for TBRG1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.
genes like me logo Genes that share phenotypes with TBRG1: view

Animal Model Products

miRNA for TBRG1 Gene

miRTarBase miRNAs that target TBRG1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBRG1 Gene

Localization for TBRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBRG1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBRG1 Gene COMPARTMENTS Subcellular localization image for TBRG1 gene
Compartment Confidence
nucleus 5
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for TBRG1 Gene

Pathways & Interactions for TBRG1 Gene

genes like me logo Genes that share pathways with TBRG1: view

Gene Ontology (GO) - Biological Process for TBRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IMP 17110379
GO:0008285 negative regulation of cell proliferation IMP 17110379
GO:0032066 nucleolus to nucleoplasm transport IDA 17110379
genes like me logo Genes that share ontologies with TBRG1: view

No data available for SIGNOR curated interactions for TBRG1 Gene

Drugs & Compounds for TBRG1 Gene

No Compound Related Data Available

Transcripts for TBRG1 Gene

Unigene Clusters for TBRG1 Gene

Transforming growth factor beta regulator 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBRG1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: - - - - - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5:
SP6: -
SP7: - - - - - - - - - -
SP8:

Relevant External Links for TBRG1 Gene

GeneLoc Exon Structure for
TBRG1
ECgene alternative splicing isoforms for
TBRG1

Expression for TBRG1 Gene

mRNA expression in normal human tissues for TBRG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TBRG1 Gene

This gene is overexpressed in Blymphocyte (61.7) and Placenta (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TBRG1 Gene



SOURCE GeneReport for Unigene cluster for TBRG1 Gene Hs.436410

mRNA Expression by UniProt/SwissProt for TBRG1 Gene

Q3YBR2-TBRG1_HUMAN
Tissue specificity: Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B-cell lymphoma.
genes like me logo Genes that share expression patterns with TBRG1: view

Protein tissue co-expression partners for TBRG1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TBRG1 Gene

Orthologs for TBRG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBRG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBRG1 35
  • 99.59 (n)
  • 99.27 (a)
TBRG1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TBRG1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBRG1 36
  • 90 (a)
OneToOne
TBRG1 35
  • 91.89 (n)
  • 89.78 (a)
mouse
(Mus musculus)
Mammalia Tbrg1 36
  • 85 (a)
OneToOne
Tbrg1 16
Tbrg1 35
  • 87.77 (n)
  • 85.22 (a)
oppossum
(Monodelphis domestica)
Mammalia TBRG1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tbrg1 35
  • 87.93 (n)
  • 84.73 (a)
lizard
(Anolis carolinensis)
Reptilia TBRG1 36
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7342 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7289 35
tbrg1 35
  • 63.07 (n)
  • 59.05 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9934 35
zebrafish
(Danio rerio)
Actinopterygii tbrg1 36
  • 40 (a)
OneToOne
tbrg1 35
  • 65.95 (n)
  • 66.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31111 35
  • 49.37 (n)
  • 41.87 (a)
CG31111 36
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for TBRG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBRG1 Gene

ENSEMBL:
Gene Tree for TBRG1 (if available)
TreeFam:
Gene Tree for TBRG1 (if available)

Paralogs for TBRG1 Gene

No data available for Paralogs for TBRG1 Gene

Variants for TBRG1 Gene

Sequence variations from dbSNP and Humsavar for TBRG1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs14348 -- 124,625,466(+) CAAGA(C/G)ATAAG intron-variant
rs678132 -- 124,623,303(+) CTGTT(A/C)CCCCT intron-variant
rs1047661 -- 124,632,364(+) ATGGA(A/G)GGTCC nc-transcript-variant, utr-variant-3-prime
rs1122198 -- 124,624,675(-) cttat(A/G)ccaga intron-variant
rs2187152 -- 124,632,025(+) TGTAT(A/G)TGTCT intron-variant

Variation tolerance for TBRG1 Gene

Gene Damage Index Score: 3.63; 56.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBRG1 Gene

HapMap Linkage Disequilibrium report
TBRG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TBRG1 Gene

Disorders for TBRG1 Gene

Relevant External Links for TBRG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TBRG1

No disorders were found for TBRG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBRG1 Gene

Publications for TBRG1 Gene

  1. A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability. (PMID: 17110379) Tompkins V.S. … Quelle D.E. (J. Biol. Chem. 2007) 2 3 4 67
  2. Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta. (PMID: 7654366) Babalola G.O. … Schultz R.M. (Mol. Reprod. Dev. 1995) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Nuclear interactor of ARF and Mdm2 regulates multiple pathways to activate p53. (PMID: 24621507) Reed S.M. … Quelle D.E. (Cell Cycle 2014) 3
  5. The structure of the FYR domain of transforming growth factor beta regulator 1. (PMID: 20506279) Garcia-Alai M.M. … Bycroft M. (Protein Sci. 2010) 3

Products for TBRG1 Gene

Sources for TBRG1 Gene

Back to Top

Content