Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TBRG1 Gene

protein-coding   GIFtS: 50
GCID: GC11P124492

transforming growth factor beta regulator 1
 Explore 12 diseases affiliated with
TBRG1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TBRG1    

Aliases
for TBRG1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transforming Growth Factor Beta Regulator 11 2
NIAM1 2 3 5
TB-51 2
Nuclear Interactor Of ARF And Mdm22 3
FLJ146211

External Ids:    HGNC: 295511   Entrez Gene: 848972   Ensembl: ENSG000001541447   OMIM: 6106145   UniProtKB: Q3YBR23   
ORGUL members:         
NONCODE:n406427    

Export aliases for TBRG1 gene to outside databases

Previous GC identifers: GC11P126493 GC11P126006 GC11P124526 GC11P124030 GC11P123997 GC11P120435


Summaries
for TBRG1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TBRG1_HUMAN, Q3YBR2
Function: Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict
proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the
nucleoplasm. Involved in maintaining chromosomal stability

Gene Wiki entry for TBRG1


Genomic Views
for TBRG1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TBRG1 gene promoter:
         E2F-4   E2F-3a   ISGF-3   E2F-5   p53   E2F-2   Evi-1   AREB6   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TBRG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TBRG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBRG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24.2

TBRG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBRG1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P124492:  view genomic region     (about GC identifiers)

Start:
 124,492,732 bp from pter      End:
 124,505,822 bp from pter
Size:
 13,091 bases      Orientation:
 plus strand

Proteins
for TBRG1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TBRG1_HUMAN, Q3YBR2 (See protein sequence)
Recommended Name: Transforming growth factor beta regulator 1  
Size: 411 amino acids; 44946 Da
Subunit: Interacts with CDKN2A and MDM2
Subcellular location: Nucleus
Sequence caution: Sequence=BAB84966.1; Type=Frameshift; Positions=229;
1 PDB 3D structure from and Proteopedia for TBRG1:
2WZO (3D)    
Secondary accessions: Q53GJ5 Q66ZJ6 Q69YS7 Q8TCS4 Q8TEI4 Q96SV0
Alternative splicing: 3 isoforms:  Q3YBR2-1   Q3YBR2-2   Q3YBR2-3   

Explore the universe of human proteins at neXtProt for TBRG1: NX_Q3YBR2

Post-translational modifications:

  • Ubiquitinated; mediated by MDM2 and leading to its subsequent proteasomal degradation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q3YBR2

    • TBRG1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_116200.2  
    ENSEMBL proteins: 
     ENSP00000436238   ENSP00000435448   ENSP00000284290   ENSP00000409016   ENSP00000395145  
     ENSP00000436599   ENSP00000364144  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): TBRG1
    OriGene Custom Protein Services for TBRG1 
    GenScript Custom Purified and Recombinant Proteins Services for TBRG1
    Novus Biologicals TBRG1 Protein
    Novus Biologicals TBRG1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17110379


    TBRG1 for ontologies           About GeneDecksing



    TBRG1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TBRG1 
    GenScript Custom Superior Antibodies Services for TBRG1
    Novus Biologicals TBRG1 Antibody
    Abcam antibodies for TBRG1 
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for TBRG1

    Assay Products for TBRG1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TBRG1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for TBRG1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TBRG1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR003889 FYrich_C
     IPR003888 FYrich_N

    Graphical View of Domain Structure for InterPro Entry Q3YBR2

    ProtoNet protein and cluster: Q3YBR2

    UniProtKB/Swiss-Prot: TBRG1_HUMAN, Q3YBR2
    Similarity: Belongs to the TBRG1 family
    Similarity: Contains 1 FYR C-terminal domain
    Similarity: Contains 1 FYR N-terminal domain


    Function
    for TBRG1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TBRG1_HUMAN, Q3YBR2
    Function: Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict
    proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the
    nucleoplasm. Involved in maintaining chromosomal stability

    miRNA
    Products:            		 OriGene 3'-UTR Clone: TBRG1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TBRG1
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate TBRG1 (see all 24):
    hsa-miR-185* hsa-miR-4251 hsa-miR-539 hsa-miR-188-5p hsa-miR-15a hsa-miR-888* hsa-miR-141* hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: TBRG1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TBRG1 (see all 7)
    OriGene shRNA RFP: TBRG1
    OriGene siRNA: TBRG1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBRG1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TBRG1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBRG1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBRG1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TBRG1 (NM_032811)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBRG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBRG1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TBRG1
    Search LifeMap BioReagents cell lines for TBRG1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBRG1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17110379


    TBRG1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for TBRG1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    2GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    4TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JAK-STAT Pathway0.57
    		MAPK Family Pathway0.60
    		JNK Pathway0.50
    5Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48

    5/54 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TBRG1 (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TBRG1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TBRG1 (Q3YBR23 ENSP000004090164) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CDKN2AENSP000003551534STRING: ENSP00000355153
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IMP17110379
    GO:0007050cell cycle arrest IMP17110379
    GO:0008285negative regulation of cell proliferation IMP17110379
    GO:0032066nucleolus to nucleoplasm transport IDA17110379
    GO:0050821protein stabilization IMP17110379


    TBRG1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TBRG1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TBRG1
    Search CenterWatch for drugs/clinical trials and news about TBRG1 

    Transcripts
    for TBRG1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TBRG1 gene: 
    NM_032811.2  

    Unigene Cluster for TBRG1:

    Transforming growth factor beta regulator 1
    Hs.436410  [show with all ESTs]
    Unigene Representative Sequence: NM_032811
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000473629 ENST00000530731 ENST00000531667 ENST00000284290(uc001qak.4 uc001qaj.4 uc009zbf.3 uc001qal.4 uc009zbh.3)
    ENST00000441174 ENST00000452080 ENST00000529543 ENST00000438907 ENST00000491010
    ENST00000531033 ENST00000375005

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TBRG1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TBRG1
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate TBRG1 (see all 24):
    hsa-miR-185* hsa-miR-4251 hsa-miR-539 hsa-miR-188-5p hsa-miR-15a hsa-miR-888* hsa-miR-141* hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: TBRG1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TBRG1 (see all 7)
    OriGene shRNA RFP: TBRG1
    OriGene siRNA: TBRG1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBRG1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBRG1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBRG1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TBRG1 (NM_032811)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBRG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBRG1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBRG1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TBRG1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBRG1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBRG1

    Additional cDNA sequence: 

    AK027527.1 AK027766.1 AK057749.1 AK074140.1 AK074594.1 AK222936.1 AL713631.1 AL831881.1 
    AY696294.1 BC018452.1 BC032312.1 BC041043.1 BC064392.1 BC073160.1 BC107428.1 BC109269.2 
    DQ144542.1 NR_016021.1 

    20 DOTS entries:

    DT.100823605  DT.100823606  DT.100802387  DT.415670  DT.100037797  DT.65286898  DT.101983949  DT.95265897 
    DT.111748  DT.40131997  DT.409069  DT.95268947  DT.120747890  DT.100823609  DT.120747892  DT.95268949 
    DT.120747909  DT.86847505  DT.91645747  DT.92416461 

    24/346 AceView cDNA sequences (see all 346):

    CR620045 CB146378 AI492243 AK027527 AI218051 AL046156 BG679681 CF593321 
    AI804107 AI288633 R00062 BF001378 BM742831 BE503387 BQ185956 CA944457 
    W81581 AI633570 AI589835 AW295964 BC041043 CR625770 AI363199 BI838497 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TBRG1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b
    SP1:                    -           -     -     -     -     -     -     -     -                                                   
    SP2:                                                                    -     -                                                   
    SP3:                                                              -     -     -                                                   
    SP4:                                                              -                                                               
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for TBRG1

    Expression
    for TBRG1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TBRG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAGGTCCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TBRG1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneRostral Skull Membranous BonesBone
    CartilageMeckel's CartilageCartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TBRG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TBRG1

    SOURCE GeneReport for Unigene cluster: Hs.436410

    UniProtKB/Swiss-Prot: TBRG1_HUMAN, Q3YBR2
    Tissue specificity: Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver.
    Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic
    lymphocytic leukemia and diffuse large B-cell lymphoma

        SABiosciences Custom PCR Arrays for TBRG1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBRG1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TBRG1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBRG1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBRG1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBRG1

    Orthologs
    for TBRG1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TBRG1 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tbrg11 , 5 transforming growth factor beta regulated gene 11, 5 87.77(n)1
    85.22(a)1    		   9 (20.79 cM)5
    213761  NM_025289.31  NP_079565.21 
     376491825 
    lizard
    (Anolis carolinensis)    		 Reptilia TBRG16
    		 --
    		 55(a)
    		 1 ↔ 1
    		 GL343279.1(488926-490351)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.73422 Xenopus laevis transcribed sequence with weak similarity more 75.38(n)    CA982487.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii tbrg11 transforming growth factor beta regulator 1 65.75(n)
    65.24(a)    		   573117  NM_001114446.1  NP_001107918.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG311111 CG31111 47.15(n)
    36.5(a)    		   318595  NM_170195.3  NP_733074.1 


    ENSEMBL Gene Tree for TBRG1 (if available)
    TreeFam Gene Tree for TBRG1 (if available) 

    Paralogs
    for TBRG1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for TBRG1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/246 NCBI SNPs in TBRG1 are shown (see all 246)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs776240211,2
    		C,F,--124490971(+) ACACAA/GGACTT 2 -- us2k12Minor allele frequency- G:0.06WA EA 238
    rs1481965291,2
    		--124491065(+) TTGCAG/TTTCCC 2 -- us2k10--------
    rs1136179851,2
    		C,--124491113(+) CATGCC/TCCCCT 2 -- us2k10--------
    rs602607551,2
    		C,--124491116(+) GCCCCC/ACTTTG 2 -- us2k12Minor allele frequency- A:0.05WA 120
    rs1503835481,2
    		--124491173(+) CAGATA/GTATCT 2 -- us2k10--------
    rs1875792101,2
    		--124491200(+) CCTATC/GTCCTC 2 -- us2k10--------
    rs1902626421,2
    		--124491225(+) TGCTGC/TCAAAT 2 -- us2k10--------
    rs760783731,2
    		F,--124491311(+) TTAAAT/CTAAGG 2 -- us2k12Minor allele frequency- C:0.03WA NA 238
    rs1820282811,2
    		--124491415(+) GCACAA/CATATC 2 -- us2k10--------
    rs1857149321,2
    		--124491482(+) TGGAAC/TTGACC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TBRG1 (124492732 - 124505822 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TBRG1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBRG1
    DNA2.0 Custom Variant and Variant Library Synthesis for TBRG1

    Disorders / Diseases
    for TBRG1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TBRG1 for disorders           About GeneDecksing

    OMIM gene information: 610614    OMIM disorders: --

    12 diseases for TBRG1:    About MalaCards
    weill-marchesani syndrome    diffuse large b-cell lymphoma    b-cell lymphomas    tracheal stenosis
    urinary bladder cancer    chronic lymphocytic leukemia    lymphocytic leukemia    leukemia
    carcinoma    breast cancer    adenocarcinoma    pancreatitis

    2 diseases from the University of Copenhagen DISEASES database for TBRG1:
    Weill-Marchesani syndrome     Tracheal stenosis

    Export disorders for TBRG1 gene to outside databases

    Publications
    for TBRG1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TBRG1 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with TBRG1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability. (PubMed id 17110379)1, 2, 3 Tompkins V.S.... Quelle D.E. (2007)
    2. The structure of the FYR domain of transforming growt h factor beta regulator 1. (PubMed id 20506279)1, 2 GarcA-a-Alai M.M....Bycroft M. (2010)
    3. Identification of novel ARF binding proteins by two-hybrid screening. (PubMed id 16582619)1, 2 Tompkins V.... Quelle D.E. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta. (PubMed id 7654366)1, 3 Babalola G.O. and Schultz R.M. (1995)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    8. Generation and characterization of monoclonal antibodies to NIAM: a nuclear interactor of ARF and Mdm2. (PubMed id 18582208)1 Hagen J....Quelle D.E. (2008)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)

    External Searches for TBRG1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TBRG1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84897 HGNC: 29551 AceView: TBRG1 Ensembl:ENSG00000154144 euGenes: HUgn84897
    ECgene: TBRG1 H-InvDB: TBRG1

    Other Databases showing TBRG1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TBRG1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TBRG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TBRG1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TBRG1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TBRG1 gene:
    Search GeneIP for patents involving TBRG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TBRG1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for TBRG1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TBRG1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBRG1  
     OriGene Protein Over-expression Lysate for TBRG1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TBRG1   OriGene 3'-UTR Clone for TBRG1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBRG1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBRG1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TBRG1   OriGene Custom Protein Services for TBRG1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TBRG1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBRG1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBRG1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBRG1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBRG1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBRG1
     GenScript Custom Purified and Recombinant Proteins Services for TBRG1 GenScript cDNA clones with any tag delivered in your preferred vector for TBRG1
     GenScript Custom Assay Services for TBRG1 GenScript Custom Superior Antibodies Services for TBRG1
     GenScript Custom overexpressing Cell Line Services for TBRG1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TBRG1 promoter
     Search Chromatin IP Primers for TBRG1
     RT2 qPCR Primer Assay in human, mouse, rat TBRG1
     GNC Network for TBRG1
     SABiosciences PCR Arrays including human, mouse, rat TBRG1
     Search Tocris compounds for TBRG1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TBRG1 antibodies
     TBRG1 proteins
     TBRG1 lysates
     Antibodies for TBRG1
     See all of Abcam's Antibodies, Kits and Proteins for TBRG1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for TBRG1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBRG1
     SwitchGear 3'UTR luciferase reporter plasmids for TBRG1
     SwitchGear Promoter luciferase reporter plasmids for TBRG1
     ThermoFisher Antibodies for TBRG1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBRG1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      TBRG1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4