External Ids for TBR1 Gene
Previous GeneCards Identifiers for TBR1 Gene
This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of this gene is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of this protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. [provided by RefSeq, Dec 2015]
GeneCards Summary for TBR1 Gene
TBR1 (T-Box, Brain 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter sequence-specific DNA binding. An important paralog of this gene is EOMES.
UniProtKB/Swiss-Prot for TBR1 Gene
Probable transcriptional regulator involved in developmental processes. Required for normal brain development.