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Aliases for TBPL2 Gene

Aliases for TBPL2 Gene

  • TATA-Box Binding Protein Like 2 2 3 5
  • TATA Box-Binding Protein-Related Factor 3 3 4
  • TBP-Related Factor 3 3 4
  • TBP-Like Protein 2 3 4
  • TBP2 3 4
  • TRF3 3 4
  • TATA Box Binding Protein Like 2 3

External Ids for TBPL2 Gene

Previous GeneCards Identifiers for TBPL2 Gene

  • GC00U906280
  • GC14M053870
  • GC14M054950
  • GC14M055884
  • GC14M055887
  • GC14M036044
  • GC14M055890
  • GC14M055893
  • GC14M055896
  • GC14M055899

Summaries for TBPL2 Gene

GeneCards Summary for TBPL2 Gene

TBPL2 (TATA-Box Binding Protein Like 2) is a Protein Coding gene. Among its related pathways are HTLV-I infection and Influenza A. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is TBPL1.

UniProtKB/Swiss-Prot for TBPL2 Gene

  • Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBPL2 Gene

Genomics for TBPL2 Gene

Regulatory Elements for TBPL2 Gene

Enhancers for TBPL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TBPL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TBPL2 Gene

Chromosome:
14
Start:
55,413,541 bp from pter
End:
55,456,726 bp from pter
Size:
43,186 bases
Orientation:
Minus strand

Genomic View for TBPL2 Gene

Genes around TBPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBPL2 Gene

Proteins for TBPL2 Gene

  • Protein details for TBPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6SJ96-TBPL2_HUMAN
    Recommended name:
    TATA box-binding protein-like protein 2
    Protein Accession:
    Q6SJ96
    Secondary Accessions:
    • Q17RU8

    Protein attributes for TBPL2 Gene

    Size:
    375 amino acids
    Molecular mass:
    41524 Da
    Quaternary structure:
    • Interacts with TAF3.

neXtProt entry for TBPL2 Gene

Proteomics data for TBPL2 Gene at MOPED

Post-translational modifications for TBPL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBPL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TBPL2 Gene

Domains & Families for TBPL2 Gene

Protein Domains for TBPL2 Gene

Suggested Antigen Peptide Sequences for TBPL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6SJ96

UniProtKB/Swiss-Prot:

TBPL2_HUMAN :
  • Belongs to the TBP family.
Family:
  • Belongs to the TBP family.
genes like me logo Genes that share domains with TBPL2: view

No data available for Gene Families for TBPL2 Gene

Function for TBPL2 Gene

Molecular function for TBPL2 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity).

Gene Ontology (GO) - Molecular Function for TBPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TBPL2: view
genes like me logo Genes that share phenotypes with TBPL2: view

Animal Models for TBPL2 Gene

MGI Knock Outs for TBPL2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TBPL2 Gene

Localization for TBPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBPL2 Gene

Cytoplasm. Nucleus. Note=Present in the cytoplasm during cytokenesis. {ECO:0000269 PubMed:14634207}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBPL2 Gene COMPARTMENTS Subcellular localization image for TBPL2 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for TBPL2 Gene

Pathways & Interactions for TBPL2 Gene

genes like me logo Genes that share pathways with TBPL2: view

Gene Ontology (GO) - Biological Process for TBPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TBPL2: view

No data available for SIGNOR curated interactions for TBPL2 Gene

Drugs & Compounds for TBPL2 Gene

No Compound Related Data Available

Transcripts for TBPL2 Gene

mRNA/cDNA for TBPL2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TBPL2 Gene

TATA box binding protein like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBPL2 Gene

No ASD Table

Relevant External Links for TBPL2 Gene

GeneLoc Exon Structure for
TBPL2
ECgene alternative splicing isoforms for
TBPL2

Expression for TBPL2 Gene

mRNA expression in normal human tissues for TBPL2 Gene

mRNA differential expression in normal tissues according to GTEx for TBPL2 Gene

This gene is overexpressed in Testis (x12.8) and Ovary (x6.5).

Protein differential expression in normal tissues from HIPED for TBPL2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TBPL2 Gene



SOURCE GeneReport for Unigene cluster for TBPL2 Gene Hs.528278

mRNA Expression by UniProt/SwissProt for TBPL2 Gene

Q6SJ96-TBPL2_HUMAN
Tissue specificity: Ubiquitously expressed in all tissues examined with highest levels in heart, lung, ovary, spleen and testes.
genes like me logo Genes that share expression patterns with TBPL2: view

Protein tissue co-expression partners for TBPL2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TBPL2 Gene

Orthologs for TBPL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TBPL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TBPL2 35
  • 88.03 (n)
  • 84.2 (a)
TBPL2 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBPL2 35
  • 88.95 (n)
  • 85.88 (a)
TBPL2 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbpl2 35
  • 79.81 (n)
  • 69.57 (a)
Tbpl2 16
Tbpl2 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TBPL2 35
  • 99.82 (n)
  • 99.47 (a)
TBPL2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbpl2 35
  • 79.22 (n)
  • 69.12 (a)
oppossum
(Monodelphis domestica)
Mammalia TBPL2 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TBPL2 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves TBPL2 35
  • 72.36 (n)
  • 74.68 (a)
TBPL2 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBPL2 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tbpl2 35
  • 70.17 (n)
  • 75.8 (a)
zebrafish
(Danio rerio)
Actinopterygii tbpl2 35
  • 66.23 (n)
  • 70.43 (a)
tbpl2 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tbp 36
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tbp-1 36
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPT15 36
  • 62 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons TBP2 35
  • 70.22 (n)
  • 81.46 (a)
rice
(Oryza sativa)
Liliopsida Os03g0657000 35
  • 69.48 (n)
  • 81.46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10479 36
  • 55 (a)
OneToMany
Species with no ortholog for TBPL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TBPL2 Gene

ENSEMBL:
Gene Tree for TBPL2 (if available)
TreeFam:
Gene Tree for TBPL2 (if available)

Paralogs for TBPL2 Gene

Paralogs for TBPL2 Gene

(2) SIMAP similar genes for TBPL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TBPL2: view

Variants for TBPL2 Gene

Sequence variations from dbSNP and Humsavar for TBPL2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs8019270 - 55,440,454(+) TGGAC(C/G/T)GTAAT reference, missense
rs7493177 -- 55,426,525(+) TTAGA(G/T)AGGCC intron-variant
rs7142204 -- 55,441,718(+) CCTGC(A/C)TAAGA upstream-variant-2KB
rs1572608 -- 55,433,208(-) gaggc(C/T)gcaat intron-variant
rs1572609 -- 55,433,137(-) ACCAA(A/C)ATAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TBPL2 Gene

Variant ID Type Subtype PubMed ID
dgv1937n71 CNV Gain 21882294
nsv901959 CNV Gain 21882294

Variation tolerance for TBPL2 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBPL2 Gene

Human Gene Mutation Database (HGMD)
TBPL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBPL2 Gene

Disorders for TBPL2 Gene

Relevant External Links for TBPL2

Genetic Association Database (GAD)
TBPL2
Human Genome Epidemiology (HuGE) Navigator
TBPL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TBPL2

No disorders were found for TBPL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBPL2 Gene

Publications for TBPL2 Gene

  1. TRF3, a TATA-box-binding protein-related factor, is vertebrate- specific and widely expressed. (PMID: 14634207) Persengiev S.P. … Green M.R. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 23 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. Characterization of the HDAC1 complex that regulates the sensitivity of cancer cells to oxidative stress. (PMID: 19351825) Kato T. … Takahashi M. (Cancer Res. 2009) 3
  4. TBP2 is a substitute for TBP in Xenopus oocyte transcription. (PMID: 19650908) Akhtar W. … Veenstra G.J. (BMC Biol. 2009) 23
  5. A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. (PMID: 18555775) Ago T. … Sadoshima J. (Cell 2008) 3

Products for TBPL2 Gene

Sources for TBPL2 Gene

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