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Aliases for TBPL2 Gene

Aliases for TBPL2 Gene

  • TATA-Box Binding Protein Like 2 2 3 5
  • TATA Box-Binding Protein-Related Factor 3 3 4
  • TBP-Related Factor 3 3 4
  • TBP-Like Protein 2 3 4
  • TBP2 3 4
  • TRF3 3 4
  • TATA Box-Binding Protein-Like Protein 2 3

External Ids for TBPL2 Gene

Previous GeneCards Identifiers for TBPL2 Gene

  • GC00U906280
  • GC14M053870
  • GC14M054950
  • GC14M055884
  • GC14M055887
  • GC14M036044
  • GC14M055890
  • GC14M055893
  • GC14M055896
  • GC14M055899

Summaries for TBPL2 Gene

GeneCards Summary for TBPL2 Gene

TBPL2 (TATA-Box Binding Protein Like 2) is a Protein Coding gene. Diseases associated with TBPL2 include Retinitis Pigmentosa 18. Among its related pathways are PI3K-Akt signaling pathway and Epstein-Barr virus infection. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is TBP.

UniProtKB/Swiss-Prot for TBPL2 Gene

  • Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity).

Additional gene information for TBPL2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBPL2 Gene

Genomics for TBPL2 Gene

GeneHancer (GH) Regulatory Elements for TBPL2 Gene

Promoters and enhancers for TBPL2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I055440 Promoter/Enhancer 1 EPDnew Ensembl 550.4 +16.2 16201 0.6 CTCF ZNF143 USF2 CUX1 TBPL2 KTN1 ENSG00000259318 ATG14 GC14P055414 GC14M054989
GH14I055578 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.6 -124.8 -124846 6.7 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 KLF13 KTN1-AS1 KTN1 ATG14 TBPL2 GC14P055652
GH14I055598 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 10.6 -143.7 -143703 3.7 SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS DEK SP5 KTN1 KTN1-AS1 ENSG00000259318 ATG14 WDHD1 TBPL2 SOCS4 GC14P055652
GH14I055585 Enhancer 1 Ensembl ENCODE dbSUPER 10.6 -130.8 -130767 4 RFX1 JUN HLF ZIC2 OSR2 PRDM6 JUND SCRT2 HMBOX1 PRDM10 KTN1-AS1 KTN1 TBPL2 GC14P055652
GH14I055556 Enhancer 0.9 Ensembl ENCODE 10.6 -100.5 -100465 1.3 PKNOX1 NFIB MAX SIN3A ZNF507 CTBP1 GATA3 POLR2A RCOR1 FOS KTN1 KTN1-AS1 TBPL2 GC14M055549 GC14M054989
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TBPL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TBPL2 gene promoter:

Genomic Locations for TBPL2 Gene

Genomic Locations for TBPL2 Gene
43,186 bases
Minus strand

Genomic View for TBPL2 Gene

Genes around TBPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBPL2 Gene

Proteins for TBPL2 Gene

  • Protein details for TBPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TATA box-binding protein-like protein 2
    Protein Accession:
    Secondary Accessions:
    • Q17RU8

    Protein attributes for TBPL2 Gene

    375 amino acids
    Molecular mass:
    41524 Da
    Quaternary structure:
    • Interacts with TAF3.

neXtProt entry for TBPL2 Gene

Post-translational modifications for TBPL2 Gene

No Post-translational modifications

Other Protein References for TBPL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TBPL2 Gene

Domains & Families for TBPL2 Gene

Gene Families for TBPL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TBPL2 Gene

Suggested Antigen Peptide Sequences for TBPL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TBP family.
  • Belongs to the TBP family.
genes like me logo Genes that share domains with TBPL2: view

Function for TBPL2 Gene

Molecular function for TBPL2 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity).

Phenotypes From GWAS Catalog for TBPL2 Gene

Gene Ontology (GO) - Molecular Function for TBPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with TBPL2: view
genes like me logo Genes that share phenotypes with TBPL2: view

Animal Models for TBPL2 Gene

MGI Knock Outs for TBPL2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TBPL2 Gene

Localization for TBPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBPL2 Gene

Cytoplasm. Nucleus. Note=Present in the cytoplasm during cytokinesis. {ECO:0000269 PubMed:14634207}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBPL2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for TBPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 14634207
GO:0005737 cytoplasm IDA,IEA 14634207
genes like me logo Genes that share ontologies with TBPL2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TBPL2 Gene

Pathways & Interactions for TBPL2 Gene

genes like me logo Genes that share pathways with TBPL2: view

Gene Ontology (GO) - Biological Process for TBPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006352 DNA-templated transcription, initiation IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TBPL2: view

No data available for SIGNOR curated interactions for TBPL2 Gene

Drugs & Compounds for TBPL2 Gene

No Compound Related Data Available

Transcripts for TBPL2 Gene

mRNA/cDNA for TBPL2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TBPL2 Gene

TATA box binding protein like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBPL2 Gene

No ASD Table

Relevant External Links for TBPL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBPL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TBPL2 Gene

mRNA differential expression in normal tissues according to GTEx for TBPL2 Gene

This gene is overexpressed in Testis (x12.8) and Ovary (x6.5).

Protein differential expression in normal tissues from HIPED for TBPL2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TBPL2 Gene

Protein tissue co-expression partners for TBPL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TBPL2 Gene:


SOURCE GeneReport for Unigene cluster for TBPL2 Gene:


mRNA Expression by UniProt/SwissProt for TBPL2 Gene:

Tissue specificity: Ubiquitously expressed in all tissues examined with highest levels in heart, lung, ovary, spleen and testes.
genes like me logo Genes that share expression patterns with TBPL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TBPL2 Gene

Orthologs for TBPL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TBPL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TBPL2 33 34
  • 99.82 (n)
(Ornithorhynchus anatinus)
Mammalia TBPL2 34
  • 97 (a)
(Canis familiaris)
Mammalia TBPL2 33 34
  • 88.95 (n)
(Bos Taurus)
Mammalia TBPL2 33 34
  • 88.03 (n)
(Mus musculus)
Mammalia Tbpl2 33 16 34
  • 79.81 (n)
(Rattus norvegicus)
Mammalia Tbpl2 33
  • 79.22 (n)
(Monodelphis domestica)
Mammalia TBPL2 34
  • 72 (a)
(Gallus gallus)
Aves TBPL2 33 34
  • 72.36 (n)
(Anolis carolinensis)
Reptilia TBPL2 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tbpl2 33
  • 70.17 (n)
(Danio rerio)
Actinopterygii tbpl2 33 34
  • 66.23 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tbp 34
  • 52 (a)
(Caenorhabditis elegans)
Secernentea tbp-1 34
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPT15 34
  • 62 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons TBP2 33
  • 70.22 (n)
(Oryza sativa)
Liliopsida Os03g0657000 33
  • 69.48 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10479 34
  • 55 (a)
Species where no ortholog for TBPL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TBPL2 Gene

Gene Tree for TBPL2 (if available)
Gene Tree for TBPL2 (if available)

Paralogs for TBPL2 Gene

Paralogs for TBPL2 Gene

(2) SIMAP similar genes for TBPL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TBPL2: view

Variants for TBPL2 Gene

Sequence variations from dbSNP and Humsavar for TBPL2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000249958 -- 55,430,758(-) C/G intron_variant
rs1000443942 -- 55,416,865(-) G/A intron_variant
rs1000577833 -- 55,441,119(-) T/C upstream_transcript_variant
rs1000671843 -- 55,422,117(-) G/C intron_variant
rs1000862009 -- 55,428,189(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TBPL2 Gene

Variant ID Type Subtype PubMed ID
esv3892547 CNV loss 25118596
nsv564874 CNV gain 21841781
nsv983827 CNV duplication 23825009

Variation tolerance for TBPL2 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TBPL2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBPL2 Gene

Disorders for TBPL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TBPL2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 18
  • rp18
- elite association - COSMIC cancer census association via MalaCards
Search TBPL2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TBPL2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TBPL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TBPL2 Gene

Publications for TBPL2 Gene

  1. TRF3, a TATA-box-binding protein-related factor, is vertebrate-specific and widely expressed. (PMID: 14634207) Persengiev SP … Green MR (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Genomics, evolution, and expression of TBPL2, a member of the TBP family. (PMID: 17570761) Di Pietro C … Purrello M (DNA and cell biology 2007) 3 4 58
  4. TBP2 gene may not be associated with primary ovarian insufficiency. (PMID: 27642674) Wang C … Wu J (Climacteric : the journal of the International Menopause Society 2016) 3 58
  5. Characterization of the HDAC1 complex that regulates the sensitivity of cancer cells to oxidative stress. (PMID: 19351825) Kato T … Takahashi M (Cancer research 2009) 3 58

Products for TBPL2 Gene

Sources for TBPL2 Gene

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