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TBPL2 Gene

protein-coding   GIFtS: 48
GCID: GC14M055899

TATA Box Binding Protein Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TATA Box Binding Protein Like 21 2     TBP-Like Protein 22 3
TBP22 3     TBP-Related Factor 32 3
TRF32 3     TATA Box-Binding Protein-Like Protein 22
TATA Box-Binding Protein-Related Factor 32 3     

External Ids:    HGNC: 198411   Entrez Gene: 3873322   Ensembl: ENSG000001825217   OMIM: 6089645   UniProtKB: Q6SJ963   

Export aliases for TBPL2 gene to outside databases

Previous GC identifers: GC00U906280 GC14M053870 GC14M054950 GC14M055884 GC14M055887 GC14M036044 GC14M055890 GC14M055893 GC14M055896


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TBPL2 Gene:
TBPL2 (TATA box binding protein like 2) is a protein-coding gene. Diseases associated with TBPL2 include reye syndrome, and huntington's disease. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TBP.

UniProtKB/Swiss-Prot: TBPL2_HUMAN, Q6SJ96
Function: Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes.
The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TBPL2 gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBPL2 promoter sequence
   Search Chromatin IP Primers for TBPL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBPL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.3   Ensembl cytogenetic band:  14q22.3   HGNC cytogenetic band: 14q22.2

TBPL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBPL2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M055899:  view genomic region     (about GC identifiers)

Start:
55,880,259 bp from pter      End:
55,923,444 bp from pter
Size:
43,186 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TBPL2_HUMAN, Q6SJ96 (See protein sequence)
Recommended Name: TATA box-binding protein-like protein 2  
Size: 375 amino acids; 41524 Da
Subunit: Interacts with TAF3 (By similarity)
Secondary accessions: Q17RU8

Explore the universe of human proteins at neXtProt for TBPL2: NX_Q6SJ96

Explore proteomics data for TBPL2 at MOPED


See TBPL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_950248.1  
ENSEMBL proteins: 
 ENSP00000247219   ENSP00000451597  

TBPL2 Human Recombinant Protein Products:

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Cloud-Clone Corp. CLIAs for TBPL2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR000814 TBP
 IPR012295 Beta2_adaptin/TBP_C_dom

Graphical View of Domain Structure for InterPro Entry Q6SJ96

ProtoNet protein and cluster: Q6SJ96

1 Blocks protein domain: IPB000814 Transcription factor TFIID

UniProtKB/Swiss-Prot: TBPL2_HUMAN, Q6SJ96
Similarity: Belongs to the TBP family


TBPL2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TBPL2_HUMAN, Q6SJ96
Function: Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes.
The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0005515protein binding ----
     
TBPL2 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for TBPL2:
 Increased HPV18 LCR reporter a 

     3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tbpl2):
 endocrine/exocrine gland  no phenotypic analysis  reproductive system 

TBPL2 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Tbpl2tm1.1Lzt for TBPL2

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBPL2
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TBPL2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TBPL2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TBPL2

miRNA
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Predesigned siRNA for gene silencing in human, mouse, rat TBPL2

Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBPL2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TBPL2_HUMAN, Q6SJ96: Cytoplasm. Nucleus. Note=Present in the cytoplasm during cytokenesis
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA14634207
GO:0005737cytoplasm IDA14634207

TBPL2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TBPL2 About   (see all 6)  
See pathways by source

SuperPathContained pathways About
1Assembly of RNA Polymerase-II Initiation Complex
Basal transcription factors0.50
2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Huntington's disease0.45
3Influenza A
Herpes simplex infection0.33
4Viral carcinogenesis
Viral carcinogenesis
5HTLV-I infection
HTLV-I infection

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



Selected Kegg Pathways  (Kegg details for TBPL2) (see all 6):
    Basal transcription factors
Huntington's disease
HTLV-I infection
Herpes simplex infection
Epstein-Barr virus infection


TBPL2 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBPL2
Interactions:

    GeneGlobe Interaction Network for TBPL2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for TBPL2 (Q6SJ963 ENSP000002472194) via UniProtKB, MINT, STRING, and/or I2D (see all 136)
InteractantInteraction Details
GeneCardExternal ID(s)
GTF2A1P526553, ENSP000002981734I2D: score=1 STRING: ENSP00000298173
NFYCQ139523, ENSP000003966204I2D: score=1 STRING: ENSP00000396620
TBPL1P623803, ENSP000002372644I2D: score=1 STRING: ENSP00000237264
DNAJB5O759533, ENSP000004136844I2D: score=1 STRING: ENSP00000413684
TAF3Q5VWG93, ENSP000003402714I2D: score=2 STRING: ENSP00000340271
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006352DNA-templated transcription, initiation IEA--
GO:0007275multicellular organismal development IEA--
GO:0045892negative regulation of transcription, DNA-templated IEA--

TBPL2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TBPL2



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TBPL2 gene: 
NM_199047.2  

Unigene Cluster for TBPL2:

TATA box binding protein like 2
Hs.528278
Unigene Representative Sequence: AY457923
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000247219(uc001xby.3) ENST00000556755
miRNA
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Clone
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBPL2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBPL2
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for TBPL2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBPL2
  QuantiTect SYBR Green Assays in human, mouse, rat TBPL2
  QuantiFast Probe-based Assays in human, mouse, rat TBPL2

Additional mRNA sequence: 

AY457923.1 BC117159.1 BC117185.1 DQ448593.1 

1 DOTS entry:

DT.101976094 

2 AceView cDNA sequences:

NM_199047 AY457923 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TBPL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTTGGAAGCT
TBPL2 Expression
About this image

TBPL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TBPL2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.528278

UniProtKB/Swiss-Prot: TBPL2_HUMAN, Q6SJ96
Tissue specificity: Ubiquitously expressed in all tissues examined with highest levels in heart, lung, ovary,
spleen and testes

    Custom PCR Arrays for TBPL2
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBPL2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for TBPL2 gene from Selected species (see all 17)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tbpl21 , 5 TATA box binding protein like 21, 5 79.81(n)1
69.57(a)1
  2 (16.14 cM)5
2276061  NM_199059.11  NP_951014.11 
 240717215 
chicken
(Gallus gallus)
Aves TBPL21 TATA box binding protein like 2 72.36(n)
74.68(a)
  776269  NM_001098853.1  NP_001092323.1 
lizard
(Anolis carolinensis)
Reptilia TBPL26
TATA box binding protein like 2
49(a)
1 ↔ 1
GL343325.1(382438-387892)
tropical clawed frog
(Xenopus tropicalis)
Amphibia tbpl21 TATA box binding protein like 2 70.17(n)
75.8(a)
  550063  NM_001017309.2  NP_001017309.1 
zebrafish
(Danio rerio)
Actinopterygii tbpl21 TATA box binding protein like 2 66.23(n)
70.43(a)
  407713  NM_214796.1  NP_999961.1 
fruit fly
(Drosophila melanogaster)
Insecta Tbp6
TATA binding protein
52(a)
1 → many
2R(17573705-17575145)
worm
(Caenorhabditis elegans)
Secernentea tbp-16
Protein TBP-1 (tbp-1) mRNA, complete cds
49(a)
1 → many
III(7384017-7386132) WBGene00006542
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPT156
TATA-binding protein, general transcription factor...
62(a)
1 → many
V(465303-466025) YER148W
thale cress
(Arabidopsis thaliana)
eudicotyledons TBP21 TBP2 70.22(n)
81.46(a)
  841999  NM_179481.2  NP_849812.1 
rice
(Oryza sativa)
Liliopsida Os03g06570001 Os03g0657000 69.48(n)
81.46(a)
  4333619  NM_001057347.1  NP_001050812.1 


ENSEMBL Gene Tree for TBPL2 (if available)
TreeFam Gene Tree for TBPL2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TBPL2 gene
TBP2  TBPL12  
2 SIMAP similar genes for TBPL2 using alignment to 2 protein entries:     TBPL2_HUMAN (see all proteins):
TBPL1    TBP

TBPL2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TBPL2 (see all 723)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs71484811,2
C,F,A,H--36072292(+) AGAACA/G/TTAGCA 1 -- us2k114EA NS NA WA CSA 531
rs727177831,2
C,F--36072422(+) CTTACG/AATGGT 1 -- us2k11Minor allele frequency- A:0.02NA 120
rs71496221,2
C,F,A,H--36072427(+) GATGGC/TATTTA 1 -- us2k112Minor allele frequency- T:0.45NA WA CSA EA 377
rs1486873591,2
--55880588(+) GTAGAC/TTCTTC 1 -- int10--------
rs1421816161,2
--55880676(+) TTTTCA/GTAGAT 1 -- int10--------
rs9460561,2
C,F,O,A--55880730(-) TTCTCT/CAGGCC 1 -- int110Minor allele frequency- C:0.34NA WA CSA EA 374
rs1478169551,2
--55880894(+) TTTACG/TTGTTC 1 -- int10--------
rs9460551,2
C,F,A--55880918(-) TCCTTC/TTGTGT 1 -- int114Minor allele frequency- T:0.47NA WA CSA EA 516
rs1424520151,2
--55880937(+) GAATAA/CGAATT 1 -- ut310--------
rs769941241,2
C,F--55880938(+) AATAAG/TAATTT 1 -- ut311Minor allele frequency- T:0.08WA 118

HapMap Linkage Disequilibrium report for TBPL2 (55880259 - 55923444 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for TBPL2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv901959CNV Gain21882294
dgv1937n71CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing TBPL2
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608964    OMIM disorders: --

3 diseases for TBPL2:    
About MalaCards
reye syndrome    huntington's disease    herpes simplex


TBPL2 for disorders           About GeneDecksing

Genetic Association Database (GAD): TBPL2
Human Genome Epidemiology (HuGE) Navigator: TBPL2 (1 document)

Export disorders for TBPL2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TBPL2 gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with TBPL2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. TRF3, a TATA-box-binding protein-related factor, is vertebrate- specific and widely expressed. (PubMed id 14634207)1, 2, 3, 9 Persengiev S.P....Green M.R. (Proc. Natl. Acad. Sci. U.S.A. 2003)
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  3. Genomics, evolution, and expression of TBPL2, a member of the TBP family. (PubMed id 17570761)1, 2 Di Pietro C.... Purrello M. (DNA Cell Biol. 2007)
  4. Characterization of the HDAC1 complex that regulates the sensitivity of cancer cells to oxidative stress. (PubMed id 19351825)1 Kato T....Takahashi M. (Cancer Res. 2009)
  5. A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. (PubMed id 18555775)1 Ago T....Sadoshima J. (Cell 2008)
  6. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
  7. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1 Jeronimo C.... Coulombe B. (Mol. Cell 2007)
  8. Switching of the core transcription machinery during myogenesis. (PubMed id 17704303)1 Deato M.D. and Tjian R. (amp 2007)
  9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 387332 HGNC: 19841 AceView: TBPL2 Ensembl:ENSG00000182521 euGenes: HUgn387332
ECgene: TBPL2 Kegg: 387332 H-InvDB: TBPL2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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PharmGKB entry for TBPL2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TBPL2 gene:
Search GeneIP for patents involving TBPL2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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