TBPL2 Gene
protein-coding GIFtS: 48
GCID: GC14M055899
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TATA box binding protein like 2
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Aliases
for TBPL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TATA Box Binding Protein Like 21 2 | | TBP-Like Protein 22 3 | | TBP21 2 3 | | TBP-Related Factor 32 3 | | TRF31 2 3 | | TATA Box-Binding Protein-Like Protein 22 | | TATA Box-Binding Protein-Related Factor 32 3 | | |
Export aliases for TBPL2 gene to outside databasesPrevious GC identifers: GC00U906280 GC14M053870 GC14M054950 GC14M055884 GC14M055887 GC14M036044 GC14M055890 GC14M055893 GC14M055896 |
Summaries
for TBPL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TBPL2_HUMAN, Q6SJ96Function: Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. Thecomplex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity)
|
Genomic Views
for TBPL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TBPL2 gene promoter:
c-Fos AP-1 ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for TBPL2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBPL2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q22.3 Ensembl cytogenetic band: 14q22.3 HGNC cytogenetic band: 14q22.2TBPL2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M055899: view genomic region
(about GC identifiers)
Start:
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55,880,259 bp from pter |
End:
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55,923,444 bp from pter |
Size:
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43,186 bases |
Orientation:
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minus strand |
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Proteins
for TBPL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TBPL2_HUMAN, Q6SJ96 (See
protein sequence)Recommended Name: TATA box-binding protein-like protein 2 Size: 375 amino acids; 41524 Da
Subunit: Interacts with TAF3 (By similarity)
Subcellular location: Cytoplasm. Nucleus. Note=Present in the cytoplasm during cytokenesis
Secondary accessions: Q17RU8Explore the universe of human proteins at neXtProt for TBPL2: NX_Q6SJ96
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6SJ96
TBPL2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_950248.1
ENSEMBL proteins: ENSP00000247219 ENSP00000451597
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TBPL2 for ontologies About GeneDecksing
TBPL2 Antibody Products:
Assay Products for TBPL2: |
Protein
Domains /
Families
for TBPL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TBPL2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6SJ96ProtoNet protein and cluster: Q6SJ96 1 Blocks protein family: IPB000814 Transcription factor TFIID
UniProtKB/Swiss-Prot: TBPL2_HUMAN, Q6SJ96Similarity: Belongs to the TBP family |
Function
for TBPL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TBPL2_HUMAN, Q6SJ96Function: Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. Thecomplex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBPL2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBPL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TBPL2 (NM_199047) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBPL2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBPL2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBPL2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0005515 | protein binding |
-- | -- |
TBPL2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TBPL2:
Animal Models:
Mouse knock-out Tbpl2tm1.1Lzt for TBPL2
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Tbpl2):
TBPL2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TBPL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Assembly of RNA Polymerase-II Initiation Complex | | | 2 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for TBPL2):
TBPL2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TBPL2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/55 Interacting proteins for TBPL2 (Q6SJ963 ENSP000002472194) via UniProtKB, MINT, STRING, and/or I2D (see all 55)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006352 | DNA-dependent transcription, initiation |
IEA | -- | | GO:0006367 | transcription initiation from RNA polymerase II promoter |
-- | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0045892 | negative regulation of transcription, DNA-dependent |
IEA | -- |
TBPL2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TBPL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TBPL2
Search CenterWatch for drugs/clinical trials and news about TBPL2
|
Transcripts
for TBPL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TBPL2 gene: NM_199047.2 Unigene Cluster for TBPL2: TATA box binding protein like 2 Hs.528278 Unigene Representative Sequence: AY4579232 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000247219(uc001xby.3) ENST00000556755
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBPL2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBPL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TBPL2 (NM_199047) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBPL2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBPL2 |
Additional cDNA sequence: AY457923.1 BC117159.1 BC117185.1 DQ448593.1 1 DOTS entry: DT.101976094 2 AceView cDNA sequences: AY457923 NM_199047
GeneLoc Exon Structure
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Expression
for TBPL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TBPL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTGGAAGCT
About this image
See TBPL2 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.528278
UniProtKB/Swiss-Prot: TBPL2_HUMAN, Q6SJ96Tissue specificity: Ubiquitously expressed in all tissues examined with highest levels in heart, lung, ovary, spleenand testes
SABiosciences Custom PCR Arrays for TBPL2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBPL2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TBPL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBPL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBPL2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBPL2 |
Orthologs
for TBPL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TBPL2 gene from 7/24 species (see all 24) About this table
ENSEMBL Gene Tree for TBPL2 (if available)
TreeFam Gene Tree for TBPL2 (if available) |
Paralogs
for TBPL2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TBPL2 gene
- TBP2 TBPL12
2 SIMAP similar genes for TBPL2 using alignment to 2 protein entries: TBPL2_HUMAN (see all proteins):TBPL1 TBP
TBPL2 for paralogs About GeneDecksing
|
Genomic Variants
for TBPL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TBPL2 (55880259 - 55923444 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TBPL2: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TBPL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TBPL2 for disorders About GeneDecksing
OMIM gene information: 608964
OMIM disorders: --
5  diseases for TBPL2: About MalaCardsreye syndrome spinocerebellar ataxia huntington's disease ataxia
malaria
Human Genome Epidemiology (HuGE) Navigator: TBPL2 (1 document)
Export disorders for TBPL2 gene to outside databases
|
Publications
for TBPL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TBPL2 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TBPL2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TRF3, a TATA-box-binding protein-related factor, is vertebrate- specific and widely expressed. (PubMed id 14634207)1, 2, 3, 9 Persengiev S.P....Green M.R. (2003)
- Genomics, evolution, and expression of TBPL2, a member of the TBP family. (PubMed id 17570761)1, 2 Di Pietro C.... Purrello M. (2007)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Characterization of the HDAC1 complex that regulates the sensitivity of cancer cells to oxidative stress. (PubMed id 19351825)1 Kato T....Takahashi M. (2009)
- A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. (PubMed id 18555775)1 Ago T....Sadoshima J. (2008)
- Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1 Jeronimo C.... Coulombe B. (2007)
- Switching of the core transcription machinery during myogenesis. (PubMed id 17704303)1 Deato M.D. and Tjian R. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- TBP2 is a substitute for TBP in Xenopus oocyte transc ription. (PubMed id 19650908)9 Akhtar W. and Veenstra G.J. (2009)
|
External Searches for TBPL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TBPL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBPL2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TBPL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TBPL2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TBPL2 gene:
Search GeneIP for patents involving TBPL2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TBPL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TBPL2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TBPL2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBPL2 | | | OriGene Protein Over-expression Lysate for TBPL2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TBPL2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBPL2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBPL2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TBPL2 | | OriGene Custom Protein Services for TBPL2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TBPL2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBPL2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBPL2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBPL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBPL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBPL2 |
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 |  |  |  | |
| | | | Search Tocris compounds for TBPL2 |
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 | | | TBPL2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBPL2 |
|  |  |  | | | | Search ThermoFisher Antibodies for TBPL2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBPL2 |
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