Aliases for TBPL1 Gene
External Ids for TBPL1 Gene
Previous GeneCards Identifiers for TBPL1 Gene
This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011]
GeneCards Summary for TBPL1 Gene
TBPL1 (TATA-Box Binding Protein Like 1) is a Protein Coding gene. Diseases associated with TBPL1 include Male Infertility. Among its related pathways are PI3K-Akt signaling pathway and Influenza A. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is TBP.
UniProtKB/Swiss-Prot for TBPL1 Gene
Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5-TCT-3 motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.