Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TBPL1 Gene

protein-coding   GIFtS: 60
GCID: GC06P134273

TBP-Like 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
TBP-Like 11 2     21-KDA TBP-Like Protein2
Second TBP Of Unique DNA Protein2 3     MGC:83892
STUD2 3     MGC:96202
TLF2 3     TATA Box-Binding Protein-Like Protein 12
TLP2 3     21 KDa TBP-Like Protein3
TRF22 3     TLP213
TATA Box-Binding Protein-Related Factor 22 3     TRP3
TBP-Related Factor 22 3     TBP-Like Factor3
TBP-Related Protein2 3     TBP-Like Protein 13

External Ids:    HGNC: 115891   Entrez Gene: 95192   Ensembl: ENSG000000288397   OMIM: 6055215   UniProtKB: P623803   

Export aliases for TBPL1 gene to outside databases

Previous GC identifers: GC06P133897 GC06P134121 GC06P134208 GC06P134254 GC06P134315 GC06P131842


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TBPL1 Gene:
This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role
in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded
protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a
critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male
infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this
gene is located on the long arm of chromosome 3. (provided by RefSeq, Nov 2011)

GeneCards Summary for TBPL1 Gene:
TBPL1 (TBP-like 1) is a protein-coding gene. Diseases associated with TBPL1 include urethral calculus, and gingival recession. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is TBP.

UniProtKB/Swiss-Prot: TBPL1_HUMAN, P62380
Function: Does not bind the TATA box. Has DNA-binding ability

Gene Wiki entry for TBPL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TBPL1 gene promoter:
         AhR   AML1a   E4BP4   E47   GATA-1   c-Rel   E2F-1   E2F   Hand1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBPL1 promoter sequence
   Search Chromatin IP Primers for TBPL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBPL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.1-q22.3   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q22.1-q22.3

TBPL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBPL1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P134273:  view genomic region     (about GC identifiers)

Start:
134,273,308 bp from pter      End:
134,311,570 bp from pter
Size:
38,263 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TBPL1_HUMAN, P62380 (See protein sequence)
Recommended Name: TATA box-binding protein-like protein 1  
Size: 186 amino acids; 20887 Da
Subunit: Binds TFIIA and TFIIB
Secondary accessions: A8K8F5 O95753 Q9BWD5 Q9Z2Z0

Explore the universe of human proteins at neXtProt for TBPL1: NX_P62380

Explore proteomics data for TBPL1 at MOPED


See TBPL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001240605.1  NP_004856.1  

ENSEMBL proteins: 
 ENSP00000402864   ENSP00000398186   ENSP00000356845   ENSP00000237264   ENSP00000356843  

TBPL1 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for TBPL1
OriGene Custom MassSpec
OriGene Custom Protein Services for TBPL1
GenScript Custom Purified and Recombinant Proteins Services for TBPL1
Novus Biologicals TBPL1 Proteins
Novus Biologicals TBPL1 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for TBPL1
Cloud-Clone Corp. Proteins for TBPL1

TBPL1 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for TBPL1
OriGene Custom Antibody Services for TBPL1
Novus Biologicals TBPL1 Antibodies
Abcam antibodies for TBPL1
Cloud-Clone Corp. Antibodies for TBPL1
ThermoFisher Antibody for TBPL1
LSBio Antibodies in human, mouse, rat for TBPL1

TBPL1 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for TBPL1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for TBPL1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for TBPL1
Cloud-Clone Corp. CLIAs for TBPL1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
2 InterPro protein domains:
 IPR000814 TBP
 IPR012295 Beta2_adaptin/TBP_C_dom

Graphical View of Domain Structure for InterPro Entry P62380

ProtoNet protein and cluster: P62380

1 Blocks protein domain: IPB000814 Transcription factor TFIID

UniProtKB/Swiss-Prot: TBPL1_HUMAN, P62380
Similarity: Belongs to the TBP family


TBPL1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TBPL1_HUMAN, P62380
Function: Does not bind the TATA box. Has DNA-binding ability

     Genatlas biochemistry entry for TBPL1:
TATA box protein (TBP)-like 1,component of the RNA polymerase II (POLR*),transcription apparatus,binding
GTF2A,GTF2B,not binding directly canonical TATA boxes

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0003713transcription coactivator activity TAS10220372
GO:0005515protein binding ----
     
TBPL1 for ontologies           About GeneDecksing


Phenotypes:
     3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tbpl1):
 cellular  endocrine/exocrine gland  reproductive system 

TBPL1 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for TBPL1: Tbpl1tm1Saco Tbpl1tm1Rgr

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBPL1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TBPL1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TBPL1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TBPL1

miRNA
Products:
    
miRTarBase miRNAs that target TBPL1:
hsa-mir-24-3p (MIRT030363), hsa-mir-9-5p (MIRT021391), hsa-mir-424-5p (MIRT042456)

Block miRNA regulation of human, mouse, rat TBPL1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate TBPL1 (see all 33):
hsa-miR-15a hsa-miR-301a hsa-miR-30d hsa-miR-9 hsa-miR-424 hsa-miR-30a hsa-miR-133a hsa-miR-2113
SwitchGear 3'UTR luciferase reporter plasmidTBPL1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for TBPL1
Predesigned siRNA for gene silencing in human, mouse, rat TBPL1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for TBPL1

Clone
Products:
     
OriGene clones in human, mouse for TBPL1 (see all 8)
OriGene ORF clones in mouse, rat for TBPL1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TBPL1 (NM_004865)
Sino Biological Human cDNA Clone for TBPL1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBPL1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBPL1

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for TBPL1
Browse ESI BIO Cell Lines and PureStem Progenitors for TBPL1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBPL1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
TBPL1_HUMAN, P62380: Cytoplasm (By similarity). Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol2
lysosome2
extracellular1
peroxisome1
vacuole1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus ----
GO:0005672transcription factor TFIIA complex IEA--
GO:0005737cytoplasm IEA--

TBPL1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for TBPL1 About   (see all 6)                                                                                              See pathways by source

SuperPathContained pathways About
1Assembly of RNA Polymerase-II Initiation Complex
Basal transcription factors0.50
2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Huntington's disease0.45
3Influenza A
Herpes simplex infection0.33
4Viral carcinogenesis
Viral carcinogenesis
5HTLV-I infection
HTLV-I infection

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways




Selected Kegg Pathways  (Kegg details for TBPL1) (see all 6):
    Basal transcription factors
Huntington's disease
HTLV-I infection
Herpes simplex infection
Epstein-Barr virus infection


TBPL1 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBPL1
Interactions:

    GeneGlobe Interaction Network for TBPL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for TBPL1 (P623803 ENSP000002372644) via UniProtKB, MINT, STRING, and/or I2D (see all 150)
InteractantInteraction Details
GeneCardExternal ID(s)
GTF2A1P526553, ENSP000002981734I2D: score=4 STRING: ENSP00000298173
ABCF3Q9NUQ83, ENSP000004114714I2D: score=3 STRING: ENSP00000411471
GTF2A1LQ9UNN43, ENSP000003845974I2D: score=1 STRING: ENSP00000384597
HSPA9P386463, ENSP000002971854I2D: score=1 STRING: ENSP00000297185
SPATA24Q86W543, ENSP000004149204I2D: score=1 STRING: ENSP00000414920
About this table

Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001675acrosome assembly IEA--
GO:0006235dTTP biosynthetic process IEA--
GO:0006352DNA-templated transcription, initiation IEA--
GO:0006366transcription from RNA polymerase II promoter TAS10220372
GO:0007283spermatogenesis ----

TBPL1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TBPL1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for TBPL1 gene (2 alternative transcripts): 
NM_001253676.1  NM_004865.3  

Unigene Cluster for TBPL1:

TBP-like 1
Hs.486507  [show with all ESTs]
Unigene Representative Sequence: NM_001253676
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000416965 ENST00000457715 ENST00000367871 ENST00000237264(uc010kgg.3 uc003qel.3)
ENST00000367869 ENST00000477527 ENST00000481694
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat TBPL1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate TBPL1 (see all 33):
hsa-miR-15a hsa-miR-301a hsa-miR-30d hsa-miR-9 hsa-miR-424 hsa-miR-30a hsa-miR-133a hsa-miR-2113
SwitchGear 3'UTR luciferase reporter plasmidTBPL1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for TBPL1
Predesigned siRNA for gene silencing in human, mouse, rat TBPL1
Clone
Products:
     
OriGene clones in human, mouse for TBPL1 (see all 8)
OriGene ORF clones in mouse, rat for TBPL1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TBPL1 (NM_004865)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBPL1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBPL1
Primer
Products:
    
OriGene qPCR primer pairs and template standards for TBPL1
OriGene qSTAR qPCR primer pairs in human, mouse for TBPL1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBPL1
  QuantiTect SYBR Green Assays in human, mouse, rat TBPL1
  QuantiFast Probe-based Assays in human, mouse, rat TBPL1

Additional mRNA sequence: 

AB020881.1 AF136570.1 AK292320.1 AK313645.1 BC000381.2 BC017559.2 

10 DOTS entries:

DT.100641620  DT.448696  DT.121391888  DT.448697  DT.100815881  DT.100815890  DT.121391986  DT.91758594 
DT.91758600  DT.121391950 

Selected AceView cDNA sequences (see all 185):

BC017559 BC000381 AA812718 NM_004865 BF447320 BG283961 AF136570 CR593032 
CB119687 BQ421860 AA864365 CA488221 BE049600 T75495 AW513824 BM769513 
AW613325 BQ436348 BM712233 BI829246 BM974794 AL157632 BU737703 AA782937 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TBPL1    About this scheme

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP1:                          -           -                                   -         
SP2:                          -           -                                             
SP3:        -     -     -     -           -                                             
SP4:                                      -                                             
SP5:                          -                                                         


ECgene alternative splicing isoforms for TBPL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

TBPL1 expression in normal human tissues (normalized intensities)      TBPL1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TCCCCATAAG
TBPL1 Expression
About this image


TBPL1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Testis (Reproductive System)    fully expand to see all 4 entries
         XY Germ Cells Testis Cord
         Testis Interstitium
 
 Gonad
         XY Germ Cells Testis Cord
TBPL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TBPL1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.486507

UniProtKB/Swiss-Prot: TBPL1_HUMAN, P62380
Tissue specificity: Ubiquitously expressed, with highest levels in the testis and ovary

    Custom PCR Arrays for TBPL1
Primer
Products:
OriGene qPCR primer pairs and template standards for TBPL1
OriGene qSTAR qPCR primer pairs in human, mouse for TBPL1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBPL1
QuantiTect SYBR Green Assays in human, mouse, rat TBPL1
QuantiFast Probe-based Assays in human, mouse, rat TBPL1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBPL1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals and fungi.

Orthologs for TBPL1 gene from Selected species (see all 18)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tbpl11 , 5 TATA box binding protein-like 11, 5 94.27(n)1
100(a)1
  10 (10.25 cM)5
2373361  NM_011603.51  NP_035733.11 
 227038795 
chicken
(Gallus gallus)
Aves TBPL11 TBP-like 1 88.89(n)
97.81(a)
  395517  NM_204755.1  NP_990086.1 
lizard
(Anolis carolinensis)
Reptilia TBPL16
TBP-like 1
97(a)
1 ↔ 1
GL344245.1(34248-49637)
African clawed frog
(Xenopus laevis)
Amphibia TLF2 TBP-like factor 78.49(n)    AJ238441.1 
zebrafish
(Danio rerio)
Actinopterygii rps92 ribosomal protein S9 75.79(n)    AF503448.1 
fruit fly
(Drosophila melanogaster)
Insecta Trf23 transcription initiation from Pol II
promoter more
55(a)     --
worm
(Caenorhabditis elegans)
Secernentea tlf-11 tlf-1 49.26(n)
40.56(a)
  172676  NM_059955.4  NP_492356.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPT156
TATA-binding protein, general transcription factor...
28(a)
1 → many
V(465303-466025) YER148W


ENSEMBL Gene Tree for TBPL1 (if available)
TreeFam Gene Tree for TBPL1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for TBPL1 gene
TBP2  TBPL22  
2 SIMAP similar genes for TBPL1 using alignment to 5 protein entries:     TBPL1_HUMAN (see all proteins):
TBPL2    TBP

TBPL1 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for TBPL1
PGOHUM00000238270


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for TBPL1 (see all 707)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs767331911,2
C--134271351(+) GCCAGC/TTCTAC 1 -- us2k10--------
rs1388093671,2
--134271394(+) CAACTG/TGATTG 1 -- us2k10--------
rs1906527711,2
--134271471(+) TTGAAC/TCAGTG 1 -- us2k10--------
rs94937661,2
C,F--134271488(+) GAAAGG/TTAGAC 1 -- us2k12Minor allele frequency- T:0.24WA 120
rs1928239321,2
--134271644(+) TGAACA/GTCGAA 1 -- us2k10--------
rs1843923771,2
--134271658(+) CAAGTG/TCTTCA 1 -- us2k10--------
rs772058741,2
C,F--134271787(+) TAGTAG/ATTATA 1 -- us2k11Minor allele frequency- A:0.04NA 120
rs94937671,2
C,F--134271827(+) CCTAAT/CAGGat 1 -- us2k12Minor allele frequency- C:0.22WA 120
rs1884480141,2
--134271847(+) TATCCC/TATTAG 1 -- us2k10--------
rs37568761,2
C--134271960(+) TACTGC/GATATT 1 -- us2k1 tfbs30--------

HapMap Linkage Disequilibrium report for TBPL1 (134273308 - 134311570 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for TBPL1:    About this table    
Variant IDTypeSubtypePubMed ID
esv2441837CNV Deletion19546169
nsv507364CNV Insertion20534489
esv34122CNV Loss18971310

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TBPL1
DNA2.0 Custom Variant and Variant Library Synthesis for TBPL1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 605521    OMIM disorders: --

15 diseases for TBPL1:    About MalaCards
urethral calculus    gingival recession    babesiosis    sleeping sickness
endometritis    male infertility    vulvovaginitis    urethritis
infertility    gingivitis    azoospermia    neurofibromatosis
huntington's disease    herpes simplex    malaria

2 diseases from the University of Copenhagen DISEASES database for TBPL1:
Sleeping sickness     Degenerative disc disease

TBPL1 for disorders           About GeneDecksing

Genetic Association Database (GAD): TBPL1
Human Genome Epidemiology (HuGE) Navigator: TBPL1 (2 documents)

Export disorders for TBPL1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for TBPL1 gene, integrated from 10 sources (see all 44):
(articles sorted by number of sources associating them with TBPL1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Isolation of cDNA, chromosome mapping, and expression of the human TBP-like protein. (PubMed id 10082669)1, 2, 3, 9 Ohbayashi T.... Tamura T.-A. (Biochem. Biophys. Res. Commun. 1999)
  2. TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family. (PubMed id 10220372)1, 2, 3 Rabenstein M.D.... Tjian R. (Proc. Natl. Acad. Sci. U.S.A. 1999)
  3. TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. (PubMed id 15767669)1, 3, 9 Chong J.A....Clapham D.E. (Mol. Cell. Biol. 2005)
  4. Identification of potentially damaging amino acid substitutions leading to human male infertility. (PubMed id 19369647)1, 4 Kuzmin A....Varmuza S. (Biol. Reprod. 2009)
  5. Iron overload in kidney transplants: prospective analysis of biochemical and genetic markers. (PubMed id 15673318)1, 4 Lorenz M....FAPdinger M. (Kidney Int. 2005)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
  8. Cell-specific nucleolar localization of TBP-related factor 2. (PubMed id 15269281)1, 9 Kieffer-Kwon P....Davidson I. (Mol. Biol. Cell 2004)
  9. Identification of a mouse TBP-like protein (TLP) distantly related to the drosophila TBP-related factor. (PubMed id 9889269)1, 9 Ohbayashi T....Tamura T.A. (Nucleic Acids Res. 1999)
  10. TATA-binding Protein (TBP)-like Protein Is Engaged in Etoposide-induced Apoptosis through Transcriptional Activation of Human TAp63 Gene. (PubMed id 19858204)1, 9 Suenaga Y....Tamura T.A. (J. Biol. Chem. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 9519 HGNC: 11589 AceView: TBPL1 Ensembl:ENSG00000028839 euGenes: HUgn9519
ECgene: TBPL1 Kegg: 9519 H-InvDB: TBPL1

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for TBPL1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for TBPL1 gene:
Search GeneIP for patents involving TBPL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for TBPL1   OriGene RNAi products in human, mouse, rat for TBPL1  
 OriGene qPCR primer pairs and template standards for TBPL1   OriGene Protein Over-expression Lysate for TBPL1  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for TBPL1  
 OriGene qSTAR qPCR primer pairs in human, mouse for TBPL1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for TBPL1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for TBPL1   OriGene Custom Protein Services for TBPL1  

 
 
 Block miRNA regulation of human, mouse, rat TBPL1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TBPL1
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBPL1 Predesigned siRNA for gene silencing in human, mouse, rat TBPL1
 QuantiFast Probe-based Assays in human, mouse, rat TBPL1 QuantiTect SYBR Green Assays in human, mouse, rat TBPL1
 Custom PCR Arrays for TBPL1 Search Chromatin IP Primers for TBPL1
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBPL1  GeneGlobe Interaction Network for TBPL1
 Regulatory tfbs in TBPL1 promoter
 GenScript Custom Purified and Recombinant Proteins Services for TBPL1 GenScript cDNA clones with any tag delivered in your preferred vector for TBPL1
 GenScript Custom Assay Services for TBPL1 GenScript Custom overexpressing Cell Line Services for TBPL1
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for TBPL1
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 cDNA Clones for TBPL1
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 TBPL1 antibodies
 TBPL1 proteins
 TBPL1 lysates
 Antibodies for TBPL1
 See all of Abcam's Antibodies, Kits and Proteins for TBPL1
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for TBPL1
 Proteins for TBPL1
 Antibodies for TBPL1
 ELISAs for TBPL1
 CLIAs for TBPL1



 Browse ESI BIO Cell Lines and PureStem Progenitors for TBPL1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBPL1
 SwitchGear 3'UTR luciferase reporter plasmids for TBPL1
 SwitchGear Promoter luciferase reporter plasmids for TBPL1
 ThermoFisher Antibody for TBPL1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBPL1
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBPL1
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TBPL1
 LSBio Antibodies in human, mouse, rat for TBPL1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      TBPL1 gene at Home site.
Version: 3.12.136 22 July 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4