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Aliases for TBL3 Gene

Aliases for TBL3 Gene

  • Transducin Beta Like 3 2 3 5
  • WD Repeat-Containing Protein SAZD 3 4
  • SAZD 3 4
  • Transducin Beta-Like Protein 3 3
  • Transducin (Beta)-Like 3 2
  • WD-Repeat Protein SAZD 3
  • UTP13 3

External Ids for TBL3 Gene

Previous GeneCards Identifiers for TBL3 Gene

  • GC16P002039
  • GC16P001962
  • GC16P002022
  • GC16P001946
  • GC16P001973
  • GC16P001980
  • GC16P001987
  • GC16P001994

Summaries for TBL3 Gene

Entrez Gene Summary for TBL3 Gene

  • The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene has multiple polyadenylation sites. It might have multiple alternatively spliced transcript variants but the variants have not been fully described yet. [provided by RefSeq, Jul 2008]

GeneCards Summary for TBL3 Gene

TBL3 (Transducin Beta Like 3) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include poly(A) RNA binding and snoRNA binding. An important paralog of this gene is ATG16L1.

Gene Wiki entry for TBL3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBL3 Gene

Genomics for TBL3 Gene

Regulatory Elements for TBL3 Gene

Enhancers for TBL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F001928 1.6 FANTOM5 Ensembl ENCODE 1.5 -42.3 -42314 1.8 ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ZNF207 ZNF143 KLF13 IFT140 CCDC154 ERVK13-1 FAHD1 EME2 NME3 HN1L ENSG00000260447 SNHG19 HAGH
GH16F002121 1.6 FANTOM5 Ensembl ENCODE 1.2 +154.1 154115 9.7 HDGF ATF1 PKNOX1 SIN3A FEZF1 ZNF2 ZNF121 GLIS2 KLF7 ZNF263 ENSG00000261123 MLST8 ENSG00000261240 TSC2 NME3 DNASE1L2 NUBP2 NTHL1 SLC9A3R2 TBL3
GH16F001530 1.4 FANTOM5 Ensembl ENCODE 1.2 -436.8 -436814 10.0 CTCF LEF1 MAX ZIC2 ZNF2 RAD21 GATA3 ZFHX2 POLR2A TCF7L2 TMEM204 TELO2 FAHD1 PTX4 IFT140 CCDC154 NME3 TSR3 FBXL16 CLCN7
GH16F001970 1.2 ENCODE 0.8 +0.0 12 2.3 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000255513 ENSG00000226890 ENSG00000200059 ENSG00000261240 PRSS29P TMEM204 IFT140 TPSG1 ENSG00000260954 PRSS30P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TBL3 on UCSC Golden Path with GeneCards custom track

Promoters for TBL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000502381 -137 1801 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for TBL3 Gene

1,972,037 bp from pter
1,982,933 bp from pter
10,897 bases
Plus strand

Genomic View for TBL3 Gene

Genes around TBL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBL3 Gene

Proteins for TBL3 Gene

  • Protein details for TBL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transducin beta-like protein 3
    Protein Accession:
    Secondary Accessions:
    • Q59GD6
    • Q8IVB7
    • Q96A78

    Protein attributes for TBL3 Gene

    808 amino acids
    Molecular mass:
    89035 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA18945.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BAD92410.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TBL3 Gene

Post-translational modifications for TBL3 Gene

  • Ubiquitination at Lys 328, Lys 453, Lys 458, Lys 593, Lys 633, and Lys 664
  • Modification sites at PhosphoSitePlus

Other Protein References for TBL3 Gene

No data available for DME Specific Peptides for TBL3 Gene

Domains & Families for TBL3 Gene

Gene Families for TBL3 Gene

Suggested Antigen Peptide Sequences for TBL3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 13 WD repeats.
  • Contains 13 WD repeats.
genes like me logo Genes that share domains with TBL3: view

Function for TBL3 Gene

Molecular function for TBL3 Gene

GENATLAS Biochemistry:
transducin (beta)-like 3,located in the region of but not mutated in PKD1

Gene Ontology (GO) - Molecular Function for TBL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0030515 snoRNA binding IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TBL3: view
genes like me logo Genes that share phenotypes with TBL3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBL3 Gene

Localization for TBL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBL3 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBL3 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TBL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0032040 small-subunit processome IEA,IBA --
GO:0034388 Pwp2p-containing subcomplex of 90S preribosome IBA --
genes like me logo Genes that share ontologies with TBL3: view

Pathways & Interactions for TBL3 Gene

genes like me logo Genes that share pathways with TBL3: view

Gene Ontology (GO) - Biological Process for TBL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing IEA,TAS --
genes like me logo Genes that share ontologies with TBL3: view

No data available for SIGNOR curated interactions for TBL3 Gene

Transcripts for TBL3 Gene

Unigene Clusters for TBL3 Gene

Transducin (beta)-like 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBL3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP3: - - -

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b

Relevant External Links for TBL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TBL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TBL3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.4) and CD8 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TBL3 Gene

Protein tissue co-expression partners for TBL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TBL3 Gene:


SOURCE GeneReport for Unigene cluster for TBL3 Gene:

genes like me logo Genes that share expression patterns with TBL3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TBL3 Gene

Orthologs for TBL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TBL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TBL3 34 35
  • 98.31 (n)
(Bos Taurus)
Mammalia TBL3 34 35
  • 88.5 (n)
(Canis familiaris)
Mammalia TBL3 34 35
  • 86.44 (n)
(Mus musculus)
Mammalia Tbl3 34 16 35
  • 83.61 (n)
(Rattus norvegicus)
Mammalia Tbl3 34
  • 82.98 (n)
(Monodelphis domestica)
Mammalia TBL3 35
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia TBL3 35
  • 65 (a)
(Gallus gallus)
Aves TBL3 34 35
  • 67.22 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 59 (a)
-- 35
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tbl3 34
  • 65.07 (n)
Str.9646 34
African clawed frog
(Xenopus laevis)
Amphibia MGC69179 34
(Danio rerio)
Actinopterygii tbl3 34 35
  • 66.06 (n)
wufc08g06 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009615 34
  • 51.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1671 36 34 35
  • 49.29 (n)
(Caenorhabditis elegans)
Secernentea Y53C12B.1 36 34 35
  • 41.56 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR180W 34
  • 42.76 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F13244g 34
  • 42.25 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP13 34 35 37
  • 41.11 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons TOZ 34
  • 45.6 (n)
(Oryza sativa)
Liliopsida Os04g0592700 34
  • 48.16 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03628 34
  • 46.92 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes utp13 34
  • 42.26 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4453 34
Species where no ortholog for TBL3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TBL3 Gene

Gene Tree for TBL3 (if available)
Gene Tree for TBL3 (if available)

Paralogs for TBL3 Gene

Paralogs for TBL3 Gene

(5) SIMAP similar genes for TBL3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TBL3: view

Variants for TBL3 Gene

Sequence variations from dbSNP and Humsavar for TBL3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111267541 -- 1,974,321(+) GGGGC(A/G)AGTGG intron-variant
rs111440237 -- 1,973,748(+) AAGGA(-/G)CCCCC intron-variant
rs111549353 -- 1,973,734(+) GCAGG(C/G)GTGTT intron-variant
rs111968775 -- 1,977,234(+) CCTCA(A/G)CTGAT reference, missense
rs111994180 -- 1,977,515(+) CCAGC(A/G)GTTCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TBL3 Gene

Variant ID Type Subtype PubMed ID
nsv952901 CNV deletion 24416366
nsv833120 CNV loss 17160897
nsv571179 CNV loss 21841781
nsv523037 CNV loss 19592680
nsv521569 CNV loss 19592680
nsv471072 CNV loss 18288195
nsv471070 CNV gain 18288195
nsv1160329 CNV deletion 26073780
esv2422427 CNV duplication 17116639
dgv4860n54 CNV loss 21841781
dgv4859n54 CNV loss 21841781
dgv4858n54 CNV loss 21841781
dgv336n27 CNV loss 19166990

Variation tolerance for TBL3 Gene

Residual Variation Intolerance Score: 88.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.65; 78.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBL3 Gene

Disorders for TBL3 Gene

Relevant External Links for TBL3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TBL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBL3 Gene

Publications for TBL3 Gene

  1. A transducin-like gene maps to the autosomal dominant polycystic kidney disease gene region. (PMID: 8307582) Weinstat-Saslow D.L. … Reeders S.T. (Genomics 1993) 2 3 4 22 64
  2. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 64
  3. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PMID: 19724895) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2009) 3 46 64
  4. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4 64
  5. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3 64

Products for TBL3 Gene

Sources for TBL3 Gene

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