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Aliases for TBL3 Gene

Aliases for TBL3 Gene

  • Transducin (Beta)-Like 3 2 3
  • WD Repeat-Containing Protein SAZD 3 4
  • SAZD 3 4
  • Transducin Beta-Like Protein 3 3
  • WD-Repeat Protein SAZD 3
  • UTP13 3

External Ids for TBL3 Gene

Previous GeneCards Identifiers for TBL3 Gene

  • GC16P002039
  • GC16P001962
  • GC16P002022
  • GC16P001946

Summaries for TBL3 Gene

Entrez Gene Summary for TBL3 Gene

  • The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene has multiple polyadenylation sites. It might have multiple alternatively spliced transcript variants but the variants have not been fully described yet. [provided by RefSeq, Jul 2008]

GeneCards Summary for TBL3 Gene

TBL3 (Transducin (Beta)-Like 3) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include receptor signaling protein activity. An important paralog of this gene is TEP1.

Gene Wiki entry for TBL3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBL3 Gene

Genomics for TBL3 Gene

Regulatory Elements for TBL3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TBL3 Gene

1,972,037 bp from pter
1,982,933 bp from pter
10,897 bases
Plus strand

Genomic View for TBL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBL3 Gene

Proteins for TBL3 Gene

  • Protein details for TBL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transducin beta-like protein 3
    Protein Accession:
    Secondary Accessions:
    • Q59GD6
    • Q8IVB7
    • Q96A78

    Protein attributes for TBL3 Gene

    808 amino acids
    Molecular mass:
    89035 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA18945.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BAD92410.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TBL3 Gene

Proteomics data for TBL3 Gene at MOPED

Post-translational modifications for TBL3 Gene

  • Ubiquitination at Lys328, Lys453, Lys458, Lys593, Lys633, and Lys664
  • Modification sites at PhosphoSitePlus

Other Protein References for TBL3 Gene

Antibody Products

No data available for DME Specific Peptides for TBL3 Gene

Domains for TBL3 Gene

Gene Families for TBL3 Gene

Suggested Antigen Peptide Sequences for TBL3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 13 WD repeats.
  • Contains 13 WD repeats.
genes like me logo Genes that share domains with TBL3: view

Function for TBL3 Gene

Molecular function for TBL3 Gene

GENATLAS Biochemistry:
transducin (beta)-like 3,located in the region of but not mutated in PKD1

Gene Ontology (GO) - Molecular Function for TBL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity TAS 8307582
GO:0005515 protein binding IPI 16189514
GO:0030515 snoRNA binding IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TBL3: view
genes like me logo Genes that share phenotypes with TBL3: view

Animal Model Products

miRNA for TBL3 Gene

miRTarBase miRNAs that target TBL3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBL3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TBL3 Gene

Localization for TBL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBL3 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for TBL3 Gene COMPARTMENTS Subcellular localization image for TBL3 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TBL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0032040 small-subunit processome IBA --
GO:0034388 Pwp2p-containing subcomplex of 90S preribosome IBA --
genes like me logo Genes that share ontologies with TBL3: view

Pathways for TBL3 Gene

genes like me logo Genes that share pathways with TBL3: view

Pathways by source for TBL3 Gene

1 KEGG pathway for TBL3 Gene

Gene Ontology (GO) - Biological Process for TBL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing --
GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger TAS 8307582
GO:0035556 intracellular signal transduction TAS 8307582
genes like me logo Genes that share ontologies with TBL3: view

Transcripts for TBL3 Gene

Unigene Clusters for TBL3 Gene

Transducin (beta)-like 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBL3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBL3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP3: - - -

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b

Relevant External Links for TBL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBL3 Gene

mRNA expression in normal human tissues for TBL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TBL3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.4) and CD8 Tcells (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TBL3 Gene

SOURCE GeneReport for Unigene cluster for TBL3 Gene Hs.513267

genes like me logo Genes that share expressions with TBL3: view

Expression partners for TBL3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TBL3 Gene

Orthologs for TBL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TBL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TBL3 35
  • 88.5 (n)
  • 89.71 (a)
TBL3 36
  • 89 (a)
(Canis familiaris)
Mammalia TBL3 35
  • 86.44 (n)
  • 89.17 (a)
TBL3 36
  • 88 (a)
(Mus musculus)
Mammalia Tbl3 35
  • 83.61 (n)
  • 89.71 (a)
Tbl3 16
Tbl3 36
  • 89 (a)
(Pan troglodytes)
Mammalia TBL3 35
  • 98.31 (n)
  • 98.51 (a)
TBL3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tbl3 35
  • 82.98 (n)
  • 89.46 (a)
(Monodelphis domestica)
Mammalia TBL3 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia TBL3 36
  • 65 (a)
(Gallus gallus)
Aves TBL3 35
  • 67.22 (n)
  • 66.08 (a)
TBL3 36
  • 63 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
-- 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9646 35
tbl3 35
  • 65.07 (n)
  • 64.02 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69179 35
(Danio rerio)
Actinopterygii tbl3 35
  • 66.06 (n)
  • 59.69 (a)
wufc08g06 35
tbl3 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1671 37
  • 31 (a)
CG1671 35
  • 49.29 (n)
  • 34.85 (a)
CG1671 36
  • 31 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009615 35
  • 51.62 (n)
  • 40.16 (a)
(Caenorhabditis elegans)
Secernentea Y53C12B.1 37
  • 31 (a)
Y53C12B.1 35
  • 41.56 (n)
  • 33.11 (a)
Y53C12B.1 36
  • 28 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR180W 35
  • 42.76 (n)
  • 32.76 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F13244g 35
  • 42.25 (n)
  • 34.35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP13 35
  • 41.11 (n)
  • 33.02 (a)
UTP13 36
  • 28 (a)
UTP13 38
thale cress
(Arabidopsis thaliana)
eudicotyledons TOZ 35
  • 45.6 (n)
  • 37.44 (a)
(Oryza sativa)
Liliopsida Os04g0592700 35
  • 48.16 (n)
  • 40.73 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4453 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03628 35
  • 46.92 (n)
  • 34.34 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes utp13 35
  • 42.26 (n)
  • 36.14 (a)
Species with no ortholog for TBL3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TBL3 Gene

Gene Tree for TBL3 (if available)
Gene Tree for TBL3 (if available)

Paralogs for TBL3 Gene

Paralogs for TBL3 Gene

(5) SIMAP similar genes for TBL3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TBL3: view

Variants for TBL3 Gene

Sequence variations from dbSNP and Humsavar for TBL3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs8460 -- 1,978,401(+) AGGCG(A/C/T)GAGGC reference, synonymous-codon
rs17602 -- 1,975,677(+) TTGCT(A/C)TACGA synonymous-codon, reference
rs17603 -- 1,976,870(+) GTGGC(C/G/T)TCTTC reference, missense
rs17604 -- 1,976,291(+) CACAG(C/T)GTGGG synonymous-codon, reference
rs17605 - 1,976,890(+) TGCTG(C/T)CCAAG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for TBL3 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2540n71 CNV Loss 21882294
dgv2544n71 CNV Loss 21882294
dgv2545n71 CNV Loss 21882294
nsv833120 CNV Loss 17160897
nsv905048 CNV Loss 21882294
dgv2546n71 CNV Loss 21882294
dgv2547n71 CNV Loss 21882294
dgv2548n71 CNV Gain 21882294
dgv2549n71 CNV Loss 21882294
dgv2550n71 CNV Loss 21882294
nsv905061 CNV Loss 21882294
dgv2551n71 CNV Loss 21882294
nsv471070 CNV Gain 18288195
nsv905070 CNV Gain+Loss 21882294
dgv2552n71 CNV Gain+Loss 21882294
dgv336n27 CNV Loss 19166990
nsv905076 CNV Gain 21882294
dgv2553n71 CNV Loss 21882294
nsv521569 CNV Loss 19592680
nsv523037 CNV Loss 19592680
nsv471072 CNV Loss 18288195
dgv2554n71 CNV Loss 21882294
nsv905082 CNV Loss 21882294

Relevant External Links for TBL3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBL3 Gene

Disorders for TBL3 Gene

Relevant External Links for TBL3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for TBL3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TBL3 Gene

Publications for TBL3 Gene

  1. A transducin-like gene maps to the autosomal dominant polycystic kidney disease gene region. (PMID: 8307582) Weinstat-Saslow D.L. … Reeders S.T. (Genomics 1993) 2 3 4 23
  2. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  3. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PMID: 19724895) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2009) 3 48
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for TBL3 Gene

Sources for TBL3 Gene

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