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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TBL2 Gene

protein-coding GIFtS: 49
GCID: GC07M072983

transducin (beta)-like 2

Explore 5 diseases affiliated with
TBL2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transducin (Beta)-Like 2¹ ²		DKFZP43N024¹
WBSCR13¹ ² ³		Transducin Beta-Like Protein 2²
WS-BetaTRP¹		Williams-Beuren Syndrome Chromosome Region 13²
WS Beta-Transducin Repeats Protein² ³		Williams-Beuren Syndrome Chromosomal Region 13 Protein³

External Ids:	HGNC: 11586¹	Entrez Gene: 26608²	Ensembl: ENSG00000106638⁷	OMIM: 605842⁵	UniProtKB: Q9Y4P3³

Export aliases for TBL2 gene to outside databases

Previous GC identifers: GC07M071624 GC07M072382 GC07M072396 GC07M072428 GC07M072621 GC07M068865

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TBL2:

This gene encodes a member of the beta-transducin protein family. Most proteins of the beta-transducin family are

involved in regulatory functions. This protein is possibly involved in some intracellular signaling pathway. This gene

is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23.

(provided by RefSeq, Jul 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079593.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TBL2 gene promoter:
HEN1 p53 Nkx5-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TBL2 promoter sequence

Search SABiosciences Chromatin IP Primers for TBL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q11.23

TBL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBL2 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M072983: view genomic region (about GC identifiers)

Start:	72,983,274 bp from pter	End:	72,993,121 bp from pter
Size:	9,848 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 72,316,346-72,326,085

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TBL2_HUMAN, Q9Y4P3 (See protein sequence)

Recommended Name: Transducin beta-like protein 2

Size: 447 amino acids; 49798 Da

Sequence caution: Sequence=AAD28083.1; Type=Erroneous initiation;

Secondary accessions: Q9UQE2

Explore the universe of human proteins at neXtProt for TBL2: NX_Q9Y4P3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y4P3

TBL2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_036585.1

ENSEMBL proteins:

ENSP00000398195 ENSP00000409820 ENSP00000307260 ENSP00000407503 ENSP00000413979

ENSP00000404242 ENSP00000410737 ENSP00000407371 ENSP00000400569 ENSP00000408255

ENSP00000414865 ENSP00000406418

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	Browse Proteins at Uscn

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

TBL2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TBL2 for domains About GeneDecksing

5 InterPro domains/families:

IPR019775 WD40_repeat_CS

IPR001680 WD40_repeat

IPR020472 G-protein_beta_WD-40_rep

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry Q9Y4P3

ProtoNet protein and cluster: Q9Y4P3

UniProtKB/Swiss-Prot: TBL2_HUMAN, Q9Y4P3

Similarity: Contains 7 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for TBL2:

transducin (beta)-like 2,expressed in heart,brain,placenta,testis,skeletal muscle and pancreas,located in the Williams

commonly deleted region

miRNA Products:		OriGene 3'-UTR Clone: TBL2 Browse MicroRNA Expression Plasmids
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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate TBL2:
		hsa-miR-1290 hsa-miR-3934 hsa-miR-520d-5p hsa-miR-532-3p hsa-miR-1193 hsa-miR-524-5p
		SwitchGear 3'UTR luciferase reporter plasmid: TBL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TBL2 (see all 4) OriGene shRNA RFP: TBL2 OriGene siRNA: TBL2
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBL2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--

TBL2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Tbl2^tm1Lex for TBL2
     1 MGI phenotypic allele

for Tbl2 (no phenotypes)

TBL2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TBL2

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/122 Interacting proteins for TBL2 (Q9Y4P3^{2, 3} ENSP00000307260⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 122)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PDPK1	O15530³, ENSP00000344220⁴	I2D: score=3 STRING: ENSP00000344220
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207
USP44	Q9H0E7³, ENSP00000258499⁴	I2D: score=2 STRING: ENSP00000258499
UBC	P0CG48², ENSP00000344818⁴	MINT-6488791 STRING: ENSP00000344818
ESR1	P03372³, ENSP00000206249⁴	I2D: score=1 STRING: ENSP00000206249

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

TBL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TBL2
Search CenterWatch for drugs/clinical trials and news about TBL2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TBL2 gene (2 alternative transcripts):

NM_012453.2 NM_032988.1

Unigene Cluster for TBL2:

Transducin (beta)-like 2

Hs.647044 [show with all ESTs]

Unigene Representative Sequence: NM_012453

18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000459913 ENST00000424598(uc011kex.2) ENST00000450285 ENST00000305632(uc003tyh.3 uc010lbg.3 uc003tyi.3 uc011key.2)

ENST00000417008 ENST00000432538 ENST00000433464 ENST00000488915 ENST00000426966

ENST00000452475 ENST00000495885 ENST00000437521 ENST00000435792 ENST00000452125

ENST00000476136 ENST00000479892 ENST00000465279 ENST00000496056

miRNA Products:		OriGene 3'-UTR Clone: TBL2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TBL2
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate TBL2:
		hsa-miR-1290 hsa-miR-3934 hsa-miR-520d-5p hsa-miR-532-3p hsa-miR-1193 hsa-miR-524-5p
		SwitchGear 3'UTR luciferase reporter plasmid: TBL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AF056183.1 AF097484.1 AK000536.1 AK074619.1 AK130791.1 AK302265.1 AK302277.1 AK314499.1

AL080162.1 AY358518.1 BC006308.2 BC012938.1 BC047354.1 BC114361.2 BC114362.1

19 DOTS entries:

DT.454088 DT.95149365 DT.100813577 DT.95149373 DT.100834647 DT.121102464 DT.95149364 DT.121102482

DT.121102456 DT.95206681 DT.101984662 DT.121102480 DT.121102496 DT.40130493 DT.97861180 DT.100813570

DT.95149367 DT.99990484 DT.102832181

24/273 AceView cDNA sequences (see all 273):

AI608789 AI167471 BM559607 AK074619 AI934755 W93789 BU164276 BQ654055

BQ647441 BM693223 AW851078 NM_012453 CK823880 BQ025092 AY358518 BC006308

BU845105 BC012938 CB126753 AL080162 AA634831 BI760683 AA868395 BU191815

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for TBL2 (see all 18) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	·	1g	·	1h	·	1i	·	1j	^	2	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	·	5d	^	6a	·	6b	·	6c	·	6d	·	6e	^	7	^	8	^	9	^
SP1:													-		-		-		-		-		-		-		-		-		-														-
SP2:													-		-		-		-		-		-		-		-		-		-										-		-		-
SP3:													-		-		-		-		-		-		-		-		-																-
SP4:													-		-		-		-		-		-		-		-		-		-														-
SP5:													-		-		-		-		-		-		-		-		-		-														-

ExUns:	10a	·	10b	·	10c	^	11a	·	11b	·	11c	^	12a	·	12b	·	12c	^	13a	·	13b
SP1:							-		-		-		-
SP2:							-		-		-		-
SP3:							-		-		-		-
SP4:
SP5:	-						-		-		-		-

ECgene alternative splicing isoforms for TBL2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TBL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

TBL2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TBL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TBL2

SOURCE GeneReport for Unigene cluster: Hs.647044

SABiosciences Custom PCR Arrays for TBL2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TBL2 gene from 8/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tbl2^{1 , 5}	transducin (beta)-like 2^{1, 5}	84.99(n)¹ 88.24(a)¹		5 (75.02 cM)⁵ 27368¹ NM_013763.2¹ NP_038791.2¹ 135149657⁵
lizard (Anolis carolinensis)	Reptilia	TBL2⁶	--	72(a)	1 ↔ 1	GL343734.1(221654-226509)
African clawed frog (Xenopus laevis)	Amphibia	tbl2-prov²	transducin (beta)-like 2	73.14(n)		BC043633.1
zebrafish (Danio rerio)	Actinopterygii	Dr.10417²	Transcribed sequence with weak similarity to protein more	74.17(n)		CF996240.1
honey bee (Apis mellifera)	Insecta	--	--	38(a)	1 ↔ 1	GroupUn.1079(11490-13104)
worm (Caenorhabditis elegans)	Secernentea	F46C5.9¹	Protein F46C5.9	43.13(n) 31.23(a)		174409 NM_063476.2 NP_495877.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G00090¹	transducin/WD40 domain-containing protein	41.78(n) 31.88(a)		828179 NM_116226.3 NP_567150.1
rice (Oryza sativa)	Liliopsida	Os03g0858400¹	hypothetical protein	43.15(n) 29.45(a)		4334851 NM_001058496.1 NP_001051961.1

ENSEMBL Gene Tree for TBL2 (if available)
TreeFam Gene Tree for TBL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs886795^1,2	C,F,H,	--	72316728(-)	`CCCCTG/CACCTC`	1	--	ut3¹		11		NA EA MN NS WA	972
rs183265339^1,2	C	--	72316836(+)	`CCCTTA/CCCTGC`	1	--	ut3¹		0	--	--	--	--
rs2079480^1,2	C,H	--	72317159(-)	`ATCTTG/TTTTAA`	1	--	ut3¹		6		NS EA NA	422
rs113390078^1,2	C,	--	72317273(+)	`CACTGA/GTTCCC`	1	--	ut3¹		0	--	--	--	--
rs2573^1,2	C,F,H,	--	72317292(+)	`CACTTT/CCATGA`	1	--	ut3¹		15		MN NA NS	1516
rs17341242^1,2	C,F,H,	--	72317372(+)	`ATATCA/GTCTTT`	1	--	ut3¹		25		NA NS EA	2922
rs62466288^1,2	C,F,	--	72319723(+)	`GTGCAC/TGCCTG`	1	--	int¹		2		NA	4
rs11553139^1,2	H	--	72320309(-)	`TCAAGT/CGCTGT`	2	/A /V	mis¹		4		NS EA	406
rs111680567^1,2		--	72320640(+)	`TTTCAG/AGCAGC`	1	--	int¹		1		CSA	2
rs113894293^1,2	C,	--	72321003(+)	`TTAAGC/GCCCTG`	1	--	int¹		2		WA	120

HapMap Linkage Disequilibrium report for TBL2 (72983274 - 72993121 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TBL2: --

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBL2

DNA2.0 Custom Variant and Variant Library Synthesis for TBL2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TBL2 for disorders About GeneDecksing

OMIM gene information: 605842 OMIM disorders: --

UniProtKB/Swiss-Prot: TBL2_HUMAN, Q9Y4P3

Note=TBL2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous

deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between

highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of TBL2 may be the cause

of certain cardiovascular and musculo-skeletal abnormalities observed in the disease

5 diseases for TBL2: About MalaCards

williams-beuren syndrome supravalvular aortic stenosis williams syndrome hypertriglyceridemia

cholesterol

1 disease from the University of Copenhagen DISEASES database for TBL2:

Supravalvular aortic stenosis

Human Genome Epidemiology (HuGE) Navigator: TBL2 (12 documents)

Export disorders for TBL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TBL2 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with TBL2)

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TBL2, a novel transducin family member in the WBS deletion: characterization of the complete sequence, genomic structure, transcriptional variants and the mouse ortholog. (PubMed id 10575226)^{1, 2, 3, 9} Perez Jurado L.A.... Cruces J. (1999)
Complete physical map of the common deletion region in Williams syndrome and identification and characterization of three novel genes. (PubMed id 9860302)^{1, 2, 3} Meng X....Keating M.T. (1998)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)¹ Wu Z....Ma L. (2012)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26608	HGNC: 11586	AceView: TBL2	Ensembl:ENSG00000106638	euGenes: HUgn26608
ECgene: TBL2	H-InvDB: TBL2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TBL2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TBL2 gene
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Patent Information for TBL2 gene:
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transducin (beta)-like 2

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transducin (beta)-like 2

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