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Aliases for TBL1Y Gene

Aliases for TBL1Y Gene

  • Transducin (Beta)-Like 1, Y-Linked 2 3
  • Transducin-Beta-Like Protein 1, Y-Linked 3 4
  • Transducin Beta-Like Protein 1Y 3 4
  • TBL1 3 4
  • F-Box-Like/WD Repeat-Containing Protein TBL1Y 3
  • Transducin Beta-Like 1 3

External Ids for TBL1Y Gene

Previous GeneCards Identifiers for TBL1Y Gene

  • GC0YP006744
  • GC0YP006482
  • GC0YP006483
  • GC0YP006822
  • GC0YP006778
  • GC0YP004338

Summaries for TBL1Y Gene

Entrez Gene Summary for TBL1Y Gene

  • The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene is highly similar to TBL1X gene in nucleotide sequence and protein sequence, but the TBL1X gene is located on chromosome X and this gene is on chromosome Y. This gene has three alternatively spliced transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for TBL1Y Gene

TBL1Y (Transducin (Beta)-Like 1, Y-Linked) is a Protein Coding gene. Among its related pathways are Wnt signaling pathway (KEGG). GO annotations related to this gene include chromatin binding and transcription regulatory region DNA binding. An important paralog of this gene is TBL1X.

UniProtKB/Swiss-Prot for TBL1Y Gene

  • F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBL1Y Gene

Genomics for TBL1Y Gene

Regulatory Elements for TBL1Y Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TBL1Y Gene

Start:
6,910,686 bp from pter
End:
7,091,936 bp from pter
Size:
181,251 bases
Orientation:
Plus strand

Genomic View for TBL1Y Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBL1Y Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBL1Y Gene

Proteins for TBL1Y Gene

  • Protein details for TBL1Y Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ87-TBL1Y_HUMAN
    Recommended name:
    F-box-like/WD repeat-containing protein TBL1Y
    Protein Accession:
    Q9BQ87
    Secondary Accessions:
    • A1L4B3

    Protein attributes for TBL1Y Gene

    Size:
    522 amino acids
    Molecular mass:
    56688 Da
    Quaternary structure:
    • Probable component of the N-Cor repressor complex and some E3 ubiquitin ligase complex.

neXtProt entry for TBL1Y Gene

Proteomics data for TBL1Y Gene at MOPED

Post-translational modifications for TBL1Y Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBL1Y Gene

No data available for DME Specific Peptides for TBL1Y Gene

Domains for TBL1Y Gene

Gene Families for TBL1Y Gene

HGNC:
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for TBL1Y Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQ87

UniProtKB/Swiss-Prot:

TBL1Y_HUMAN :
  • Q9BQ87
Domain:
  • The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.
  • Contains 1 F-box-like domain.
  • Contains 1 LisH domain.
Family:
  • Belongs to the WD repeat EBI family.
Similarity:
  • Contains 8 WD repeats.
genes like me logo Genes that share domains with TBL1Y: view

Function for TBL1Y Gene

Molecular function for TBL1Y Gene

UniProtKB/Swiss-Prot Function: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity).

Gene Ontology (GO) - Molecular Function for TBL1Y Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003714 transcription corepressor activity IBA --
GO:0005515 protein binding --
GO:0044212 transcription regulatory region DNA binding IEA --
genes like me logo Genes that share ontologies with TBL1Y: view

Phenotypes for TBL1Y Gene

genes like me logo Genes that share phenotypes with TBL1Y: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TBL1Y Gene

Localization for TBL1Y Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBL1Y Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBL1Y Gene COMPARTMENTS Subcellular localization image for TBL1Y gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TBL1Y Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IBA --
GO:0005634 nucleus --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with TBL1Y: view

Pathways for TBL1Y Gene

SuperPathways for TBL1Y Gene

Superpath Contained pathways
1 Wnt signaling pathway (KEGG)
genes like me logo Genes that share pathways with TBL1Y: view

Pathways by source for TBL1Y Gene

1 KEGG pathway for TBL1Y Gene

Interacting Proteins for TBL1Y Gene

Gene Ontology (GO) - Biological Process for TBL1Y Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0016575 histone deacetylation IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with TBL1Y: view

Transcripts for TBL1Y Gene

Unigene Clusters for TBL1Y Gene

Transducin (beta)-like 1, Y-linked:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBL1Y

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TBL1Y
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBL1Y Gene

No ASD Table

Relevant External Links for TBL1Y Gene

GeneLoc Exon Structure for
TBL1Y
ECgene alternative splicing isoforms for
TBL1Y

Expression for TBL1Y Gene

mRNA expression in normal human tissues for TBL1Y Gene

mRNA differential expression in normal tissues according to GTEx for TBL1Y Gene

This gene is overexpressed in Thyroid (8.7) and Prostate (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TBL1Y Gene

SOURCE GeneReport for Unigene cluster for TBL1Y Gene Hs.664560

mRNA Expression by UniProt/SwissProt for TBL1Y Gene

Q9BQ87-TBL1Y_HUMAN
Tissue specificity: Fetal brain and prostate.
genes like me logo Genes that share expressions with TBL1Y: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TBL1Y Gene

Orthologs for TBL1Y Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TBL1Y Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBL1Y 35
  • 98.08 (n)
  • 96.93 (a)
TBL1Y 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TBL1X 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBL1Y 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbl1x 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
OneToMany
chicken
(Gallus gallus)
Aves TBL1X 36
  • 92 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 90 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tbl1x 36
  • 83 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ebi 36
  • 53 (a)
OneToMany
ebi 37
  • 73 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIF2 36
  • 25 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.12601 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2193 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2678 36
  • 68 (a)
OneToMany
Species with no ortholog for TBL1Y:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBL1Y Gene

ENSEMBL:
Gene Tree for TBL1Y (if available)
TreeFam:
Gene Tree for TBL1Y (if available)

Paralogs for TBL1Y Gene

Paralogs for TBL1Y Gene

Selected SIMAP similar genes for TBL1Y Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TBL1Y Gene

genes like me logo Genes that share paralogs with TBL1Y: view

Variants for TBL1Y Gene

Sequence variations from dbSNP and Humsavar for TBL1Y Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs768983 -- 6,950,250(-) GGAGC(A/G)TACTC intron-variant
rs1140014 -- 6,966,237(-) ctcta(C/T)taaaa intron-variant
rs1865680 -- 7,000,077(+) TAGCC(A/G)TTCTT intron-variant
rs2099504 -- 6,977,616(+) CCCCC(A/C)CCTAT intron-variant
rs2202097 -- 7,024,294(-) AACTA(C/G)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TBL1Y Gene

Variant ID Type Subtype PubMed ID
nsv7473 OTHER Inversion 18451855

Relevant External Links for TBL1Y Gene

HapMap Linkage Disequilibrium report
TBL1Y
Human Gene Mutation Database (HGMD)
TBL1Y

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBL1Y Gene

Disorders for TBL1Y Gene

(1) Novoseek inferred disease relationships for TBL1Y Gene

Disease -log(P) Hits PubMed IDs
deafness sensorineural 74.9 3

Relevant External Links for TBL1Y

Genetic Association Database (GAD)
TBL1Y
Human Genome Epidemiology (HuGE) Navigator
TBL1Y
genes like me logo Genes that share disorders with TBL1Y: view

No data available for UniProtKB/Swiss-Prot for TBL1Y Gene

Publications for TBL1Y Gene

  1. Association of Y chromosome haplotypes with autism. (PMID: 19605777) Serajee F.J. … Mahbubul Huq A.H. (J. Child Neurol. 2009) 3 23 48
  2. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 3 4
  3. Genetic variants of Y chromosome are associated with a protective lipid profile in black men. (PMID: 18511697) Russo P. … Cappuccio F.P. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 48
  4. Transducin I^-like protein 1 recruits nuclear factor I_B to the target gene promoter for transcriptional activation. (PMID: 21189284) Ramadoss S. … Wang C.Y. (Mol. Cell. Biol. 2011) 3
  5. Functional null mutations in the gonosomal homologue gene TBL1Y are associated with non-syndromic coarctation of the aorta. (PMID: 22280357) Tagariello A. … Toka O. (Curr. Mol. Med. 2012) 3

Products for TBL1Y Gene

Sources for TBL1Y Gene

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