Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TBL1Y Gene

protein-coding   GIFtS: 51
GCID: GC0YP006778

Transducin (Beta)-Like 1, Y-Linked

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Transducin (Beta)-Like 1, Y-Linked1 2
Transducin Beta-Like Protein 1Y2 3
Transducin-Beta-Like Protein 1, Y-Linked2 3
TBL12 3
F-Box-Like/WD Repeat-Containing Protein TBL1Y2
Transducin Beta-Like 12

External Ids:    HGNC: 185021   Entrez Gene: 906652   Ensembl: ENSG000000923777   OMIM: 4000335   UniProtKB: Q9BQ873   

Export aliases for TBL1Y gene to outside databases

Previous GC identifers: GC0YP006744 GC0YP006482 GC0YP006483 GC0YP006822 GC0YP004338


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TBL1Y Gene:
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein
family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed
that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal
transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role
in the control of cytotypic differentiation. This gene is highly similar to TBL1X gene in nucleotide sequence and
protein sequence, but the TBL1X gene is located on chromosome X and this gene is on chromosome Y. This gene has
three alternatively spliced transcript variants encoding the same protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for TBL1Y Gene:
TBL1Y (transducin (beta)-like 1, Y-linked) is a protein-coding gene. Diseases associated with TBL1Y include lissencephaly, and thyroiditis. GO annotations related to this gene include chromatin binding and transcription regulatory region DNA binding. An important paralog of this gene is THOC3.

UniProtKB/Swiss-Prot: TBL1Y_HUMAN, Q9BQ87
Function: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear
receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear
receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S
proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes,
thereby allowing cofactor exchange (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000024.10  NT_011896.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the TBL1Y gene promoter:
         TBP   USF1   Pax-5   CUTL1   Nkx2-5   LCR-F1   E4BP4   MZF-1   TFIID   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBL1Y promoter sequence
   Search Chromatin IP Primers for TBL1Y

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBL1Y


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Yp11.2   Ensembl cytogenetic band:  Yp11.2   HGNC cytogenetic band: Yp11.2

TBL1Y Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBL1Y gene location

GeneLoc information about chromosome Y         GeneLoc Exon Structure

GeneLoc location for GC0YP006778:  view genomic region     (about GC identifiers)

Start:
6,778,727 bp from pter      End:
6,959,724 bp from pter
Size:
180,998 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TBL1Y_HUMAN, Q9BQ87 (See protein sequence)
Recommended Name: F-box-like/WD repeat-containing protein TBL1Y  
Size: 522 amino acids; 56688 Da
Subunit: Probable component of the N-Cor repressor complex and some E3 ubiquitin ligase complex (By similarity)
Secondary accessions: A1L4B3

Explore the universe of human proteins at neXtProt for TBL1Y: NX_Q9BQ87

Explore proteomics data for TBL1Y at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TBL1Y Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_150600.1  NP_599020.1  NP_599021.1  

    ENSEMBL proteins: 
     ENSP00000372499   ENSP00000347289   ENSP00000328879  

    TBL1Y Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for TBL1Y
    OriGene Protein Over-expression Lysate for TBL1Y
    OriGene MassSpec for TBL1Y
    OriGene Custom Protein Services for TBL1Y
    GenScript Custom Purified and Recombinant Proteins Services for TBL1Y
    Novus Biologicals TBL1Y Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    TBL1Y Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TBL1Y
    Novus Biologicals TBL1Y Antibody
    Abcam antibodies for TBL1Y
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for TBL1Y
    LSBio Antibodies in human, mouse, rat for TBL1Y

    TBL1Y Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TBL1Y
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TBL1Y
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 7):
     IPR013720 LisH_dimerisation_subgr
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q9BQ87

    ProtoNet protein and cluster: Q9BQ87

    1 Blocks protein domain: IPB006594 Lissencephaly type-1-like homology motif

    UniProtKB/Swiss-Prot: TBL1Y_HUMAN, Q9BQ87
    Domain: The F-box-like domain is related to the F-box domain, and apparently displays the same function as
    component of ubiquitin E3 ligase complexes (By similarity)
    Similarity: Belongs to the WD repeat EBI family
    Similarity: Contains 1 F-box-like domain
    Similarity: Contains 1 LisH domain
    Similarity: Contains 8 WD repeats


    TBL1Y for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBL1Y_HUMAN, Q9BQ87
    Function: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear
    receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear
    receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S
    proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes,
    thereby allowing cofactor exchange (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding ----
    GO:0044212transcription regulatory region DNA binding IEA--
         
    TBL1Y for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TBL1Y:
     Decreased viability with pacli  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBL1Y
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TBL1Y

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TBL1Y
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TBL1Y

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TBL1Y using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TBL1Y
    SwitchGear 3'UTR luciferase reporter plasmidTBL1Y 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TBL1Y
    Predesigned siRNA for gene silencing in human, mouse, rat TBL1Y

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TBL1Y

    Clone
    Products:
         
    OriGene clones in human, mouse for TBL1Y (see all 18)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TBL1Y (NM_033284)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBL1Y
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBL1Y

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TBL1Y
    Browse ESI BIO Cell Lines and PureStem Progenitors for TBL1Y 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBL1Y


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TBL1Y_HUMAN, Q9BQ87: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IEA--

    TBL1Y for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TBL1Y About    
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for TBL1Y):
        Wnt signaling pathway


    TBL1Y for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBL1Y
    Interactions:

        Search GeneGlobe Interaction Network for TBL1Y

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TBL1Y (Q9BQ873 ENSP000003288794) via UniProtKB, MINT, STRING, and/or I2D (see all 150)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAB2Q9NYJ83I2D: score=1 
    APCENSP000002574304STRING: ENSP00000257430
    APC2ENSP000002336074STRING: ENSP00000233607
    CTNNB1ENSP000003444564STRING: ENSP00000344456
    KPNB1ENSP000002901584STRING: ENSP00000290158
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process IEA--
    GO:0043627response to estrogen IEA--
    GO:0045444fat cell differentiation IEA--

    TBL1Y for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TBL1Y



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TBL1Y gene (3 alternative transcripts): 
    NM_033284.1  NM_134258.1  NM_134259.1  

    Unigene Cluster for TBL1Y:

    Transducin (beta)-like 1, Y-linked
    Hs.664560  [show with all ESTs]
    Unigene Representative Sequence: AK298210
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000383032(uc004frb.3) ENST00000355162(uc004frc.3) ENST00000346432(uc004frd.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TBL1Y using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TBL1Y
    SwitchGear 3'UTR luciferase reporter plasmidTBL1Y 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TBL1Y
    Predesigned siRNA for gene silencing in human, mouse, rat TBL1Y
    Clone
    Products:
         
    OriGene clones in human, mouse for TBL1Y (see all 18)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TBL1Y (NM_033284)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBL1Y
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBL1Y
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TBL1Y
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TBL1Y
      QuantiTect SYBR Green Assays in human, mouse, rat TBL1Y
      QuantiFast Probe-based Assays in human, mouse, rat TBL1Y

    Additional mRNA sequence: 

    AF332220.1 AF332221.1 AF332222.1 AK298210.1 BC130471.1 BC130473.1 

    7 DOTS entries:

    DT.97846704  DT.97846706  DT.97846705  DT.102834496  DT.102845423  DT.421601  DT.95142272 

    21 AceView cDNA sequences:

    AF332221 CO247621 NM_134259 NM_033284 AF332222 AF332220 NM_134258 CO246469 
    CO246297 AK056903 CO249000 CO245684 CO246355 CO245876 CO245808 CO245555 
    CO245717 CO249720 CO247757 CO247684 CO246218 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TBL1Y expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTTGCAGC
    TBL1Y Expression
    About this image

    TBL1Y Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TBL1Y Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.664560

    UniProtKB/Swiss-Prot: TBL1Y_HUMAN, Q9BQ87
    Tissue specificity: Fetal brain and prostate

        Custom PCR Arrays for TBL1Y
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TBL1Y
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TBL1Y
    QuantiTect SYBR Green Assays in human, mouse, rat TBL1Y
    QuantiFast Probe-based Assays in human, mouse, rat TBL1Y
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBL1Y

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TBL1Y gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TBL1X6
    Gallus gallus transducin (beta)-like 1X-linked (TB...
    92(a)
    1 → many
    1(124584256-124724404)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    90(a)
    1 → many
    3(118514453-118546473)
    zebrafish
    (Danio rerio)
    Actinopterygii tbl1x6
    transducin (beta)-like 1X-linked
    83(a)
    1 → many
    9(57098950-57134711) ENSDARG00000060438
    fruit fly
    (Drosophila melanogaster)
    Insecta ebi3 regulation of cell cycle GTP binding 73(a)   21C4   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SIF26
    WD40 repeat-containing subunit of the Set3C histon...
    25(a)
    1 → many
    II(447709-449316) YBR103W
    soybean
    (Glycine max)
    eudicotyledons Gma.126012 Transcribed sequence with moderate similarity to protein more 77(n)  
            Species with no ortholog for TBL1Y

    ENSEMBL Gene Tree for TBL1Y (if available)
    TreeFam Gene Tree for TBL1Y (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TBL1Y gene
    THOC32  TBL1XR12  TBL1X2  
    3 SIMAP similar genes for TBL1Y using alignment to 1 protein entry:     TBL1Y_HUMAN:
    TBL1X    TBL1XR1    WDR83

    TBL1Y for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TBL1Y
    PGOHUM00000234006


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TBL1Y (see all 1218)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr Y posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs726176881,2
    C--6779609(+) TCCCCC/GGCCCA 3 -- int10--------
    rs38600331,2
    C--6781398(+) AGGCTC/TGGTTT 3 -- int11Minor allele frequency- T:0.00NA 2
    rs97864371,2
    C--6792400(+) tgaggC/Tgggcg 3 -- int11Minor allele frequency- T:0.00NA 2
    rs133052431,2
    C--6796065(+) GACTCA/CCCGCC 3 -- int10--------
    rs1130773111,2
    C--6798574(+) CCAGCC/TGGGCT 3 -- int11Minor allele frequency- T:0.00CSA 1
    rs117992001,2
    C,A,H--6801186(+) tctgcC/Ttgcct 3 -- int11Minor allele frequency- T:0.00NA 2
    rs117991801,2
    C,A,H--6801187(+) ctgccC/Tgcctt 3 -- int10--------
    rs117992011,2
    C,A,H--6801198(+) ggcctC/Tccaaa 3 -- int10--------
    rs117990971,2
    C,A,H--6801204(+) ccaaaA/Gtactg 3 -- int11Minor allele frequency- G:0.00NA 2
    rs117990981,2
    C,A,H--6801206(+) aaaatA/Gctggg 3 -- int11Minor allele frequency- G:0.00NA 2

    HapMap Linkage Disequilibrium report for TBL1Y (6778727 - 6959724 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TBL1Y:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7473OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): TBL1Y
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TBL1Y
    DNA2.0 Custom Variant and Variant Library Synthesis for TBL1Y

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 400033    OMIM disorders: --

    4 diseases for TBL1Y:    
    About MalaCards
    lissencephaly    thyroiditis    leukemia    prostatitis


    TBL1Y for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TBL1Y gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    deafness sensorineural 74.9 4 15834507 (2), 10809664 (1)

    Genetic Association Database (GAD): TBL1Y
    Human Genome Epidemiology (HuGE) Navigator: TBL1Y (2 documents)

    Export disorders for TBL1Y gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TBL1Y gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with TBL1Y)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of Y chromosome haplotypes with autism. (PubMed id 19605777)1, 4, 9 Serajee F.J. and Mahbubul Huq A.H. (J. Child Neurol. 2009)
    2. Genetic variants of Y chromosome are associated with a protective lipid profile in black men. (PubMed id 18511697)1, 4 Russo P....Cappuccio F.P. (Arterioscler. Thromb. Vasc. Biol. 2008)
    3. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2 Skaletsky H.... Page D.C. (Nature 2003)
    4. Functional null mutations in the gonosomal homologue gene TBL1Y are associated with non-syndromic coarctation of the aorta. (PubMed id 22280357)1 Tagariello A....Toka O. (Curr. Mol. Med. 2012)
    5. Transducin I^-like protein 1 recruits nuclear factor I_B to the target gene promoter for transcriptional activation. (PubMed id 21189284)1 Ramadoss S....Wang C.Y. (Mol. Cell. Biol. 2011)
    6. Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches. (PubMed id 14660691)1 Agate R.J....Arnold A.P. (Mol. Biol. Evol. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Molecular analysis of TBL1Y, a Y-linked homologue of TBL1X related with X-linked late-onset sensorineural deafness. (PubMed id 15834507)9 Yan H.T....Nakahori Y. (J. Hum. Genet. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 90665 HGNC: 18502 AceView: TBL1Y Ensembl:ENSG00000092377 euGenes: HUgn90665
    ECgene: TBL1Y Kegg: 90665 H-InvDB: TBL1Y

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TBL1Y Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TBL1Y gene:
    Search GeneIP for patents involving TBL1Y

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TBL1Y  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TBL1Y  
     OriGene MassSpec something-or-other for TBL1Y   OriGene clones in human, mouse for TBL1Y  
     OriGene qSTAR qPCR primer pairs in human, mouse for TBL1Y   OriGene Purified Protein for TBL1Y  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TBL1Y   OriGene Custom Protein Services for TBL1Y  

     
     
     Block miRNA regulation of human, mouse, rat TBL1Y using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TBL1Y
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBL1Y Predesigned siRNA for gene silencing in human, mouse, rat TBL1Y
     QuantiFast Probe-based Assays in human, mouse, rat TBL1Y QuantiTect SYBR Green Assays in human, mouse, rat TBL1Y
     Custom PCR Arrays for TBL1Y Search Chromatin IP Primers for TBL1Y
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TBL1Y  Search GeneGlobe Interaction Network for TBL1Y
     Regulatory tfbs in TBL1Y promoter
     GenScript Custom Purified and Recombinant Proteins Services for TBL1Y GenScript cDNA clones with any tag delivered in your preferred vector for TBL1Y
     GenScript Custom Assay Services for TBL1Y GenScript Custom overexpressing Cell Line Services for TBL1Y
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TBL1Y
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TBL1Y antibodies
     TBL1Y lysates
     Antibodies for TBL1Y
     See all of Abcam's Antibodies, Kits and Proteins for TBL1Y
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for TBL1Y
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBL1Y
     SwitchGear 3'UTR luciferase reporter plasmids for TBL1Y
     SwitchGear Promoter luciferase reporter plasmids for TBL1Y
     Search ThermoFisher Antibodies for TBL1Y
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBL1Y
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBL1Y
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TBL1Y
     LSBio Antibodies in human, mouse, rat for TBL1Y
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TBL1Y gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4