Aliases for TBL1Y Gene
External Ids for TBL1Y Gene
Previous GeneCards Identifiers for TBL1Y Gene
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene is highly similar to TBL1X gene in nucleotide sequence and protein sequence, but the TBL1X gene is located on chromosome X and this gene is on chromosome Y. This gene has three alternatively spliced transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for TBL1Y Gene
TBL1Y (Transducin Beta Like 1 Y-Linked) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathway and Pluripotency. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription corepressor activity. An important paralog of this gene is TBL1X.
UniProtKB/Swiss-Prot for TBL1Y Gene
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity).