TBL1Y Gene
protein-coding GIFtS: 51
GCID: GC0YP006778
|
|
transducin (beta)-like 1, Y-linked
| |
Aliases
for TBL1Y gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transducin (Beta)-Like 1, Y-Linked1 2 | | TBL11 2 3 | | Transducin Beta-Like Protein 1Y2 3 | | Transducin-Beta-Like Protein 1, Y-Linked2 3 | | F-Box-Like/WD Repeat-Containing Protein TBL1Y2 | | Transducin Beta-Like 12 |
Export aliases for TBL1Y gene to outside databasesPrevious GC identifers: GC0YP006744 GC0YP006482 GC0YP006483 GC0YP006822 GC0YP004338 |
Summaries
for TBL1Y gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TBL1Y:
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. TheWD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNAprocessing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control ofcytotypic differentiation. This gene is highly similar to TBL1X gene in nucleotide sequence and protein sequence, butthe TBL1X gene is located on chromosome X and this gene is on chromosome Y. This gene has three alternatively splicedtranscript variants encoding the same protein. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TBL1Y_HUMAN, Q9BQ87Function: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclearreceptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclearreceptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19Sproteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, therebyallowing cofactor exchange (By similarity)
|
Genomic Views
for TBL1Y gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000024.9 NT_011896.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TBL1Y gene promoter:
TBP USF1 Pax-5 CUTL1 Nkx2-5 LCR-F1 E4BP4 MZF-1 TFIID USF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TBL1Y
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBL1Y |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Yp11.2 Ensembl cytogenetic band: Yp11.2 HGNC cytogenetic band: Yp11.2TBL1Y Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome Y GeneLoc Exon Structure GeneLoc location for GC0YP006778: view genomic region
(about GC identifiers)
Start:
|
6,778,727 bp from pter |
End:
|
6,959,977 bp from pter |
Size:
|
181,251 bases |
Orientation:
|
plus strand |
|
Proteins
for TBL1Y gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TBL1Y_HUMAN, Q9BQ87 (See
protein sequence)Recommended Name: F-box-like/WD repeat-containing protein TBL1Y Size: 522 amino acids; 56688 Da
Subunit: Probable component of the N-Cor repressor complex and some E3 ubiquitin ligase complex (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: A1L4B3Explore the universe of human proteins at neXtProt for TBL1Y: NX_Q9BQ87
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BQ87
TBL1Y Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_150600.1 NP_599020.1 NP_599021.1
ENSEMBL proteins: ENSP00000372499 ENSP00000347289 ENSP00000328879 ENSP00000437721
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | | GO:0005667 | transcription factor complex |
-- | -- |
TBL1Y for ontologies About GeneDecksing
TBL1Y Antibody Products:
Assay Products for TBL1Y: |
Protein
Domains /
Families
for TBL1Y gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TBL1Y for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9BQ87ProtoNet protein and cluster: Q9BQ87 1 Blocks protein family: IPB006594 Lissencephaly type-1-like homology motif
UniProtKB/Swiss-Prot: TBL1Y_HUMAN, Q9BQ87Domain: The F-box-like domain is related to the F-box domain, and apparently displays the same function as component ofubiquitin E3 ligase complexes (By similarity)Similarity: Belongs to the WD repeat EBI familySimilarity: Contains 1 F-box-like domainSimilarity: Contains 1 LisH domainSimilarity: Contains 8 WD repeats |
Function
for TBL1Y gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TBL1Y_HUMAN, Q9BQ87Function: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclearreceptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclearreceptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19Sproteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, therebyallowing cofactor exchange (By similarity)
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBL1Y |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003682 | chromatin binding |
-- | -- | | GO:0003714 | transcription corepressor activity |
-- | -- | | GO:0044212 | transcription regulatory region DNA binding |
-- | -- |
TBL1Y for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TBL1Y:
|
Pathways & Interactions
for TBL1Y gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Wnt Signaling Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for TBL1Y):
TBL1Y for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBL1Y
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/10 Interacting proteins for TBL1Y (Q9BQ873 ENSP000003288794) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0043161 | proteasomal ubiquitin-dependent protein catabolic process |
-- | -- | | GO:0043627 | response to estrogen stimulus |
-- | -- | | GO:0045444 | fat cell differentiation |
-- | -- |
TBL1Y for ontologies About GeneDecksing
|
Drugs & Compounds
for TBL1Y gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TBL1Y
Search CenterWatch for drugs/clinical trials and news about TBL1Y
|
Transcripts
for TBL1Y gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TBL1Y gene (3 alternative transcripts): NM_033284.1 NM_134258.1 NM_134259.1 Unigene Cluster for TBL1Y: Transducin (beta)-like 1, Y-linked Hs.664560 [show with all ESTs]Unigene Representative Sequence: AK2982104 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000383032(uc004frb.3) ENST00000355162(uc004frc.3) ENST00000346432(uc004frd.3)
ENST00000540077(uc011nap.2)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBL1Y (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): TBL1Y (NM_033284) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBL1Y | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBL1Y |
Additional cDNA sequence: AF332220.1 AF332221.1 AF332222.1 AK298210.1 BC130471.1 BC130473.1 7 DOTS entries: DT.97846704 DT.97846706 DT.97846705 DT.102834496 DT.102845423 DT.421601 DT.95142272 21 AceView cDNA sequences: AF332221 NM_033284 AF332220 NM_134258 NM_134259 AF332222 CO247621 CO249000 AK056903 CO246297 CO245684 CO246469 CO245808 CO245876 CO246355 CO245555 CO245717 CO249720 CO247757 CO247684 CO246218
GeneLoc Exon Structure
|
Expression
for TBL1Y gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TBL1Y expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGTTGCAGC
About this image
See TBL1Y Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TBL1Y
SOURCE GeneReport for Unigene cluster: Hs.664560
UniProtKB/Swiss-Prot: TBL1Y_HUMAN, Q9BQ87Tissue specificity: Fetal brain and prostate
SABiosciences Custom PCR Arrays for TBL1Y
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBL1Y
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBL1Y |
Orthologs
for TBL1Y gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TBL1Y gene from 5/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TBL1X6 |
Uncharacterized protein |
92(a) |
1 → many |
1(129009396-129109929) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
90(a) |
1 → many |
3(118514453-118546364) |
fruit fly
(Drosophila melanogaster) |
Insecta |
ebi3 |
regulation of cell cycle GTP binding |
73(a) |
|
21C4 -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
HOS156 |
WD-40 repeat family protein |
43(a) |
1 → many |
5(26857154-26861119) |
rice
(Oryza sativa) |
Liliopsida |
-- |
F-box-like/WD repeat-containing protein TBL1XR1-A,... |
48(a) |
1 → many |
7(12423067-12439493) |
ENSEMBL Gene Tree for TBL1Y (if available)
TreeFam Gene Tree for TBL1Y (if available) |
Paralogs
for TBL1Y gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TBL1Y gene
- THOC32 TBL1XR12 TBL1X2
9 SIMAP similar genes for TBL1Y using alignment to 2 protein entries: TBL1Y_HUMAN (see all proteins):TBL1X TBL1XR1 THOC3 WSB1 PF20 WDR83
GNB5 GNB2L1 PLRG1
TBL1Y for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TBL1Y
PGOHUM00000234006
|
Genomic Variants
for TBL1Y gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr Y pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TBL1Y (6778727 - 6959977 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TBL1Y: --
Human Gene Mutation Database (HGMD): TBL1Y
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBL1Y |
|
Disorders
/ Diseases
for TBL1Y gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TBL1Y for disorders About GeneDecksing
OMIM gene information: 400033
OMIM disorders: --
4  diseases for TBL1Y: About MalaCardslissencephaly thyroiditis leukemia prostatitis
1 Novoseek disease relationship for TBL1Y gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| deafness sensorineural |
74.9 |
4 |
15834507 (2), 10809664 (1) |
Human Genome Epidemiology (HuGE) Navigator: TBL1Y (2 documents)
Export disorders for TBL1Y gene to outside databases
|
Publications
for TBL1Y gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TBL1Y gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with TBL1Y) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2 Skaletsky H.... Page D.C. (2003)
- Association of Y chromosome haplotypes with autism. (PubMed id 19605777)1, 9 Serajee F.J. and Mahbubul Huq A.H. (2009)
- Functional null mutations in the gonosomal homologue g ene TBL1Y are associated with non-syndromic coarctation of the aorta. (PubMed id 22280357)1 Tagariello A....Toka O. (2012)
- Transducin I^-like protein 1 recruits nuclear factor I_B to the target gene promoter for transcriptional activation. (PubMed id 21189284)1 Ramadoss S....Wang C.Y. (2011)
- Genetic variants of y chromosome are associated with a protective lipid profile in black men. (PubMed id 18511697)1 Russo P....Cappuccio F.P. (2008)
- Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches. (PubMed id 14660691)1 Agate R.J....Arnold A.P. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Molecular analysis of TBL1Y, a Y-linked homologue of TBL1X related with X-linked late-onset sensorineural deafness. (PubMed id 15834507)9 Yan H.T....Nakahori Y. (2005)
|
External Searches for TBL1Y gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TBL1Y gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBL1Y gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TBL1Y gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TBL1Y | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TBL1Y gene:
Search GeneIP for patents involving TBL1Y
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TBL1Y gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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