Aliases for TBL1XR1 Gene
External Ids for TBL1XR1 Gene
Previous GeneCards Identifiers for TBL1XR1 Gene
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. [provided by RefSeq, Jul 2008]
GeneCards Summary for TBL1XR1 Gene
TBL1XR1 (Transducin (Beta)-Like 1 X-Linked Receptor 1) is a Protein Coding gene. Diseases associated with TBL1XR1 include leukemia, acute promyelocytic, somatic and west syndrome. Among its related pathways are Signaling by GPCR and Downstream signaling events of B Cell Receptor (BCR). GO annotations related to this gene include transcription regulatory region DNA binding and histone binding. An important paralog of this gene is TBL1X.
UniProtKB/Swiss-Prot for TBL1XR1 Gene
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.