Aliases for TBL1XR1 Gene
External Ids for TBL1XR1 Gene
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. [provided by RefSeq, Jul 2008]
GeneCards Summary for TBL1XR1 Gene
TBL1XR1 (Transducin (Beta)-Like 1 X-Linked Receptor 1) is a Protein Coding gene. Diseases associated with TBL1XR1 include leukemia, acute promyelocytic. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include transcription corepressor activity and protein N-terminus binding. An important paralog of this gene is TBL1X.
UniProtKB/Swiss-Prot for TBL1XR1 Gene
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.