TBL1XR1 Gene
protein-coding GIFtS: 56
GCID: GC03M176737
|
|
transducin (beta)-like 1 X-linked receptor 1(Previous name: transducin (beta)-like 1X-linked receptor 1 )
| |
Aliases
for TBL1XR1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transducin (Beta)-Like 1 X-Linked Receptor 11 2 | | Transducin Beta-Like 1X-Related Protein 12 3 | | IRA11 2 3 | | TBL1-Related Protein 12 3 | | TBLR11 2 3 | | FLJ128941 | | C211 2 | | Transducin (Beta)-Like 1X-Linked Receptor 11 | | DC421 2 | | F-Box-Like/WD Repeat-Containing Protein TBL1XR12 | | Nuclear Receptor Corepressor/HDAC3 Complex Subunit TBLR12 3 | | Nuclear Receptor Co-Repressor/HDAC3 Complex Subunit2 |
Export aliases for TBL1XR1 gene to outside databasesPrevious GC identifers: GC03M178221 GC03M174119 |
Summaries
for TBL1XR1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TBL1XR1:
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. TheWD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNAprocessing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control ofcytotypic differentiation. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TBL1R_HUMAN, Q9BZK7Function: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclearreceptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclearreceptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactorexchange, and transcription activation
Gene Wiki entry for TBL1XR1
|
Genomic Views
for TBL1XR1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TBL1XR1 gene promoter:
C/EBPbeta NF-YA NF-kappaB NF-YB CBF-A CBF-B CP1A NF-kappaB1 NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for TBL1XR1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBL1XR1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q26.32 Ensembl cytogenetic band: 3q26.32 HGNC cytogenetic band: 3q26.33TBL1XR1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M176737: view genomic region
(about GC identifiers)
Start:
|
176,737,143 bp from pter |
End:
|
176,915,261 bp from pter |
Size:
|
178,119 bases |
Orientation:
|
minus strand |
|
Proteins
for TBL1XR1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TBL1R_HUMAN, Q9BZK7 (See
protein sequence)Recommended Name: F-box-like/WD repeat-containing protein TBL1XR1 Size: 514 amino acids; 55595 Da
Subunit: Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A andGPS2. Probable component of some E3 ubiquitin ligase complex. Interacts with histones H2B and H4
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH60320.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence;
Secondary accessions: D3DNQ9 Q14DC3 Q9H2I1 Q9H9A1Explore the universe of human proteins at neXtProt for TBL1XR1: NX_Q9BZK7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BZK7
TBL1XR1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_078941.2
ENSEMBL proteins: ENSP00000405574 ENSP00000413251 ENSP00000391559 ENSP00000404863 ENSP00000263964 ENSP00000392180 ENSP00000402402 ENSP00000406297 ENSP00000397450 ENSP00000398477 ENSP00000396120 ENSP00000387849 ENSP00000401044 ENSP00000415506 Reactome Protein details: Q9BZK7
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
TBL1XR1 for ontologies About GeneDecksing
TBL1XR1 Antibody Products:
Assay Products for TBL1XR1: |
Protein
Domains /
Families
for TBL1XR1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TBL1XR1 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9BZK7ProtoNet protein and cluster: Q9BZK7 1 Blocks protein family: IPB006594 Lissencephaly type-1-like homology motif
UniProtKB/Swiss-Prot: TBL1R_HUMAN, Q9BZK7Domain: The F-box-like domain is related to the F-box domain, and apparently displays the same function as component ofubiquitin E3 ligase complexes (By similarity)Similarity: Belongs to the WD repeat EBI familySimilarity: Contains 1 F-box-like domainSimilarity: Contains 1 LisH domainSimilarity: Contains 8 WD repeats |
Function
for TBL1XR1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TBL1R_HUMAN, Q9BZK7Function: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclearreceptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclearreceptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactorexchange, and transcription activation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBL1XR1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBL1XR1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TBL1XR1 (NM_024665) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBL1XR1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBL1XR1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBL1XR1 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
TBL1XR1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TBL1XR1:
|
Pathways & Interactions
for TBL1XR1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant | | | 2 | Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | | | 3 | Metabolism | | | 4 | Disease | | | 5 | Regulation of Wnt-mediated beta catenin signaling and target gene transcription | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for TBL1XR1
5/17 
Reactome Pathways for TBL1XR1 (see all 17)
1 
Kegg Pathway (Kegg details for TBL1XR1):
TBL1XR1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TBL1XR1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/972 Interacting proteins for TBL1XR1 (Q9BZK72, 3 ENSP000004055744) via UniProtKB, MINT, STRING, and/or I2D (see all 972)About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IDA | 12628926 | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0007219 | Notch signaling pathway |
TAS | -- | | GO:0016568 | chromatin modification |
IEA | -- | | GO:0043161 | proteasomal ubiquitin-dependent protein catabolic process |
ISS | -- |
TBL1XR1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TBL1XR1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TBL1XR1
Search CenterWatch for drugs/clinical trials and news about TBL1XR1 / TBL1R
|
Transcripts
for TBL1XR1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TBL1XR1 gene: NM_024665.4 Unigene Cluster for TBL1XR1: Transducin (beta)-like 1 X-linked receptor 1 Hs.744001 [show with all ESTs]Unigene Representative Sequence: BX64893516 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000430069(uc003fiw.4 uc003fix.4 uc011bpz.2) ENST00000474363
ENST00000457928(uc003fiy.2) ENST00000428970 ENST00000424913 ENST00000352800
ENST00000437738 ENST00000431421 ENST00000450267 ENST00000431674 ENST00000422066
ENST00000443315 ENST00000422442 ENST00000427349 ENST00000413084 ENST00000491623
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBL1XR1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBL1XR1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TBL1XR1 (NM_024665) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBL1XR1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBL1XR1 |
Additional cDNA sequence: AF086399.1 AF267864.1 AF268193.1 AF268194.1 AF314544.1 AK022956.1 AK025746.1 AK296946.1 BC034712.1 BC048298.1 BC060320.1 BC070134.1 BC092400.1 BC113421.1 BX640629.1 BX641010.1 BX648080.1 BX648935.1 22 DOTS entries: DT.97766289 DT.217020 DT.95153832 DT.100653900 DT.95153836 DT.95097854 DT.120906951 DT.95153842 DT.120906897 DT.120907020 DT.120907053 DT.120907068 DT.91710385 DT.95153847 DT.120906905 DT.120906986 DT.95153849 DT.99970710 DT.100836177 DT.100876486 DT.120906969 DT.95180576 24/445 AceView cDNA sequences (see all 445): BQ009747 CR604897 AI749288 AA287414 BM542034 AI336386 AW385089 BF059312 BP368049 AI433493 AW069598 AI923627 N47636 AW305033 AA804479 AA287499 F09478 AI082427 AF086399 BM801254 AK022956 AW273451 AW264574 AW073259
GeneLoc Exon Structure
|
Expression
for TBL1XR1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TBL1XR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAATTACAC
About this image
See TBL1XR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TBL1XR1
SOURCE GeneReport for Unigene cluster: Hs.744001
UniProtKB/Swiss-Prot: TBL1R_HUMAN, Q9BZK7Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for TBL1XR1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBL1XR1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TBL1XR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBL1XR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBL1XR1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBL1XR1 |
Orthologs
for TBL1XR1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TBL1XR1 gene from 7/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TBL1XR11 |
transducin (beta)-like 1 X-linked receptor 1 |
88.39(n)
99.15(a) |
|
426284 NM_001031369.1 NP_001026540.1 |
lizard
(Anolis carolinensis) |
Reptilia |
TBL1XR16 |
-- |
99(a) |
1 ↔ 1 |
3(3379212-3409810) |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3986082 |
nuclear receptor co-repressor complex subunit TBLR1 |
84.68(n) |
|
AY225088.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc636172 |
hypothetical protein MGC63617 |
80.25(n) |
|
393581 BC056790.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
ebi6 |
ebi |
53(a) |
possible ortholog |
2L(415067-418536) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
HOS151 |
WD-40 repeat family protein |
61.68(n)
61.02(a) |
|
836867 NM_126132.4 NP_201533.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.195222 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
74.59(n) |
|
AK111882.1 |
ENSEMBL Gene Tree for TBL1XR1 (if available)
TreeFam Gene Tree for TBL1XR1 (if available) |
Paralogs
for TBL1XR1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TBL1XR1 gene
- TBL1Y2 THOC32 TBL1X2
4 SIMAP similar genes for TBL1XR1 using alignment to 13 protein entries: TBL1R_HUMAN (see all proteins):TBL1X TBL1Y WDR83 WDR5
TBL1XR1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for TBL1XR1
PGOHUM00000243356 PGOHUM00000243771
|
Genomic Variants
for TBL1XR1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TBL1XR1 (176737143 - 176915261 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TBL1XR1
1 CNV: 63669
Human Gene Mutation Database (HGMD): TBL1XR1
| SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing TBL1XR1: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBL1XR1 |
|
Disorders
/ Diseases
for TBL1XR1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TBL1XR1 for disorders About GeneDecksing
OMIM gene information: 608628
OMIM disorders: --
15  diseases for TBL1XR1: About MalaCardsestrogen-receptor negative breast cancer squamous cell carcinoma polycystic ovary syndrome esophageal squamous cell carcinoma
adrenal hyperplasia lung squamous cell carcinoma acute lymphoblastic leukemia lymphoblastic leukemia
lissencephaly neurofibromatosis breast cancer esophagitis
leukemia carcinoma thyroiditis
Human Genome Epidemiology (HuGE) Navigator: TBL1XR1 (1 document)
Export disorders for TBL1XR1 gene to outside databases
|
Publications
for TBL1XR1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TBL1XR1 gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with TBL1XR1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. (PubMed id 11931768)1, 2, 3 Zhang J....Roeder R.G. (2002)
- Identification of four human cDNAs that are differentially expressed by early hematopoietic progenitors. (PubMed id 11063877)1, 2, 3 Zhang X.... Basch R.S. (2000)
- Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. (PubMed id 12628926)1, 2, 9 Yoon H.-G....Wong J. (2003)
- A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. (PubMed id 14980219)1, 2, 9 Perissi V.... Rosenfeld M.G. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- TBLR1 regulates the expression of nuclear hormone receptor co-repressors. (PubMed id 16893456)1, 9 Zhang X.M....Basch R.S. (2006)
- Function of multiple Lis-Homology domain/WD-40 repeat-containing proteins in feed-forward transcriptional repression by silencing mediator for retinoic and thyroid receptor/nuclear receptor corepressor complexes. (PubMed id 18202150)1, 9 Choi H.K....Yoon H.G. (2008)
- TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints. (PubMed id 18374649)1, 9 Perissi V....Rosenfeld M.G. (2008)
- An emerin 'proteome': purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. (PubMed id 17620012)1, 9 Holaska J.M. and Wilson K.L. (2007)
|
External Searches for TBL1XR1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TBL1XR1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBL1XR1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TBL1XR1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TBL1XR1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TBL1XR1 gene:
Search GeneIP for patents involving TBL1XR1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TBL1XR1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for TBL1XR1 | | OriGene shRNA RFP for TBL1XR1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TBL1XR1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBL1XR1 | | | OriGene Protein Over-expression Lysate for TBL1XR1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for TBL1XR1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBL1XR1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBL1XR1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TBL1XR1 | | OriGene Custom Protein Services for TBL1XR1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TBL1XR1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBL1XR1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBL1XR1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBL1XR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBL1XR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBL1XR1 |
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| | | | Search Tocris compounds for TBL1XR1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBL1XR1 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBL1XR1 |
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