TBL1X Gene
protein-coding GIFtS: 56
GCID: GC0XP009431
|
|
transducin (beta)-like 1X-linked(Previous name: transducin (beta)-like 1 )
(Previous symbol: TBL1)
| |
Aliases
for TBL1X gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transducin (Beta)-Like 1X-Linked1 2 | | Transducin-Beta-Like Protein 1, X-Linked2 3 | | TBL11 2 3 5 | | SMAP552 3 | | EBI1 2 | | Transducin (Beta)-Like 11 | | Transducin Beta-Like Protein 1X2 3 | | F-Box-Like/WD Repeat-Containing Protein TBL1X2 |
Export aliases for TBL1X gene to outside databasesPrevious GC identifers: GC0XP008459 GC0XP008247 GC0XP008777 GC0XP008844 GC0XP009242 GC0XP009391 GC0XP007267 |
Summaries
for TBL1X gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TBL1X:
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. TheWD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNAprocessing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control ofcytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator forretinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to theocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onsetsensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for thisgene. This gene is highly similar to the Y chromosome TBL1Y gene. (provided by RefSeq, Nov 2008)
UniProtKB/Swiss-Prot: TBL1X_HUMAN, O60907Function: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclearreceptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclearreceptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19Sproteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, therebyallowing cofactor exchange
Gene Wiki entry for TBL1X
|
Genomic Views
for TBL1X gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167197.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TBL1X gene promoter:
GATA-3 Sox9 Nkx2-5 NF-kappaB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TBL1X
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBL1X |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp22.3 Ensembl cytogenetic band: Xp22.31 HGNC cytogenetic band: Xp22.3TBL1X Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP009431: view genomic region
(about GC identifiers)
Start:
|
9,431,335 bp from pter |
End:
|
9,687,780 bp from pter |
Size:
|
256,446 bases |
Orientation:
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plus strand |
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Proteins
for TBL1X gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TBL1X_HUMAN, O60907 (See
protein sequence)Recommended Name: F-box-like/WD repeat-containing protein TBL1X Size: 577 amino acids; 62496 Da
Subunit: Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A andGPS2. Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Probablypart of other corepressor complexes, that do not contain NCOR1 and NCOR2. Interacts with histones H2B, H3a and H4
Subcellular location: Nucleus (Probable)
3 PDB 3D structures from  and Proteopedia  for TBL1X:2XTC (3D)
2XTD (3D)
2XTE (3D)
Secondary accessions: A8K044 A8K4J7 Q86UY2Alternative splicing: 2 isoforms: O60907-1 O60907-2 Explore the universe of human proteins at neXtProt for TBL1X: NX_O60907
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60907
TBL1X Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001132938.1 NP_001132939.1 NP_001132940.1 NP_005638.1
ENSEMBL proteins: ENSP00000402923 ENSP00000370348 ENSP00000407069 ENSP00000217964 ENSP00000415508 ENSP00000397878 ENSP00000385988 ENSP00000394097 ENSP00000445317 Reactome Protein details: O60907
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
TBL1X for ontologies About GeneDecksing
TBL1X Antibody Products:
Assay Products for TBL1X: |
Protein
Domains /
Families
for TBL1X gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TBL1X for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry O60907ProtoNet protein and cluster: O60907 2 Blocks protein families: IPB001680 G-protein beta WD-40 repeat signature IPB006594 Lissencephaly type-1-like homology motif
UniProtKB/Swiss-Prot: TBL1X_HUMAN, O60907Domain: The F-box-like domain is related to the F-box domain, and apparently displays the same function as component ofubiquitin E3 ligase complexes (By similarity)Similarity: Belongs to the WD repeat EBI familySimilarity: Contains 1 F-box-like domainSimilarity: Contains 1 LisH domainSimilarity: Contains 8 WD repeats |
Function
for TBL1X gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TBL1X_HUMAN, O60907Function: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclearreceptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclearreceptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19Sproteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, therebyallowing cofactor exchange
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBL1X (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBL1X (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): TBL1X (NM_001139467) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBL1X | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBL1X |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBL1X |
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
TBL1X for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TBL1X:
|
Pathways & Interactions
for TBL1X gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant | | | 2 | Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | | | 3 | Metabolism | | | 4 | Disease | | | 5 | Regulation of Wnt-mediated beta catenin signaling and target gene transcription | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for TBL1X
5/17 
Reactome Pathways for TBL1X (see all 17)
1 
Kegg Pathway (Kegg details for TBL1X):
TBL1X for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TBL1X
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/96 Interacting proteins for TBL1X (O609073 ENSP000002179644) via UniProtKB, MINT, STRING, and/or I2D (see all 96)About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table
TBL1X for ontologies About GeneDecksing
|
Drugs & Compounds
for TBL1X gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TBL1X
Search CenterWatch for drugs/clinical trials and news about TBL1X
|
Transcripts
for TBL1X gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TBL1X gene (4 alternative transcripts): NM_001139466.1 NM_001139467.1 NM_001139468.1 NM_005647.3 Unigene Cluster for TBL1X: Transducin (beta)-like 1X-linked Hs.495656 [show with all ESTs]Unigene Representative Sequence: Y1278110 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000441088 ENST00000380961 ENST00000415293 ENST00000217964(uc004csr.3)
ENST00000422314 ENST00000452824 ENST00000497555 ENST00000407597(uc010ndq.3)
ENST00000424279(uc004csq.4 uc010ndr.3 uc004css.3) ENST00000536365
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBL1X (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBL1X (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): TBL1X (NM_001139467) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBL1X | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBL1X |
Additional cDNA sequence: AB209608.1 AK126050.1 AK289409.1 AK290962.1 BC020374.1 BC029394.1 BC032708.1 BC052304.1 Y12781.1 16 DOTS entries: DT.450114 DT.91753893 DT.95173138 DT.121292063 DT.40116314 DT.121292124 DT.75105430 DT.100014673 DT.101970533 DT.91790494 DT.100792815 DT.121292099 DT.121292126 DT.40261694 DT.95173122 DT.121292033 24/335 AceView cDNA sequences (see all 335): AI082187 BQ433019 AA335482 BE550146 BQ711071 AA814049 AI089857 AA902536 CA437319 AA936270 BC029394 AA365052 CK824079 AI203834 AL039261 BX951415 BF054987 BE297208 AI292205 AI189949 AW500219 BM706326 AI202087 BU616441
GeneLoc Exon Structure
|
Expression
for TBL1X gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TBL1X expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTCTATTG
About this image
See TBL1X Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TBL1X
SOURCE GeneReport for Unigene cluster: Hs.495656
UniProtKB/Swiss-Prot: TBL1X_HUMAN, O60907Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for TBL1X
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBL1X
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TBL1X | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBL1X | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBL1X | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBL1X |
Orthologs
for TBL1X gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TBL1X gene from 7/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TBL1X1 |
transducin (beta)-like 1X-linked |
83.24(n)
94.84(a) |
|
426045 NM_001159754.1 NP_001153226.1 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
92(a) |
1 → many |
3(118514453-118546364) |
zebrafish
(Danio rerio) |
Actinopterygii |
tbl1x1 |
transducin (beta)-like 1X-linked |
74.97(n)
85.1(a) |
|
560294 NM_001082994.1 NP_001076463.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
ebi1 , 3 |
regulation of cell cycle GTP binding3
CG4063-PA1 |
75(a)3
64.19(n)1
73.44(a)1 |
|
21C43
332121 NM_057981.31 NP_477329.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
SIF21 |
Sif2p |
40.91(n)
27.69(a) |
|
852399 NP_009661.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
HOS156 |
WD-40 repeat family protein |
43(a) |
1 → many |
5(26857154-26861119) |
rice
(Oryza sativa) |
Liliopsida |
-- |
F-box-like/WD repeat-containing protein TBL1XR1-A,... |
48(a) |
1 → many |
7(12423067-12439493) |
ENSEMBL Gene Tree for TBL1X (if available)
TreeFam Gene Tree for TBL1X (if available) |
Paralogs
for TBL1X gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TBL1X gene
- TBL1Y2 THOC32 TBL1XR12
3 SIMAP similar genes for TBL1X using alignment to 5 protein entries: TBL1X_HUMAN (see all proteins):TBL1XR1 TBL1Y WDR83
TBL1X for paralogs About GeneDecksing
|
Genomic Variants
for TBL1X gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TBL1X (9431335 - 9681335 bp, first 250kb of TBL1X)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for TBL1X
7 CNVs: 39571 2275 96466 96468 4144 83331 73935
6 Indels: 103225 96467 83333 83332 83334 96465
Human Gene Mutation Database (HGMD): TBL1X
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBL1X |
|
Disorders
/ Diseases
for TBL1X gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TBL1X for disorders About GeneDecksing
OMIM gene information: 300196
OMIM disorders: --
5  diseases for TBL1X: About MalaCardsocular albinism albinism thyroiditis intellectual disability
lissencephaly
1 Novoseek disease relationship for TBL1X gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| deafness sensorineural |
62.6 |
3 |
10330347 (2), 10809664 (1) |
Export disorders for TBL1X gene to outside databases
|
Publications
for TBL1X gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TBL1X gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with TBL1X) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats. (PubMed id 10330347)1, 2, 3, 9 Bassi M.T.... Borsani G. (1999)
- A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40- repeat protein linked to deafness. (PubMed id 10809664)1, 2, 9 Guenther M.G....Shiekhattar R. (2000)
- A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. (PubMed id 14980219)1, 2, 9 Perissi V.... Rosenfeld M.G. (2004)
- Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. (PubMed id 12628926)1, 2, 9 Yoon H.-G....Wong J. (2003)
- Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. (PubMed id 10944117)1, 2, 9 Li J.... Wong J. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. (PubMed id 11931768)1, 2 Zhang J....Roeder R.G. (2002)
- Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. (PubMed id 11389839)1, 2 Matsuzawa S. and Reed J.C. (2001)
- Direct ubiquitination of beta-catenin by Siah-1 and r egulation by the exchange factor TBL1. (PubMed id 20181957)1, 9 Dimitrova Y.N....Chazin W.J. (2010)
- Function of multiple Lis-Homology domain/WD-40 repeat-containing proteins in feed-forward transcriptional repression by silencing mediator for retinoic and thyroid receptor/nuclear receptor corepressor complexes. (PubMed id 18202150)1, 9 Choi H.K....Yoon H.G. (2008)
|
External Searches for TBL1X gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TBL1X gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBL1X gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TBL1X gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TBL1X | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TBL1X gene:
Search GeneIP for patents involving TBL1X
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TBL1X gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for TBL1X | | OriGene shRNA RFP for TBL1X | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TBL1X | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBL1X | | | OriGene Protein Over-expression Lysate for TBL1X | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TBL1X | | OriGene 3'-UTR Clone for TBL1X | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBL1X | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBL1X | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TBL1X | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TBL1X | | OriGene Custom Protein Services for TBL1X | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TBL1X | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBL1X | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBL1X | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBL1X | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBL1X | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBL1X |
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| | | | Search Tocris compounds for TBL1X |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBL1X |
|  |  |  | | | | ThermoFisher Antibodies for TBL1X |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBL1X |
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