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Aliases for TBKBP1 Gene

Aliases for TBKBP1 Gene

  • TBK1 Binding Protein 1 2 3 5
  • TBK1-Binding Protein 1 3 4
  • SINTBAD 3 4
  • ProSAPiP2 3
  • KIAA0775 4

External Ids for TBKBP1 Gene

Previous GeneCards Identifiers for TBKBP1 Gene

  • GC17P043127
  • GC17P045772
  • GC17P041141

Summaries for TBKBP1 Gene

Entrez Gene Summary for TBKBP1 Gene

  • TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 [PubMed 14743216]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TBKBP1 Gene

TBKBP1 (TBK1 Binding Protein 1) is a Protein Coding gene. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and NF-kappaB Signaling.

UniProtKB/Swiss-Prot for TBKBP1 Gene

  • Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBKBP1 Gene

Genomics for TBKBP1 Gene

Regulatory Elements for TBKBP1 Gene

Enhancers for TBKBP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TBKBP1 on UCSC Golden Path with GeneCards custom track

Promoters for TBKBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TBKBP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TBKBP1 Gene

47,694,065 bp from pter
47,712,063 bp from pter
17,999 bases
Plus strand

Genomic View for TBKBP1 Gene

Genes around TBKBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBKBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBKBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBKBP1 Gene

Proteins for TBKBP1 Gene

  • Protein details for TBKBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TANK-binding kinase 1-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • B2RZG6
    • O94873
    • Q14DW3

    Protein attributes for TBKBP1 Gene

    615 amino acids
    Molecular mass:
    67702 Da
    Quaternary structure:
    • Homodimer. May form a heterodimer with NAP1. Interacts with TKB1 and IKBKE.
    • Sequence=BAA34495.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TBKBP1 Gene


neXtProt entry for TBKBP1 Gene

Proteomics data for TBKBP1 Gene at MOPED

Post-translational modifications for TBKBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBKBP1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TBKBP1 (TBKBP1)

No data available for DME Specific Peptides for TBKBP1 Gene

Domains & Families for TBKBP1 Gene

Protein Domains for TBKBP1 Gene


Suggested Antigen Peptide Sequences for TBKBP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TBKBP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TBKBP1 Gene

Function for TBKBP1 Gene

Molecular function for TBKBP1 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.
genes like me logo Genes that share phenotypes with TBKBP1: view

Animal Models for TBKBP1 Gene

MGI Knock Outs for TBKBP1:

Animal Model Products

miRNA for TBKBP1 Gene

miRTarBase miRNAs that target TBKBP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TBKBP1 Gene

Localization for TBKBP1 Gene

Subcellular locations from

Jensen Localization Image for TBKBP1 Gene COMPARTMENTS Subcellular localization image for TBKBP1 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TBKBP1 Gene

Pathways & Interactions for TBKBP1 Gene

genes like me logo Genes that share pathways with TBKBP1: view

Pathways by source for TBKBP1 Gene

1 Cell Signaling Technology pathway for TBKBP1 Gene
1 KEGG pathway for TBKBP1 Gene

Gene Ontology (GO) - Biological Process for TBKBP1 Gene


No data available for SIGNOR curated interactions for TBKBP1 Gene

Drugs & Compounds for TBKBP1 Gene

No Compound Related Data Available

Transcripts for TBKBP1 Gene

Unigene Clusters for TBKBP1 Gene

TBK1 binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBKBP1 Gene

No ASD Table

Relevant External Links for TBKBP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBKBP1 Gene

mRNA expression in normal human tissues for TBKBP1 Gene

mRNA differential expression in normal tissues according to GTEx for TBKBP1 Gene

This gene is overexpressed in Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for TBKBP1 Gene

This gene is overexpressed in Heart (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TBKBP1 Gene

SOURCE GeneReport for Unigene cluster for TBKBP1 Gene Hs.94790

mRNA Expression by UniProt/SwissProt for TBKBP1 Gene

Tissue specificity: Detected in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, muscle, heart, brain and at low levels in thymus.
genes like me logo Genes that share expression patterns with TBKBP1: view

Protein tissue co-expression partners for TBKBP1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TBKBP1 Gene

Orthologs for TBKBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TBKBP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TBKBP1 35
  • 91.69 (n)
  • 95.6 (a)
  • 96 (a)
(Canis familiaris)
Mammalia TBKBP1 35
  • 89.53 (n)
  • 92.89 (a)
  • 92 (a)
(Mus musculus)
Mammalia Tbkbp1 35
  • 86.54 (n)
  • 92.28 (a)
Tbkbp1 16
Tbkbp1 36
  • 93 (a)
(Pan troglodytes)
Mammalia TBKBP1 35
  • 93.71 (n)
  • 91.95 (a)
  • 94 (a)
(Rattus norvegicus)
Mammalia Tbkbp1 35
  • 86.27 (n)
  • 92.32 (a)
(Ornithorhynchus anatinus)
Mammalia TBKBP1 36
  • 70 (a)
(Gallus gallus)
Aves TBKBP1 35
  • 72.66 (n)
  • 68.91 (a)
  • 68 (a)
(Anolis carolinensis)
Reptilia TBKBP1 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tbkbp1 35
  • 63.47 (n)
  • 60.69 (a)
(Danio rerio)
Actinopterygii tbkbp1 35
  • 58.18 (n)
  • 54.55 (a)
tbkbp1 36
  • 45 (a)
Species with no ortholog for TBKBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBKBP1 Gene

Gene Tree for TBKBP1 (if available)
Gene Tree for TBKBP1 (if available)

Paralogs for TBKBP1 Gene

(1) SIMAP similar genes for TBKBP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TBKBP1: view

No data available for Paralogs for TBKBP1 Gene

Variants for TBKBP1 Gene

Sequence variations from dbSNP and Humsavar for TBKBP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1801887 -- 47,711,981(+) GGGGC(C/G)TGGAG nc-transcript-variant, utr-variant-3-prime
rs4267364 -- 47,703,898(+) AAGAA(A/G)TTCAG intron-variant
rs4439799 -- 47,704,233(+) GGATT(C/T)GTGGC intron-variant
rs4561509 -- 47,704,433(+) GGGTC(A/G)GGCGG intron-variant
rs4794053 -- 47,692,185(+) ATTGG(A/G)GGAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TBKBP1 Gene

Variant ID Type Subtype PubMed ID
nsv908571 CNV Loss 21882294
nsv9570 CNV Gain 18304495

Variation tolerance for TBKBP1 Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.76; 66.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TBKBP1 Gene

Disorders for TBKBP1 Gene

Relevant External Links for TBKBP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TBKBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBKBP1 Gene

Publications for TBKBP1 Gene

  1. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PMID: 14743216) Bouwmeester T. … Superti-Furga G. (Nat. Cell Biol. 2004) 2 3 4 67
  2. ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3. (PMID: 19481056) Liebau S. … Boeckers T.M. (Biochem. Biophys. Res. Commun. 2009) 2 3
  3. Genetic loci associated with circulating levels of very long-chain saturated fatty acids. (PMID: 25378659) Lemaitre R.N. … Friedlander Y. (J. Lipid Res. 2015) 3
  4. Analysis of clinical indexes and RUNX3, TBKBP1, PPARGC1B polymorphisms in Chinese Han patients with ankylosing spondylitis. (PMID: 25494292) Liu J. … Wang Y. (Genet Test Mol Biomarkers 2015) 3
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3

Products for TBKBP1 Gene

Sources for TBKBP1 Gene