Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TBKBP1 Gene

protein-coding   GIFtS: 51
GCID: GC17P045772

TBK1 Binding Protein 1

  See TBKBP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
TBK1 Binding Protein 11 2     ProSAPiP22
SINTBAD2 3     TANK-Binding Kinase 1-Binding Protein 12
TBK1-Binding Protein 12 3     PROSAPIP25
KIAA07753 5     

External Ids:    HGNC: 301401   Entrez Gene: 97552   Ensembl: ENSG000001989337   OMIM: 6084765   UniProtKB: A7MCY63   

Export aliases for TBKBP1 gene to outside databases

Previous GC identifers: GC17P043127 GC17P041141


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TBKBP1 Gene:
TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF
(MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 (PubMed 14743216)).(supplied by OMIM, Mar
2008)

GeneCards Summary for TBKBP1 Gene:
TBKBP1 (TBK1 binding protein 1) is a protein-coding gene. Diseases associated with TBKBP1 include low tension glaucoma.

UniProtKB/Swiss-Prot: TBKB1_HUMAN, A7MCY6
Function: Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TBKBP1 gene promoter:
         AhR   RREB-1   Lmo2   POU3F2   NF-E2 p45   Arnt   HOXA5   c-Myb   LyF-1   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBKBP1 promoter sequence
   Search Chromatin IP Primers for TBKBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBKBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

TBKBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBKBP1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P045772:  view genomic region     (about GC identifiers)

Start:
45,771,447 bp from pter      End:
45,789,429 bp from pter
Size:
17,983 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TBKB1_HUMAN, A7MCY6 (See protein sequence)
Recommended Name: TANK-binding kinase 1-binding protein 1  
Size: 615 amino acids; 67702 Da
Subunit: Homodimer. May form a heterodimer with NAP1. Interacts with TKB1 and IKBKE
Sequence caution: Sequence=BAA34495.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RZG6 O94873 Q14DW3
Alternative splicing: 2 isoforms:  A7MCY6-1   A7MCY6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TBKBP1: NX_A7MCY6

Explore proteomics data for TBKBP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TBKBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055541.1  
    ENSEMBL proteins: 
     ENSP00000462339   ENSP00000446365   ENSP00000354777  

    TBKBP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TBKBP1
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TBKBP1
    GenScript Custom Purified and Recombinant Proteins Services for TBKBP1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TBKBP1

     
    Search eBioscience for Proteins for TBKBP1 

     
    antibodies-online proteins for TBKBP1 (3 products) 

     
    antibodies-online peptides for TBKBP1

    TBKBP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for TBKBP1 
    OriGene Antibodies for TBKBP1
    OriGene Custom Antibody Services for TBKBP1
    Novus Biologicals TBKBP1 Antibodies
    Abcam antibodies for TBKBP1
    Cloud-Clone Corp. Antibodies for TBKBP1
    ThermoFisher Antibodies for TBKBP1
    antibodies-online antibodies for TBKBP1 (30 products) 

    TBKBP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TBKBP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TBKBP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TBKBP1
    Cloud-Clone Corp. CLIAs for TBKBP1
    Search eBioscience for ELISAs for TBKBP1 
    antibodies-online kits for TBKBP1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR024581 TBD

    Graphical View of Domain Structure for InterPro Entry A7MCY6

    ProtoNet protein and cluster: A7MCY6


    Find genes that share domains with TBKBP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBKB1_HUMAN, A7MCY6
    Function: Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14743216
         
    Find genes that share ontologies with TBKBP1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tbkbp1):
     hematopoietic system  immune system 

    Find genes that share phenotypes with TBKBP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tbkbp1tm1Aki for TBKBP1

       genOway: Develop your customized and physiologically relevant rodent model for TBKBP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TBKBP1:
    hsa-mir-335-5p (MIRT017616)

    Block miRNA regulation of human, mouse, rat TBKBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TBKBP1 (see all 39):
    hsa-let-7d hsa-miR-513a-5p hsa-miR-3921 hsa-let-7g hsa-let-7a hsa-miR-637 hsa-miR-3116 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidTBKBP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TBKBP1
    Predesigned siRNA for gene silencing in human, mouse, rat TBKBP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TBKBP1

    Clone
    Products:
         
    OriGene clones in human, mouse for TBKBP1 (see all 6)
    OriGene ORF clones in mouse, rat for TBKBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TBKBP1 (NM_014726)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBKBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBKBP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TBKBP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TBKBP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBKBP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TBKBP1 About    
    See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I-like receptor signaling pathway0.47
    2NF-kappaB Signaling
    NF-kappaB Signaling


    Find genes that share SuperPaths with TBKBP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for TBKBP1
        NF-kappaB Signaling


    1 Kegg Pathway  (Kegg details for TBKBP1):
        RIG-I-like receptor signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBKBP1
    Interactions:

        Search GeneGlobe Interaction Network for TBKBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for TBKBP1 (A7MCY61, 2, 3 ENSP000003547774) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBK1Q9UHD21, 2, 3, ENSP000003299674EBI-359969,EBI-356402 MINT-5114931 MINT-5114886 MINT-49254 MINT-48041 MINT-5114907 MINT-5115080 I2D: score=6 STRING: ENSP00000329967
    RB1CC1Q8TDY21, 3, ENSP000000250084EBI-359969,EBI-1047793 I2D: score=2 STRING: ENSP00000025008
    IKBKEQ141641, 2, 3, ENSP000003560874EBI-359969,EBI-307369 MINT-5114952 MINT-5114886 I2D: score=3 STRING: ENSP00000356087
    AGO2Q9UKV81, 3, ENSP000002205924EBI-359969,EBI-528269 I2D: score=1 STRING: ENSP00000220592
    APBA3O960181, 3, ENSP000003151364EBI-359969,EBI-6115839 I2D: score=1 STRING: ENSP00000315136
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045087innate immune response IEA--

    Find genes that share ontologies with TBKBP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TBKBP1 (TBKB1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TBKBP1 gene: 
    NM_014726.2  

    Unigene Cluster for TBKBP1:

    TBK1 binding protein 1
    Hs.94790  [show with all ESTs]
    Unigene Representative Sequence: NM_014726
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000578982 ENST00000537587 ENST00000361722(uc002ilu.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TBKBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TBKBP1 (see all 39):
    hsa-let-7d hsa-miR-513a-5p hsa-miR-3921 hsa-let-7g hsa-let-7a hsa-miR-637 hsa-miR-3116 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidTBKBP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TBKBP1
    Predesigned siRNA for gene silencing in human, mouse, rat TBKBP1
    Clone
    Products:
         
    OriGene clones in human, mouse for TBKBP1 (see all 6)
    OriGene ORF clones in mouse, rat for TBKBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TBKBP1 (NM_014726)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBKBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBKBP1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TBKBP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBKBP1
      QuantiTect SYBR Green Assays in human, mouse, rat TBKBP1
      QuantiFast Probe-based Assays in human, mouse, rat TBKBP1

    Additional mRNA sequence: 

    AB018318.1 BC111418.1 BC152407.1 BC167150.1 

    4 DOTS entries:

    DT.211461  DT.120946908  DT.95365893  DT.102824607 

    Selected AceView cDNA sequences (see all 64):

    AI014800 BQ941075 BM709305 AB018318 CR620734 BU733532 AI146283 CB243387 
    AA833948 BX393869 BM708383 BX280712 AI242025 CN479801 BU732451 AA340006 
    BQ003943 AI935912 AW302581 BE299966 AI475535 AI278474 CA439465 BM475165 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TBKBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCGCTCTT
    TBKBP1 Expression
    About this image

    TBKBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TBKBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.94790

    UniProtKB/Swiss-Prot: TBKB1_HUMAN, A7MCY6
    Tissue specificity: Detected in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, muscle, heart,
    brain and at low levels in thymus

        Custom PCR Arrays for TBKBP1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TBKBP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBKBP1
    QuantiTect SYBR Green Assays in human, mouse, rat TBKBP1
    QuantiFast Probe-based Assays in human, mouse, rat TBKBP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBKBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TBKBP1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbkbp11 , 5 TBK1 binding protein 11, 5 86.54(n)1
    92.28(a)1
      11 (60.95 cM)5
    731741  NM_198100.21  NP_932768.21 
     971361735 
    chicken
    (Gallus gallus)
    Aves TBKBP11 TBK1 binding protein 1 72.66(n)
    68.91(a)
      430679  XM_428232.4  XP_428232.3 
    lizard
    (Anolis carolinensis)
    Reptilia TBKBP16
    TBK1 binding protein 1
    65(a)
    1 ↔ 1
    6(74276973-74326865)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tbkbp11 TBK1 binding protein 1 63.47(n)
    60.69(a)
      100496177  XM_002940153.2  XP_002940199.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tbkbp11 TBK1 binding protein 1 58.18(n)
    54.55(a)
      559568  XM_005156249.1  XP_005156306.1 


    ENSEMBL Gene Tree for TBKBP1 (if available)
    TreeFam Gene Tree for TBKBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TBKBP1 gene
    1 SIMAP similar gene for TBKBP1 using alignment to 4 protein entries:     TBKB1_HUMAN (see all proteins):
    AZI2

    Find genes that share paralogs with TBKBP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TBKBP1 (see all 367)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1382292031,2
    --41139674(+) TTCCTC/TCATGA 1 -- us2k10--------
    rs1509947081,2
    C--45770828(+) GTGTG-/GGGA  
            
    GGGAG
    1 -- us2k10--------
    rs1869577371,2
    --45770936(+) CAATGC/TATTTA 1 -- us2k10--------
    rs80755661,2
    C,F,A,H--45771037(+) AGCCAA/GATAAA 1 -- us2k119Minor allele frequency- G:0.36NS EA WA CSA NA 2336
    rs1932534741,2
    --45771297(+) GCGGCA/GGGGTC 1 -- us2k10--------
    rs1495557301,2
    --45771774(+) CCTTCA/CCCGGC 1 -- us2k10--------
    rs620740541,2
    C,F--45771816(+) GCCGGC/TTGTGG 1 -- us2k16Minor allele frequency- T:0.32NA CSA WA EA 363
    rs679192081,2
    C--45771873(+) ATTTCC/TGTCGG 1 -- us2k15Minor allele frequency- T:0.43NA CSA WA EA 361
    rs620740551,2
    C--45771933(+) GCCCGC/GGCCGA 1 -- us2k14Minor allele frequency- G:0.44NA CSA WA 241
    rs1853867441,2
    C--45771936(+) CGGGCA/CGACAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TBKBP1 (45771447 - 45789429 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TBKBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908571CNV Loss21882294
    nsv9570CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TBKBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for TBKBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608476    OMIM disorders: --

    1 disease for TBKBP1:    
    About MalaCards
    low tension glaucoma

    1 disease from the University of Copenhagen DISEASES database for TBKBP1:
    Low tension glaucoma

    Find genes that share disorders with TBKBP1           About GenesLikeMe


    Export disorders for TBKBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TBKBP1 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with TBKBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PubMed id 14743216)1, 2, 3 Bouwmeester T....Superti-Furga G. (Nat. Cell Biol. 2004)
    2. ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3. (PubMed id 19481056)1, 3 Liebau S....Boeckers T.M. (Biochem. Biophys. Res. Commun. 2009)
    3. SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. (PubMed id 17568778)1, 2 Ryzhakov G. and Randow F. (EMBO J. 2007)
    4. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    5. Identification of proteins that interact with TANK binding kinase 1 and testing for mutations associated with glaucoma. (PubMed id 23286385)1 Seo S....Fingert J.H. (Curr. Eye Res. 2013)
    6. Analysis of PPARGC1B, RUNX3 and TBKBP1 polymorphisms in Chinese Han patients with ankylosing spondylitis: a case-control study. (PubMed id 23637848)1 Lian Z....Wang Y. (PLoS ONE 2013)
    7. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    8. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    9. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    10. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. (PubMed id 22190364)1 Patsopoulos N.A....de Bakker P.I. (Ann. Neurol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9755 HGNC: 30140 AceView: ProSAPiP2 Ensembl:ENSG00000198933 euGenes: HUgn9755
    ECgene: TBKBP1 Kegg: 9755 H-InvDB: TBKBP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0775

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TBKBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TBKBP1 gene:
    Search GeneIP for patents involving TBKBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TBKBP1   OriGene RNAi products in human, mouse, rat for TBKBP1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TBKBP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for TBKBP1   OriGene Purified Protein for TBKBP1  
     OriGene ORF clones in mouse, rat for TBKBP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TBKBP1   OriGene Custom Protein Services for TBKBP1  

     
     
     Block miRNA regulation of human, mouse, rat TBKBP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TBKBP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBKBP1 Predesigned siRNA for gene silencing in human, mouse, rat TBKBP1
     QuantiFast Probe-based Assays in human, mouse, rat TBKBP1 QuantiTect SYBR Green Assays in human, mouse, rat TBKBP1
     Custom PCR Arrays for TBKBP1 Search Chromatin IP Primers for TBKBP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBKBP1  Search GeneGlobe Interaction Network for TBKBP1
     Regulatory tfbs in TBKBP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TBKBP1 GenScript cDNA clones with any tag delivered in your preferred vector for TBKBP1
     GenScript Custom Assay Services for TBKBP1 GenScript Custom overexpressing Cell Line Services for TBKBP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for TBKBP1 

     Search Tocris compounds for TBKBP1 (TBKB1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TBKBP1 antibodies
     Antibodies for TBKBP1
     See all of Abcam's Antibodies, Kits and Proteins for TBKBP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TBKBP1
     Antibodies for TBKBP1
     ELISAs for TBKBP1
     CLIAs for TBKBP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for TBKBP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBKBP1
     SwitchGear 3'UTR luciferase reporter plasmids for TBKBP1
     SwitchGear Promoter luciferase reporter plasmids for TBKBP1
     ThermoFisher Antibodies for TBKBP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBKBP1
     Browse compounds at ApexBio
     Search Addgene for plasmids for TBKBP1
      Search eBioscience for proteins for TBKBP1
      Search eBioscience for elisas for TBKBP1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for TBKBP1
     antibodies-online antibodies for TBKBP1 (30 products)
     antibodies-online kits for TBKBP1 (6 products)
     antibodies-online peptides for TBKBP1
     antibodies-online proteins for TBKBP1 (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TBKBP1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4