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Aliases for TBKBP1 Gene

Aliases for TBKBP1 Gene

  • TBK1 Binding Protein 1 2 3
  • TBK1-Binding Protein 1 3 4
  • ProSAPiP2 3 6
  • KIAA0775 4 6
  • SINTBAD 3 4
  • TANK-Binding Kinase 1-Binding Protein 1 3

External Ids for TBKBP1 Gene

Summaries for TBKBP1 Gene

Entrez Gene Summary for TBKBP1 Gene

  • TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 [PubMed 14743216]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TBKBP1 Gene

TBKBP1 (TBK1 Binding Protein 1) is a Protein Coding gene. Diseases associated with TBKBP1 include low tension glaucoma. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and NF-kappaB Signaling.

UniProtKB/Swiss-Prot for TBKBP1 Gene

  • Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBKBP1 Gene

Genomics for TBKBP1 Gene

Genomic Location for TBKBP1 Gene

Start:
47,694,061 bp from pter
End:
47,712,063 bp from pter
Size:
18,003 bases
Orientation:
Plus strand

Genomic View for TBKBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBKBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBKBP1 Gene

Regulatory Elements for TBKBP1 Gene

Proteins for TBKBP1 Gene

  • Protein details for TBKBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A7MCY6-TBKB1_HUMAN
    Recommended name:
    TANK-binding kinase 1-binding protein 1
    Protein Accession:
    A7MCY6
    Secondary Accessions:
    • B2RZG6
    • O94873
    • Q14DW3

    Protein attributes for TBKBP1 Gene

    Size:
    615 amino acids
    Molecular mass:
    67702 Da
    Quaternary structure:
    • Homodimer. May form a heterodimer with NAP1. Interacts with TKB1 and IKBKE.
    SequenceCaution:
    • Sequence=BAA34495.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TBKBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBKBP1 Gene

Proteomics data for TBKBP1 Gene at MOPED

Post-translational modifications for TBKBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBKBP1 Gene

No data available for DME Specific Peptides for TBKBP1 Gene

Domains for TBKBP1 Gene

Protein Domains for TBKBP1 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with TBKBP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TBKBP1 Gene

Function for TBKBP1 Gene

Molecular function for TBKBP1 Gene

UniProtKB/Swiss-Prot Function: Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.

Gene Ontology (GO) - Molecular Function for TBKBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14743216
genes like me logo Genes that share ontologies with TBKBP1: view

Phenotypes for TBKBP1 Gene

genes like me logo Genes that share phenotypes with TBKBP1: view

Animal Models for TBKBP1 Gene

MGI Knock Outs for TBKBP1:

miRNA for TBKBP1 Gene

miRTarBase miRNAs that target TBKBP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TBKBP1 Gene

Localization for TBKBP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBKBP1 Gene COMPARTMENTS Subcellular localization image for TBKBP1 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for TBKBP1 Gene

Pathways for TBKBP1 Gene

genes like me logo Genes that share pathways with TBKBP1: view

Pathways by source for TBKBP1 Gene

1 Cell Signaling Technology pathway for TBKBP1 Gene
1 KEGG pathway for TBKBP1 Gene

Gene Ontology (GO) - Biological Process for TBKBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with TBKBP1: view

Transcripts for TBKBP1 Gene

Unigene Clusters for TBKBP1 Gene

TBK1 binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBKBP1 Gene

No ASD Table

Relevant External Links for TBKBP1 Gene

GeneLoc Exon Structure for
TBKBP1
ECgene alternative splicing isoforms for
TBKBP1

Expression for TBKBP1 Gene

mRNA expression in normal human tissues for TBKBP1 Gene

mRNA differential expression in normal tissues according to GTEx for TBKBP1 Gene

This gene is overexpressed in Whole Blood (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TBKBP1 Gene

SOURCE GeneReport for Unigene cluster for TBKBP1 Gene Hs.94790

mRNA Expression by UniProt/SwissProt for TBKBP1 Gene

A7MCY6-TBKB1_HUMAN
Tissue specificity: Detected in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, muscle, heart, brain and at low levels in thymus.
genes like me logo Genes that share expressions with TBKBP1: view

Orthologs for TBKBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TBKBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBKBP1 36
  • 93.71 (n)
  • 91.95 (a)
TBKBP1 37
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TBKBP1 36
  • 91.69 (n)
  • 95.6 (a)
TBKBP1 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBKBP1 36
  • 89.53 (n)
  • 92.89 (a)
TBKBP1 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbkbp1 36
  • 86.54 (n)
  • 92.28 (a)
Tbkbp1 16
Tbkbp1 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TBKBP1 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbkbp1 36
  • 86.27 (n)
  • 92.32 (a)
chicken
(Gallus gallus)
Aves TBKBP1 36
  • 72.66 (n)
  • 68.91 (a)
TBKBP1 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBKBP1 37
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tbkbp1 36
  • 63.47 (n)
  • 60.69 (a)
zebrafish
(Danio rerio)
Actinopterygii tbkbp1 36
  • 58.18 (n)
  • 54.55 (a)
tbkbp1 37
  • 45 (a)
OneToOne
Species with no ortholog for TBKBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBKBP1 Gene

ENSEMBL:
Gene Tree for TBKBP1 (if available)
TreeFam:
Gene Tree for TBKBP1 (if available)

Paralogs for TBKBP1 Gene

Selected SIMAP similar genes for TBKBP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TBKBP1: view

No data available for Paralogs for TBKBP1 Gene

Variants for TBKBP1 Gene

Sequence variations from dbSNP and Humsavar for TBKBP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1801887 -- 47,711,981(+) GGGGC(C/G)TGGAG utr-variant-3-prime
rs4267364 -- 47,703,898(+) AAGAA(A/G)TTCAG intron-variant
rs4439799 -- 47,704,233(+) GGATT(C/T)GTGGC intron-variant
rs4561509 -- 47,704,433(+) GGGTC(A/G)GGCGG intron-variant
rs4794053 -- 47,692,185(+) ATTGG(A/G)GGAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TBKBP1 Gene

Variant ID Type Subtype PubMed ID
nsv908571 CNV Loss 21882294
nsv9570 CNV Gain 18304495

Relevant External Links for TBKBP1 Gene

HapMap Linkage Disequilibrium report
TBKBP1

Disorders for TBKBP1 Gene

(1) MalaCards Diseases for TBKBP1 Gene

Search for TBKBP1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TBKBP1 Gene

genes like me logo Genes that share disorders with TBKBP1: view

No data available for UniProtKB/Swiss-Prot for TBKBP1 Gene

Publications for TBKBP1 Gene

  1. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PMID: 14743216) Bouwmeester T. … Superti-Furga G. (Nat. Cell Biol. 2004) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  3. SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. (PMID: 17568778) Ryzhakov G. … Randow F. (EMBO J. 2007) 3 4
  4. ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3. (PMID: 19481056) Liebau S. … Boeckers T.M. (Biochem. Biophys. Res. Commun. 2009) 2 3
  5. The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. (PMID: 19820708) Thurston T.L. … Randow F. (Nat. Immunol. 2009) 3

Products for TBKBP1 Gene

Sources for TBKBP1 Gene

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