TBKBP1 Gene
protein-coding GIFtS: 51
GCID: GC17P045772
|
|
TBK1 binding protein 1
| |
Aliases
for TBKBP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TBK1 Binding Protein 11 2 | | ProSAPiP21 2 | | KIAA07751 3 | | TBK1-Binding Protein 12 3 | | SINTBAD2 | | TANK-Binding Kinase 1-Binding Protein 12 |
Export aliases for TBKBP1 gene to outside databasesPrevious GC identifers: GC17P043127 GC17P041141 |
Summaries
for TBKBP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TBKBP1:
TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 (PubMed 14743216)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: TBKB1_HUMAN, A7MCY6Function: Adapter protein which constitutively binds TBK1 and IKBKE and may play a role in antiviral innate immunity(By similarity)
|
Genomic Views
for TBKBP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TBKBP1 gene promoter:
AhR RREB-1 Lmo2 POU3F2 NF-E2 p45 Arnt HOXA5 c-Myb LyF-1 NF-E2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TBKBP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBKBP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.32 Ensembl cytogenetic band: 17q21.32 HGNC cytogenetic band: 17q21.32TBKBP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P045772: view genomic region
(about GC identifiers)
Start:
|
45,771,447 bp from pter |
End:
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45,789,429 bp from pter |
Size:
|
17,983 bases |
Orientation:
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plus strand |
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Proteins
for TBKBP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TBKB1_HUMAN, A7MCY6 (See
protein sequence)Recommended Name: TANK-binding kinase 1-binding protein 1 Size: 615 amino acids; 67702 Da
Subunit: Homodimer. May form a heterodimer with NAP1. Interacts with TKB1 and IKBKE (By similarity)
Sequence caution: Sequence=BAA34495.2; Type=Erroneous initiation;
Secondary accessions: B2RZG6 O94873 Q14DW3Alternative splicing: 2 isoforms: A7MCY6-1 A7MCY6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TBKBP1: NX_A7MCY6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A7MCY6
TBKBP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055541.1
ENSEMBL proteins: ENSP00000462339 ENSP00000446365 ENSP00000354777
Human Recombinant Protein Products:
TBKBP1 Antibody Products:
Assay Products for TBKBP1: |
Protein
Domains /
Families
for TBKBP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TBKBP1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A7MCY6ProtoNet protein and cluster: A7MCY6 |
Function
for TBKBP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TBKB1_HUMAN, A7MCY6Function: Adapter protein which constitutively binds TBK1 and IKBKE and may play a role in antiviral innate immunity(By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBKBP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBKBP1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
TBKBP1 for ontologies About GeneDecksing
|
Pathways & Interactions
for TBKBP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | NF-kappaB Signaling | | | 2 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for TBKBP1
1 
Kegg Pathway (Kegg details for TBKBP1):
TBKBP1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBKBP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/16 Interacting proteins for TBKBP1 (A7MCY61, 2, 3 ENSP000003547774) via UniProtKB, MINT, STRING, and/or I2D (see all 16)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| TBK1 | Q9UHD22, 3, ENSP000003299674 | MINT-5114931 MINT-5114886 MINT-49254 MINT-48041 MINT-5114907 MINT-5115080 I2D:
score=6 STRING: ENSP00000329967 | | RB1CC1 | Q8TDY21, 3, ENSP000000250084 | EBI-359969,EBI-1047793 I2D:
score=2 STRING: ENSP00000025008 | | EIF2C2 | Q9UKV81, 3 | EBI-359969,EBI-528269 I2D:
score=1 | | IKBKE | Q141642, 3, ENSP000003560874 | MINT-5114952 MINT-5114886 I2D:
score=3 STRING: ENSP00000356087 | | AGO2 | Q9UKV81, 3, ENSP000002205924 | EBI-359969,EBI-528269 I2D:
score=1 STRING: ENSP00000220592 |
About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045087 | innate immune response |
IEA | -- |
TBKBP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TBKBP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TBKBP1
Search CenterWatch for drugs/clinical trials and news about TBKBP1 / TBKB1
|
Transcripts
for TBKBP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TBKBP1 gene: NM_014726.2 Unigene Cluster for TBKBP1: TBK1 binding protein 1 Hs.94790 [show with all ESTs]Unigene Representative Sequence: NM_0147263 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000578982 ENST00000537587 ENST00000361722(uc002ilu.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBKBP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBKBP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TBKBP1 (NM_014726) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBKBP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBKBP1 |
Additional cDNA sequence: AB018318.1 BC111418.1 BC152407.1 BC167150.1 4 DOTS entries: DT.211461 DT.120946908 DT.95365893 DT.102824607 24/64 AceView cDNA sequences (see all 64): AI242025 BM709305 BU733532 BQ003943 BX280712 BM708383 BX393869 BU732451 AI146283 AB018318 BQ941075 CB243387 AA833948 AA340006 CR620734 AI014800 CN479801 BM669266 BG910616 AI278474 BU732140 AV742609 BM424049 AI475535
GeneLoc Exon Structure
|
Expression
for TBKBP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TBKBP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCCGCTCTT
About this image
See TBKBP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TBKBP1
SOURCE GeneReport for Unigene cluster: Hs.94790
SABiosciences Custom PCR Arrays for TBKBP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBKBP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TBKBP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBKBP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBKBP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBKBP1 |
Orthologs
for TBKBP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TBKBP1 gene from 3/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TBKBP11 |
TBK1 binding protein 1 |
71.96(n)
68.63(a) |
|
430679 XM_428232.3 XP_428232.3 |
lizard
(Anolis carolinensis) |
Reptilia |
TBKBP16 |
-- |
66(a) |
1 ↔ 1 |
6(74277032-74326865) |
zebrafish
(Danio rerio) |
Actinopterygii |
CR932059.26 |
-- |
44(a) |
1 ↔ 1 |
12(30165379-30226482) |
ENSEMBL Gene Tree for TBKBP1 (if available)
TreeFam Gene Tree for TBKBP1 (if available) |
Paralogs
for TBKBP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TBKBP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TBKBP1 (45771447 - 45789429 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TBKBP1
1 CNV: 30841 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBKBP1 |
|
Disorders
/ Diseases
for TBKBP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TBKBP1 for disorders About GeneDecksing
OMIM gene information: 608476
OMIM disorders: --
1  disease for TBKBP1: About MalaCardsparkinson's disease
1 disease from the University of Copenhagen DISEASES database for TBKBP1:Low tension glaucoma Export disorders for TBKBP1 gene to outside databases
|
Publications
for TBKBP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TBKBP1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with TBKBP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PubMed id 14743216)1, 2, 3 Bouwmeester T....Superti-Furga G. (2004)
- ProSAPiP2, a novel postsynaptic density protein that i nteracts with ProSAP2/Shank3. (PubMed id 19481056)1, 3 Liebau S....Boeckers T.M. (2009)
- Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (1998)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
- Genome-wide meta-analysis identifies novel multiple sc lerosis susceptibility loci. (PubMed id 22190364)1 Patsopoulos N.A....de Bakker P.I. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interaction between ERAP1 and HLA-B27 in ankylosing sp ondylitis implicates peptide handling in the mechanism for HLA-B27 in disease su sceptibility. (PubMed id 21743469)1 Evans D.M.... . (2011)
- The TBK1 adaptor and autophagy receptor NDP52 restric ts the proliferation of ubiquitin-coated bacteria. (PubMed id 19820708)1 Thurston T.L....Randow F. (2009)
- Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
|
External Searches for TBKBP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TBKBP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBKBP1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TBKBP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TBKBP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TBKBP1 gene:
Search GeneIP for patents involving TBKBP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TBKBP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for TBKBP1 | | OriGene shRNA RFP for TBKBP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TBKBP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBKBP1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TBKBP1 | | OriGene 3'-UTR Clone for TBKBP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBKBP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBKBP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TBKBP1 | | OriGene Custom Protein Services for TBKBP1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TBKBP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBKBP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBKBP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBKBP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBKBP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBKBP1 |
| |
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| |  |  |  |  | | | | |
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 | | | TBKBP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBKBP1 |
|  |  |  | | | | ThermoFisher Antibodies for TBKBP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBKBP1 |
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