TBK1 Gene
protein-coding GIFtS: 64
GCID: GC12P064845
|
|
TANK-binding kinase 1
| |
Aliases
for TBK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TANK-Binding Kinase 11 2 3 | | NF-KB-Activating Kinase2 | | NAK1 2 3 | | Serine/Threonine-Protein Kinase TBK12 | | T2K2 3 | | EC 2.7.11.13 | | NF-Kappa-B-Activating Kinase2 3 | | EC 2.7.118 |
Export aliases for TBK1 gene to outside databasesPrevious GC identifers: GC00U990677 GC13U900006 GC12P064562 GC12P063132 GC12P061898 |
Summaries
for TBK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TBK1:
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trappingit in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destructionvia the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The proteinencoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.(provided by RefSeq, Oct 2010)
UniProtKB/Swiss-Prot: TBK1_HUMAN, Q9UHD2Function: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents.Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK andphosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequenthomodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory andantiviral genes including IFN-alpha and IFN-beta. In order to establish such an antiviral state, TBK1 form severaldifferent complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffoldingmolecules including FADD, TRADD, MAVS or SINTBAD can be recruited to the TBK1-containing-complexes. Under particularconditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA totranslocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptorOPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy. Attenuates retroviralbudding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C.Phosphorylates and activates AKT1. Phosphorylates Borna disease virus (BDV) P protein
Gene Wiki entry for TBK1 (TANK-binding kinase 1)
|
Genomic Views
for TBK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TBK1 gene promoter:
AREB6 AP-1 ATF-2 c-Jun Nkx2-5
Other transcription factors
Search SABiosciences Chromatin IP Primers for TBK1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBK1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q14.1 Ensembl cytogenetic band: 12q14.2 HGNC cytogenetic band: 12q14.2TBK1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P064845: view genomic region
(about GC identifiers)
Start:
|
64,845,660 bp from pter |
End:
|
64,895,891 bp from pter |
Size:
|
50,232 bases |
Orientation:
|
plus strand |
|
Proteins
for TBK1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TBK1_HUMAN, Q9UHD2 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase TBK1 Size: 729 amino acids; 83642 Da
Subunit: Self-associates. Interacts with TIRAP, TANK and TRAF2. Part of a ternary complex consisting of TANK, TRAF2 andTBK1. Interacts with AZI2; this interaction mediates TBK1 activation. Interacts with GSK3B; this interaction promotesTBK1 self-association and autophosphorylation. Interacts with SIKE1; SIKE1 is associated with TBK1 under physiologicalcondition and dissociated from TBK1 upon viral infection or TLR3 stimulation. Interacts with TICAM1/TRIF, IRF3 andDDX58/RIG-I. Interacts with CYLD. Interacts with HCV NS3, Ebola virus VP35 and Borna disease virus protein P; theseinteractions lead to inhibition of cellular antiviral response by blocking necessary interactions between the TBK1 andits substrates IRF3 and IRF7. Interacts with OPTN and TRAF3. Interacts with SRC. Interacts with the exocyst complexsubunit SEC5/EXOC2; this interaction is sufficient to trigger TBK1 activity. Interacts with TMEM173/MITA. Interactswith IFIT3 (via N-terminus). Interacts with MAVS only in the presence of IFIT3
Subcellular location: Cytoplasm. Note=Upon mitogen stimulation or triggering of the immune system, TBK1 is recruited tothe exocyst by EXOC2
Miscellaneous: In cancer cells, pathological TBK1 activation promotes oncogenic transformation by suppressingprogrammed cell death. Mechanistically, the RALB-SEC5/EXOC2-TBK1 signaling cascade seems to participate in both innateimmune signaling and cell transformation. Additionally, TBK1 supports oncogenesis by directly phosphorylating andactivating AKT1 at the exocyst (PubMed:21042276)
Sequence caution: Sequence=BAA92129.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
3 PDB 3D structures from  and Proteopedia  for TBK1:4EFO (3D)
4EUT (3D)
4EUU (3D)
Secondary accessions: A8K4S4 Q8IYV3 Q9NUJ5Explore the universe of human proteins at neXtProt for TBK1: NX_Q9UHD2
Post-translational modifications:
Autophosphorylation at Ser-172 activates the kinase, and is an essential step for virus-triggered signaling.Phosphorylated by IKBKB/IKKB at Ser-1721
'Lys-63'-linked polyubiquitination by MIB1 after RNA virus infection, or by NRDP1 after LPS stimulation, mayparticipate in kinase activation. 'Lys-48'-linked polyubiquitination at Lys-670 by DTX4 leads to proteasomaldegradation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UHD2
4/5 DME Specific Peptides for TBK1 (Q9UHD2) (see all 5)
TBK1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_037386.1
ENSEMBL proteins: ENSP00000329967 ENSP00000445834 ENSP00000445628 ENSP00000444428 Reactome Protein details: Q9UHD2
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
TBK1 for ontologies About GeneDecksing
TBK1 Antibody Products:
Assay Products for TBK1: |
Protein
Domains /
Families
for TBK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TBK1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UHD2ProtoNet protein and cluster: Q9UHD2 UniProtKB/Swiss-Prot: TBK1_HUMAN, Q9UHD2Domain: Comprises A N-terminal kinase domain, an ubiquitin-like domain and a C-terminal leucine-zipperSimilarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamilySimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 ubiquitin-like domain |
Function
for TBK1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TBK1_HUMAN, Q9UHD2Function: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents.Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK andphosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequenthomodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory andantiviral genes including IFN-alpha and IFN-beta. In order to establish such an antiviral state, TBK1 form severaldifferent complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffoldingmolecules including FADD, TRADD, MAVS or SINTBAD can be recruited to the TBK1-containing-complexes. Under particularconditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA totranslocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptorOPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy. Attenuates retroviralbudding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C.Phosphorylates and activates AKT1. Phosphorylates Borna disease virus (BDV) P proteinCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.11
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBK1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TBK1 (NM_013254) | |  | Sino Biological Human cDNA Clone for TBK1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBK1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBK1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBK1 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
TBK1 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for TBK1:
Animal Models:
Mouse knock-outs for TBK1: Tbk1tm1Yeh Tbk1tm1.1Lex Tbk1tm1Aki
10 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Tbk1):
TBK1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TBK1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | Toll-like receptor signaling pathway | | | 3 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | | | 4 | Immune System | | | 5 | Measles | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for TBK1
1  R&D Systems Pathway for TBK1
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TBK1
3 
Cell Signaling Technology (CST) Pathways for TBK1
2  BioSystems Pathways for TBK1
5/17 
Reactome Pathways for TBK1 (see all 17)
5/6 
Kegg Pathways (Kegg details for TBK1) (see all 6):
TBK1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TBK1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/140 Interacting proteins for TBK1 (Q9UHD21, 2, 3 ENSP000003299674) via UniProtKB, MINT, STRING, and/or I2D (see all 140)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| TANK | Q928441, 2, 3, ENSP000002590754 | EBI-1383470,EBI-356349 MINT-5114997 MINT-8144259 MINT-49268 MINT-49290 MINT-48040 MINT-6492446 MINT-8151323 MINT-48264 I2D:
score=8 STRING: ENSP00000259075 | | OPTN | Q96CV91, 2, 3, ENSP000002630364 | EBI-1383470,EBI-748974 MINT-6492491 MINT-6492320 MINT-6492337 MINT-6492467 MINT-6492519 MINT-6492303 MINT-6492427 MINT-6492355 I2D:
score=4 STRING: ENSP00000263036 | | TBKBP1 | A7MCY62, 3, ENSP000003547774 | STRING: ENSP00000354777 MINT-5114931 MINT-5114886 MINT-49254 MINT-48041 MINT-5114907 MINT-5115080 I2D:
score=6 | | CALM2 | P621582, 3 | MINT-49274 I2D:
score=2 | | CALM3 | P621582, 3 | MINT-49274 I2D:
score=2 |
About this table
Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002218 | activation of innate immune response |
-- | -- | | GO:0002756 | MyD88-independent toll-like receptor signaling pathway |
TAS | -- | | GO:0006468 | protein phosphorylation |
-- | -- | | GO:0006954 | inflammatory response |
TAS | -- | | GO:0007249 | I-kappaB kinase/NF-kappaB cascade |
TAS | -- |
TBK1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TBK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TBK1 for compounds About GeneDecksing
 Browse Tocris compounds for TBK1
2 HMDB Compounds for TBK1 About this table
6 Novoseek chemical compound relationships for TBK1 gene About this table
Search CenterWatch for drugs/clinical trials and news about TBK1
|
Transcripts
for TBK1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TBK1 gene: NM_013254.3 Unigene Cluster for TBK1: TANK-binding kinase 1 Hs.505874 [show with all ESTs]Unigene Representative Sequence: NM_0132548 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000331710(uc001ssc.2) ENST00000538890 ENST00000540417 ENST00000539810
ENST00000545025 ENST00000536906 ENST00000541805 ENST00000545392
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBK1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TBK1 (NM_013254) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBK1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBK1 |
Additional cDNA sequence: AF174536.1 AF191838.1 AK002192.1 AK291039.1 AK303683.1 BC034950.2 6 DOTS entries: DT.215961 DT.100748957 DT.40280149 DT.75155342 DT.75175835 DT.95080140 3 AceView cDNA sequences: BC009864 CB528778 AI972136
GeneLoc Exon Structure
|
Expression
for TBK1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TBK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAAAAATA
About this image
See TBK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TBK1
SOURCE GeneReport for Unigene cluster: Hs.505874
UniProtKB/Swiss-Prot: TBK1_HUMAN, Q9UHD2Tissue specificity: Ubiquitous with higher expression in testis
SABiosciences Expression via Pathway-Focused PCR Arrays including TBK1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBK1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TBK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBK1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBK1 |
Orthologs
for TBK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TBK1 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for TBK1 (if available)
TreeFam Gene Tree for TBK1 (if available) |
Paralogs
for TBK1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TBK1 gene
- IKBKB2 CHUK2 IKBKE2
10 SIMAP similar genes for TBK1 using alignment to 4 protein entries: TBK1_HUMAN (see all proteins):IKBKE MAP4K4 MYO3B PRKACA ULK3 MELK
AURKB MARK2 JAK2 MAP4K1
TBK1 for paralogs About GeneDecksing
|
Genomic Variants
for TBK1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TBK1 (64845660 - 64895891 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TBK1: --
Human Gene Mutation Database (HGMD): TBK1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBK1 |
|
Disorders
/ Diseases
for TBK1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TBK1 for disorders About GeneDecksing
OMIM gene information: 604834
OMIM disorders: --
20  diseases for TBK1: About MalaCardsopen-angle glaucoma primary open angle glaucoma dengue hemorrhagic fever hantavirus pulmonary syndrome
hemorrhagic fever borna disease glaucoma cytomegalovirus infection
chronic lymphocytic leukemia stomatitis lymphocytic leukemia kawasaki disease
hepatitis c hepatitis b measles medulloblastoma
hepatitis immunodeficiency influenza leukemia
5 Novoseek disease relationships for TBK1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: TBK1 (6 documents)
Export disorders for TBK1 gene to outside databases
|
Publications
for TBK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TBK1 gene, integrated from 9 sources (see all 189):
(articles sorted by number of sources associating them with TBK1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- NAK is an IkappaB kinase-activating kinase. (PubMed id 10783893)1, 2, 3, 9 Tojima Y....Nakanishi M. (2000)
- NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase. (PubMed id 10581243)1, 2, 3, 9 Pomerantz J.L. and Baltimore D. (1999)
- The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response. (PubMed id 18583960)1, 2, 9 Soulat D....Superti-Furga G. (2008)
- Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. (PubMed id 15367631)1, 2, 9 tenOever B.R....Hiscott J. (2004)
- Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. (PubMed id 14530355)1, 2, 9 Sato S....Akira S. (2003)
- Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. (PubMed id 17599067)1, 2, 9 Ikeda F....Dikic I. (2007)
- SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus- triggered IRF-3 activation pathways. (PubMed id 16281057)1, 2, 9 Huang J.... Shu H.-B. (2005)
- IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. (PubMed id 12692549)1, 2, 9 Fitzgerald K.A.... Maniatis T. (2003)
- IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2. (PubMed id 11839743)1, 2, 9 Kishore N.... Tripp C.S. (2002)
- Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription. (PubMed id 15489227)1, 2, 9 Buss H....Kracht M. (2004)
|
External Searches for TBK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TBK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBK1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TBK1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TBK1 gene:
Search GeneIP for patents involving TBK1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TBK1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for TBK1 | | OriGene shRNA RFP for TBK1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TBK1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBK1 | | | OriGene Protein Over-expression Lysate for TBK1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TBK1 | | OriGene 3'-UTR Clone for TBK1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBK1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBK1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TBK1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TBK1 | | OriGene Custom Protein Services for TBK1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TBK1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBK1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBK1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBK1 |
| |
 |  |  |  | |
| | Antibodies & Assays for TBK1 |
| | | | Search Tocris compounds for TBK1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | TBK1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBK1 |
|  |  |  | | | | ThermoFisher Antibodies for TBK1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBK1 |
|
|
|
|
