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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TBK1 Gene

protein-coding   GIFtS: 68
GCID: GC12P064845

TANK-Binding Kinase 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TANK-Binding Kinase 11 2 3     NF-KB-Activating Kinase2
NAK2 3     Serine/Threonine-Protein Kinase TBK12
T2K2 3     EC 2.7.11.13
NF-Kappa-B-Activating Kinase2 3     EC 2.7.118

External Ids:    HGNC: 115841   Entrez Gene: 291102   Ensembl: ENSG000001837357   OMIM: 6048345   UniProtKB: Q9UHD23   

Export aliases for TBK1 gene to outside databases

Previous GC identifers: GC00U990677 GC13U900006 GC12P064562 GC12P063132 GC12P061898


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TBK1 Gene:
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by
trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them
for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB
complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response
to certain growth factors. (provided by RefSeq, Oct 2010)

GeneCards Summary for TBK1 Gene: 
TBK1 (TANK-binding kinase 1) is a protein-coding gene. Diseases associated with TBK1 include borna disease, and hantavirus pulmonary syndrome, and among its related super-pathways are Toll-like receptor signaling pathway and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is IKBKB.

UniProtKB/Swiss-Prot: TBK1_HUMAN, Q9UHD2
Function: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign
agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and
TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows
subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of
pro-inflammatory and antiviral genes including IFN-alpha and IFN-beta. In order to establish such an antiviral
state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli.
Thus, several scaffolding molecules including FADD, TRADD, MAVS or SINTBAD can be recruited to the
TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating
NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial
proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding
affinity and antibacterial autophagy. Attenuates retroviral budding by phosphorylating the endosomal sorting
complex required for transport-I (ESCRT-I) subunit VPS37C. Phosphorylates and activates AKT1. Phosphorylates
Borna disease virus (BDV) P protein

Gene Wiki entry for TBK1 (TANK-binding kinase 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TBK1 gene promoter:
         AREB6   AP-1   ATF-2   c-Jun   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TBK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.1   Ensembl cytogenetic band:  12q14.2   HGNC cytogenetic band: 12q14.2

TBK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBK1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P064845:  view genomic region     (about GC identifiers)

Start:
64,845,660 bp from pter      End:
64,895,899 bp from pter
Size:
50,240 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TBK1_HUMAN, Q9UHD2 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase TBK1  
Size: 729 amino acids; 83642 Da
Subunit: Self-associates. Interacts with TIRAP, TANK and TRAF2. Part of a ternary complex consisting of TANK,
TRAF2 and TBK1. Interacts with AZI2; this interaction mediates TBK1 activation. Interacts with GSK3B; this
interaction promotes TBK1 self-association and autophosphorylation. Interacts with SIKE1; SIKE1 is associated
with TBK1 under physiological condition and dissociated from TBK1 upon viral infection or TLR3 stimulation.
Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Interacts with CYLD. Interacts with HCV NS3, Ebola virus VP35
and Borna disease virus protein P; these interactions lead to inhibition of cellular antiviral response by
blocking necessary interactions between the TBK1 and its substrates IRF3 and IRF7. Interacts with OPTN and TRAF3.
Interacts with SRC. Interacts with the exocyst complex subunit SEC5/EXOC2; this interaction is sufficient to
trigger TBK1 activity. Interacts with TMEM173/MITA. Interacts with IFIT3 (via N-terminus). Interacts with MAVS
only in the presence of IFIT3
Subcellular location: Cytoplasm. Note=Upon mitogen stimulation or triggering of the immune system, TBK1 is
recruited to the exocyst by EXOC2
Miscellaneous: In cancer cells, pathological TBK1 activation promotes oncogenic transformation by suppressing
programmed cell death. Mechanistically, the RALB-SEC5/EXOC2-TBK1 signaling cascade seems to participate in both
innate immune signaling and cell transformation. Additionally, TBK1 supports oncogenesis by directly
phosphorylating and activating AKT1 at the exocyst (PubMed:21042276)
Sequence caution: Sequence=BAA92129.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
6/10 PDB 3D structures from and Proteopedia for TBK1 (see all 10):
4EFO (3D)        4EUT (3D)        4EUU (3D)        4IM0 (3D)        4IM2 (3D)        4IM3 (3D)    
Secondary accessions: A8K4S4 Q8IYV3 Q9NUJ5

Explore the universe of human proteins at neXtProt for TBK1: NX_Q9UHD2

Explore proteomics data for TBK1 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylation at Ser-172 activates the kinase, and is an essential step for virus-triggered signaling.
    Phosphorylated by IKBKB/IKKB at Ser-172
  • UniProtKB: 'Lys-63'-linked polyubiquitination by MIB1 after RNA virus infection, or by NRDP1 after LPS stimulation, may
    participate in kinase activation. 'Lys-48'-linked polyubiquitination at Lys-670 by DTX4 leads to proteasomal
    degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UHD2

  • 4/5 DME Specific Peptides for TBK1 (Q9UHD2) (see all 5)
     GPRRNKE  HRDIKPGN  YNEEQIHK  YHAATGSLPF 

    TBK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TBK1 Protein Expression
    REFSEQ proteins: NP_037386.1  
    ENSEMBL proteins: 
     ENSP00000329967   ENSP00000445834   ENSP00000445628   ENSP00000444428  
    Reactome Protein details: Q9UHD2
    Human Recombinant Protein Products for TBK1: 
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    Novus Biologicals TBK1 Proteins
    Novus Biologicals TBK1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TBK1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0010008endosome membrane TAS--

    TBK1 for ontologies           About GeneDecksing



    TBK1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TBK1
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    Novus Biologicals TBK1 Antibodies
    Abcam antibodies for TBK1
    Cloud-Clone Corp. Antibodies for TBK1 
    ThermoFisher Antibody for TBK1
    LSBio Antibodies in human, mouse, rat for TBK1 

    Assay Products for TBK1: 
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    GenScript TBK1-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TBK1 
    Cloud-Clone Corp. CLIAs for TBK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: TANK-binding kinase 1 
    IKK family

    3 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9UHD2

    ProtoNet protein and cluster: Q9UHD2

    UniProtKB/Swiss-Prot: TBK1_HUMAN, Q9UHD2
    Domain: Comprises A N-terminal kinase domain, an ubiquitin-like domain and a C-terminal leucine-zipper
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 ubiquitin-like domain


    TBK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBK1_HUMAN, Q9UHD2
    Function: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign
    agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and
    TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows
    subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of
    pro-inflammatory and antiviral genes including IFN-alpha and IFN-beta. In order to establish such an antiviral
    state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli.
    Thus, several scaffolding molecules including FADD, TRADD, MAVS or SINTBAD can be recruited to the
    TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating
    NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial
    proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding
    affinity and antibacterial autophagy. Attenuates retroviral budding by phosphorylating the endosomal sorting
    complex required for transport-I (ESCRT-I) subunit VPS37C. Phosphorylates and activates AKT1. Phosphorylates
    Borna disease virus (BDV) P protein
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.11

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004672protein kinase activity TAS--
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI15841462
         
    TBK1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for TBK1:
     Decreased Hepatitis C virus re  Decreased focal adhesion (FA)   Increased Salmonella enterica   Increased Salmonella enterica  
     Increased colony dispersion (i 

         10 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Tbk1):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     integument  liver/biliary system  mortality/aging  no phenotypic analysis  renal/urinary system 

    TBK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TBK1: Tbk1tm1Yeh Tbk1tm1.1Lex Tbk1tm1Aki

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TBK1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TBK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TBK1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TBK1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TBK1
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate TBK1 (see all 18):
    hsa-miR-539 hsa-miR-429 hsa-miR-578 hsa-miR-373* hsa-miR-219-2-3p hsa-miR-200b hsa-miR-365 hsa-miR-203
    SwitchGear 3'UTR luciferase reporter plasmidTBK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TBK1
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of TBK1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for TBK1
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    GenScript: all cDNA clones in your preferred vector: TBK1 (NM_013254)
    Sino Biological Human cDNA Clone for TBK1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBK1
    Sirion Biotech Customized lentivirus for stable overexpression of TBK1 
                         Customized lentivirus expression plasmids for stable overexpression of TBK1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBK1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TBK1 About   (see all 23)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Hepatitis B0.31
    Toll-like receptor signaling pathway0.93
    2RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.52
    Negative regulators of RIG-I/MDA5 signaling0.49
    RIG-I-like receptor signaling pathway0.52
    3Cytosolic DNA-sensing pathway
    Cytosolic DNA-sensing pathway0.36
    Cytosolic sensors of pathogen-associated DNA 0.36
    4TRAF6 Mediated Induction of proinflammatory cytokines
    Activated TLR4 signalling0.87
    Toll Like Receptor 4 (TLR4) Cascade0.87
    MyD88-independent cascade 0.87
    Toll-Like Receptors Cascades0.87
    Toll Like Receptor 3 (TLR3) Cascade0.87
    TRIF-mediated TLR3/TLR4 signaling 0.86
    5IRF3-mediated induction of type I IFN
    IRF3-mediated induction of type I IFN0.50
    IRF3 mediated activation of type 1 IFN0.50
    STAT6-mediated induction of chemokines0.50
    STING mediated induction of host immune responses0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TBK1
        Selected targets of ESR1

    1 R&D Systems Pathway for TBK1
        Toll-Like receptor Signaling Pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TBK1
        Toll-Like Receptors Pathway
    TNFR2 Pathway

    3 Cell Signaling Technology (CST) Pathways for TBK1
        Lymphocyte Signaling
    TGF-beta/Smad Signaling
    NF-kappaB Signaling

    2 BioSystems Pathways for TBK1
        Toll-like receptor signaling pathway
    TNF-alpha/NF-kB Signaling Pathway

    2 Sino Biological Pathways for TBK1 
        Notch Signaling Pathway
    NF-kB (NFkB) Pathway

    5/20        Reactome Pathways for TBK1 (see all 20)
        RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Regulation of innate immune responses to cytosolic DNA
    TRAF6 mediated IRF7 activation
    Toll-Like Receptors Cascades
    Toll Like Receptor 3 (TLR3) Cascade


    5/9         Kegg Pathways  (Kegg details for TBK1) (see all 9):
        Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway
    Cytosolic DNA-sensing pathway
    Hepatitis C
    Hepatitis B


    TBK1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TBK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/158 Interacting proteins for TBK1 (Q9UHD21, 2, 3 ENSP000003299674) via UniProtKB, MINT, STRING, and/or I2D (see all 158)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TANKQ928441, 2, 3, ENSP000002590754EBI-356402,EBI-356349 MINT-5114997 MINT-8144259 MINT-49268 MINT-49290 MINT-48040 MINT-6492446 MINT-8151323 MINT-48264 I2D: score=8 STRING: ENSP00000259075
    OPTNQ96CV91, 2, 3, ENSP000002630364EBI-356402,EBI-748974 MINT-6492491 MINT-6492320 MINT-6492337 MINT-6492467 MINT-6492519 MINT-6492303 MINT-6492427 MINT-6492355 I2D: score=4 STRING: ENSP00000263036
    ENSG00000183311P074372, 3MINT-49276 I2D: score=2 
    ENSG00000224156P074372, 3MINT-49276 I2D: score=2 
    ENSG00000227739P074372, 3MINT-49276 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002218activation of innate immune response ----
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006468protein phosphorylation ----
    GO:0006954inflammatory response TAS--

    TBK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TBK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TBK1

    2 HMDB Compounds for TBK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    6 Novoseek inferred chemical compound relationships for TBK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    poly(i-c) 73.9 1 16849320 (1)
    rantes 61.5 4 17599067 (1), 19656901 (1), 18282411 (1)
    serine 39.7 9 14679297 (1), 9621042 (1), 9418906 (1), 9792838 (1) (see all 9)
    inosine monophosphate 38.7 1 17157040 (1)
    threonine 38.2 6 9621042 (1), 9418906 (1), 9792838 (1), 11070003 (1) (see all 6)
    tyrosine 0 1 17056502 (1)

    Search CenterWatch for drugs/clinical trials and news about TBK1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TBK1 gene: 
    NM_013254.3  

    Unigene Cluster for TBK1:

    TANK-binding kinase 1
    Hs.505874  [show with all ESTs]
    Unigene Representative Sequence: NM_013254
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331710(uc001ssc.2) ENST00000538890 ENST00000540417 ENST00000539810
    ENST00000545025 ENST00000536906 ENST00000541805 ENST00000545392
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate TBK1 (see all 18):
    hsa-miR-539 hsa-miR-429 hsa-miR-578 hsa-miR-373* hsa-miR-219-2-3p hsa-miR-200b hsa-miR-365 hsa-miR-203
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBK1
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    Additional mRNA sequence: 

    AF174536.1 AF191838.1 AK002192.1 AK291039.1 AK303683.1 BC034950.2 

    6 DOTS entries:

    DT.215961  DT.100748957  DT.40280149  DT.75155342  DT.75175835  DT.95080140 

    3 AceView cDNA sequences:

    BC009864 CB528778 AI972136 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TBK1 expression in normal human tissues (normalized intensities)      TBK1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAAAAATA
    TBK1 Expression
    About this image


    TBK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
             ganglion/cranial   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Lung (Respiratory System)
             Stem Bronchi

    See TBK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TBK1

    SOURCE GeneReport for Unigene cluster: Hs.505874

    UniProtKB/Swiss-Prot: TBK1_HUMAN, Q9UHD2
    Tissue specificity: Ubiquitous with higher expression in testis

        SABiosciences Expression via Pathway-Focused PCR Arrays including TBK1: 
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              Apoptosis 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TBK1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbk11 , 5 TANK-binding kinase 11, 5 86.37(n)1
    94.1(a)1
      10 (69.84 cM)5
    564801  NM_019786.41  NP_062760.31 
     1215464555 
    chicken
    (Gallus gallus)
    Aves TBK11 TANK-binding kinase 1 80.29(n)
    86.56(a)
      417825  NM_001199558.1  NP_001186487.1 
    lizard
    (Anolis carolinensis)
    Reptilia TBK16
    Uncharacterized protein
    82(a)
    1 ↔ 1
    5(50456954-50477532)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.149202 Xenopus laevis transcribed sequence with weak similarity more 75.57(n)    CD327798.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tbk11 TANK-binding kinase 1 69.85(n)
    84.62(a)
      692289  NM_001044748.1  NP_001038213.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ik21 , 3 defense response protein kinase3
    IkappaB kinase-like 21
    38(a)3
    46.54(n)1
    38.77(a)1
      38D43
    353291  NM_165337.11  NP_724278.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y39G8B.56
    ikke-16
    Protein Y39G8B.5
    Inhibitor of nuclear factor kappa-B kinase epsilon...
    16(a)
    15(a)
    many ↔ many
    many ↔ many
    II(13987616-13991838)
    III(9046011-9050695)


    ENSEMBL Gene Tree for TBK1 (if available)
    TreeFam Gene Tree for TBK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TBK1 gene
    IKBKB2  IKBKE2  CHUK2  
    8 SIMAP similar genes for TBK1 using alignment to 4 protein entries:     TBK1_HUMAN (see all proteins):
    IKBKE    MAP4K4    MYO3B    PRKACA    ULK3    AURKB
    MARK2    JAK2

    TBK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1004 SNPs in TBK1 are shown (see all 1004)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0412114
    A colorectal adenocarcinoma sample4--see VAR_0412112 G R mis40--------
    VAR_0412104
    A breast pleomorphic lobular carcinoma sample4--see VAR_0412102 D H mis40--------
    rs1902400741,2
    --64843862(+) ACATAA/CAGACT 1 -- us2k10--------
    rs1162822791,2
    F--64843891(+) ATGCTA/GTCTCA 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs2013051291,2
    C--64843929(+) TCACT-/AATACT 1 -- us2k10--------
    rs1821718721,2
    --64844080(+) GTGTGC/TACCAC 1 -- us2k10--------
    rs1129406811,2
    C--64844095(+) CCCAGT/CTACAT 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs123134491,2
    C,F--64844129(+) TCACTA/GTGTTA 1 -- us2k18Minor allele frequency- G:0.42NA WA EA 252
    rs1880421731,2
    --64844294(+) CAGAAG/TATTTA 1 -- us2k10--------
    rs123676401,2
    C--64844712(+) GCTCAG/ATTAAT 1 -- us2k1 tfbs32Minor allele frequency- A:0.00NA 4

    HapMap Linkage Disequilibrium report for TBK1 (64845660 - 64895899 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TBK1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832443CNV Loss17160897


    Human Gene Mutation Database (HGMD): TBK1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604834    OMIM disorders: --

    20/29 diseases for TBK1 (see all 29):    About MalaCards
    borna disease    hantavirus pulmonary syndrome    herpes simplex encephalitis    stomatitis
    open-angle glaucoma    primary open angle glaucoma    dengue hemorrhagic fever    cytomegalovirus infection
    kawasaki disease    glaucoma    hemorrhagic fever    measles
    medulloblastoma    encephalitis    kaposi's sarcoma    herpes simplex
    influenza    chronic lymphocytic leukemia    esophageal squamous cell carcinoma    type 1 diabetes


    TBK1 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for TBK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 55.8 12 17376932 (1), 15210742 (1), 16281057 (1), 19307177 (1) (see all 8)
    vesicular stomatitis 46.8 2 15367631 (2)
    necrosis 16.7 7 19307177 (2), 18450748 (1)
    immunodeficiency 16.6 7 10713183 (1), 10607567 (1), 11070003 (1), 9371615 (1) (see all 5)
    tumors 0 8 19307177 (2), 18450748 (1), 11745462 (1)

    Genetic Association Database (GAD): TBK1
    Human Genome Epidemiology (HuGE) Navigator: TBK1 (6 documents)

    Export disorders for TBK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TBK1 gene, integrated from 9 sources (see all 204):
    (articles sorted by number of sources associating them with TBK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NAK is an IkappaB kinase-activating kinase. (PubMed id 10783893)1, 2, 3, 9 Tojima Y....Nakanishi M. (2000)
    2. NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase. (PubMed id 10581243)1, 2, 3, 9 Pomerantz J.L. and Baltimore D. (1999)
    3. The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response. (PubMed id 18583960)1, 2, 9 Soulat D....Superti-Furga G. (2008)
    4. Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. (PubMed id 15367631)1, 2, 9 tenOever B.R....Hiscott J. (2004)
    5. Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. (PubMed id 14530355)1, 2, 9 Sato S....Akira S. (2003)
    6. Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. (PubMed id 17599067)1, 2, 9 Ikeda F....Dikic I. (2007)
    7. SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus- triggered IRF-3 activation pathways. (PubMed id 16281057)1, 2, 9 Huang J.... Shu H.-B. (2005)
    8. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. (PubMed id 12692549)1, 2, 9 Fitzgerald K.A.... Maniatis T. (2003)
    9. IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2. (PubMed id 11839743)1, 2, 9 Kishore N.... Tripp C.S. (2002)
    10. Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription. (PubMed id 15489227)1, 2, 9 Buss H....Kracht M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29110 HGNC: 11584 AceView: TBK1.1 Ensembl:ENSG00000183735 euGenes: HUgn29110
    ECgene: TBK1 Kegg: 29110 H-InvDB: TBK1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TBK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TBK1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TBK1 gene:
    Search GeneIP for patents involving TBK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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