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TBCK Gene

protein-coding   GIFtS: 50
GCID: GC04M106967

TBC1 Domain Containing Kinase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TBC1 Domain Containing Kinase1 2
TBCKL2 3
TBC Domain-Containing Protein Kinase-Like Protein2

External Ids:    HGNC: 282611   Entrez Gene: 936272   Ensembl: ENSG000001453487   UniProtKB: Q8TEA73   

Export aliases for TBCK gene to outside databases

Previous GC identifer: GC04M102701


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TBCK Gene:
This gene encodes a protein that contains a protein kinase domain, a Rhodanase-like domain and the
Tre-2/Bub2/Cdc16 (TBC) domain. The encoded protein is thought to play a role in actin organization, cell growth
and cell proliferation by regulating the mammalian target of the rapamycin (mTOR) signaling pathway. This protein
may also be involved in the transcriptional regulation of the components of the mTOR complex. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Mar 2014)

GeneCards Summary for TBCK Gene:
TBCK (TBC1 domain containing kinase) is a protein-coding gene. Diseases associated with TBCK include alcohol dependence, and malaria. GO annotations related to this gene include Rab GTPase activator activity and protein kinase activity. An important paralog of this gene is TBC1D22B.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TBCK
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TBCK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBCK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q24   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q24

TBCK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBCK gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M106967:  view genomic region     (about GC identifiers)

Start:
106,962,756 bp from pter      End:
107,242,652 bp from pter
Size:
279,897 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TBCK_HUMAN, Q8TEA7 (See protein sequence)
Recommended Name: TBC domain-containing protein kinase-like protein  
Size: 893 amino acids; 100679 Da
Sequence caution: Sequence=AAF28980.1; Type=Frameshift; Positions=507, 516, 660, 665, 672; Sequence=BAC05244.1;
Type=Miscellaneous discrepancy; Note=intron retention;
Secondary accessions: B9A6J1 Q4W5B3 Q4W5E1 Q6NUP4 Q8N7M8 Q8WW57 Q96GV6 Q9P080
Alternative splicing: 3 isoforms:  Q8TEA7-1   Q8TEA7-2   Q8TEA7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TBCK: NX_Q8TEA7

Explore proteomics data for TBCK at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys349, Lys706
  • Modification sites at PhosphoSitePlus

  • See TBCK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001156907.1  NP_001156908.1  NP_001156909.1  NP_001277697.1  NP_149106.2  

    ENSEMBL proteins: 
     ENSP00000273980   ENSP00000355338   ENSP00000378196   ENSP00000421182   ENSP00000378198  
     ENSP00000422160   ENSP00000423834   ENSP00000426093   ENSP00000423092   ENSP00000420985  
     ENSP00000425197   ENSP00000423637   ENSP00000405847  

    TBCK Human Recombinant Protein Products:

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    Novus Biologicals TBCK Lysate
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    Cloud-Clone Corp. Proteins for TBCK

    TBCK Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: TBC1 domain containing kinase
    TBCK family

    4 InterPro protein domains:
     IPR001763 Rhodanese-like_dom
     IPR000195 Rab-GTPase-TBC_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q8TEA7

    ProtoNet protein and cluster: Q8TEA7

    2 Blocks protein domains:
    IPB000195 RabGAP/TBC domain
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: TBCK_HUMAN, Q8TEA7
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 Rab-GAP TBC domain
    Similarity: Contains 1 rhodanese domain


    TBCK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity RCA12471243
    GO:0004713protein tyrosine kinase activity ----
    GO:0005097Rab GTPase activator activity IEA--
    GO:0005524ATP binding RCA12471243
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    TBCK for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TBCK:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBCK
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    miRTarBase miRNAs that target TBCK:
    hsa-mir-335-5p (MIRT018768)

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    8 qRT-PCR Assays for microRNAs that regulate TBCK:
    hsa-miR-4291 hsa-miR-34c-5p hsa-miR-449b hsa-miR-526b hsa-miR-3942-5p hsa-miR-449a hsa-miR-34a hsa-miR-1208
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBCK
    Interactions:

        Search GeneGlobe Interaction Network for TBCK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for TBCK (ENSP000003553384) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COG6ENSP000003974414STRING: ENSP00000397441
    MOB1AENSP000003793644STRING: ENSP00000379364
    MOB1BENSP000003101894STRING: ENSP00000310189
    MOB3AENSP000003495754STRING: ENSP00000349575
    MOB3BENSP000002622444STRING: ENSP00000262244
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468NOT protein phosphorylation RCA12471243
    GO:0032313regulation of Rab GTPase activity ----

    TBCK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TBCK



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TBCK gene (5 alternative transcripts): 
    NM_001163435.2  NM_001163436.2  NM_001163437.2  NM_001290768.1  NM_033115.4  

    Unigene Cluster for TBCK:

    TBC1 domain containing kinase
    Hs.292986  [show with all ESTs]
    Unigene Representative Sequence: BX647851
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000273980 ENST00000510927(uc003hyb.2) ENST00000361687(uc003hyc.2)
    ENST00000394706(uc003hye.2) ENST00000467183(uc010ilv.2 uc003hyd.2)
    ENST00000394708 ENST00000514689 ENST00000515705 ENST00000506384 ENST00000511011
    ENST00000506615 ENST00000508666 ENST00000503516 ENST00000505574 ENST00000503832
    ENST00000506280 ENST00000509532 ENST00000509862
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate TBCK:
    hsa-miR-4291 hsa-miR-34c-5p hsa-miR-449b hsa-miR-526b hsa-miR-3942-5p hsa-miR-449a hsa-miR-34a hsa-miR-1208
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBCK
      QuantiTect SYBR Green Assays in human, mouse, rat TBCK
      QuantiFast Probe-based Assays in human, mouse, rat TBCK

    Additional mRNA sequence: 

    AB449876.1 AF161420.1 AK074305.1 AK098157.1 AK315571.1 BC009208.2 BC020853.2 BC068496.1 
    BX647851.1 

    19 DOTS entries:

    DT.414340  DT.99980522  DT.97858376  DT.92061166  DT.97763994  DT.121258677  DT.100776500  DT.95228097 
    DT.108438  DT.121258697  DT.95175678  DT.121258768  DT.40229008  DT.444201  DT.91694314  DT.92421351 
    DT.97763840  DT.121258672  DT.121258696 

    Selected AceView cDNA sequences (see all 135):

    AA702160 BG741592 AA872305 BP366532 Z44040 CA449749 AK098157 BC009208 
    BP376059 CA432811 BE513284 BC068496 CR608976 AI633963 AL708757 AI248799 
    AI239417 BU192178 AA922021 AI457618 BE670030 BF432144 BU625385 AI025923 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TBCK    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                      -     -                     
    SP2:                                                                  
    SP3:                                                                  


    ECgene alternative splicing isoforms for TBCK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TBCK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTGCTGAA
    TBCK Expression
    About this image

    TBCK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TBCK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.292986
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TBCK gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbck1 , 5 TBC1 domain containing kinase1, 5 89.14(n)1
    95.41(a)1
      3 (61.49 cM)5
    2719811  NM_001163455.11  NP_001156927.11 
     1326841445 
    chicken
    (Gallus gallus)
    Aves TBCK1 TBC1 domain containing kinase 79.25(n)
    87.23(a)
      422534  NM_001012577.1  NP_001012595.1 
    lizard
    (Anolis carolinensis)
    Reptilia TBCK6
    TBC1 domain containing kinase
    87(a)
    1 ↔ 1
    GL343375.1(21921-122209)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tbck1 TBC1 domain containing kinase 73.89(n)
    81.46(a)
      100124764  NM_001102743.1  NP_001096213.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tbck1 TBC1 domain containing kinase 69.17(n)
    76.71(a)
      791155  NM_001080637.2  NP_001074106.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG40411 CG4041 49.29(n)
    47.88(a)
      31422  NM_131969.4  NP_572197.4 
    worm
    (Caenorhabditis elegans)
    Secernentea tbck-11 tbck-1 44.87(n)
    33.92(a)
      173832  NM_062465.4  NP_494866.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GYP16
    Cis-golgi GTPase-activating protein (GAP) for the ...
    14(a)
    1 → many
    XV(455907-457820) YOR070C


    ENSEMBL Gene Tree for TBCK (if available)
    TreeFam Gene Tree for TBCK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TBCK gene
    TBC1D22B2  TBC1D22A2  
    5 SIMAP similar genes for TBCK using alignment to 8 protein entries:     TBCK_HUMAN (see all proteins):
    DKFZp313C1916    STK25    CDK10    MARK4    NUAK1

    TBCK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TBCK (see all 4429)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0413874
    A head & Neck squamous cell carcinoma sample4--see VAR_0413872 I V mis40--------
    VAR_0413854
    A colorectal adenocarcinoma sample4--see VAR_0413852 R I mis40--------
    rs1837129481,2
    --106768755(+) CCCTCC/TTTCTT 4 -- ds50010--------
    rs1896492631,2
    --106768921(+) TTAATC/GATCAG 4 -- ds50010--------
    rs1463150191,2
    --106768934(+) AACCAA/GTAGAC 4 -- ds50010--------
    rs1819041011,2
    C--106768994(+) ATTTGC/TTTAAG 4 -- ds50010--------
    rs1847620591,2
    C--106769033(+) AAATAC/TTCTAT 4 -- ds50010--------
    rs1453323511,2
    C--106769121(+) CCTAT-/ACACACA 4 -- ds50010--------
    rs12271,2
    C,F,H--106769194(+) AGGAAT/CGCATT 4 -- ut31 ese314Minor allele frequency- C:0.08MN NS EA NA 1546
    rs1891506201,2
    C--106769233(+) AAAGAC/TGATGA 4 -- ut310--------

    HapMap Linkage Disequilibrium report for TBCK (106962756 - 107212756 bp, first 250kb of TBCK)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TBCK (see all 26):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv966e199CNV Deletion23128226
    esv3779CNV Deletion18987735
    esv2728105CNV Deletion23290073
    esv2659170CNV Deletion23128226
    nsv820470CNV Deletion20802225
    esv2525124CNV Deletion19546169
    esv268595CNV Insertion20981092
    nsv514239CNV Loss21397061
    dgv890n67CNV Loss20364138
    nsv4450CNV Loss18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for TBCK:    About MalaCards
    alcohol dependence    malaria


    TBCK for disorders           About GeneDecksing

    Genetic Association Database (GAD): TBCK
    Human Genome Epidemiology (HuGE) Navigator: TBCK (1 document)

    Export disorders for TBCK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TBCK gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with TBCK)
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    1. The protein kinase complement of the human genome. (PubMed id 12471243)1, 2, 3 Manning G.... Sudarsanam S. (Science 2002)
    2. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    3. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1, 2 Ishibashi K.... Fukuda M. (Genes Cells 2009)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. A Long Type of TBCK Is a Novel Cytoplasmic and Mitotic Apparatus-Associated Protein Likely Suppressing Cell Proliferation. (PubMed id 24576458)1 Wu J....Zeng C. (J Genet Genomics 2014)
    8. TBCK influences cell proliferation, cell size and mTOR signaling pathway. (PubMed id 23977024)1 Liu Y....Zhou T. (PLoS ONE 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. (PubMed id 22837378)1 Wilk J.B....Stricker B.H. (Am. J. Respir. Crit. Care Med. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 93627 HGNC: 28261 AceView: MGC16169 Ensembl:ENSG00000145348 euGenes: HUgn93627
    ECgene: TBCK H-InvDB: TBCK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TBCK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TBCK gene:
    Search GeneIP for patents involving TBCK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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