Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TBCK Gene

Aliases for TBCK Gene

  • TBC1 Domain Containing Kinase 2 3
  • TBCKL 3 4
  • TBC Domain-Containing Protein Kinase-Like Protein 3
  • HSPC302 3

External Ids for TBCK Gene

Previous GeneCards Identifiers for TBCK Gene

  • GC04M106967
  • GC04M102701

Summaries for TBCK Gene

Entrez Gene Summary for TBCK Gene

  • This gene encodes a protein that contains a protein kinase domain, a Rhodanase-like domain and the Tre-2/Bub2/Cdc16 (TBC) domain. The encoded protein is thought to play a role in actin organization, cell growth and cell proliferation by regulating the mammalian target of the rapamycin (mTOR) signaling pathway. This protein may also be involved in the transcriptional regulation of the components of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for TBCK Gene

TBCK (TBC1 Domain Containing Kinase) is a Protein Coding gene. GO annotations related to this gene include protein kinase activity. An important paralog of this gene is TBC1D22A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBCK Gene

Genomics for TBCK Gene

Genomic Location for TBCK Gene

106,041,599 bp from pter
106,321,495 bp from pter
279,897 bases
Minus strand

Genomic View for TBCK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBCK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBCK Gene

No data available for Regulatory Elements for TBCK Gene

Proteins for TBCK Gene

  • Protein details for TBCK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TBC domain-containing protein kinase-like protein
    Protein Accession:
    Secondary Accessions:
    • B9A6J1
    • Q4W5B3
    • Q4W5E1
    • Q6NUP4
    • Q8N7M8
    • Q8WW57
    • Q96GV6
    • Q9P080

    Protein attributes for TBCK Gene

    893 amino acids
    Molecular mass:
    100679 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF28980.1; Type=Frameshift; Positions=507, 516, 660, 665, 672; Evidence={ECO:0000305}; Sequence=BAC05244.1; Type=Miscellaneous discrepancy; Note=intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for TBCK Gene


neXtProt entry for TBCK Gene

Proteomics data for TBCK Gene at MOPED

Post-translational modifications for TBCK Gene

  • Ubiquitination at Lys349 and Lys706
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TBCK Gene

Domains for TBCK Gene

Gene Families for TBCK Gene

Suggested Antigen Peptide Sequences for TBCK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily.
  • The protein kinase domain is predicted to be catalytically inactive.
  • Contains 1 protein kinase domain.
  • Contains 1 Rab-GAP TBC domain.
  • Contains 1 rhodanese domain.
  • Belongs to the protein kinase superfamily.
genes like me logo Genes that share domains with TBCK: view

Function for TBCK Gene

Gene Ontology (GO) - Molecular Function for TBCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity NAS 12471243
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding NAS 12471243
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with TBCK: view

Phenotypes for TBCK Gene

GenomeRNAi human phenotypes for TBCK:
genes like me logo Genes that share phenotypes with TBCK: view

Animal Model Products

miRNA for TBCK Gene

miRTarBase miRNAs that target TBCK

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TBCK Gene

Localization for TBCK Gene

Subcellular locations from

Jensen Localization Image for TBCK Gene COMPARTMENTS Subcellular localization image for TBCK gene
Compartment Confidence
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TBCK Gene

Pathways for TBCK Gene

SuperPathways for TBCK Gene

No Data Available

Interacting Proteins for TBCK Gene

Gene Ontology (GO) - Biological Process for TBCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 NOT protein phosphorylation NAS 12471243
genes like me logo Genes that share ontologies with TBCK: view

No data available for Pathways by source for TBCK Gene

Transcripts for TBCK Gene

Unigene Clusters for TBCK Gene

TBC1 domain containing kinase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBCK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBCK Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -

Relevant External Links for TBCK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBCK Gene

mRNA expression in normal human tissues for TBCK Gene

Protein differential expression in normal tissues for TBCK Gene

This gene is overexpressed in Testis (10.4), Peripheral blood mononuclear cells (9.8), and Spleen (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TBCK Gene

SOURCE GeneReport for Unigene cluster for TBCK Gene Hs.292986

genes like me logo Genes that share expressions with TBCK: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for TBCK Gene

Orthologs for TBCK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TBCK Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TBCK 35
  • 92.68 (n)
  • 96.53 (a)
  • 96 (a)
(Canis familiaris)
Mammalia TBCK 35
  • 93.24 (n)
  • 96.75 (a)
  • 97 (a)
(Mus musculus)
Mammalia Tbck 35
  • 89.14 (n)
  • 95.41 (a)
Tbck 16
Tbck 36
  • 95 (a)
(Pan troglodytes)
Mammalia TBCK 35
  • 99.44 (n)
  • 99.55 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Tbck 35
  • 87.62 (n)
  • 94.06 (a)
(Monodelphis domestica)
Mammalia TBCK 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia TBCK 36
  • 89 (a)
(Gallus gallus)
Aves TBCK 35
  • 79.25 (n)
  • 87.23 (a)
  • 87 (a)
(Anolis carolinensis)
Reptilia TBCK 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tbck 35
  • 73.89 (n)
  • 81.46 (a)
(Danio rerio)
Actinopterygii tbck 35
  • 69.17 (n)
  • 76.71 (a)
tbck 36
  • 76 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000552 35
  • 47.47 (n)
  • 46.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4041 35
  • 49.29 (n)
  • 47.88 (a)
CG4041 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea tbck-1 35
  • 44.87 (n)
  • 33.92 (a)
tbck-1 36
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GYP1 36
  • 14 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8382 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for TBCK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TBCK Gene

Gene Tree for TBCK (if available)
Gene Tree for TBCK (if available)

Paralogs for TBCK Gene

Paralogs for TBCK Gene

genes like me logo Genes that share paralogs with TBCK: view

Variants for TBCK Gene

Sequence variations from dbSNP and Humsavar for TBCK Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1227 -- 106,046,125(+) AGGAA(C/T)GCATT utr-variant-3-prime
rs14733 -- 106,046,273(+) CTTGA(A/T)AATGC utr-variant-3-prime
rs727618 -- 106,257,969(+) TCTAA(C/T)CCAAA intron-variant
rs1988695 -- 106,281,106(-) AACTA(C/T)AAAAC intron-variant
rs2097058 -- 106,055,703(-) TAAGA(A/G)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TBCK Gene

Variant ID Type Subtype PubMed ID
nsv522792 CNV Gain 19592680
esv2525124 CNV Deletion 19546169
nsv511247 CNV Gain 21212237
nsv879701 CNV Loss 21882294
nsv4450 CNV Loss 18451855
nsv508301 CNV Loss 20534489
dgv97n17 CNV Loss 16327808
nsv437411 CNV Loss 16327808
dgv890n67 CNV Loss 20364138
nsv820470 CNV Deletion 20802225
nsv819407 CNV Gain 19587683
esv3779 CNV Deletion 18987735
esv28666 CNV Gain 19812545
esv2728105 CNV Deletion 23290073
esv6293 CNV Loss 19470904
nsv499056 CNV Loss 21111241
dgv966e199 CNV Deletion 23128226
nsv514238 CNV Loss 21397061
nsv514239 CNV Loss 21397061
dgv5672n71 CNV Loss 21882294
nsv879704 CNV Loss 21882294
esv268595 CNV Insertion 20981092
nsv879705 CNV Loss 21882294
esv2659170 CNV Deletion 23128226
nsv830029 CNV Gain 17160897
esv23259 CNV Loss 19812545

Relevant External Links for TBCK Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBCK Gene

Disorders for TBCK Gene

Relevant External Links for TBCK

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for TBCK Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TBCK Gene

Publications for TBCK Gene

  1. The protein kinase complement of the human genome. (PMID: 12471243) Manning G. … Sudarsanam S. (Science 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K. … Fukuda M. (Genes Cells 2009) 3 4

Products for TBCK Gene

Sources for TBCK Gene

Back to Top