TBCK Gene
protein-coding GIFtS: 45
GCID: GC04M106967
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|
TBC1 domain containing kinase
| |
Aliases
for TBCK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TBC1 Domain Containing Kinase1 2 | | TBCKL2 3 | | HSPC3021 | | MGC161691 | | TBC Domain-Containing Protein Kinase-Like Protein2 |
Export aliases for TBCK gene to outside databasesPrevious GC identifer: GC04M102701 |
Summaries
for TBCK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TBCK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TBCK
Other transcription factors
Search SABiosciences Chromatin IP Primers for TBCK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBCK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q24 Ensembl cytogenetic band: 4q24 HGNC cytogenetic band: 4q24TBCK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M106967: view genomic region
(about GC identifiers)
Start:
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106,965,474 bp from pter |
End:
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107,242,652 bp from pter |
Size:
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277,179 bases |
Orientation:
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minus strand |
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Proteins
for TBCK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TBCK_HUMAN, Q8TEA7 (See
protein sequence)Recommended Name: TBC domain-containing protein kinase-like protein Size: 893 amino acids; 100679 Da
Sequence caution: Sequence=AAF28980.1; Type=Frameshift; Positions=507, 516, 660, 665, 672; Sequence=BAC05244.1;Type=Miscellaneous discrepancy; Note=intron retention;
Secondary accessions: B9A6J1 Q4W5B3 Q4W5E1 Q6NUP4 Q8N7M8 Q8WW57 Q96GV6 Q9P080Alternative splicing: 3 isoforms: Q8TEA7-1 Q8TEA7-2 Q8TEA7-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TBCK: NX_Q8TEA7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TEA7
TBCK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001156907.1 NP_001156908.1 NP_001156909.1 NP_149106.2
ENSEMBL proteins: ENSP00000273980 ENSP00000355338 ENSP00000378196 ENSP00000421182 ENSP00000378198 ENSP00000422160 ENSP00000423834 ENSP00000426093 ENSP00000423092 ENSP00000420985 ENSP00000425197 ENSP00000423637 ENSP00000405847
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
TBCK for ontologies About GeneDecksing
TBCK Antibody Products:
Assay Products for TBCK: |
Protein
Domains /
Families
for TBCK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TBCK for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TEA7ProtoNet protein and cluster: Q8TEA7 2 Blocks protein families: IPB000195 RabGAP/TBC domain IPB001763 Rhodanese-like
UniProtKB/Swiss-Prot: TBCK_HUMAN, Q8TEA7Domain: The protein kinase domain is predicted to be catalytically inactiveSimilarity: Belongs to the protein kinase superfamilySimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 Rab-GAP TBC domainSimilarity: Contains 1 rhodanese domain |
Function
for TBCK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBCK (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBCK (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): TBCK (NM_033115) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBCK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBCK |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBCK |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TBCK for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TBCK:
|
Pathways & Interactions
for TBCK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBCK
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
TBCK for ontologies About GeneDecksing
|
Drugs & Compounds
for TBCK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TBCK
Search CenterWatch for drugs/clinical trials and news about TBCK
|
Transcripts
for TBCK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TBCK gene (4 alternative transcripts): NM_001163435.1 NM_001163436.1 NM_001163437.1 NM_033115.3 Unigene Cluster for TBCK: TBC1 domain containing kinase Hs.292986 [show with all ESTs]Unigene Representative Sequence: BX64785118/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20): ENST00000273980 ENST00000510927(uc003hyb.2) ENST00000361687(uc003hyc.2)
ENST00000394706(uc003hye.2) ENST00000467183(uc010ilv.2 uc003hyd.2)
ENST00000394708 ENST00000514689 ENST00000515705 ENST00000506384 ENST00000511011
ENST00000506615 ENST00000508666 ENST00000503516 ENST00000505574 ENST00000503832
ENST00000506280 ENST00000509532 ENST00000509862
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBCK (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBCK (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): TBCK (NM_033115) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBCK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBCK |
Additional cDNA sequence: AB449876.1 AF161420.1 AK074305.1 AK098157.1 AK315571.1 BC009208.2 BC020853.2 BC068496.1 BX647851.1 19 DOTS entries: DT.414340 DT.99980522 DT.97858376 DT.92061166 DT.97763994 DT.121258677 DT.100776500 DT.95228097 DT.108438 DT.121258697 DT.95175678 DT.121258768 DT.40229008 DT.444201 DT.91694314 DT.92421351 DT.97763840 DT.121258672 DT.121258696 24/135 AceView cDNA sequences (see all 135): BC020853 AI457618 BF432144 Z44727 BC068496 AI248799 CR608976 NM_033115 AI633963 BE513284 AA872305 AA922021 CB992214 AA702160 AI239417 CA449749 BP376059 BU192178 BU625385 AL708757 CA432811 AK074305 BG741592 BE670030
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for TBCK About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
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| SP1: | | | | | | | | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TBCK
|
Expression
for TBCK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TBCK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTGCTGAA
About this image
See TBCK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TBCK
SOURCE GeneReport for Unigene cluster: Hs.292986
SABiosciences Custom PCR Arrays for TBCK
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBCK
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TBCK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBCK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBCK | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBCK |
Orthologs
for TBCK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TBCK gene from 6/22 species (see all 22) About this table
ENSEMBL Gene Tree for TBCK (if available)
TreeFam Gene Tree for TBCK (if available) |
Paralogs
for TBCK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TBCK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for TBCK
7 CNVs: 92294 63917 59160 98834 43638 36173 62245
1 Indel: 68779 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBCK |
|
Disorders
/ Diseases
for TBCK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TBCK for disorders About GeneDecksing
2  diseases for TBCK: About MalaCardsalcohol dependence alcoholism
Human Genome Epidemiology (HuGE) Navigator: TBCK (1 document)
Export disorders for TBCK gene to outside databases
|
Publications
for TBCK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TBCK gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with TBCK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The protein kinase complement of the human genome. (PubMed id 12471243)1, 2, 3 Manning G.... Sudarsanam S. (2002)
- Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1, 2 Ishibashi K.... Fukuda M. (2009)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. (PubMed id 22837378)1 Wilk J.B....Stricker B.H. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1 Kalsi G....Riley B.P. (2010)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
|
External Searches for TBCK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TBCK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBCK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TBCK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TBCK | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TBCK gene:
Search GeneIP for patents involving TBCK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TBCK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for TBCK | | OriGene shRNA RFP for TBCK | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TBCK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBCK | | | OriGene Protein Over-expression Lysate for TBCK | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for TBCK | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBCK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBCK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TBCK | | OriGene Custom Protein Services for TBCK | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TBCK | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBCK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBCK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBCK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBCK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBCK |
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 | | | TBCK Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBCK |
|  |  |  | | | | Search ThermoFisher Antibodies for TBCK |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBCK |
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