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Aliases for TBCEL Gene

Aliases for TBCEL Gene

  • Tubulin Folding Cofactor E-Like 2 3
  • LRRC35 3 4 6
  • El 3 4 6
  • Leucine-Rich Repeat-Containing Protein 35 3 4
  • Leucine Rich Repeat Containing 35 2 3
  • Tubulin-Specific Chaperone E-Like 2 3
  • Tubulin-Specific Chaperone Cofactor E-Like Protein 3
  • Catastrophin 3
  • E-Like 3

External Ids for TBCEL Gene

Previous Symbols for TBCEL Gene

  • LRRC35

Summaries for TBCEL Gene

GeneCards Summary for TBCEL Gene

TBCEL (Tubulin Folding Cofactor E-Like) is a Protein Coding gene. An important paralog of this gene is TBCE.

UniProtKB/Swiss-Prot for TBCEL Gene

  • Acts as a regulator of tubulin stability.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBCEL Gene

Genomics for TBCEL Gene

Genomic Location for TBCEL Gene

121,024,072 bp from pter
121,092,078 bp from pter
68,007 bases
Plus strand

Genomic View for TBCEL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBCEL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBCEL Gene

Regulatory Elements for TBCEL Gene

Proteins for TBCEL Gene

  • Protein details for TBCEL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tubulin-specific chaperone cofactor E-like protein
    Protein Accession:
    Secondary Accessions:
    • Q0VAN6

    Protein attributes for TBCEL Gene

    424 amino acids
    Molecular mass:
    48195 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TBCEL Gene

Proteomics data for TBCEL Gene at MOPED

Post-translational modifications for TBCEL Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys236

No data available for DME Specific Peptides for TBCEL Gene

Domains for TBCEL Gene

Protein Domains for TBCEL Gene


  • Contains 1 LRRCT domain.:
    • Q5QJ74
  • Contains 1 ubiquitin-like domain.:
    • Q5QJ74
  • Contains 7 LRR (leucine-rich) repeats.:
    • Q5QJ74
genes like me logo Genes that share domains with TBCEL: view

No data available for Gene Families for TBCEL Gene

Function for TBCEL Gene

Molecular function for TBCEL Gene

UniProtKB/Swiss-Prot Function: Acts as a regulator of tubulin stability.

Gene Ontology (GO) - Molecular Function for TBCEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TBCEL: view

miRNA for TBCEL Gene

miRTarBase miRNAs that target TBCEL

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TBCEL Gene

Localization for TBCEL Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBCEL Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for TBCEL Gene COMPARTMENTS Subcellular localization image for TBCEL gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TBCEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TBCEL: view

Pathways for TBCEL Gene

SuperPathways for TBCEL Gene

No Data Available

Interacting Proteins for TBCEL Gene

Gene Ontology (GO) - Biological Process for TBCEL Gene


No data available for Pathways by source for TBCEL Gene

Transcripts for TBCEL Gene

Unigene Clusters for TBCEL Gene

Tubulin folding cofactor E-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBCEL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5: -
SP6: - - - - - - -

Relevant External Links for TBCEL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBCEL Gene

mRNA expression in normal human tissues for TBCEL Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TBCEL Gene

SOURCE GeneReport for Unigene cluster for TBCEL Gene Hs.504136

mRNA Expression by UniProt/SwissProt for TBCEL Gene

Tissue specificity: Abundantly expressed in testis, but is also present in several tissues at a much lower level.
genes like me logo Genes that share expressions with TBCEL: view

Orthologs for TBCEL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TBCEL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TBCEL 36
  • 99.76 (n)
  • 99.76 (a)
  • 100 (a)
(Bos Taurus)
Mammalia LRRC35 37
  • 99 (a)
  • 94.18 (n)
  • 99.29 (a)
(Canis familiaris)
Mammalia TBCEL 36
  • 95.83 (n)
  • 99.53 (a)
  • 100 (a)
(Mus musculus)
Mammalia Tbcel 36
  • 88.92 (n)
  • 97.41 (a)
Tbcel 16
Tbcel 37
  • 97 (a)
(Monodelphis domestica)
Mammalia TBCEL 37
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia TBCEL 37
  • 90 (a)
(Rattus norvegicus)
Mammalia Tbcel 36
  • 88.21 (n)
  • 96.93 (a)
(Gallus gallus)
Aves TBCEL 36
  • 80.42 (n)
  • 89.39 (a)
  • 89 (a)
(Anolis carolinensis)
Reptilia TBCEL 37
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tbcel 36
  • 73.9 (n)
  • 79.25 (a)
(Danio rerio)
Actinopterygii tbcela 37
  • 66 (a)
tbcelb 36
  • 61.78 (n)
  • 63.83 (a)
tbcelb 37
  • 63 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011141 36
  • 48.28 (n)
  • 42.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12214 36
  • 48.33 (n)
  • 42 (a)
CG12214 37
  • 37 (a)
(Caenorhabditis elegans)
Secernentea coel-1 36
  • 44.23 (n)
  • 31.87 (a)
coel-1 37
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAC2 37
  • 17 (a)
Species with no ortholog for TBCEL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TBCEL Gene

Gene Tree for TBCEL (if available)
Gene Tree for TBCEL (if available)

Paralogs for TBCEL Gene

Paralogs for TBCEL Gene

genes like me logo Genes that share paralogs with TBCEL: view

Variants for TBCEL Gene

Sequence variations from dbSNP and Humsavar for TBCEL Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs484656 -- 121,046,662(+) TAATT(G/T)GAGGT intron-variant, upstream-variant-2KB
rs540001 -- 121,022,915(-) AGAAT(G/T)GTATC upstream-variant-2KB
rs554701 -- 121,068,206(-) agttt(G/T)ggaca intron-variant
rs593476 -- 121,035,465(-) ACGTT(G/T)GTTTT intron-variant, utr-variant-5-prime, upstream-variant-2KB
rs598280 -- 121,063,038(+) tgaac(A/C)aagtt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TBCEL Gene

Variant ID Type Subtype PubMed ID
nsv524651 CNV Loss 19592680

Relevant External Links for TBCEL Gene

HapMap Linkage Disequilibrium report

Disorders for TBCEL Gene

Relevant External Links for TBCEL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TBCEL: view

No data available for UniProtKB/Swiss-Prot for TBCEL Gene

Publications for TBCEL Gene

  1. Identification of a novel tubulin-destabilizing protein related to the chaperone cofactor E. (PMID: 15728251) Bartolini F. … Cowan N.J. (J. Cell Sci. 2005) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for TBCEL Gene

Sources for TBCEL Gene

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