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Aliases for TBCEL Gene

Aliases for TBCEL Gene

  • Tubulin Folding Cofactor E-Like 2 3 5
  • Leucine-Rich Repeat-Containing Protein 35 3 4
  • Leucine Rich Repeat Containing 35 2 3
  • Tubulin-Specific Chaperone E-Like 2 3
  • LRRC35 3 4
  • EL 3 4
  • Catastrophin 3
  • E-Like 3

External Ids for TBCEL Gene

Previous HGNC Symbols for TBCEL Gene

  • LRRC35

Previous GeneCards Identifiers for TBCEL Gene

  • GC11P120403
  • GC11P120894
  • GC11P116834

Summaries for TBCEL Gene

GeneCards Summary for TBCEL Gene

TBCEL (Tubulin Folding Cofactor E-Like) is a Protein Coding gene. An important paralog of this gene is TBCE.

UniProtKB/Swiss-Prot for TBCEL Gene

  • Acts as a regulator of tubulin stability.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBCEL Gene

Genomics for TBCEL Gene

Regulatory Elements for TBCEL Gene

Promoters for TBCEL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TBCEL on UCSC Golden Path with GeneCards custom track

Genomic Location for TBCEL Gene

Chromosome:
11
Start:
121,024,072 bp from pter
End:
121,090,775 bp from pter
Size:
66,704 bases
Orientation:
Plus strand

Genomic View for TBCEL Gene

Genes around TBCEL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBCEL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBCEL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBCEL Gene

Proteins for TBCEL Gene

  • Protein details for TBCEL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5QJ74-TBCEL_HUMAN
    Recommended name:
    Tubulin-specific chaperone cofactor E-like protein
    Protein Accession:
    Q5QJ74
    Secondary Accessions:
    • Q0VAN6

    Protein attributes for TBCEL Gene

    Size:
    424 amino acids
    Molecular mass:
    48195 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TBCEL Gene

Proteomics data for TBCEL Gene at MOPED

Post-translational modifications for TBCEL Gene

  • Ubiquitination at Lys 236
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TBCEL Gene

Domains & Families for TBCEL Gene

Protein Domains for TBCEL Gene

Graphical View of Domain Structure for InterPro Entry

Q5QJ74

UniProtKB/Swiss-Prot:

TBCEL_HUMAN :
  • Contains 1 LRRCT domain.
  • Contains 7 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 LRRCT domain.
  • Contains 1 ubiquitin-like domain.
Similarity:
  • Contains 7 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with TBCEL: view

No data available for Gene Families for TBCEL Gene

Function for TBCEL Gene

Molecular function for TBCEL Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulator of tubulin stability.

Phenotypes for TBCEL Gene

genes like me logo Genes that share phenotypes with TBCEL: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBCEL Gene

Localization for TBCEL Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBCEL Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBCEL Gene COMPARTMENTS Subcellular localization image for TBCEL gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for TBCEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TBCEL: view

Pathways & Interactions for TBCEL Gene

SuperPathways for TBCEL Gene

No Data Available

Interacting Proteins for TBCEL Gene

Gene Ontology (GO) - Biological Process for TBCEL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TBCEL Gene

Drugs & Compounds for TBCEL Gene

No Compound Related Data Available

Transcripts for TBCEL Gene

Unigene Clusters for TBCEL Gene

Tubulin folding cofactor E-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBCEL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5: -
SP6: - - - - - - -

Relevant External Links for TBCEL Gene

GeneLoc Exon Structure for
TBCEL
ECgene alternative splicing isoforms for
TBCEL

Expression for TBCEL Gene

mRNA expression in normal human tissues for TBCEL Gene

Protein differential expression in normal tissues from HIPED for TBCEL Gene

This gene is overexpressed in Testis (6.8) and Prostate (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TBCEL Gene



SOURCE GeneReport for Unigene cluster for TBCEL Gene Hs.504136

mRNA Expression by UniProt/SwissProt for TBCEL Gene

Q5QJ74-TBCEL_HUMAN
Tissue specificity: Abundantly expressed in testis, but is also present in several tissues at a much lower level.
genes like me logo Genes that share expression patterns with TBCEL: view

Protein tissue co-expression partners for TBCEL Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TBCEL Gene

Orthologs for TBCEL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TBCEL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TBCEL 35
  • 94.18 (n)
  • 99.29 (a)
LRRC35 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBCEL 35
  • 95.83 (n)
  • 99.53 (a)
TBCEL 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbcel 35
  • 88.92 (n)
  • 97.41 (a)
Tbcel 16
Tbcel 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TBCEL 35
  • 99.76 (n)
  • 99.76 (a)
TBCEL 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbcel 35
  • 88.21 (n)
  • 96.93 (a)
oppossum
(Monodelphis domestica)
Mammalia TBCEL 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TBCEL 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves TBCEL 35
  • 80.42 (n)
  • 89.39 (a)
TBCEL 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBCEL 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tbcel 35
  • 73.9 (n)
  • 79.25 (a)
zebrafish
(Danio rerio)
Actinopterygii tbcelb 35
  • 61.78 (n)
  • 63.83 (a)
tbcela 36
  • 66 (a)
OneToMany
tbcelb 36
  • 63 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011141 35
  • 48.28 (n)
  • 42.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12214 35
  • 48.33 (n)
  • 42 (a)
CG12214 36
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea coel-1 35
  • 44.23 (n)
  • 31.87 (a)
coel-1 36
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAC2 36
  • 17 (a)
OneToMany
Species with no ortholog for TBCEL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TBCEL Gene

ENSEMBL:
Gene Tree for TBCEL (if available)
TreeFam:
Gene Tree for TBCEL (if available)

Paralogs for TBCEL Gene

Paralogs for TBCEL Gene

genes like me logo Genes that share paralogs with TBCEL: view

Variants for TBCEL Gene

Sequence variations from dbSNP and Humsavar for TBCEL Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs484656 -- 121,046,662(+) TAATT(G/T)GAGGT intron-variant
rs554701 -- 121,068,206(-) agttt(G/T)ggaca intron-variant
rs608215 -- 121,060,502(+) TTCAC(A/C)AAATA intron-variant
rs540001 -- 121,022,915(+) AGAAT(A/C/G/T)GTATC upstream-variant-2KB
rs634051 -- 121,068,438(-) gaagc(A/C)gtagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TBCEL Gene

Variant ID Type Subtype PubMed ID
nsv524651 CNV Loss 19592680

Variation tolerance for TBCEL Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBCEL Gene

HapMap Linkage Disequilibrium report
TBCEL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBCEL Gene

Disorders for TBCEL Gene

Relevant External Links for TBCEL

Genetic Association Database (GAD)
TBCEL
Human Genome Epidemiology (HuGE) Navigator
TBCEL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TBCEL

No disorders were found for TBCEL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBCEL Gene

Publications for TBCEL Gene

  1. Identification of a novel tubulin-destabilizing protein related to the chaperone cofactor E. (PMID: 15728251) Bartolini F. … Cowan N.J. (J. Cell Sci. 2005) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Op18/Stathmin counteracts the activity of overexpressed tubulin-disrupting proteins in a human leukemia cell line. (PMID: 18262179) Sellin M.E. … Gullberg M. (Exp. Cell Res. 2008) 3
  5. Possible regulation of microtubules through destabilization of tubulin. (PMID: 16202601) Keller C.E. … Lauring B.P. (Trends Cell Biol. 2005) 23

Products for TBCEL Gene

Sources for TBCEL Gene

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