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Aliases for TBCEL Gene

Aliases for TBCEL Gene

  • Tubulin Folding Cofactor E Like 2 3 5
  • Leucine-Rich Repeat-Containing Protein 35 3 4
  • Leucine Rich Repeat Containing 35 2 3
  • Tubulin-Specific Chaperone E-Like 2 3
  • LRRC35 3 4
  • EL 3 4
  • Tubulin-Specific Chaperone Cofactor E-Like Protein 3
  • Catastrophin 3
  • E-Like 3

External Ids for TBCEL Gene

Previous HGNC Symbols for TBCEL Gene

  • LRRC35

Previous GeneCards Identifiers for TBCEL Gene

  • GC11P120403
  • GC11P120894
  • GC11P116834

Summaries for TBCEL Gene

GeneCards Summary for TBCEL Gene

TBCEL (Tubulin Folding Cofactor E Like) is a Protein Coding gene. An important paralog of this gene is TBCE.

UniProtKB/Swiss-Prot for TBCEL Gene

  • Acts as a regulator of tubulin stability.

Additional gene information for TBCEL Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBCEL Gene

Genomics for TBCEL Gene

Regulatory Elements for TBCEL Gene

Enhancers for TBCEL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H120347 1.3 ENCODE dbSUPER 72.4 -676.7 -676715 1 PKNOX1 FEZF1 GLI4 ZNF2 YY1 ZNF302 KLF7 YY2 TSHZ1 ZNF488 TMEM136 TBCEL TECTA HMGB1P42 ENSG00000254892 THY1 ARHGEF12 PIR31602
GH11H120328 1.7 Ensembl ENCODE dbSUPER 11.1 -688.6 -688550 14 YBX1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 SP3 ZC3H11A MEF2D SSRP1 TMEM136 THY1 TBCEL ARHGEF12
GH11H121446 1.6 FANTOM5 ENCODE dbSUPER 11.7 +428.4 428423 11 HDGF FOXA2 MLX ARNT SIN3A ARID4B YY1 SLC30A9 ZNF143 ZNF207 SORL1 TBCEL SC5D LOC105369536
GH11H121023 1.3 FANTOM5 ENCODE 6.6 +0.3 316 1 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ETS1 GLIS2 ZNF143 ATF7 TBCEL GRIK4 TECTA GC11P121063
GH11H121047 0.5 ENCODE 15.3 +24.5 24489 1 ZNF316 EMSY MAFK TBCEL GC11P121063
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TBCEL on UCSC Golden Path with GeneCards custom track

Promoters for TBCEL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045964 128 1201 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ETS1 GLIS2 ZNF143 RUNX3

Genomic Location for TBCEL Gene

Chromosome:
11
Start:
121,024,072 bp from pter
End:
121,090,775 bp from pter
Size:
66,704 bases
Orientation:
Plus strand

Genomic View for TBCEL Gene

Genes around TBCEL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBCEL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBCEL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBCEL Gene

Proteins for TBCEL Gene

  • Protein details for TBCEL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5QJ74-TBCEL_HUMAN
    Recommended name:
    Tubulin-specific chaperone cofactor E-like protein
    Protein Accession:
    Q5QJ74
    Secondary Accessions:
    • Q0VAN6

    Protein attributes for TBCEL Gene

    Size:
    424 amino acids
    Molecular mass:
    48195 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TBCEL Gene

Post-translational modifications for TBCEL Gene

  • Ubiquitination at Lys236
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TBCEL Gene

Domains & Families for TBCEL Gene

Gene Families for TBCEL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TBCEL Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TBCEL: view

No data available for UniProtKB/Swiss-Prot for TBCEL Gene

Function for TBCEL Gene

Molecular function for TBCEL Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulator of tubulin stability.

Phenotypes From GWAS Catalog for TBCEL Gene

Gene Ontology (GO) - Molecular Function for TBCEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TBCEL: view

Phenotypes for TBCEL Gene

genes like me logo Genes that share phenotypes with TBCEL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TBCEL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBCEL Gene

Localization for TBCEL Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBCEL Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBCEL gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TBCEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TBCEL: view

Pathways & Interactions for TBCEL Gene

SuperPathways for TBCEL Gene

No Data Available

Interacting Proteins for TBCEL Gene

Gene Ontology (GO) - Biological Process for TBCEL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TBCEL Gene

Drugs & Compounds for TBCEL Gene

No Compound Related Data Available

Transcripts for TBCEL Gene

Unigene Clusters for TBCEL Gene

Tubulin folding cofactor E-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TBCEL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TBCEL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5: -
SP6: - - - - - - -

Relevant External Links for TBCEL Gene

GeneLoc Exon Structure for
TBCEL
ECgene alternative splicing isoforms for
TBCEL

Expression for TBCEL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TBCEL Gene

Protein differential expression in normal tissues from HIPED for TBCEL Gene

This gene is overexpressed in Testis (6.8) and Prostate (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TBCEL Gene



Protein tissue co-expression partners for TBCEL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TBCEL Gene:

TBCEL

SOURCE GeneReport for Unigene cluster for TBCEL Gene:

Hs.504136

mRNA Expression by UniProt/SwissProt for TBCEL Gene:

Q5QJ74-TBCEL_HUMAN
Tissue specificity: Abundantly expressed in testis, but is also present in several tissues at a much lower level.

Evidence on tissue expression from TISSUES for TBCEL Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with TBCEL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TBCEL Gene

Orthologs for TBCEL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TBCEL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBCEL 33 34
  • 99.76 (n)
cow
(Bos Taurus)
Mammalia LRRC35 34
  • 99 (a)
OneToOne
TBCEL 33
  • 94.18 (n)
oppossum
(Monodelphis domestica)
Mammalia TBCEL 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBCEL 33 34
  • 95.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TBCEL 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbcel 33 16 34
  • 88.92 (n)
rat
(Rattus norvegicus)
Mammalia Tbcel 33
  • 88.21 (n)
chicken
(Gallus gallus)
Aves TBCEL 33 34
  • 80.42 (n)
lizard
(Anolis carolinensis)
Reptilia TBCEL 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tbcel 33
  • 73.9 (n)
zebrafish
(Danio rerio)
Actinopterygii tbcela 34
  • 66 (a)
OneToMany
tbcelb 33 34
  • 61.78 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12214 33 34
  • 48.33 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011141 33
  • 48.28 (n)
worm
(Caenorhabditis elegans)
Secernentea coel-1 33 34
  • 44.23 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAC2 34
  • 17 (a)
OneToMany
Species where no ortholog for TBCEL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TBCEL Gene

ENSEMBL:
Gene Tree for TBCEL (if available)
TreeFam:
Gene Tree for TBCEL (if available)

Paralogs for TBCEL Gene

Paralogs for TBCEL Gene

genes like me logo Genes that share paralogs with TBCEL: view

Variants for TBCEL Gene

Sequence variations from dbSNP and Humsavar for TBCEL Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000025049 -- 121,075,883(+) AGGAT(A/G)CGGAT intron-variant
rs1000049066 -- 121,033,968(+) TGTCA(A/G)ATTTT intron-variant
rs1000072174 -- 121,031,332(+) CTTCT(A/G)CATTT intron-variant
rs1000083220 -- 121,056,881(+) AACAG(G/T)TCTTT intron-variant
rs1000275535 -- 121,052,184(+) TTAAA(C/T)GATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TBCEL Gene

Variant ID Type Subtype PubMed ID
esv3627914 CNV loss 21293372
nsv1039908 CNV loss 25217958
nsv524651 CNV loss 19592680

Variation tolerance for TBCEL Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBCEL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TBCEL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBCEL Gene

Disorders for TBCEL Gene

Relevant External Links for TBCEL

Genetic Association Database (GAD)
TBCEL
Human Genome Epidemiology (HuGE) Navigator
TBCEL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TBCEL

No disorders were found for TBCEL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBCEL Gene

Publications for TBCEL Gene

  1. Identification of a novel tubulin-destabilizing protein related to the chaperone cofactor E. (PMID: 15728251) Bartolini F … Cowan NJ (Journal of cell science 2005) 2 3 4 60
  2. Identification of 526 conserved metazoan genetic innovations exposes a new role for cofactor E-like in neuronal microtubule homeostasis. (PMID: 24098140) Frédéric MY … Leroux MR (PLoS genetics 2013) 2 3 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 60

Products for TBCEL Gene

Sources for TBCEL Gene

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