TBCEL Gene
protein-coding GIFtS: 44
GCID: GC11P120894
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tubulin folding cofactor E-like(Previous names: leucine rich repeat containing 35, tubulin-specific chaperone...) (Previous symbol: LRRC35)
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Aliases for TBCEL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Tubulin Folding Cofactor E-Like1 2 | | E-Like1 | | LRRC351 2 3 | | El2 | | Leucine Rich Repeat Containing 351 2 | | Catastrophin1 | | Tubulin-Specific Chaperone E-Like1 2 | | Tubulin-Specific Chaperone Cofactor E-Like Protein2 | | Leucine-Rich Repeat-Containing Protein 352 3 | | EL3 | | MGC102331 | | |
Export aliases for TBCEL gene to outside databasesPrevious GC identifers: GC11P120403 GC11P116834 |
Summaries for TBCEL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: TBCEL_HUMAN, Q5QJ74Function: Acts as a regulator of tubulin stability
|
Genomic Views for TBCEL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TBCEL gene promoter: p53 NRSF form 1 NF-kappaB1 NF-kappaB NRSF form 2 Other transcription factors
Search SABiosciences Chromatin IP Primers for TBCEL
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBCEL |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23.3 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3TBCEL Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P120894: view genomic region
(about GC identifiers)
Start:
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120,894,781 bp from pter |
End:
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120,961,484 bp from pter |
Size:
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66,704 bases |
Orientation:
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plus strand |
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Proteins for TBCEL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: TBCEL_HUMAN, Q5QJ74 (See
protein sequence)Recommended Name: Tubulin-specific chaperone cofactor E-like protein Size: 424 amino acids; 48195 Da
Subcellular location: Cytoplasm, cytoskeleton (Probable)
Secondary accessions: Q0VAN6Explore the universe of human proteins at neXtProt for TBCEL: NX_Q5QJ74
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5QJ74 TBCEL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001123519.1 NP_689928.3 ENSEMBL proteins: ENSP00000437184 ENSP00000284259 ENSP00000431803 ENSP00000433365 ENSP00000403925 ENSP00000431156 ENSP00000432783 ENSP00000436419 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TBCEL for ontologies About GeneDecksing
TBCEL Antibody Products: Assay Products for TBCEL: |
Protein
Domains / Families for TBCEL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TBCEL for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5QJ74ProtoNet protein and cluster: Q5QJ74 2 Blocks protein families: IPB000626 Ubiquitin domain IPB001611 Leucine-rich repeat signature
UniProtKB/Swiss-Prot: TBCEL_HUMAN, Q5QJ74Similarity: Contains 7 LRR (leucine-rich) repeatsSimilarity: Contains 1 LRRCT domainSimilarity: Contains 1 ubiquitin-like domain |
Function for TBCEL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: TBCEL_HUMAN, Q5QJ74Function: Acts as a regulator of tubulin stability
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBCEL (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBCEL (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TBCEL (NM_152715) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBCEL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBCEL  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBCEL |
|
Pathways & Interactions for TBCEL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBCEL
|
Drugs & Compounds for TBCEL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for TBCEL Search CenterWatch for drugs/clinical trials and news about TBCEL 
|
Transcripts for TBCEL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for TBCEL gene (2 alternative transcripts): NM_001130047.1 NM_152715.3 Unigene Cluster for TBCEL: Tubulin folding cofactor E-like Hs.504136 [show with all ESTs]Unigene Representative Sequence: NM_15271510 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000529397 ENST00000284259 ENST00000528512 ENST00000531148 ENST00000422003(uc009zay.3 uc001pxo.3 uc001pxp.3 uc001pxq.3) ENST00000533712 ENST00000524726 ENST00000530362 ENST00000533134 ENST00000533169
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBCEL (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBCEL (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TBCEL (NM_152715) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBCEL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBCEL  |
Additional cDNA sequence: AK024239.1 AK295673.1 AK313324.1 AY398644.1 BC020501.1 BC120988.1 BC120989.1 6 DOTS entries: DT.446404 DT.412432 DT.95367827 DT.92038208 DT.97813987 DT.99965230 24/109 AceView cDNA sequences (see all 109): AI359838 CR616944 CA389856 AI655722 AI884394 AI801110 AW451951 AI200940 AW117238 BQ890649 AW594223 AA809962 BM672023 AI569190 H98807 CK818750 AA041434 BE672045 AA860582 AI653257 AW614827 AW594566 NM_152715 BM126946 GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TBCEL (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | |
| SP1: | |   | |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for TBCEL
|
Expression for TBCEL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TBCEL expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TGTACTTATA
About this image See TBCEL Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TBCEL
SOURCE GeneReport for Unigene cluster: Hs.504136 UniProtKB/Swiss-Prot: TBCEL_HUMAN, Q5QJ74Tissue specificity: Abundantly expressed in testis, but is also present in several tissues at a much lower level SABiosciences Custom PCR Arrays for TBCEL
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBCEL Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TBCEL | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBCEL | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBCEL | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBCEL |
Orthologs for TBCEL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TBCEL gene from 7/22 species (see all 22) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
TBCEL1 |
tubulin folding cofactor E-like |
80.42(n) 89.39(a) |
  |
429536 XM_427094.2 XP_427094.2 |
lizard (Anolis carolinensis) |
Reptilia |
TBCEL6 |
-- |
88(a) |
1 ↔ 1 |
LGa(2123968-2137306) |
zebrafish (Danio rerio) |
Actinopterygii |
BM342099.12 |
-- |
73.99(n) |
  |
BM342099.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
CG122141 |
CG12214 |
49.34(n) 43.31(a) |
  |
36072 NM_165754.1 NP_724901.1 |
worm (Caenorhabditis elegans) |
Secernentea |
coel-11 |
Protein COEL-1 |
44.23(n) 31.87(a) |
  |
180700 NM_171665.2 NP_741764.1 |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
PFI6 |
tubulin folding cofactor E / Pfifferling (PFI) |
21(a) |
1 ↔ 1 |
1(26921060-26924386) |
rice (Oryza sativa) |
Liliopsida |
-- |
tubulin-specific chaperone E, putative, expressed |
18(a) |
1 ↔ 1 |
5(291425-296877) |
ENSEMBL Gene Tree for TBCEL (if available) TreeFam Gene Tree for TBCEL (if available)  |
Paralogs for TBCEL gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for TBCEL gene
- TBCE2
TBCEL for paralogs About GeneDecksing
|
Genomic Variants for TBCEL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 11 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for TBCEL (120894781 - 120961484 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TBCEL: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBCEL |
|
Disorders
/ Diseases for TBCEL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TBCEL for disorders About GeneDecksing
OMIM gene information: 610451
OMIM disorders: --
1 disease for TBCEL: About MalaCardsleukemia Human Genome Epidemiology (HuGE) Navigator: TBCEL (1 document) Export disorders for TBCEL gene to outside databases
|
Publications for TBCEL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TBCEL gene integrated from 9 sources: (articles sorted by number of sources associating them with TBCEL) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Identification of a novel tubulin-destabilizing protein related to the chaperone cofactor E. (PubMed id 15728251)1, 2, 3 Bartolini F....Cowan N.J. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Op18/Stathmin counteracts the activity of overexpressed tubulin-disrupting proteins in a human leukemia cell line. (PubMed id 18262179)1 Sellin M.E....Gullberg M. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Possible regulation of microtubules through destabilization of tubulin. (PubMed id 16202601)9 Keller C.E. and Lauring B.P. (2005)
|
External Searches for TBCEL gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TBCEL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBCEL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TBCEL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for TBCEL | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TBCEL gene: Search GeneIP for patents involving TBCEL
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for TBCEL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | OriGene Custom Antibody Services for TBCEL | | OriGene Custom Protein Services for TBCEL | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TBCEL | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBCEL | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBCEL | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBCEL | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBCEL | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBCEL |
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 |  |  |  | |
| | | Search Tocris compounds for TBCEL |
| |  |  |  |  | | | | |
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 | | TBCEL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBCEL |
|  |  |  | | | Search ThermoFisher Antibodies for TBCEL |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBCEL |
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