Aliases for TBCE Gene
External Ids for TBCE Gene
Previous HGNC Symbols for TBCE Gene
Previous GeneCards Identifiers for TBCE Gene
Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TBCE Gene
TBCE (Tubulin Folding Cofactor E) is a Protein Coding gene. Diseases associated with TBCE include hypoparathyroidism-retardation-dysmorphism syndrome and kenny-caffey syndrome, type 1. Among its related pathways are Transport to the Golgi and subsequent modification and Protein folding. GO annotations related to this gene include structural constituent of ribosome and chaperone binding. An important paralog of this gene is TBCEL.
UniProtKB/Swiss-Prot for TBCE Gene
Tubulin-folding protein; involved in the second step of the tubulin folding pathway. Seems to be implicated in the maintenance of the neuronal microtubule network. Involved in regulation of tubulin heterodimer dissociation.