Aliases for TBCE Gene
External Ids for TBCE Gene
Previous HGNC Symbols for TBCE Gene
Previous GeneCards Identifiers for TBCE Gene
Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TBCE Gene
TBCE (Tubulin Folding Cofactor E) is a Protein Coding gene. Diseases associated with TBCE include hypoparathyroidism-retardation-dysmorphism syndrome and kenny-caffey syndrome-1. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Protein folding. GO annotations related to this gene include chaperone binding. An important paralog of this gene is TBCEL.
UniProtKB/Swiss-Prot for TBCE Gene
Tubulin-folding protein; involved in the second step of the tubulin folding pathway. Seems to be implicated in the maintenance of the neuronal microtubule network. Involved in regulation of tubulin heterodimer dissociation.