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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TBCD Gene

protein-coding GIFtS: 61
GCID: GC17P080709

tubulin folding cofactor D

(Previous name: tubulin-specific chaperone d )

Explore 9 diseases affiliated with
TBCD via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tubulin Folding Cofactor D¹ ²		TfcD¹
Tubulin-Specific Chaperone D¹ ²		KIAA0988³
Beta-Tubulin Cofactor D² ³		SSD1³
Tubulin-Folding Cofactor D² ³		TFCD³
SSD-1² ³

External Ids:	HGNC: 11581¹	Entrez Gene: 6904²	Ensembl: ENSG00000141556⁷	OMIM: 604649⁵	UniProtKB: Q9BTW9³

Export aliases for TBCD gene to outside databases

Previous GC identifers: GC17P079838 GC17P083992 GC17P081239 GC17P081388 GC17P078303 GC17P076109

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TBCD:

Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded

beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing

beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex;

interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native

state. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TBCD_HUMAN, Q9BTW9

Function: Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule

dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase-activating protein (GAP) for ARL2. Its ability

to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of

ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell

detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell

membrane

Gene Wiki entry for TBCD

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010663.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TBCD gene promoter:
Tal-1 MyoD AP-4 MIF-1 E47 YY1 CREB AREB6 deltaCREB SEF-1 (1)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TBCD promoter sequence

Search SABiosciences Chromatin IP Primers for TBCD

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBCD

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3

TBCD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBCD gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P080709: view genomic region (about GC identifiers)

Start:	80,709,940 bp from pter	End:	80,901,062 bp from pter
Size:	191,123 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TBCD_HUMAN, Q9BTW9 (See protein sequence)

Recommended Name: Tubulin-specific chaperone D

Size: 1192 amino acids; 132600 Da

Subunit: Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with PPP2CB.

Interacts with ARL2 (By similarity). Supercomplex made of cofactors A to E. Cofactors A and D function by capturing

and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex;

interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

Interacts with ARL2; interaction is enhanced with the GDP-bound form of ARL2. Does not interact with ARL3, ARL4A and

ARL4D. Interacts with beta tubulin

Subcellular location: Cell junction, tight junction (By similarity). Lateral cell membrane (By similarity). Cytoplasm

(By similarity). Cell junction, adherens junction (By similarity). Note=Localized in cell-cell contacts (By

similarity)

Sequence caution: Sequence=AAH39654.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAA76832.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: O95458 Q7L8K1 Q8IXP6 Q8NAX0 Q8WYH4 Q96E74 Q9UF82 Q9UG46 Q9Y2J3

Alternative splicing: 5 isoforms: Q9BTW9-1 Q9BTW9-2 Q9BTW9-3 Q9BTW9-4 Q9BTW9-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TBCD: NX_Q9BTW9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BTW9

TBCD Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005984.3

ENSEMBL proteins:

ENSP00000347719 ENSP00000440671 ENSP00000458535 ENSP00000459063 ENSP00000460450

ENSP00000458365 ENSP00000460949 ENSP00000461167 ENSP00000461680 ENSP00000458556

ENSP00000458599 ENSP00000458512 ENSP00000458916 ENSP00000380608

Reactome Protein details: Q9BTW9
Human Recombinant Protein Products:

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	Novus Biologicals TBCD Protein Novus Biologicals TBCD Lysates
	Browse Sino Biological Recombinant Proteins
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	Uscn Proteins for TBCD

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005874	microtubule	TAS	8706133
GO:0005912	adherens junction	ISS	--
GO:0005923	tight junction	ISS	--
GO:0016328	lateral plasma membrane	ISS	--

TBCD for ontologies About GeneDecksing

TBCD Antibody Products:

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	Uscn Antibodies for TBCD
	ThermoFisher Antibodies for TBCD

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	Uscn ELISAs and CLIAs for TBCD

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TBCD for domains About GeneDecksing

3 InterPro domains/families:

IPR022577 Tubulin_specific_chaperoneD_C

IPR011989 ARM-like

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q9BTW9

ProtoNet protein and cluster: Q9BTW9

1 Blocks protein family: IPB000357 HEAT repeat

UniProtKB/Swiss-Prot: TBCD_HUMAN, Q9BTW9

Similarity: Belongs to the TBCD family

Similarity: Contains 3 HEAT repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TBCD_HUMAN, Q9BTW9

Function: Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule

dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase-activating protein (GAP) for ARL2. Its ability

to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of

ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell

detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell

membrane

Induction: Down-regulated by shear stress

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBCD

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005096	GTPase activator activity	IMP	10831612
GO:0005515	protein binding	IPI	10831612
GO:0048487	beta-tubulin binding	IDA	10831612
GO:0051087	chaperone binding	TAS	8706133

TBCD for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for TBCD:

Increased gamma-H2AX phosphory

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Chaperonin-mediated protein folding

Protein folding

0.91

Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane

Post-chaperonin tubulin folding pathway

0.67

Asparagine N-linked glycosylation

Metabolism of proteins

0.15

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for TBCD

	Post-chaperonin tubulin folding pathway
	Metabolism of proteins
	Protein folding

TBCD for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TBCD

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/21 Interacting proteins for TBCD (Q9BTW9^{2, 3} ENSP00000347719⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
XRCC6	P12956²^,³	MINT-65799 I2D: score=5
SMAD9	O15198²^,³	MINT-62136 I2D: score=3
IKBKG	Q9Y6K9²^,³	MINT-48180 I2D: score=2
ARL2	P36404²^,³, ENSP00000246747⁴	MINT-6602322 I2D: score=4 STRING: ENSP00000246747
ARL3	P36405²^,³, ENSP00000260746⁴	MINT-6602333 I2D: score=1 STRING: ENSP00000260746

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006457	protein folding	TAS	8706133
GO:0007023	post-chaperonin tubulin folding pathway	IDA	11847227
GO:0010812	negative regulation of cell-substrate adhesion	ISS	--
GO:0031115	negative regulation of microtubule polymerization	IDA	--
GO:0034333	adherens junction assembly	ISS	--

TBCD for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TBCD

1 HMDB Compound for TBCD About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about TBCD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TBCD gene (2 alternative transcripts):

NM_005993.4 NM_001033052.1

Unigene Cluster for TBCD:

Tubulin folding cofactor D

Hs.464391 [show with all ESTs]

Unigene Representative Sequence: NM_005993

18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):

ENST00000355528(uc002kfx.1 uc002kfz.3) ENST00000539345(uc002kfy.1)

ENST00000576160 ENST00000571712 ENST00000576996 ENST00000574801 ENST00000571316

ENST00000576760 ENST00000572984 ENST00000574975 ENST00000572953 ENST00000571796(uc002kgb.1)

ENST00000574422 ENST00000571618 ENST00000574818 ENST00000574886 ENST00000570679

ENST00000577051

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Additional cDNA sequence:

AB023205.1 AF052173.1 AF193042.1 AJ006417.1 AK057975.1 AK091959.1 AK129619.1 AK293471.1

AL096745.1 AL133562.1 BC003094.1 BC012824.2 BC024167.1 BC039654.1 BC150142.1

24/32 DOTS entries (see all 32):

DT.454741 DT.100673985 DT.118523 DT.95168149 DT.100814770 DT.100814775 DT.100814771 DT.91982660

DT.97790524 DT.100704661 DT.92447496 DT.92447500 DT.95168151 DT.102843133 DT.40115473 DT.95317658

DT.100030683 DT.100814773 DT.100814776 DT.102843138 DT.120973984 DT.120974001 DT.120974125 DT.120974127

24/434 AceView cDNA sequences (see all 434):

BM783727 BM783758 AI659063 BF345976 F09256 AW247323 AA635108 BQ056753

BF345804 AA324892 BM783294 CR607508 BU187073 BX337078 AW769005 AI199465

BC006364 BM728485 BU552893 BM678619 NM_005993 BI834229 BM703854 BU164758

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TBCD (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^
SP1:																																					-
SP2:																																					-
SP3:
SP4:
SP5:																	-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-

ExUns:	22	^	23	^	24	^	25	^	26	^	27	^	28a	·	28b	^	29	^	30	^	31a	·	31b	^	32a	·	32b	·	32c	^	33	^	34	^	35a	·	35b	·	35c	^	36	^	37	^	38	^	39a	·	39b	^	40	^
SP1:							-		-				-												-														-								-		-
SP2:							-		-				-												-														-								-
SP3:
SP4:
SP5:	-		-		-		-		-		-		-		-		-								-

ExUns:	41	^	42a	·	42b	·	42c	^	43a	·	43b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for TBCD

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TBCD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACCAAGAAA

About this image
See TBCD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TBCD

SOURCE GeneReport for Unigene cluster: Hs.464391

UniProtKB/Swiss-Prot: TBCD_HUMAN, Q9BTW9

Tissue specificity: Ubiquitously expressed

SABiosciences Custom PCR Arrays for TBCD

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TBCD gene from 8/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tbcd^{1 , 5}	tubulin-specific chaperone d^{1, 5}	80.66(n)¹ 82.34(a)¹		11 (85.41 cM)⁵ 108903¹ NM_029878.3¹ NP_084154.1¹ 121451949⁵
chicken (Gallus gallus)	Aves	TBCD¹	tubulin folding cofactor D	69.11(n) 71.01(a)		417334 NM_001012801.1 NP_001012819.1
lizard (Anolis carolinensis)	Reptilia	--	--	73(a)	1 ↔ 1	2(108276955-108403230)
zebrafish (Danio rerio)	Actinopterygii	tbcd¹	tubulin-specific chaperone d	64.01(n) 65.24(a)		553265 XM_001922549.1 XP_001922584.2
fruit fly (Drosophila melanogaster)	Insecta	BcDNA:LD22320³ CG7261¹	CG7261¹	39(a)³ 51.54(n)¹ 41.88(a)¹		22D1³ 33389¹ NM_134804.3¹ NP_608648.1¹
worm (Caenorhabditis elegans)	Secernentea	F16D3.4³	--	28(a)		I(8372284-8377977) --
thale cress (Arabidopsis thaliana)	eudicotyledons	TTN1¹	armadillo/beta-catenin-like repeat-containing protein	46.05(n) 38.5(a)		825245 NM_115938.5 NP_191633.3
rice (Oryza sativa)	Liliopsida	Os.17209²	Oryza sativa (japonica cultivar-group) putative tubulin-folding more	72.23(n)		NM_197281.1

ENSEMBL Gene Tree for TBCD (if available)
TreeFam Gene Tree for TBCD (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75802527^1,2	C,	--	76188375(+)	`CCCATA/GTACCC`	1	--	ds500¹		2		WA	120
rs78402343^1,2	C,	--	76188411(+)	`CCCGCG/AGATAT`	1	--	ds500¹		1		WA	2
rs3834573^1,2	C,	--	76188700(-)	`GGGGG-/GTGTGC`	1	--	ds500¹		0	--	--	--	--
rs74002539^1,2	C	--	76188701(+)	`CACACC/ACCCCC`	1	--	ds500¹		1		WA	2
rs111901976^1,2	C,F,	--	76188775(+)	`TTAATC/TGCTGC`	1	--	ds500¹		4		CSA WA NA	242
rs55979649^1,2	C	--	76188813(+)	`TGTTAA/-CGGCA`	1	--	ds500¹		2		NA CSA	4
rs34475134^1,2	C	--	76189389(+)	`GGTTTTTTG/- TTTGT`	2	--	ut3¹		1		NA	2
rs184215391^1,2	C	--	76189408(+)	`TGTTTG/TTTTTT`	1	--	ut3¹		0	--	--	--	--
rs74002540^1,2	C,	--	76191970(+)	`CTATCG/AGAAGC`	1	--	ut5¹		1		WA	2
rs76445273^1,2	C,F,	--	76192228(+)	`CCCACC/TGTGTT`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for TBCD (80709940 - 80901062 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for TBCD
3 CNVs: 102563 23537 73078
10 Indels: 25968 41358 45614 42447 102564 45613 73084 45612 67282 11906

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TBCD for disorders           About GeneDecksing

OMIM gene information: 604649    OMIM disorders: --

9 diseases for TBCD:    About MalaCards

gilles de la tourette syndrome retinitis pigmentosa-2 retinitis pigmentosa tourette syndrome

corneal dystrophy kidney disease retinitis choroiditis

neuronitis

3 diseases from the University of Copenhagen DISEASES database for TBCD:

Lattice corneal dystrophy Gilles de la Tourette syndrome Corneal granular dystrophy

Human Genome Epidemiology (HuGE) Navigator: TBCD (3 documents)

Export disorders for TBCD gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TBCD gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with TBCD)

Utopia: connect your pdf to the dynamic
world of online information

Shear stress-dependent regulation of the human beta-tubulin folding cofactor D gene. (PubMed id 11110777)^{1, 2, 9} Schubert A....Morawietz H. (2000)
ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin. (PubMed id 10831612)^{1, 2, 9} Bhamidipati A....Cowan N.J. (2000)
Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity. (PubMed id 20740604)^{1, 2} Tian G.... Cowan N.J. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C. (PubMed id 11847227)^{1, 2} Bartolini F....Cowan N.J. (2002)
Tubulin folding cofactor D is a microtubule destabilizing protein. (PubMed id 10722852)^{1, 2} Martin L.... Zabala J.C. (2000)
Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)^{1, 2} Nagase T.... Ohara O. (1999)
Beta-tubulin cofactor D and ARL2 take part in apical junctional complex disassembly and abrogate epithelial structure. (PubMed id 17704193)^{1, 9} Shultz T....Altschuler Y. (2008)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6904	HGNC: 11581	AceView: TBCD	Ensembl:ENSG00000141556	euGenes: HUgn6904
ECgene: TBCD	H-InvDB: TBCD

(According to HUGE)
About This Section

HUGE: KIAA0988

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TBCD	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TBCD gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TBCD gene:
Search GeneIP for patents involving TBCD

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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