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Aliases for TBCCD1 Gene

Aliases for TBCCD1 Gene

  • TBCC Domain Containing 1 2 3 5

External Ids for TBCCD1 Gene

Previous GeneCards Identifiers for TBCCD1 Gene

  • GC03M187739
  • GC03M186263
  • GC03M183672

Summaries for TBCCD1 Gene

GeneCards Summary for TBCCD1 Gene

TBCCD1 (TBCC Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include actin binding.

UniProtKB/Swiss-Prot for TBCCD1 Gene

  • Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBCCD1 Gene

Genomics for TBCCD1 Gene

Regulatory Elements for TBCCD1 Gene

Enhancers for TBCCD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TBCCD1 on UCSC Golden Path with GeneCards custom track

Promoters for TBCCD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TBCCD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TBCCD1 Gene

186,546,067 bp from pter
186,570,543 bp from pter
24,477 bases
Minus strand

Genomic View for TBCCD1 Gene

Genes around TBCCD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBCCD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBCCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBCCD1 Gene

Proteins for TBCCD1 Gene

  • Protein details for TBCCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TBCC domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B3KW69
    • D3DNU6
    • G5E9J4

    Protein attributes for TBCCD1 Gene

    557 amino acids
    Molecular mass:
    63530 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TBCCD1 Gene


neXtProt entry for TBCCD1 Gene

Proteomics data for TBCCD1 Gene at MOPED

Post-translational modifications for TBCCD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBCCD1 Gene

No data available for DME Specific Peptides for TBCCD1 Gene

Domains & Families for TBCCD1 Gene

Suggested Antigen Peptide Sequences for TBCCD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-CAP/cofactor C-like domain.
  • Belongs to the TBCC family.
  • Contains 1 C-CAP/cofactor C-like domain.
  • Belongs to the TBCC family.
genes like me logo Genes that share domains with TBCCD1: view

No data available for Gene Families for TBCCD1 Gene

Function for TBCCD1 Gene

Molecular function for TBCCD1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration.
genes like me logo Genes that share phenotypes with TBCCD1: view

Animal Models for TBCCD1 Gene

MGI Knock Outs for TBCCD1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TBCCD1 Gene

Localization for TBCCD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBCCD1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes at the spindle midzone, midbody and basal bodies of primary and motile cilia.

Subcellular locations from

Jensen Localization Image for TBCCD1 Gene COMPARTMENTS Subcellular localization image for TBCCD1 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 3
cytosol 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for TBCCD1 Gene

Pathways & Interactions for TBCCD1 Gene

SuperPathways for TBCCD1 Gene

No Data Available

Interacting Proteins for TBCCD1 Gene

Gene Ontology (GO) - Biological Process for TBCCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0007010 cytoskeleton organization IEA --
GO:0008360 regulation of cell shape IMP 20168327
GO:0051661 maintenance of centrosome location IMP 20168327
GO:0051684 maintenance of Golgi location IMP 20168327
genes like me logo Genes that share ontologies with TBCCD1: view

No data available for Pathways by source and SIGNOR curated interactions for TBCCD1 Gene

Drugs & Compounds for TBCCD1 Gene

No Compound Related Data Available

Transcripts for TBCCD1 Gene

Unigene Clusters for TBCCD1 Gene

TBCC domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBCCD1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c
SP3: -
SP6: - -

Relevant External Links for TBCCD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBCCD1 Gene

mRNA expression in normal human tissues for TBCCD1 Gene

Protein differential expression in normal tissues from HIPED for TBCCD1 Gene

This gene is overexpressed in CD8 Tcells (36.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TBCCD1 Gene

SOURCE GeneReport for Unigene cluster for TBCCD1 Gene Hs.518469

genes like me logo Genes that share expression patterns with TBCCD1: view

Protein tissue co-expression partners for TBCCD1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TBCCD1 Gene

Orthologs for TBCCD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TBCCD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TBCCD1 35
  • 90.42 (n)
  • 91.92 (a)
  • 92 (a)
(Canis familiaris)
Mammalia TBCCD1 35
  • 92.16 (n)
  • 93.36 (a)
  • 93 (a)
(Mus musculus)
Mammalia Tbccd1 35
  • 84 (n)
  • 83.15 (a)
Tbccd1 16
Tbccd1 36
  • 83 (a)
(Pan troglodytes)
Mammalia TBCCD1 35
  • 99.58 (n)
  • 99.1 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Tbccd1 35
  • 84.11 (n)
  • 82.19 (a)
(Monodelphis domestica)
Mammalia TBCCD1 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia TBCCD1 36
  • 73 (a)
(Gallus gallus)
Aves TBCCD1 35
  • 68.42 (n)
  • 71.64 (a)
  • 71 (a)
(Anolis carolinensis)
Reptilia TBCCD1 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tbccd1 35
  • 63.86 (n)
  • 59.52 (a)
(Danio rerio)
Actinopterygii tbccd1 35
  • 58.42 (n)
  • 56.14 (a)
tbccd1 36
  • 54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for TBCCD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBCCD1 Gene

Gene Tree for TBCCD1 (if available)
Gene Tree for TBCCD1 (if available)

Paralogs for TBCCD1 Gene Pseudogenes for TBCCD1 Gene

genes like me logo Genes that share paralogs with TBCCD1: view

No data available for Paralogs for TBCCD1 Gene

Variants for TBCCD1 Gene

Sequence variations from dbSNP and Humsavar for TBCCD1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs7619912 - 186,558,463(+) GAGAT(C/T)TGTTT reference, missense
rs1868141 -- 186,553,974(-) tctac(G/T)tggga intron-variant
rs9815378 -- 186,561,799(+) aaaaa(A/T)aaata intron-variant
rs7613514 -- 186,556,160(+) ATATA(C/T)GGTTA intron-variant
rs998870 -- 186,560,287(+) tagta(C/G)ataat intron-variant

Variation tolerance for TBCCD1 Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TBCCD1 Gene

Disorders for TBCCD1 Gene

Relevant External Links for TBCCD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TBCCD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBCCD1 Gene

Publications for TBCCD1 Gene

  1. TBCCD1, a new centrosomal protein, is required for centrosome and Golgi apparatus positioning. (PMID: 20168327) Goncalves J. … Soares H. (EMBO Rep. 2010) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for TBCCD1 Gene

Sources for TBCCD1 Gene