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Aliases for TBCCD1 Gene

Aliases for TBCCD1 Gene

  • TBCC Domain Containing 1 2 3

External Ids for TBCCD1 Gene

Previous GeneCards Identifiers for TBCCD1 Gene

  • GC03M187739
  • GC03M186263
  • GC03M183672

Summaries for TBCCD1 Gene

GeneCards Summary for TBCCD1 Gene

TBCCD1 (TBCC Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include actin binding.

UniProtKB/Swiss-Prot for TBCCD1 Gene

  • Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBCCD1 Gene

Genomics for TBCCD1 Gene

Regulatory Elements for TBCCD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TBCCD1 Gene

Start:
186,546,067 bp from pter
End:
186,570,543 bp from pter
Size:
24,477 bases
Orientation:
Minus strand

Genomic View for TBCCD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBCCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBCCD1 Gene

Proteins for TBCCD1 Gene

  • Protein details for TBCCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVR7-TBCC1_HUMAN
    Recommended name:
    TBCC domain-containing protein 1
    Protein Accession:
    Q9NVR7
    Secondary Accessions:
    • B3KW69
    • D3DNU6
    • G5E9J4

    Protein attributes for TBCCD1 Gene

    Size:
    557 amino acids
    Molecular mass:
    63530 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TBCCD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBCCD1 Gene

Proteomics data for TBCCD1 Gene at MOPED

Post-translational modifications for TBCCD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBCCD1 Gene

No data available for DME Specific Peptides for TBCCD1 Gene

Domains for TBCCD1 Gene

Suggested Antigen Peptide Sequences for TBCCD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVR7

UniProtKB/Swiss-Prot:

TBCC1_HUMAN :
  • Q9NVR7
Domain:
  • Contains 1 C-CAP/cofactor C-like domain.
Family:
  • Belongs to the TBCC family.
genes like me logo Genes that share domains with TBCCD1: view

No data available for Gene Families for TBCCD1 Gene

Function for TBCCD1 Gene

Molecular function for TBCCD1 Gene

UniProtKB/Swiss-Prot Function: Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration.

Gene Ontology (GO) - Molecular Function for TBCCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with TBCCD1: view

Phenotypes for TBCCD1 Gene

genes like me logo Genes that share phenotypes with TBCCD1: view

Animal Model Products

CRISPR Products

miRNA for TBCCD1 Gene

miRTarBase miRNAs that target TBCCD1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TBCCD1 Gene

Localization for TBCCD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBCCD1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes at the spindle midzone, midbody and basal bodies of primary and motile cilia.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBCCD1 Gene COMPARTMENTS Subcellular localization image for TBCCD1 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
golgi apparatus 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TBCCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0031616 spindle pole centrosome IDA 20168327
genes like me logo Genes that share ontologies with TBCCD1: view

Pathways for TBCCD1 Gene

SuperPathways for TBCCD1 Gene

No Data Available

Interacting Proteins for TBCCD1 Gene

Gene Ontology (GO) - Biological Process for TBCCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0007010 cytoskeleton organization IEA --
GO:0008360 regulation of cell shape IMP 20168327
GO:0030334 regulation of cell migration IMP 20168327
GO:0051661 maintenance of centrosome location IMP 20168327
genes like me logo Genes that share ontologies with TBCCD1: view

No data available for Pathways by source for TBCCD1 Gene

Transcripts for TBCCD1 Gene

Unigene Clusters for TBCCD1 Gene

TBCC domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBCCD1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBCCD1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6: - -
SP7:

Relevant External Links for TBCCD1 Gene

GeneLoc Exon Structure for
TBCCD1
ECgene alternative splicing isoforms for
TBCCD1

Expression for TBCCD1 Gene

mRNA expression in normal human tissues for TBCCD1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TBCCD1 Gene

SOURCE GeneReport for Unigene cluster for TBCCD1 Gene Hs.518469

genes like me logo Genes that share expressions with TBCCD1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TBCCD1 Gene

Orthologs for TBCCD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TBCCD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBCCD1 35
  • 99.58 (n)
  • 99.1 (a)
TBCCD1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TBCCD1 35
  • 90.42 (n)
  • 91.92 (a)
TBCCD1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBCCD1 35
  • 92.16 (n)
  • 93.36 (a)
TBCCD1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbccd1 35
  • 84 (n)
  • 83.15 (a)
Tbccd1 16
Tbccd1 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TBCCD1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TBCCD1 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbccd1 35
  • 84.11 (n)
  • 82.19 (a)
chicken
(Gallus gallus)
Aves TBCCD1 35
  • 68.42 (n)
  • 71.64 (a)
TBCCD1 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBCCD1 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tbccd1 35
  • 63.86 (n)
  • 59.52 (a)
zebrafish
(Danio rerio)
Actinopterygii tbccd1 35
  • 58.42 (n)
  • 56.14 (a)
tbccd1 36
  • 54 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToOne
Species with no ortholog for TBCCD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBCCD1 Gene

ENSEMBL:
Gene Tree for TBCCD1 (if available)
TreeFam:
Gene Tree for TBCCD1 (if available)

Paralogs for TBCCD1 Gene

Pseudogenes.org Pseudogenes for TBCCD1 Gene

genes like me logo Genes that share paralogs with TBCCD1: view

No data available for Paralogs for TBCCD1 Gene

Variants for TBCCD1 Gene

Sequence variations from dbSNP and Humsavar for TBCCD1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs998870 -- 186,560,287(+) tagta(C/G)ataat intron-variant
rs1530640 -- 186,549,306(+) taaaT(A/T)AATTA intron-variant
rs1868141 -- 186,553,974(-) tctac(G/T)tggga intron-variant
rs2139543 -- 186,561,623(+) CTCTA(C/T)TAAAA intron-variant
rs2176810 -- 186,561,508(+) aatag(G/T)gccgg intron-variant

Relevant External Links for TBCCD1 Gene

HapMap Linkage Disequilibrium report
TBCCD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TBCCD1 Gene

Disorders for TBCCD1 Gene

Relevant External Links for TBCCD1

Genetic Association Database (GAD)
TBCCD1
Human Genome Epidemiology (HuGE) Navigator
TBCCD1
genes like me logo Genes that share disorders with TBCCD1: view

No data available for UniProtKB/Swiss-Prot for TBCCD1 Gene

Publications for TBCCD1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. TBCCD1, a new centrosomal protein, is required for centrosome and Golgi apparatus positioning. (PMID: 20168327) Goncalves J. … Soares H. (EMBO Rep. 2010) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for TBCCD1 Gene

Sources for TBCCD1 Gene

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