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TBCC Gene

protein-coding   GIFtS: 59
GCID: GC06M042712

Tubulin Folding Cofactor C

(Previous name: tubulin-specific chaperone c)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tubulin Folding Cofactor C1 2
Tubulin-Specific Chaperone C1 2
Tubulin-Folding Cofactor C2 3
CFC2 3

External Ids:    HGNC: 115801   Entrez Gene: 69032   Ensembl: ENSG000001246597   OMIM: 6029715   UniProtKB: Q158143   

Export aliases for TBCC gene to outside databases

Previous GC identifers: GC06M042714 GC06M042759 GC06M042820 GC06M042430


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TBCC Gene:
Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded
beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and
stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor
D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are
committed to the native state. (provided by RefSeq, Jul 2008)

GeneCards Summary for TBCC Gene:
TBCC (tubulin folding cofactor C) is a protein-coding gene. Diseases associated with TBCC include retinitis pigmentosa 2, and spastic quadriplegia. GO annotations related to this gene include chaperone binding and GTPase activity. An important paralog of this gene is RP2.

UniProtKB/Swiss-Prot: TBCC_HUMAN, Q15814
Function: Tubulin-folding protein; involved in the final step of the tubulin folding pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TBCC gene promoter:
         Spz1   AML1a   CUTL1   RelA   Nkx2-5   Ik-3   Egr-4   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBCC promoter sequence
   Search Chromatin IP Primers for TBCC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBCC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

TBCC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBCC gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M042712:  view genomic region     (about GC identifiers)

Start:
42,712,219 bp from pter      End:
42,714,558 bp from pter
Size:
2,340 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TBCC_HUMAN, Q15814 (See protein sequence)
Recommended Name: Tubulin-specific chaperone C  
Size: 346 amino acids; 39248 Da
Subunit: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in
a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then
causes the release of tubulin polypeptides that are committed to the native state
2 PDB 3D structures from and Proteopedia for TBCC:
2L3L (3D)        2YUH (3D)    
Secondary accessions: Q53Y43 Q5T787

Explore the universe of human proteins at neXtProt for TBCC: NX_Q15814

Explore proteomics data for TBCC at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys312
  • Modification sites at PhosphoSitePlus

  • See TBCC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003183.1  
    ENSEMBL proteins: 
     ENSP00000361967   ENSP00000244625  
    Reactome Protein details: Q15814

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    Cloud-Clone Corp. CLIAs for TBCC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR027684 TBCC
     IPR016098 CAP/MinC_C
     IPR006599 CARP_motif
     IPR017901 C-CAP_CF_C-like
     IPR012945 Tubulin-bd_cofactor_C_dom

    Graphical View of Domain Structure for InterPro Entry Q15814

    ProtoNet protein and cluster: Q15814

    1 Blocks protein domain: IPB012945 Tubulin binding cofactor C

    UniProtKB/Swiss-Prot: TBCC_HUMAN, Q15814
    Similarity: Belongs to the TBCC family
    Similarity: Contains 1 C-CAP/cofactor C-like domain


    TBCC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBCC_HUMAN, Q15814
    Function: Tubulin-folding protein; involved in the final step of the tubulin folding pathway

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA11847227
    GO:0051087chaperone binding TAS8706133
         
    TBCC for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBCC
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    miRNA
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    hsa-mir-93-5p (MIRT048814), hsa-mir-877-5p (MIRT037213)

    Block miRNA regulation of human, mouse, rat TBCC using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TBCC:
    hsa-miR-548p hsa-miR-3622b-3p hsa-miR-3688-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidTBCC 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TBCC_HUMAN, Q15814: Cytoplasm. Note=Detected predominantly in the photoreceptor connecting cilium
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    nucleus3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005856cytoskeleton TAS8706133
    GO:0005874microtubule TAS8706133
    GO:0032391photoreceptor connecting cilium IDA12417528

    TBCC for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TBCC About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein folding
    Protein folding0.91
    Post-chaperonin tubulin folding pathway0.00
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for TBCC
        Post-chaperonin tubulin folding pathway



    TBCC for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBCC
    Interactions:

        Search GeneGlobe Interaction Network for TBCC

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for TBCC (Q158143 ENSP000002446254) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SULT1E1P498883I2D: score=1 
    TBCDENSP000003477194STRING: ENSP00000347719
    TBCEENSP000003555604STRING: ENSP00000355560
    TUBB1ENSP000002171334STRING: ENSP00000217133
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis IEA--
    GO:0006184GTP catabolic process IDA11847227
    GO:0006457protein folding TAS8706133
    GO:0007023post-chaperonin tubulin folding pathway IDA11847227
    GO:0044267cellular protein metabolic process TAS--

    TBCC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TBCC



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TBCC gene: 
    NM_003192.2  

    Unigene Cluster for TBCC:

    Tubulin folding cofactor C
    Hs.75064  [show with all ESTs]
    Unigene Representative Sequence: BC017479
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372876(uc003osl.3) ENST00000244625
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate TBCC:
    hsa-miR-548p hsa-miR-3622b-3p hsa-miR-3688-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidTBCC 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TBCC (NM_003192)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBCC
    Primer
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    OriGene qPCR primer pairs and template standards for TBCC
    OriGene qSTAR qPCR primer pairs in human, mouse for TBCC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBCC
      QuantiTect SYBR Green Assays in human, mouse, rat TBCC
      QuantiFast Probe-based Assays in human, mouse, rat TBCC

    Additional mRNA sequence: 

    AK312681.1 BC017479.1 BC020170.1 BT007002.1 U61234.1 

    6 DOTS entries:

    DT.217954  DT.100791445  DT.100791451  DT.100791449  DT.95318606  DT.100791458 

    6 AceView cDNA sequences:

    BQ685338 BQ690260 AW961731 CF128410 BF971571 BE349632 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TBCC expression in normal human tissues (normalized intensities)      TBCC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTCCGGGC
    TBCC Expression
    About this image


    TBCC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Heart (Cardiovascular System)
             Outflow Tract
    TBCC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TBCC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75064

    UniProtKB/Swiss-Prot: TBCC_HUMAN, Q15814
    Tissue specificity: Expressed in the retina. Expressed in the rod and cone photoreceptors, extending from the
    inner segments (IS), through the outer nuclear layer (ONL) and into the synapses in the outer plexiform layer
    (OPL). Strongly expressed to the photoreceptor connecting cilium at the tips of the IS (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TBCC gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbcc1 , 5 tubulin-specific chaperone C1, 5 78.79(n)1
    76.83(a)1
      17 (22.90 cM)5
    727261  NM_178385.31  NP_848472.21 
     468906215 
    chicken
    (Gallus gallus)
    Aves TBCC1 tubulin folding cofactor C 66.1(n)
    60.8(a)
      428567  XM_003640938.2  XP_003640986.2 
    lizard
    (Anolis carolinensis)
    Reptilia TBCC6
    tubulin folding cofactor C
    50(a)
    1 ↔ 1
    1(236613088-236614089)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.347752 Xenopus laevis transcribed sequence with weak similarity more 82.7(n)    BG813106.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tbccl1 tubulin-specific chaperone c-like 56.13(n)
    49.68(a)
      553378  NM_001256248.1  NP_001243177.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:LD345823
    CG319611
    CG319611 31(a)3
    48.78(n)1
    35.46(a)1
      3190481  NM_164571.21  NP_722960.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71H2AM.246
    Protein Y71H2AM.24 (Y71H2AM.24) mRNA, complete cds...
    20(a)
    1 ↔ 1
    III(2788445-2792975) WBGene00044609
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons POR1 POR 44.59(n)
    34.8(a)
      830151  NM_120155.3  NP_195702.1 


    ENSEMBL Gene Tree for TBCC (if available)
    TreeFam Gene Tree for TBCC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TBCC gene
    RP22  

    TBCC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TBCC (see all 126)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1152408051,2
    F--42622484(+) AAGCAG/ATTCTC 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs592233751,2
    C,F--42622650(+) GCCCCC/TGGGCT 1 -- ds50012Minor allele frequency- T:0.50WA 4
    rs1481986511,2
    C--42622713(+) GTCTAC/TAATCC 1 -- ds50010--------
    rs1165288331,2
    F--42622722(+) CCGAGT/CGTTTT 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1127610661,2
    C--42622816(+) ACAAA-/ACACACA 1 -- ds50011Minor allele frequency- AC:0.50CSA 2
    rs1886991461,2
    --42623005(+) GCCTGC/TAATGC 1 -- ut310--------
    rs412738221,2
    C,F--42623228(+) TGTTAC/TGAATT 1 -- ut312Minor allele frequency- T:0.01WA NA 238
    rs1162233011,2
    C,F--42623255(+) TAGGAG/ACCCAT 1 -- ut311Minor allele frequency- A:0.02WA 118
    rs1411669811,2
    --42623307(+) GACAAC/TAAGTA 1 -- ut310--------
    rs1509012401,2
    C,F--42623412(+) TCGCTC/GCTCTT 2 Q E mis11Minor allele frequency- G:0.00NA 4550

    HapMap Linkage Disequilibrium report for TBCC (42712219 - 42714558 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TBCC:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830650CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TBCC
    DNA2.0 Custom Variant and Variant Library Synthesis for TBCC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602971    OMIM disorders: --

    8 diseases for TBCC:    About MalaCards
    retinitis pigmentosa 2    spastic quadriplegia    quadriplegia    retinitis pigmentosa
    spasticity    retinitis    intellectual disability    breast cancer

    1 disease from the University of Copenhagen DISEASES database for TBCC:
    Retinitis pigmentosa

    TBCC for disorders           About GeneDecksing

    Genetic Association Database (GAD): TBCC

    Export disorders for TBCC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TBCC gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with TBCC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C. (PubMed id 11847227)1, 2, 3 Bartolini F....Cowan N.J. (J. Biol. Chem. 2002)
    2. Pathway leading to correctly folded beta-tubulin. (PubMed id 8706133)1, 2, 3 Tian G....Cowan N.J. (Cell 1996)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3. (PubMed id 12417528)1, 2 Grayson C.... Cheetham M.E. (Hum. Mol. Genet. 2002)
    6. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Recessive mutations in ELOVL4 cause ichthyosis, intellectual disability, and spastic quadriplegia. (PubMed id 22100072)2 Aldahmesh M.A.... Alkuraya F.S. (Am. J. Hum. Genet. 2011)
    10. The solution structure of the N-terminal domain of human tubulin binding cofactor C reveals a platform for tubulin interaction. (PubMed id 22028797)1 Garcia-Mayoral M.F....Bruix M. (PLoS ONE 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6903 HGNC: 11580 AceView: TBCC Ensembl:ENSG00000124659 euGenes: HUgn6903
    ECgene: TBCC H-InvDB: TBCC

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TBCC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TBCC Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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    Patent Information for TBCC gene:
    Search GeneIP for patents involving TBCC

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