Aliases for TBCC Gene
External Ids for TBCC Gene
Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]
GeneCards Summary for TBCC Gene
TBCC (Tubulin Folding Cofactor C) is a Protein Coding gene. Diseases associated with TBCC include retinitis pigmentosa 2 and spastic quadriplegia. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Protein folding. GO annotations related to this gene include GTPase activity and chaperone binding. An important paralog of this gene is RP2.
UniProtKB/Swiss-Prot for TBCC Gene
Tubulin-folding protein; involved in the final step of the tubulin folding pathway.