TBCC Gene
protein-coding GIFtS: 51
GCID: GC06M042712
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tubulin folding cofactor C(Previous name: tubulin-specific chaperone c )
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Aliases
for TBCC gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tubulin Folding Cofactor C1 2 | | CFC1 2 3 | | Tubulin-Specific Chaperone C1 2 | | Tubulin-Folding Cofactor C2 3 |
Export aliases for TBCC gene to outside databasesPrevious GC identifers: GC06M042714 GC06M042759 GC06M042820 GC06M042430 |
Summaries
for TBCC gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TBCC:
Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly foldedbeta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizingbeta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex;interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the nativestate. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TBCC_HUMAN, Q15814Function: Tubulin-folding protein; involved in the final step of the tubulin folding pathway
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Genomic Views
for TBCC gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TBCC gene promoter:
Spz1 AML1a CUTL1 RelA Nkx2-5 Ik-3 Egr-4 Pax-4a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TBCC
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBCC |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p21.1TBCC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M042712: view genomic region
(about GC identifiers)
Start:
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42,712,219 bp from pter |
End:
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42,714,558 bp from pter |
Size:
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2,340 bases |
Orientation:
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minus strand |
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Proteins
for TBCC gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TBCC_HUMAN, Q15814 (See
protein sequence)Recommended Name: Tubulin-specific chaperone C Size: 346 amino acids; 39248 Da
Subunit: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in aquasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causesthe release of tubulin polypeptides that are committed to the native state
Subcellular location: Cytoplasm. Note=Detected predominantly in the photoreceptor connecting cilium
2 PDB 3D structures from  and Proteopedia  for TBCC:2L3L (3D)
2YUH (3D)
Secondary accessions: Q53Y43 Q5T787Explore the universe of human proteins at neXtProt for TBCC: NX_Q15814
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15814
TBCC Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003183.1
ENSEMBL proteins: ENSP00000361967 ENSP00000244625 Reactome Protein details: Q15814
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
TBCC for ontologies About GeneDecksing
TBCC Antibody Products:
Assay Products for TBCC: |
Protein
Domains /
Families
for TBCC gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TBCC for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15814ProtoNet protein and cluster: Q15814 1 Blocks protein family: IPB012945 Tubulin binding cofactor C
UniProtKB/Swiss-Prot: TBCC_HUMAN, Q15814Similarity: Belongs to the TBCC familySimilarity: Contains 1 C-CAP/cofactor C-like domain |
Function
for TBCC gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TBCC_HUMAN, Q15814Function: Tubulin-folding protein; involved in the final step of the tubulin folding pathway
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBCC (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBCC
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for TBCC | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBCC |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBCC |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
TBCC for ontologies About GeneDecksing
|
Pathways & Interactions
for TBCC gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Chaperonin-mediated protein folding | | | 2 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | | | 3 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for TBCC
TBCC for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBCC
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for TBCC (Q158143 ENSP000002446254) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
TBCC for ontologies About GeneDecksing
|
Drugs & Compounds
for TBCC gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TBCC
Search CenterWatch for drugs/clinical trials and news about TBCC
|
Transcripts
for TBCC gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TBCC gene: NM_003192.2 Unigene Cluster for TBCC: Tubulin folding cofactor C Hs.75064 [show with all ESTs]Unigene Representative Sequence: BC0174793 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372876(uc003osl.3) ENST00000490059 ENST00000244625
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBCC (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBCC
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TBCC (NM_003192) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBCC | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBCC |
Additional cDNA sequence: AK312681.1 BC017479.1 BC020170.1 BT007002.1 U61234.1 6 DOTS entries: DT.217954 DT.100791445 DT.100791451 DT.100791449 DT.95318606 DT.100791458 6 AceView cDNA sequences: BQ685338 BQ690260 AW961731 CF128410 BF971571 BE349632
GeneLoc Exon Structure
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Expression
for TBCC gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TBCC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTCCGGGC
About this image
See TBCC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TBCC
SOURCE GeneReport for Unigene cluster: Hs.75064
UniProtKB/Swiss-Prot: TBCC_HUMAN, Q15814Tissue specificity: Expressed in the retina. Expressed in the rod and cone photoreceptors, extending from the innersegments (IS), through the outer nuclear layer (ONL) and into the synapses in the outer plexiform layer (OPL).Strongly expressed to the photoreceptor connecting cilium at the tips of the IS (at protein level)
SABiosciences Custom PCR Arrays for TBCC
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBCC
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TBCC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBCC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBCC | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBCC |
Orthologs
for TBCC gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TBCC gene from 8/27 species (see all 27) About this table
ENSEMBL Gene Tree for TBCC (if available)
TreeFam Gene Tree for TBCC (if available) |
Paralogs
for TBCC gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TBCC gene
- RP22
TBCC for paralogs About GeneDecksing
|
Genomic Variants
for TBCC gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBCC |
|
Disorders
/ Diseases
for TBCC gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TBCC for disorders About GeneDecksing
OMIM gene information: 602971
OMIM disorders: --
9  diseases for TBCC: About MalaCardsretinitis pigmentosa-2 retinitis pigmentosa retinitis breast cancer
malaria spastic quadriplegia quadriplegia ichthyosis
spasticity
Export disorders for TBCC gene to outside databases
|
Publications
for TBCC gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TBCC gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with TBCC) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C. (PubMed id 11847227)1, 2, 3 Bartolini F....Cowan N.J. (2002)
- Pathway leading to correctly folded beta-tubulin. (PubMed id 8706133)1, 2, 3 Tian G....Cowan N.J. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3. (PubMed id 12417528)1, 2 Grayson C....Cheetham M.E. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Recessive mutations in ELOVL4 cause ichthyosis, intel lectual disability, and spastic quadriplegia. (PubMed id 22100072)2 Aldahmesh M.A....Alkuraya F.S. (2011)
- The solution structure of the N-terminal domain of hum an tubulin binding cofactor C reveals a platform for tubulin interaction. (PubMed id 22028797)1 Garcia-Mayoral M.F....Bruix M. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Tubulin binding cofactor C (TBCC) suppresses tumor gr owth and enhances chemosensitivity in human breast cancer cells. (PubMed id 20384997)1 Hage-Sleiman R....Dumontet C. (2010)
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External Searches for TBCC gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TBCC gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBCC gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TBCC gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TBCC gene:
Search GeneIP for patents involving TBCC
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TBCC gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | OriGene Antibodies for TBCC | | OriGene shRNA RFP for TBCC | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TBCC | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBCC | | | OriGene Protein Over-expression Lysate for TBCC | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TBCC | | OriGene 3'-UTR Clone for TBCC | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBCC | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBCC | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TBCC | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TBCC | | OriGene Custom Protein Services for TBCC | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TBCC | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBCC | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBCC | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBCC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBCC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBCC |
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 |  |  |  | |
| | | | Search Tocris compounds for TBCC |
| |  |  |  |  | | | | | | Recombinant Protein for TBCC |
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 | | | TBCC Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBCC |
|  |  |  | | | | ThermoFisher Antibodies for TBCC |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBCC |
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