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Aliases for TBCB Gene

Aliases for TBCB Gene

  • Tubulin Folding Cofactor B 2 3
  • CKAP1 3 4 6
  • Cytoskeleton-Associated Protein CKAPI 3 4
  • Cytoskeleton-Associated Protein 1 2 4
  • Cytoskeleton Associated Protein 1 2 3
  • Tubulin-Specific Chaperone B 3 4
  • CG22 3 4
  • Tubulin-Folding Cofactor B 3
  • CKAPI 3

External Ids for TBCB Gene

Previous HGNC Symbols for TBCB Gene

  • CKAP1

Previous GeneCards Identifiers for TBCB Gene

  • GC19P041299
  • GC19P036605
  • GC19P033111

Summaries for TBCB Gene

GeneCards Summary for TBCB Gene

TBCB (Tubulin Folding Cofactor B) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Protein folding. An important paralog of this gene is CLIP4.

UniProtKB/Swiss-Prot for TBCB Gene

  • Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth

Gene Wiki entry for TBCB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBCB Gene

Genomics for TBCB Gene

Regulatory Elements for TBCB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TBCB Gene

Start:
36,114,289 bp from pter
End:
36,125,947 bp from pter
Size:
11,659 bases
Orientation:
Plus strand

Genomic View for TBCB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBCB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBCB Gene

Proteins for TBCB Gene

  • Protein details for TBCB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99426-TBCB_HUMAN
    Recommended name:
    Tubulin-folding cofactor B
    Protein Accession:
    Q99426
    Secondary Accessions:
    • O00111
    • O00674
    • O14728
    • Q6FGY5

    Protein attributes for TBCB Gene

    Size:
    244 amino acids
    Molecular mass:
    27326 Da
    Quaternary structure:
    • Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. Cofactors B and E can form a heterodimer which binds to alpha-tubulin and enhances their ability to dissociate tubulin heterodimers. Binds to GAN.
    SequenceCaution:
    • Sequence=AAB51182.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TBCB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBCB Gene

Proteomics data for TBCB Gene at MOPED

Post-translational modifications for TBCB Gene

  • Phosphorylation by PAK1 is required for normal function.
  • Ubiquitinated in the presence of GAN which targets it for degradation by the proteasome.
  • Ubiquitination at Lys106, Lys153, Lys203, and Lys219
  • Modification sites at PhosphoSitePlus

Other Protein References for TBCB Gene

No data available for DME Specific Peptides for TBCB Gene

Domains for TBCB Gene

Protein Domains for TBCB Gene

Suggested Antigen Peptide Sequences for TBCB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99426

UniProtKB/Swiss-Prot:

TBCB_HUMAN :
  • Q99426
Domain:
  • Contains 1 CAP-Gly domain.
Family:
  • Belongs to the TBCB family.
genes like me logo Genes that share domains with TBCB: view

No data available for Gene Families for TBCB Gene

Function for TBCB Gene

Molecular function for TBCB Gene

UniProtKB/Swiss-Prot Function: Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth

Gene Ontology (GO) - Molecular Function for TBCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16303566
genes like me logo Genes that share ontologies with TBCB: view

Phenotypes for TBCB Gene

GenomeRNAi human phenotypes for TBCB:
genes like me logo Genes that share phenotypes with TBCB: view

Animal Model Products

CRISPR Products

miRNA for TBCB Gene

miRTarBase miRNAs that target TBCB

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBCB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TBCB Gene

Localization for TBCB Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBCB Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBCB Gene COMPARTMENTS Subcellular localization image for TBCB gene
Compartment Confidence
cytoskeleton 5
cytosol 3
extracellular 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TBCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005874 microtubule IEA --
GO:0015630 microtubule cytoskeleton TAS 8978778
genes like me logo Genes that share ontologies with TBCB: view

Pathways for TBCB Gene

genes like me logo Genes that share pathways with TBCB: view

Pathways by source for TBCB Gene

Gene Ontology (GO) - Biological Process for TBCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
GO:0044267 cellular protein metabolic process TAS --
GO:0051084 de novo posttranslational protein folding TAS --
genes like me logo Genes that share ontologies with TBCB: view

Transcripts for TBCB Gene

Unigene Clusters for TBCB Gene

Tubulin folding cofactor B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBCB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBCB Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - -
SP9: - - - - - - - - - - - - -
SP10: - -

Relevant External Links for TBCB Gene

GeneLoc Exon Structure for
TBCB
ECgene alternative splicing isoforms for
TBCB

Expression for TBCB Gene

mRNA expression in normal human tissues for TBCB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TBCB Gene

SOURCE GeneReport for Unigene cluster for TBCB Gene Hs.31053

mRNA Expression by UniProt/SwissProt for TBCB Gene

Q99426-TBCB_HUMAN
Tissue specificity: Found in most tissues
genes like me logo Genes that share expressions with TBCB: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TBCB Gene

Orthologs for TBCB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TBCB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBCB 35
  • 99.73 (n)
  • 100 (a)
TBCB 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TBCB 35
  • 86.75 (n)
  • 87.7 (a)
TBCB 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBCB 35
  • 90.16 (n)
  • 93.85 (a)
TBCB 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbcb 35
  • 85.93 (n)
  • 89.34 (a)
Tbcb 16
Tbcb 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TBCB 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TBCB 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBCB 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33445 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19899 35
tbcb 35
  • 63.76 (n)
  • 69.29 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.860 35
tbcb 35
  • 64.33 (n)
  • 62.4 (a)
tbcb 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000120 35
  • 56.24 (n)
  • 50.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11242 36
  • 41 (a)
OneToOne
TBCB 35
  • 52.69 (n)
  • 44.1 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_F53F4.3 35
  • 48.72 (n)
  • 44.8 (a)
F53F4.3 36
  • 44 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR054W 35
  • 51.13 (n)
  • 44.92 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALF1 35
  • 41 (n)
  • 32.3 (a)
ALF1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22859g 35
  • 43.63 (n)
  • 39.84 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G10220 35
  • 48.78 (n)
  • 39.45 (a)
rice
(Oryza sativa)
Liliopsida Os04g0692100 35
  • 52.05 (n)
  • 40.64 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01713 35
  • 48.25 (n)
  • 36.99 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes alp11 35
  • 42.58 (n)
  • 36.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for TBCB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TBCB Gene

ENSEMBL:
Gene Tree for TBCB (if available)
TreeFam:
Gene Tree for TBCB (if available)

Paralogs for TBCB Gene

Paralogs for TBCB Gene

genes like me logo Genes that share paralogs with TBCB: view

Variants for TBCB Gene

Sequence variations from dbSNP and Humsavar for TBCB Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1046975 -- 36,121,555(+) CGCAG(A/C)AAGCT missense, reference
rs1801989 -- 36,125,751(+) CTTCC(C/T)GGAGG reference, missense
rs1801990 -- 36,125,502(+) TGAGC(A/C)ACTGG missense, reference
rs1803271 -- 36,121,707(+) CACCG(A/T)CATGT missense, reference
rs1803272 -- 36,125,795(+) GGAAT(G/T)CCCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TBCB Gene

Variant ID Type Subtype PubMed ID
nsv833815 CNV Loss 17160897

Relevant External Links for TBCB Gene

HapMap Linkage Disequilibrium report
TBCB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBCB Gene

Disorders for TBCB Gene

(1) University of Copenhagen DISEASES for TBCB Gene

Relevant External Links for TBCB

Genetic Association Database (GAD)
TBCB
Human Genome Epidemiology (HuGE) Navigator
TBCB
genes like me logo Genes that share disorders with TBCB: view

No data available for UniProtKB/Swiss-Prot for TBCB Gene

Publications for TBCB Gene

  1. Cloning, expression, and mapping of CKAPI, which encodes a putative cytoskeleton-associated protein containing a CAP-Gly domain. (PMID: 8978778) Watanabe T.K. … Hirai Y. (Cytogenet. Cell Genet. 1996) 2 3 4
  2. Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors. (PMID: 9265649) Tian G. … Cowan N.J. (J. Cell Biol. 1997) 3 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4

Products for TBCB Gene

Sources for TBCB Gene

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