TBCA Gene
protein-coding GIFtS : 55
GCID: GC05 M077022
tubulin folding cofactor A (Previous name: tubulin-specific chaperone a )
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Aliasesfor TBCA gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Tubulin Folding Cofactor A 1 2 Tubulin-Specific Chaperone A1 2 Tubulin-Folding Cofactor A2 3 CFA2 3 TCP1-Chaperonin Cofactor A2 3 Chaperonin Cofactor A2
Export aliases for TBCA gene to outside databases Previous GC identifers: GC05M075792 GC05M077221 GC05M077025 GC05M077071 GC05M072194
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Summariesfor TBCA gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for TBCA : The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: TBCA_HUMAN, O75347 Function : Tubulin-folding protein; involved in the early step of the tubulin folding pathwayGene Wiki entry for TBCA
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Genomic Viewsfor TBCA gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000005.9 NC_018916.1 NT_006713.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TBCA gene promoter: GR Pbx1a AML1a POU3F2 (N-Oct-5a) RelA POU3F2 NF-kappaB LCR-F1 GR-alpha NF-kappaB1 Other transcription factors Search SABiosciences Chromatin IP Primers for TBCA Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBCA
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 5q14.1 Ensembl cytogenetic band: 5q14.1 HGNC cytogenetic band: 5q14.1 TBCA Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 5 GeneLoc Exon Structure
GeneLoc location for GC05M077022: view genomic region
(about GC identifiers )
Start:
76,986,991 bp from pter
End:
77,164,604 bp from pter
Size:
177,614 bases
Orientation:
minus strand
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Proteinsfor TBCA gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TBCA_HUMAN, O75347 (See
protein sequence )Recommended Name: Tubulin-specific chaperone A Size : 108 amino acids; 12855 Da
Subunit : Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in aquasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state
Subcellular location : Cytoplasm, cytoskeleton
1 PDB 3D structure from and Proteopedia for TBCA :1H7C (3D)
 Explore the universe of human proteins at neXtProt for TBCA: NX_O75347 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O75347 TBCA Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_004598.1 ENSEMBL proteins: ENSP00000369736 ENSP00000429083 ENSP00000306362 ENSP00000429288 ENSP00000429793 ENSP00000429313 ENSP00000429046 Reactome Protein details: O75347 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
TBCA for ontologies About GeneDecksing TBCA Antibody Products: Assay Products for TBCA:
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Protein
Domains / Familiesfor TBCA gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TBCA for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry O75347 ProtoNet protein and cluster: O75347
1 Blocks protein family : IPB004226 Tubulin binding cofactor A UniProtKB/Swiss-Prot: TBCA_HUMAN, O75347 Similarity : Belongs to the TBCA family
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Functionfor TBCA gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: TBCA_HUMAN, O75347 Function : Tubulin-folding protein; involved in the early step of the tubulin folding pathway
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TBCA (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TBCAOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TBCA (NM_004607 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBCA Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TBCA
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
TBCA for ontologies About GeneDecksing 3 GenomeRNAi human phenotypes for TBCA :
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Pathways & Interactionsfor TBCA gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Chaperonin-mediated protein folding 2 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 3 Asparagine N-linked glycosylation
Pathway sources See GeneCards unified pathways Show all pathways 3
Reactome Pathways for TBCA
TBCA for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBCA STRING Interaction
Network Preview (showing 5 interactants - click image to see 21)5/25 Interacting proteins for TBCA (O75347 3 ENSP00000369736 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 25 )About this table Gene Ontology (GO): 5 biological process terms (GO ID links to tree view) : About this table
TBCA for ontologies About GeneDecksing
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Drugs & Compoundsfor TBCA gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TBCA Search CenterWatch for drugs/clinical trials and news about TBCA
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Transcriptsfor TBCA gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TBCA gene: NM_004607.2 Unigene Cluster for TBCA:
Tubulin folding cofactor A Hs.291212 [show with all ESTs ] Unigene Representative Sequence: BC067837 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000380377 (uc003kfh.1 ) ENST00000518218 ENST00000517679 ENST00000306388 (uc003kfi.1 )ENST00000520361 ENST00000518338 ENST00000517881 ENST00000522370 ENST00000520039 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TBCA (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TBCAOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TBCA (NM_004607 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBCA Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TBCA
Additional cDNA sequence: AF038952.1 AK300031.1 AK312207.1 BC018210.1 BC067837.1 BC105285.1 BT007354.1 CR542170.1 CR542186.1
17 DOTS entries : DT.215722 DT.86846553
DT.208079 DT.121283223 DT.97858949 DT.100822339 DT.95279247 DT.120834597 DT.97858950 DT.100044565 DT.100641832 DT.120834615 DT.121283207 DT.75100797 DT.120866799 DT.92439561 DT.92439565 24/227 AceView cDNA sequences (see all 227 ):
BG235959 AA371456 BM841505 BQ187731 AI656476 BI492241 AI633758 BX102390 AI479967 BF726655 CR542170 AI355069 BE349922 BU070385 CA337813 AI199999 AA649574 BG030197 BU676261 BQ436639 BF940058 BF055320 CB068556 BC018210 GeneLoc Exon Structure
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Expression for TBCA gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TBCA expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCCGATCCTC
About this image TBCA expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See TBCA Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TBCA SOURCE GeneReport for Unigene cluster: Hs.291212 SABiosciences Custom PCR Arrays for TBCA Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TBCABrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TBCA QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TBCA QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TBCA
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Orthologsfor TBCA gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for TBCA gene from 9/28 species (see all 28 ) About this table
ENSEMBL Gene Tree for TBCA (if available)TreeFam Gene Tree for TBCA (if available)
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Paralogsfor TBCA gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TBCA gene
TBCA for paralogs About GeneDecksing 2 Pseudogenes.org Pseudogenes for TBCA PGOHUM00000256861 PGOHUM00000241692
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Genomic Variantsfor TBCA gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 5 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TBCA (76986991 - 77164604 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 7 variations for TBCA 1 CNV : 99178 6 Indels : 46919 62387 28004 12701 42095 62386
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TBCA
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Disorders
/ Diseasesfor TBCA gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TBCA for disorders About GeneDecksing
OMIM gene information: 610058
OMIM disorders : --4 diseases for TBCA : About MalaCards parkinson's disease osteoporosis gastric cancer obesity 1 disease from the University of Copenhagen DISEASES database for TBCA :Osteoporosis Human Genome Epidemiology (HuGE) Navigator: TBCA (3 documents) Export disorders for TBCA gene to outside databases
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Publicationsfor TBCA gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TBCA gene, integrated from 9 sources (see all 26 ): (articles sorted by number of sources associating them with TBCA) Utopia : connect your pdf to the dynamic world of online information
Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160) 1 , 2 , 3 Mao M.... Chen Z. (1998) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Three-dimensional structure of human tubulin chaperone cofactor A. (PubMed id 12054808) 1 , 2 Guasch A.... Coll M. (2002) Pathway leading to correctly folded beta-tubulin. (PubMed id 8706133) 1 , 3 Tian G....Cowan N.J. (1996) Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931) 1 Oshikawa K....Nakayama K.I. (2012) A census of human soluble protein complexes. (PubMed id 22939629) 1 Havugimana P.C....Emili A. (2012) Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724) 1 Udeshi N.D....Carr S.A. (2012) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011)
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External Searches for TBCA gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TBCA gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TBCA gene
(According to HUGE )
About This Section --
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Specialized Databases showing TBCA gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TBCA Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TBCA gene: Search GeneIP for patents involving TBCA GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TBCA gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TBCA OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TBCA OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TBCA OriGene Protein Over-expression Lysate for TBCA Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TBCA OriGene 3'-UTR Clone for TBCA OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TBCA OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TBCA Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for TBCA OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TBCA OriGene Custom Protein Services for TBCA OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TBCA QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TBCA QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBCA QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TBCA QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TBCA QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TBCA
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Recombinant Protein for TBCA
TBCA Proteins, Antibodies, CLIAs, and ELISAs
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TBCA
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