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Aliases for TBC1D9B Gene

Aliases for TBC1D9B Gene

  • TBC1 Domain Family, Member 9B (With GRAM Domain) 2 3
  • KIAA0676 4

External Ids for TBC1D9B Gene

Previous GeneCards Identifiers for TBC1D9B Gene

  • GC05M179222
  • GC05M179223
  • GC05M179289
  • GC05M174013

Summaries for TBC1D9B Gene

GeneCards Summary for TBC1D9B Gene

TBC1D9B (TBC1 Domain Family, Member 9B (With GRAM Domain)) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is TBC1D30.

UniProtKB/Swiss-Prot for TBC1D9B Gene

  • May act as a GTPase-activating protein for Rab family protein(s)

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D9B Gene

Genomics for TBC1D9B Gene

Regulatory Elements for TBC1D9B Gene

Genomic Location for TBC1D9B Gene

Start:
179,862,066 bp from pter
End:
179,907,859 bp from pter
Size:
45,794 bases
Orientation:
Minus strand

Genomic View for TBC1D9B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBC1D9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D9B Gene

Proteins for TBC1D9B Gene

  • Protein details for TBC1D9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q66K14-TBC9B_HUMAN
    Recommended name:
    TBC1 domain family member 9B
    Protein Accession:
    Q66K14
    Secondary Accessions:
    • D3DWQ5
    • D3DWQ6
    • O75163
    • Q53EY0
    • Q6MZI2
    • Q96H49

    Protein attributes for TBC1D9B Gene

    Size:
    1250 amino acids
    Molecular mass:
    140525 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH08919.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TBC1D9B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBC1D9B Gene

Proteomics data for TBC1D9B Gene at MOPED

Post-translational modifications for TBC1D9B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBC1D9B Gene

No data available for DME Specific Peptides for TBC1D9B Gene

Domains for TBC1D9B Gene

Gene Families for TBC1D9B Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for TBC1D9B Gene

Graphical View of Domain Structure for InterPro Entry

Q66K14

UniProtKB/Swiss-Prot:

TBC9B_HUMAN :
  • Q66K14
Domain:
  • The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rabs switch 2 glutamine and insert in Rabs active site.
  • Contains 1 EF-hand domain.
  • Contains 2 GRAM domains.
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with TBC1D9B: view

Function for TBC1D9B Gene

Molecular function for TBC1D9B Gene

UniProtKB/Swiss-Prot Function: May act as a GTPase-activating protein for Rab family protein(s)

Gene Ontology (GO) - Molecular Function for TBC1D9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 22354992
genes like me logo Genes that share ontologies with TBC1D9B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TBC1D9B Gene

Localization for TBC1D9B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBC1D9B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBC1D9B Gene COMPARTMENTS Subcellular localization image for TBC1D9B gene
Compartment Confidence
cytosol 3
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TBC1D9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TBC1D9B: view

Pathways for TBC1D9B Gene

SuperPathways for TBC1D9B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TBC1D9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
GO:1902017 NOT regulation of cilium assembly IMP 17646400
genes like me logo Genes that share ontologies with TBC1D9B: view

No data available for Pathways by source for TBC1D9B Gene

Transcripts for TBC1D9B Gene

Unigene Clusters for TBC1D9B Gene

TBC1 domain family, member 9B (with GRAM domain):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBC1D9B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TBC1D9B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D9B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^
SP1: - - - -
SP2: - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:

ExUns: 20 ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for TBC1D9B Gene

GeneLoc Exon Structure for
TBC1D9B
ECgene alternative splicing isoforms for
TBC1D9B

Expression for TBC1D9B Gene

mRNA expression in normal human tissues for TBC1D9B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TBC1D9B Gene

SOURCE GeneReport for Unigene cluster for TBC1D9B Gene Hs.155829

genes like me logo Genes that share expressions with TBC1D9B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TBC1D9B Gene

Orthologs for TBC1D9B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TBC1D9B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBC1D9B 35
  • 99.48 (n)
  • 99.21 (a)
cow
(Bos Taurus)
Mammalia TBC1D9B 35
  • 89.33 (n)
  • 91.66 (a)
TBC1D9B 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBC1D9B 35
  • 89.11 (n)
  • 93.32 (a)
TBC1D9B 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbc1d9b 35
  • 87.45 (n)
  • 92.06 (a)
Tbc1d9b 16
Tbc1d9b 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TBC1D9B 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tbc1d9b 35
  • 87.49 (n)
  • 92.48 (a)
chicken
(Gallus gallus)
Aves TBC1D9B 35
  • 75.82 (n)
  • 80.96 (a)
TBC1D9B 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBC1D9B 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tbc1d9b 35
  • 70.26 (n)
  • 74.52 (a)
zebrafish
(Danio rerio)
Actinopterygii TBC1D9B 36
  • 76 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BUB2 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3902 36
  • 34 (a)
OneToMany
Species with no ortholog for TBC1D9B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBC1D9B Gene

ENSEMBL:
Gene Tree for TBC1D9B (if available)
TreeFam:
Gene Tree for TBC1D9B (if available)

Paralogs for TBC1D9B Gene

Paralogs for TBC1D9B Gene

genes like me logo Genes that share paralogs with TBC1D9B: view

Variants for TBC1D9B Gene

Sequence variations from dbSNP and Humsavar for TBC1D9B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1298 -- 179,862,895(-) CTGCG(C/T)ACAGG utr-variant-3-prime
rs9957 -- 179,863,154(-) CATTA(C/G)AGGCT utr-variant-3-prime
rs13936 -- 179,862,659(-) GGGGC(C/T)CTGGC utr-variant-3-prime
rs27410 -- 179,892,473(+) ACCCA(C/G)GGAAC intron-variant
rs27411 -- 179,892,375(+) GACCA(C/T)AGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TBC1D9B Gene

Variant ID Type Subtype PubMed ID
nsv883270 CNV Loss 21882294
nsv483062 CNV Loss 15286789
nsv469579 CNV Loss 16826518
dgv6400n71 CNV Loss 21882294
nsv823362 CNV Loss 20364138
nsv883286 CNV Loss 21882294
esv4887 CNV Deletion 18987735
esv2731312 CNV Deletion 23290073
esv990502 CNV Deletion 20482838
nsv327239 CNV Loss 16902084

Relevant External Links for TBC1D9B Gene

HapMap Linkage Disequilibrium report
TBC1D9B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D9B Gene

Disorders for TBC1D9B Gene

No disorders were found for TBC1D9B Gene.

No data available for UniProtKB/Swiss-Prot for TBC1D9B Gene

Publications for TBC1D9B Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
  5. Functional dissection of Rab GTPases involved in primary cilium formation. (PMID: 17646400) Yoshimura S. … Barr F.A. (J. Cell Biol. 2007) 3

Products for TBC1D9B Gene

Sources for TBC1D9B Gene

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