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TBC1D8 Gene

protein-coding   GIFtS: 52
GCID: GC02M101622

TBC1 Domain Family, Member 8 (With GRAM Domain)

  Search for TBC1D8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TBC1 Domain Family, Member 8 (With GRAM Domain)1 2     AD32
Vascular Rab-GAP/TBC-Containing Protein1 2 3     HBLP12
BUB2-Like Protein 11 2     TBC1D8A2
VRP2 3     TBC1 Domain Family Member 82
AD 32 3     TBC1 Domain Family, Member 8A2

External Ids:    HGNC: 177911   Entrez Gene: 111382   Ensembl: ENSG000002046347   UniProtKB: O957593   

Export aliases for TBC1D8 gene to outside databases

Previous GC identifers: GC02M101228 GC02M101245 GC02M101082 GC02M100990 GC02M095387


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TBC1D8 Gene:
TBC1D8 (TBC1 domain family, member 8 (with GRAM domain)) is a protein-coding gene. GO annotations related to this gene include Rab GTPase activator activity and calcium ion binding. An important paralog of this gene is TBC1D2.

UniProtKB/Swiss-Prot: TBCD8_HUMAN, O95759
Function: May act as a GTPase-activating protein for Rab family protein(s)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TBC1D8 gene promoter:
         MEF-2   Pax-2   Pax-2a   RORalpha1   MEF-2A   Pax-2b   FOXO4   FOXO1a   aMEF-2   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TBC1D8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBC1D8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q12.1

TBC1D8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBC1D8 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M101622:  view genomic region     (about GC identifiers)

Start:
101,623,690 bp from pter      End:
101,869,328 bp from pter
Size:
245,639 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TBCD8_HUMAN, O95759 (See protein sequence)
Recommended Name: TBC1 domain family member 8  
Size: 1140 amino acids; 130835 Da
Sequence caution: Sequence=AAY14824.1; Type=Erroneous gene model prediction; Sequence=BAF85515.1; Type=Erroneous
initiation;
Secondary accessions: A6NDL4 A8K9W1 B9A6K4 Q53SQ4 Q9UQ32
Alternative splicing: 2 isoforms:  O95759-1   O95759-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TBC1D8: NX_O95759

Explore proteomics data for TBC1D8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TBC1D8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001095896.1  
    ENSEMBL proteins: 
     ENSP00000366036   ENSP00000386856  

    TBC1D8 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TBC1D8

     
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    Cloud-Clone Corp. ELISAs for TBC1D8
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    Search eBioscience for ELISAs for TBC1D8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR000195 Rab-GTPase-TBC_dom
     IPR004182 GRAM

    Graphical View of Domain Structure for InterPro Entry O95759

    ProtoNet protein and cluster: O95759

    2 Blocks protein domains:
    IPB000195 RabGAP/TBC domain
    IPB004182 GRAM domain


    UniProtKB/Swiss-Prot: TBCD8_HUMAN, O95759
    Similarity: Contains 2 GRAM domains
    Similarity: Contains 1 Rab-GAP TBC domain


    Find genes that share domains with TBC1D8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBCD8_HUMAN, O95759
    Function: May act as a GTPase-activating protein for Rab family protein(s)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005097Rab GTPase activator activity IEA--
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with TBC1D8           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TBC1D8:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBC1D8
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TBC1D8

    miRNA
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    miRTarBase miRNAs that target TBC1D8:
    hsa-mir-335-5p (MIRT019002)

    Block miRNA regulation of human, mouse, rat TBC1D8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TBC1D8 (see all 38):
    hsa-miR-25 hsa-let-7a-2* hsa-miR-301a hsa-miR-4275 hsa-miR-9 hsa-miR-3613-3p hsa-miR-130b hsa-miR-92b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat TBC1D8

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TBC1D8 (NM_001102426)
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane TAS10373574

    Find genes that share ontologies with TBC1D8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TBC1D8 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59


    1 BioSystems Pathway for TBC1D8
        Cell cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBC1D8
    Interactions:

        Search GeneGlobe Interaction Network for TBC1D8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for TBC1D8 (O957593 ENSP000003660364) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000204221O152133I2D: score=1 
    ENSG00000206284O152133I2D: score=1 
    ENSG00000226916O152133I2D: score=1 
    ENSG00000236222O152133I2D: score=1 
    WDR46O152133I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008015blood circulation TAS10373574
    GO:0008284positive regulation of cell proliferation TAS10373574
    GO:0032313regulation of Rab GTPase activity ----

    Find genes that share ontologies with TBC1D8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TBC1D8 (TBCD8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TBC1D8 gene (2 alternative transcripts): 
    NM_007063.3  NM_001102426.1  

    Unigene Cluster for TBC1D8:

    TBC1 domain family, member 8 (with GRAM domain)
    Hs.442657  [show with all ESTs]
    Unigene Representative Sequence: NM_001102426
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376840(uc002tau.4) ENST00000409318(uc010fiv.3 uc010yvw.2)
    ENST00000494011 ENST00000473937 ENST00000485875 ENST00000481317 ENST00000487392
    ENST00000463469 ENST00000462819 ENST00000485851
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TBC1D8 (see all 38):
    hsa-miR-25 hsa-let-7a-2* hsa-miR-301a hsa-miR-4275 hsa-miR-9 hsa-miR-3613-3p hsa-miR-130b hsa-miR-92b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TBC1D8
    Predesigned siRNA for gene silencing in human, mouse, rat TBC1D8
    Clone
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    OriGene clones in human, mouse for TBC1D8 (see all 9)
    OriGene ORF clones in mouse, rat for TBC1D8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TBC1D8 (NM_001102426)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBC1D8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D8
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TBC1D8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBC1D8
      QuantiTect SYBR Green Assays in human, mouse, rat TBC1D8
      QuantiFast Probe-based Assays in human, mouse, rat TBC1D8

    Additional mRNA sequence: 

    AB017114.1 AB449889.1 AK292826.1 AK300533.1 

    17 DOTS entries:

    DT.95195859  DT.95182293  DT.92446975  DT.95082825  DT.75101776  DT.100718822  DT.92446959  DT.121029634 
    DT.310629  DT.95170333  DT.40279099  DT.40198534  DT.95170318  DT.95221048  DT.431589  DT.436293 
    DT.65288702 

    Selected AceView cDNA sequences (see all 2190):

    AL047855 AI718211 AW467197 BM887650 BF792777 BM908990 AU126694 BM785753 
    BE792579 BM693095 AI061389 R56957 AI439727 AL037873 BG339832 BM920297 
    AA075386 AW023985 T53406 BE742410 BE729915 AI718870 AA501631 AA147989 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TBC1D8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTCAATGT
    TBC1D8 Expression
    About this image


    TBC1D8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
    TBC1D8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TBC1D8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.442657
        Custom PCR Arrays for TBC1D8
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TBC1D8 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbc1d81 , 5 TBC1 domain family, member 81, 5 87.08(n)1
    92.23(a)1
      1 (18.30 cM)5
    546101  NM_018775.41  NP_061245.31 
     393714995 
    chicken
    (Gallus gallus)
    Aves TBC1D81 TBC1 domain family, member 8 (with GRAM domain) 76.26(n)
    81.99(a)
      428012  XM_004938504.1  XP_004938561.1 
    lizard
    (Anolis carolinensis)
    Reptilia TBC1D86
    TBC1 domain family, member 8 (with GRAM domain)
    79(a)
    1 ↔ 1
    GL343542.1(178573-227910)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480557592   -- 76.91(n)    48055759 
    zebrafish
    (Danio rerio)
    Actinopterygii tbc1d81 TBC1 domain family, member 8 (with GRAM domain) 60.62(n)
    55.98(a)
      100333881  XM_002663446.3  XP_002663492.3 


    ENSEMBL Gene Tree for TBC1D8 (if available)
    TreeFam Gene Tree for TBC1D8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TBC1D8 gene
    TBC1D22  TBC1D8B2  SGSM32  TBC1D302  TBC1D2B2  TBC1D9B2  TBC1D92  
    9 SIMAP similar genes for TBC1D8 using alignment to 2 protein entries:     TBCD8_HUMAN (see all proteins):
    TBC1D8B    TBC1D9    TBC1D6    TBC1D9B    SGSM3    GRTP1
    FLJ00006    TBC1D10A    FLJ00288

    Find genes that share paralogs with TBC1D8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TBC1D8 (see all 2788)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1449901631,2
    C--101626283(+) GGAGC-/ATTTTT 1 -- int10--------
    rs2003729481,2
    --101634799(+) TTCAT-/TCAG  
            
    GTTTT
    1 -- int10--------
    rs1902477051,2
    --101636692(+) ATAATA/GTTTGT 1 -- int10--------
    rs75614111,2
    C,F,A,H--101636719(+) AATAAT/CAGAGT 1 -- int119Minor allele frequency- C:0.17NS EA NA WA 2234
    rs713781401,2
    C--101636805(+) ATGAT-/G/GAT 
            
    ATGAT
    2 -- int1 cds11NA 2
    rs75708391,2
    C,F,A,H--101636892(+) AATTTG/ATATTG 1 -- int117Minor allele frequency- A:0.50NA NS EA WA CSA 931
    rs1828332471,2
    --101636931(+) CTAAAC/GAATTT 1 -- int10--------
    rs176634431,2
    C,F,H--101637009(+) AGTCAT/CAATAG 1 -- int122Minor allele frequency- C:0.07NA NS EA CSA WA 2450
    rs1418705961,2
    --101637050(+) GACTGC/TGTGGC 1 -- int10--------
    rs116808871,2
    C,F,A,H--101637051(+) ACTGCG/ATGGCC 1 -- int116Minor allele frequency- A:0.16NS EA NA WA 1150

    HapMap Linkage Disequilibrium report for TBC1D8 (101623690 - 101869328 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TBC1D8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720446CNV Deletion23290073
    nsv834317CNV Loss17160897
    nsv519123CNV Loss19592680
    esv34123CNV Loss18971310
    nsv834316CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TBC1D8
    DNA2.0 Custom Variant and Variant Library Synthesis for TBC1D8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with TBC1D8           About GenesLikeMe

    Genetic Association Database (GAD): TBC1D8
    Human Genome Epidemiology (HuGE) Navigator: TBC1D8 (1 document)

    Export disorders for TBC1D8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TBC1D8 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with TBC1D8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Antisense display -- a method for functional gene screening: evaluation in a cell-free system and isolation of angiogenesis-related genes. (PubMed id 10373574)1, 2, 3 Yonekura H.... Yamamoto H. (Nucleic Acids Res. 1999)
    2. An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. (PubMed id 20548944)1, 4 Hsu Y.H....Kiel D.P. (PLoS Genet. 2010)
    3. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1, 2 Ishibashi K.... Fukuda M. (Genes Cells 2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)1 Long P....Rose S. (Eur. J. Neurosci. 2012)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)
    9. A Rab-GAP TBC domain protein binds hepatitis C virus NS5A and mediates viral replication. (PubMed id 17686842)1 Sklan E.H.... Glenn J.S. (J. Virol. 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11138 HGNC: 17791 AceView: RPL31 Ensembl:ENSG00000204634 euGenes: HUgn11138
    ECgene: TBC1D8 H-InvDB: TBC1D8

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TBC1D8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TBC1D8 gene:
    Search GeneIP for patents involving TBC1D8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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