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TBC1D5 Gene

protein-coding   GIFtS: 50
GCID: GC03M017198

TBC1 Domain Family, Member 5

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TBC1 Domain Family, Member 51 2
TBC1 Domain Family Member 52
KIAA02103

External Ids:    HGNC: 191661   Entrez Gene: 97792   Ensembl: ENSG000001313747   UniProtKB: Q926093   

Export aliases for TBC1D5 gene to outside databases

Previous GC identifers: GC03M017129 GC03M017174 GC03M017133


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TBC1D5 Gene:
TBC1D5 (TBC1 domain family, member 5) is a protein-coding gene. Diseases associated with TBC1D5 include ataxia. GO annotations related to this gene include Rab GTPase activator activity. An important paralog of this gene is TBC1D13.

UniProtKB/Swiss-Prot: TBCD5_HUMAN, Q92609
Function: May act as a GTPase-activating protein for Rab family protein(s)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TBC1D5 gene promoter:
         SRF   Pax-5   GATA-3   Pax-6   SRF (504 AA)   GATA-1   GATA-2   FOXC1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TBC1D5 promoter sequence
   Search Chromatin IP Primers for TBC1D5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBC1D5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.3   Ensembl cytogenetic band:  3p24.3   HGNC cytogenetic band: 3p24.3

TBC1D5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBC1D5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M017198:  view genomic region     (about GC identifiers)

Start:
17,198,654 bp from pter      End:
18,486,309 bp from pter
Size:
1,287,656 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TBCD5_HUMAN, Q92609 (See protein sequence)
Recommended Name: TBC1 domain family member 5  
Size: 795 amino acids; 89004 Da
Sequence caution: Sequence=BAA13201.2; Type=Erroneous initiation;
Secondary accessions: A6NP25 C9JP52
Alternative splicing: 2 isoforms:  Q92609-1   Q92609-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TBC1D5: NX_Q92609

Explore proteomics data for TBC1D5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys456
  • Modification sites at PhosphoSitePlus

  • See TBC1D5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001127853.1  NP_055559.1  

    ENSEMBL proteins: 
     ENSP00000253692   ENSP00000398127   ENSP00000402935   ENSP00000411925   ENSP00000396239  
     ENSP00000405886   ENSP00000414250   ENSP00000387395   ENSP00000399967   ENSP00000411780  
     ENSP00000410596   ENSP00000393882   ENSP00000424998   ENSP00000415379   ENSP00000414159  
     ENSP00000396850   ENSP00000408603  

    TBC1D5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000195 Rab-GTPase-TBC_dom

    Graphical View of Domain Structure for InterPro Entry Q92609

    ProtoNet protein and cluster: Q92609

    1 Blocks protein domain: IPB000195 RabGAP/TBC domain

    UniProtKB/Swiss-Prot: TBCD5_HUMAN, Q92609
    Similarity: Contains 1 Rab-GAP TBC domain


    TBC1D5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBCD5_HUMAN, Q92609
    Function: May act as a GTPase-activating protein for Rab family protein(s)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005097Rab GTPase activator activity IEA--
    GO:0005515protein binding IPI16713569
         
    TBC1D5 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBC1D5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TBC1D5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TBC1D5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TBC1D5

    miRNA
    Products:
        
    miRTarBase miRNAs that target TBC1D5:
    hsa-mir-375 (MIRT019683)

    Block miRNA regulation of human, mouse, rat TBC1D5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TBC1D5 (see all 17):
    hsa-miR-194* hsa-miR-3673 hsa-miR-148b hsa-miR-181a-2* hsa-miR-3150a-3p hsa-miR-520g hsa-miR-219-2-3p hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidTBC1D5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TBC1D5
    Predesigned siRNA for gene silencing in human, mouse, rat TBC1D5

    Gene Editing
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    endosome1
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030904retromer complex IDA--

    TBC1D5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBC1D5
    Interactions:

        Search GeneGlobe Interaction Network for TBC1D5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TBC1D5 (Q926091, 2, 3 ENSP000004029354) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542531, 2, 3, ENSP000002447694EBI-742381,EBI-930964 MINT-2855315 MINT-2867482 I2D: score=2 STRING: ENSP00000244769
    GABARAPL2P605202, 3, ENSP000000372434MINT-66261 I2D: score=4 STRING: ENSP00000037243
    AP2M1Q96CW12, 3, ENSP000002928074MINT-67652 I2D: score=4 STRING: ENSP00000292807
    TUBP506073, ENSP000003054264I2D: score=5 STRING: ENSP00000305426
    MAP1LC3CQ9BXW43I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032313regulation of Rab GTPase activity ----

    TBC1D5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TBC1D5 (TBCD5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TBC1D5 gene (3 alternative transcripts): 
    NM_001134380.1  NM_001134381.1  NM_014744.2  

    Unigene Cluster for TBC1D5:

    TBC1 domain family, member 5
    Hs.475629  [show with all ESTs]
    Unigene Representative Sequence: NM_014744
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000253692(uc010heu.3 uc010hev.3 uc003cbf.3 uc003cbe.3)
    ENST00000429383 ENST00000414318 ENST00000446818 ENST00000429924(uc010hew.1)
    ENST00000465884 ENST00000415814 ENST00000452492 ENST00000412981 ENST00000428355
    ENST00000425944 ENST00000430169 ENST00000445294 ENST00000414349 ENST00000443499
    ENST00000443386 ENST00000497531 ENST00000444756
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TBC1D5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TBC1D5 (see all 17):
    hsa-miR-194* hsa-miR-3673 hsa-miR-148b hsa-miR-181a-2* hsa-miR-3150a-3p hsa-miR-520g hsa-miR-219-2-3p hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidTBC1D5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TBC1D5
    Predesigned siRNA for gene silencing in human, mouse, rat TBC1D5
    Clone
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    OriGene clones in human, mouse for TBC1D5 (see all 19)
    OriGene ORF clones in mouse, rat for TBC1D5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TBC1D5 (NM_001134381)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBC1D5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D5
    Primer
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    OriGene qPCR primer pairs and template standards for TBC1D5
    OriGene qSTAR qPCR primer pairs in human, mouse for TBC1D5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBC1D5
      QuantiTect SYBR Green Assays in human, mouse, rat TBC1D5
      QuantiFast Probe-based Assays in human, mouse, rat TBC1D5

    Additional mRNA sequence: 

    AB449886.1 AK097990.1 AK309374.1 AK310539.1 BC013145.1 D86965.1 

    20 DOTS entries:

    DT.417592  DT.95371166  DT.97843238  DT.95371170  DT.91760164  DT.91760158  DT.95156888  DT.120924459 
    DT.120924485  DT.120924524  DT.95371167  DT.120924443  DT.120924457  DT.70104648  DT.100812269  DT.101970022 
    DT.102843197  DT.120924520  DT.120924573  DT.97762430 

    Selected AceView cDNA sequences (see all 295):

    CK430991 CR619208 AU143495 AI239783 AW203970 BQ705978 AW594113 BF448408 
    AI086250 AW292031 AI146801 BU070375 Z40285 BM802699 BM126836 AA977666 
    CD370108 AA503016 AW499739 BX280292 BU156051 AA243266 W21163 AI248128 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D5    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
    SP1:              -                                                                                                                           
    SP2:                                                                                                                                          
    SP3:                                                                                            -                                             


    ECgene alternative splicing isoforms for TBC1D5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TBC1D5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGCCCTAT
    TBC1D5 Expression
    About this image

    TBC1D5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TBC1D5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.475629
        Custom PCR Arrays for TBC1D5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TBC1D5 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbc1d51 , 5 TBC1 domain family, member 51, 5 87.55(n)1
    89.27(a)1
      17 (26.47 cM)5
    722381  NM_001285991.11  NP_001272920.11 
     507331275 
    chicken
    (Gallus gallus)
    Aves TBC1D51 TBC1 domain family, member 5 75.59(n)
    77.71(a)
      420646  XM_004939398.1  XP_004939455.1 
    lizard
    (Anolis carolinensis)
    Reptilia TBC1D56
    TBC1 domain family, member 5
    74(a)
    1 ↔ 1
    6(34298821-34592210)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX846636.12   -- 77.22(n)    BX846636.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636242 hypothetical protein MGC63624 73.99(n)   393583  BC056792.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG84496
    --
    28(a)
    1 ↔ 1
    3R(9094859-9097748)
    worm
    (Caenorhabditis elegans)
    Secernentea rbg-36
    Protein RBG-3 (rbg-3) mRNA, complete cds
    31(a)
    1 ↔ 1
    III(4754432-4757019) WBGene00007167


    ENSEMBL Gene Tree for TBC1D5 (if available)
    TreeFam Gene Tree for TBC1D5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TBC1D5 gene
    TBC1D132  

    TBC1D5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TBC1D5 (see all 10356)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1810393451,2
    --17198158(+) GGGTGC/TGACCC 3 -- int10--------
    rs1436046701,2
    --17198163(+) CGACCC/TGGGCC 3 -- int10--------
    rs1836524221,2
    --17198176(+) CCAGCA/TGCCTC 3 -- int10--------
    rs1480269261,2
    --17198252(+) GCATCA/GTCTTT 3 -- int10--------
    rs562794371,2
    C,F--17198302(+) TAAGTC/ACTTTC 3 -- int13Minor allele frequency- A:0.12WA NA 240
    rs46854391,2
    C,F,A,H--17198623(+) GCCCCC/AACGCG 3 -- int125Minor allele frequency- A:0.16NS EA NA WA CSA 2353
    rs1410274061,2
    --17198625(+) CCCAAC/TGCGTG 3 -- int10--------
    rs1880189191,2
    --17198988(+) TGCCAA/TCCTCA 3 -- ut310--------
    rs793273551,2
    C--17199065(+) GGGGS-/ASGGGG 6 -- ut310--------
    rs107184931,2
    C--17199066(+) GGGCC-/AGGGGC 3 -- ut311Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for TBC1D5 (17198654 - 17448654 bp, first 250kb of TBC1D5)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TBC1D5 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663694CNV Deletion23128226
    esv4814CNV Deletion18987735
    esv2724981CNV Deletion23290073
    esv2211188CNV Deletion18987734
    esv2724980CNV Deletion23290073
    esv2669615CNV Deletion23128226
    esv2583047CNV Deletion19546169
    esv1204331CNV Deletion17803354
    esv2622635CNV Insertion19546169
    nsv470439CNV Loss18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TBC1D5
    DNA2.0 Custom Variant and Variant Library Synthesis for TBC1D5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for TBC1D5:    
    About MalaCards
    ataxia


    TBC1D5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TBC1D5
    Human Genome Epidemiology (HuGE) Navigator: TBC1D5 (1 document)

    Export disorders for TBC1D5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TBC1D5 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with TBC1D5)
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    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5. (PubMed id 19531583)1, 3 Seaman M.N....Bright N. (J. Cell. Sci. 2009)
    3. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T.... Nomura N. (DNA Res. 1996)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    9. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. (PubMed id 22354992)1 Popovic D....Dikic I. (Mol. Cell. Biol. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9779 HGNC: 19166 AceView: TBC1D5 Ensembl:ENSG00000131374 euGenes: HUgn9779
    ECgene: TBC1D5 H-InvDB: TBC1D5

    (According to HUGE)
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    HUGE: KIAA0210

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TBC1D5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TBC1D5 gene:
    Search GeneIP for patents involving TBC1D5

    GeneCards and IP:
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