TBC1D3G Gene
protein-coding GIFtS: 37
GCID: GC17M034746
|
|
TBC1 domain family, member 3G
| |
Aliases
for TBC1D3G gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TBC1 Domain Family, Member 3G1 2 | | TBC1 Domain Family Member 3G2 |
Export aliases for TBC1D3G gene to outside databasesPrevious GC identifers: GC17M031872 GC17M034797 |
Summaries
for TBC1D3G gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TBC3G_HUMAN, Q6DHY5Function: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity)
|
Genomic Views
for TBC1D3G gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TBC1D3G gene promoter:
NF-1 NF-1/L HNF-4alpha2 HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TBC1D3G
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBC1D3G |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q12TBC1D3G Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M034746: view genomic region
(about GC identifiers)
Start:
|
34,745,936 bp from pter |
End:
|
34,808,104 bp from pter |
Size:
|
62,169 bases |
Orientation:
|
minus strand |
|
Proteins
for TBC1D3G gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TBC3G_HUMAN, Q6DHY5 (See
protein sequence)Recommended Name: TBC1 domain family member 3G Size: 549 amino acids; 62231 Da
Secondary accessions: A8K8H9Explore the universe of human proteins at neXtProt for TBC1D3G: NX_Q6DHY5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6DHY5
TBC1D3G Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001035372.2
ENSEMBL proteins: ENSP00000377966 ENSP00000468205 ENSP00000467534 ENSP00000345014 ENSP00000466750 ENSP00000467346 ENSP00000332729 ENSP00000438443 ENSP00000441318
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
TBC1D3G for ontologies About GeneDecksing
TBC1D3G Antibody Products:
Assay Products for TBC1D3G: |
Protein
Domains /
Families
for TBC1D3G gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TBC1D3G for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6DHY5ProtoNet protein and cluster: Q6DHY5 1 Blocks protein family: IPB000195 RabGAP/TBC domain
UniProtKB/Swiss-Prot: TBC3G_HUMAN, Q6DHY5Similarity: Contains 1 Rab-GAP TBC domain |
Function
for TBC1D3G gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TBC3G_HUMAN, Q6DHY5Function: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D3G
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D3G
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TBC1D3G (NM_001040282) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBC1D3G | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D3G |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D3G |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005097 | Rab GTPase activator activity |
IEA | -- |
TBC1D3G for ontologies About GeneDecksing
|
Pathways & Interactions
for TBC1D3G gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBC1D3G
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TBC1D3G (ENSP000003450144) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TBC1D3G gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TBC1D3G
Search CenterWatch for drugs/clinical trials and news about TBC1D3G / TBC3G
|
Transcripts
for TBC1D3G gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TBC1D3G gene: NM_001040282.2 Unigene Cluster for TBC1D3G: TBC1 domain family, member 3G Hs.617010 Unigene Representative Sequence: NM_00104028218/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000394453 ENST00000589602 ENST00000592614 ENST00000590913 ENST00000341264(uc002hmm.4)
ENST00000589513 ENST00000587378 ENST00000587756 ENST00000588999 ENST00000589896
ENST00000591542 ENST00000586554 ENST00000591233 ENST00000592987 ENST00000588834
ENST00000589650 ENST00000330458 ENST00000535592(uc002hll.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D3G
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D3G
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TBC1D3G (NM_001040282) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBC1D3G | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D3G |
Additional cDNA sequence: AK225985.1 AK292344.1 BC075809.1 2 DOTS entries: DT.102843582 DT.97771291
GeneLoc Exon Structure
|
Expression
for TBC1D3G gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TBC1D3G expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TBC1D3G Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.617010
SABiosciences Custom PCR Arrays for TBC1D3G
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBC1D3G
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TBC1D3G | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBC1D3G | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBC1D3G | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D3G |
Orthologs
for TBC1D3G gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TBC1D3G gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
USP6NL6 |
Uncharacterized protein |
26(a) |
1 → many |
5(17180663-17259945) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
32(a) |
1 → many |
1(74862925-74883702) |
zebrafish
(Danio rerio) |
Actinopterygii |
si:ch211-288d18.16si:dkeyp-19e1.36 |
si:dkeyp-19e1.3 |
20(a)17(a) |
many ↔ manymany ↔ many |
7(50477638-50513235) 25(24844950-24903338) |
fruit fly
(Drosophila melanogaster) |
Insecta |
RN-tre6 |
tre oncogene-related protein |
15(a) |
1 → many |
2R(9872320-9878215) |
worm
(Caenorhabditis elegans) |
Secernentea |
tbc-176 |
TBC (Tre-2/Bub2/Cdc16) domain family member (tbc-1... |
11(a) |
1 → many |
II(12694340-12725413) |
ENSEMBL Gene Tree for TBC1D3G (if available)
TreeFam Gene Tree for TBC1D3G (if available) |
Paralogs
for TBC1D3G gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TBC1D3G gene
- TBC1D3H1 2 TBC1D3C1 2 TBC1D3B1 2 TBC1D31 2 TBC1D3F1 2 SGSM32 TBC1D2B2 GRTP12
- TBC1D10C2 TBC1D10B2 TBC1D262 ENSG000002487512 TBC1D10A2 TBC1D22 USP6NL2 TBC1D282
18 SIMAP similar genes for TBC1D3G using alignment to 6 protein entries: TBC3G_HUMAN (see all proteins):TBC1D3B TBC1D3F TBC1D3H TBC1D3 TBC1D3C USP6-short
USP6 TRE17 CDH11/USP6 fusion oncogene LOC440419 tre TBC1D26
TBC1D28 TBC1D29 TBC1D10A TBC1D10B FLJ00050 TBC1D10C
TBC1D3G for paralogs About GeneDecksing
|
Genomic Variants
for TBC1D3G gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TBC1D3G (34745936 - 34808104 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 20 variations for TBC1D3G
15/20 CNVs (see all 20): 88436 8841 72893 77583 30824 88433 72899 72894 77576 32171 3142 77575 34477 8843 0799 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBC1D3G |
|
Disorders
/ Diseases
for TBC1D3G gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TBC1D3G for disorders About GeneDecksing
OMIM gene information: 610810
OMIM disorders: --
1  disease for TBC1D3G: About MalaCardsmalaria
Export disorders for TBC1D3G gene to outside databases
|
Publications
for TBC1D3G gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TBC1D3G gene integrated from 9 sources:
(articles sorted by number of sources associating them with TBC1D3G) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12. (PubMed id 16863688)1, 3 Hodzic D....Stahl P.D. (2006)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
|
External Searches for TBC1D3G gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TBC1D3G gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBC1D3G gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TBC1D3G gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TBC1D3G | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TBC1D3G gene:
Search GeneIP for patents involving TBC1D3G
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TBC1D3G gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TBC1D3G | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TBC1D3G | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBC1D3G | | | OriGene Protein Over-expression Lysate for TBC1D3G | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TBC1D3G | | OriGene 3'-UTR Clone for TBC1D3G | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D3G | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D3G | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TBC1D3G | | OriGene Custom Protein Services for TBC1D3G | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TBC1D3G | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBC1D3G | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBC1D3G | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBC1D3G | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBC1D3G | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBC1D3G |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TBC1D3G |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D3G |
|  |  |  | | | | ThermoFisher Antibodies for TBC1D3G |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D3G |
|
|
|
|
