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Aliases for TBC1D3F Gene

Aliases for TBC1D3F Gene

  • TBC1 Domain Family, Member 3F 2 3
  • Prostate Cancer Gene 17 Protein 3
  • TBC1 Domain Family Member 3 3
  • Protein TRE17-Alpha 3
  • TBC1D3E 4
  • TBC1D3 3

External Ids for TBC1D3F Gene

Previous GeneCards Identifiers for TBC1D3F Gene

  • GC17M031607
  • GC17U900818
  • GC17P033363
  • GC17M033595
  • GC17P036283
  • GC17M030678

Summaries for TBC1D3F Gene

GeneCards Summary for TBC1D3F Gene

TBC1D3F (TBC1 Domain Family, Member 3F) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is TBC1D3.

UniProtKB/Swiss-Prot for TBC1D3F Gene

  • Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).

Gene Wiki entry for TBC1D3F Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D3F Gene

Genomics for TBC1D3F Gene

Regulatory Elements for TBC1D3F Gene

Genomic Location for TBC1D3F Gene

Chromosome:
17
Start:
36,377,846 bp from pter
End:
36,439,566 bp from pter
Size:
61,721 bases
Orientation:
Minus strand

Genomic View for TBC1D3F Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBC1D3F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D3F Gene

Proteins for TBC1D3F Gene

  • Protein details for TBC1D3F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NER0-TBC3F_HUMAN
    Recommended name:
    TBC1 domain family member 3F
    Protein Accession:
    A6NER0

    Protein attributes for TBC1D3F Gene

    Size:
    549 amino acids
    Molecular mass:
    62185 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog, some human genomes encoding well over 50 copies depending on ethnic origin of the donor.

neXtProt entry for TBC1D3F Gene

Proteomics data for TBC1D3F Gene at MOPED

Post-translational modifications for TBC1D3F Gene

  • Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination.
  • Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBC1D3F Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TBC1D3F Gene

Domains & Families for TBC1D3F Gene

Protein Domains for TBC1D3F Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TBC1D3F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NER0

UniProtKB/Swiss-Prot:

TBC3F_HUMAN :
  • Contains 1 Rab-GAP TBC domain.
Domain:
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with TBC1D3F: view

No data available for Gene Families for TBC1D3F Gene

Function for TBC1D3F Gene

Molecular function for TBC1D3F Gene

UniProtKB/Swiss-Prot Function:
Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).

Gene Ontology (GO) - Molecular Function for TBC1D3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with TBC1D3F: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBC1D3F

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TBC1D3F Gene

Localization for TBC1D3F Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBC1D3F Gene

Cell membrane; Lipid-anchor. Note=Associated with lipid rafts. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBC1D3F Gene COMPARTMENTS Subcellular localization image for TBC1D3F gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TBC1D3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with TBC1D3F: view

Pathways & Interactions for TBC1D3F Gene

SuperPathways for TBC1D3F Gene

No Data Available

Interacting Proteins for TBC1D3F Gene

Selected Interacting proteins: A6NER0-TBC3F_HUMAN for TBC1D3F Gene via I2D

Gene Ontology (GO) - Biological Process for TBC1D3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with TBC1D3F: view

No data available for Pathways by source and SIGNOR curated interactions for TBC1D3F Gene

Drugs & Compounds for TBC1D3F Gene

No Compound Related Data Available

Transcripts for TBC1D3F Gene

mRNA/cDNA for TBC1D3F Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBC1D3F

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D3F Gene

No ASD Table

Relevant External Links for TBC1D3F Gene

GeneLoc Exon Structure for
TBC1D3F
ECgene alternative splicing isoforms for
TBC1D3F

Expression for TBC1D3F Gene

mRNA expression in normal human tissues for TBC1D3F Gene

mRNA Expression by UniProt/SwissProt for TBC1D3F Gene

A6NER0-TBC3F_HUMAN
Tissue specificity: Expressed in most tissues including pancreas, thymus and testis.
genes like me logo Genes that share expression patterns with TBC1D3F: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TBC1D3F Gene

Orthologs for TBC1D3F Gene

Evolution for TBC1D3F Gene

ENSEMBL:
Gene Tree for TBC1D3F (if available)
TreeFam:
Gene Tree for TBC1D3F (if available)

No data available for Orthologs for TBC1D3F Gene

Paralogs for TBC1D3F Gene

Paralogs for TBC1D3F Gene

genes like me logo Genes that share paralogs with TBC1D3F: view

Variants for TBC1D3F Gene

Structural Variations from Database of Genomic Variants (DGV) for TBC1D3F Gene

Variant ID Type Subtype PubMed ID
dgv957e1 CNV Complex 17122850
nsv908172 CNV Loss 21882294
nsv471398 CNV Duplication 19718026
nsv820624 CNV Duplication 20802225
nsv833435 CNV Gain+Loss 17160897

Variation tolerance for TBC1D3F Gene

Gene Damage Index Score: 0.25; 5.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBC1D3F Gene

HapMap Linkage Disequilibrium report
TBC1D3F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TBC1D3F Gene

Disorders for TBC1D3F Gene

Relevant External Links for TBC1D3F

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TBC1D3F
genes like me logo Genes that share disorders with TBC1D3F: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D3F Gene

Publications for TBC1D3F Gene

  1. The primate-specific protein TBC1D3 is required for optimal macropinocytosis in a novel ARF6-dependent pathway. (PMID: 18199687) Frittoli E. … Confalonieri S. (Mol. Biol. Cell 2008) 23 67
  2. TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12. (PMID: 16863688) Hodzic D. … Stahl P.D. (Genomics 2006) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PMID: 23535730) Pharoah P.D. … Sellers T.A. (Nat. Genet. 2013) 67
  5. Diversity of human copy number variation and multicopy genes. (PMID: 21030649) Sudmant P.H. … Eichler E.E. (Science 2010) 67

Products for TBC1D3F Gene

Sources for TBC1D3F Gene

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