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Aliases for TBC1D3F Gene

Aliases for TBC1D3F Gene

  • TBC1 Domain Family, Member 3F 2 3
  • Prostate Cancer Gene 17 Protein 3
  • TBC1 Domain Family, Member 3G 3
  • TBC1 Domain Family Member 3F 3
  • TBC1 Domain Family Member 3 3
  • Protein TRE17-Alpha 3
  • TBC1D3G 3
  • TBC1D3E 4
  • TBC1D3 3

External Ids for TBC1D3F Gene

Summaries for TBC1D3F Gene

GeneCards Summary for TBC1D3F Gene

TBC1D3F (TBC1 Domain Family, Member 3F) is a Protein Coding gene. Diseases associated with TBC1D3F include prostate cancer. An important paralog of this gene is TBC1D3.

UniProtKB/Swiss-Prot for TBC1D3F Gene

  • Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).

Gene Wiki entry for TBC1D3F Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D3F Gene

Genomics for TBC1D3F Gene

Genomic Location for TBC1D3F Gene

Start:
36,377,532 bp from pter
End:
36,439,566 bp from pter
Size:
62,035 bases
Orientation:
Minus strand

Genomic View for TBC1D3F Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBC1D3F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D3F Gene

Regulatory Elements for TBC1D3F Gene

Proteins for TBC1D3F Gene

  • Protein details for TBC1D3F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NER0-TBC3F_HUMAN
    Recommended name:
    TBC1 domain family member 3F
    Protein Accession:
    A6NER0
    Secondary Accessions:

    Protein attributes for TBC1D3F Gene

    Size:
    549 amino acids
    Molecular mass:
    62185 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog, some human genomes encoding well over 50 copies depending on ethnic origin of the donor.

neXtProt entry for TBC1D3F Gene

Proteomics data for TBC1D3F Gene at MOPED

Post-translational modifications for TBC1D3F Gene

  • Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination.
  • Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation.

Other Protein References for TBC1D3F Gene

No data available for DME Specific Peptides for TBC1D3F Gene

Domains for TBC1D3F Gene

Protein Domains for TBC1D3F Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TBC3F_HUMAN
Domain:
  • Contains 1 Rab-GAP TBC domain.:
    • A6NER0
genes like me logo Genes that share domains with TBC1D3F: view

No data available for Gene Families for TBC1D3F Gene

Function for TBC1D3F Gene

Molecular function for TBC1D3F Gene

UniProtKB/Swiss-Prot Function: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).

Gene Ontology (GO) - Molecular Function for TBC1D3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with TBC1D3F: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TBC1D3F Gene

Localization for TBC1D3F Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBC1D3F Gene

Cell membrane; Lipid-anchor. Note=Associated with lipid rafts. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBC1D3F Gene COMPARTMENTS Subcellular localization image for TBC1D3F gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
endosome 1

Gene Ontology (GO) - Cellular Components for TBC1D3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with TBC1D3F: view

Pathways for TBC1D3F Gene

SuperPathways for TBC1D3F Gene

No Data Available

Interacting Proteins for TBC1D3F Gene

Selected Interacting proteins: A6NER0-TBC3F_HUMAN for TBC1D3F Gene via I2D

Gene Ontology (GO) - Biological Process for TBC1D3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with TBC1D3F: view

No data available for Pathways by source for TBC1D3F Gene

Transcripts for TBC1D3F Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D3F Gene

No ASD Table

Relevant External Links for TBC1D3F Gene

GeneLoc Exon Structure for
TBC1D3F
ECgene alternative splicing isoforms for
TBC1D3F

Expression for TBC1D3F Gene

mRNA expression in normal human tissues for TBC1D3F Gene

mRNA Expression by UniProt/SwissProt for TBC1D3F Gene

A6NER0-TBC3F_HUMAN
Tissue specificity: Expressed in most tissues including pancreas, thymus and testis.
genes like me logo Genes that share expressions with TBC1D3F: view

Orthologs for TBC1D3F Gene

Evolution for TBC1D3F Gene

ENSEMBL:
Gene Tree for TBC1D3F (if available)
TreeFam:
Gene Tree for TBC1D3F (if available)

No data available for Orthologs for TBC1D3F Gene

Paralogs for TBC1D3F Gene

Paralogs for TBC1D3F Gene

genes like me logo Genes that share paralogs with TBC1D3F: view

Variants for TBC1D3F Gene

Sequence variations from dbSNP and Humsavar for TBC1D3F Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs7221592 -- 36,428,797(+) TGAAT(C/G)TCTCT utr-variant-3-prime
rs78351615 -- 36,441,419(+) AGGTT(C/G/T)CTCCC upstream-variant-2KB
rs79095614 -- 36,428,828(+) TACAT(A/T)TTCAT utr-variant-3-prime
rs112039081 -- 36,440,467(+) GTCAT(C/T)ATTCC upstream-variant-2KB
rs138015336 -- 36,429,139(+) CACGG(A/G)CCCAG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for TBC1D3F Gene

Variant ID Type Subtype PubMed ID
dgv957e1 CNV Complex 17122850
nsv908172 CNV Loss 21882294
nsv471398 CNV Duplication 19718026
nsv820624 CNV Duplication 20802225
nsv833435 CNV Gain+Loss 17160897

Relevant External Links for TBC1D3F Gene

HapMap Linkage Disequilibrium report
TBC1D3F

Disorders for TBC1D3F Gene

(1) MalaCards Diseases for TBC1D3F Gene

Search for TBC1D3F Gene in MalaCards »
genes like me logo Genes that share disorders with TBC1D3F: view

No data available for UniProtKB/Swiss-Prot for TBC1D3F Gene

Publications for TBC1D3F Gene

  1. TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12. (PMID: 16863688) Hodzic D. … Stahl P.D. (Genomics 2006) 2 3 4
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4
  3. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K. … Fukuda M. (Genes Cells 2009) 3
  4. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3
  5. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PMID: 23535730) Pharoah P.D. … Sellers T.A. (Nat. Genet. 2013) 3

Products for TBC1D3F Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate TBC1D3F
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TBC1D3F
    • Block miRNA regulation of TBC1D3F using miScript Target Protectors

    Sources for TBC1D3F Gene

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