TBC1D3F Gene
protein-coding GIFtS: 43
GCID: GC17P036283
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|
TBC1 domain family, member 3F
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Aliases
for TBC1D3F gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TBC1 Domain Family, Member 3F1 2 | | TBC1 Domain Family Member 32 | | TBC1D32 | | TBC1 Domain Family Member 3F2 | | Prostate Cancer Gene 17 Protein2 | | TBC1D3E3 | | Protein TRE17-Alpha2 | | |
Export aliases for TBC1D3F gene to outside databasesPrevious GC identifers: GC17M031607 GC17U900818 GC17P033363 GC17M033595 GC17M030678 |
Summaries
for TBC1D3F gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TBC3F_HUMAN, A6NER0Function: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity)
Gene Wiki entry for TBC1D3F (TBC1D3)
|
Genomic Views
for TBC1D3F gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TBC1D3F gene promoter:
NF-1/L NF-1 HTF Lmo2 ATF Egr-4
Other transcription factors
Search SABiosciences Chromatin IP Primers for TBC1D3F
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBC1D3F |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q12TBC1D3F Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P036283: view genomic region
(about GC identifiers)
Start:
|
36,283,960 bp from pter |
End:
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36,294,915 bp from pter |
Size:
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10,956 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr17-,PATCHES 34,770,219-34,781,173 |
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Proteins
for TBC1D3F gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TBC3F_HUMAN, A6NER0 (See
protein sequence)Recommended Name: TBC1 domain family member 3F Size: 549 amino acids; 62156 DaExplore the universe of human proteins at neXtProt for TBC1D3F: NX_A6NER0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NER0
TBC1D3F Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115634.2
ENSEMBL proteins: ENSP00000329256 ENSP00000467535 ENSP00000421962 ENSP00000367416 ENSP00000443859
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
TBC1D3F for ontologies About GeneDecksing
TBC1D3F Antibody Products:
Assay Products for TBC1D3F: |
Protein
Domains /
Families
for TBC1D3F gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TBC1D3F for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A6NER0ProtoNet protein and cluster: A6NER0 UniProtKB/Swiss-Prot: TBC3F_HUMAN, A6NER0Similarity: Contains 1 Rab-GAP TBC domain |
Function
for TBC1D3F gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TBC3F_HUMAN, A6NER0Function: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D3F
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D3F
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D3F |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005097 | Rab GTPase activator activity |
IEA | -- |
TBC1D3F for ontologies About GeneDecksing
|
Pathways & Interactions
for TBC1D3F gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBC1D3F
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for TBC1D3F (A6NER03 ENSP000003292564) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TBC1D3F gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TBC1D3F
Search CenterWatch for drugs/clinical trials and news about TBC1D3F / TBC3F
|
Transcripts
for TBC1D3F gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TBC1D3F gene: NM_032258.2 6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000327454(uc002hoo.2 uc010cvf.1) ENST00000442786(uc002hop.2 uc010wdj.1)
ENST00000513862 ENST00000505415(uc002hoq.2) ENST00000378174 ENST00000539424(uc010wdk.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D3F
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D3F
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TBC1D3F (NM_032258) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBC1D3F | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D3F |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBC1D3F
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TBC1D3F | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBC1D3F | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBC1D3F |
24/48 AceView cDNA sequences (see all 48): BX281608 CA394892 BU542901 BC033670 BI829764 CD653466 AK095385 BM842553 BG718044 AV650439 AX775945 BM846014 BF091359 BM563571 BX279913 BC075809 BQ942166 BQ923700 BM762465 BI832051 BX644661 BM914524 BF809416 BI828272
GeneLoc Exon Structure
|
Expression
for TBC1D3F gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TBC1D3F expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTGAAATA
About this image
See TBC1D3F Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TBC1D3F
UniProtKB/Swiss-Prot: TBC3F_HUMAN, A6NER0Tissue specificity: Expressed in most tissues including pancreas, thymus and testis
SABiosciences Custom PCR Arrays for TBC1D3F
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBC1D3F
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TBC1D3F | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBC1D3F | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBC1D3F | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D3F |
Orthologs
for TBC1D3F gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TBC1D3F gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
USP6NL6 |
Uncharacterized protein |
26(a) |
1 → many |
5(17180663-17259945) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
32(a) |
1 → many |
1(74862925-74883702) |
zebrafish
(Danio rerio) |
Actinopterygii |
si:ch211-288d18.16si:dkeyp-19e1.36 |
si:dkeyp-19e1.3 |
20(a)17(a) |
many ↔ manymany ↔ many |
7(50477638-50513235) 25(24844950-24903338) |
fruit fly
(Drosophila melanogaster) |
Insecta |
RN-tre6 |
tre oncogene-related protein |
15(a) |
1 → many |
2R(9872320-9878215) |
worm
(Caenorhabditis elegans) |
Secernentea |
tbc-176 |
TBC (Tre-2/Bub2/Cdc16) domain family member (tbc-1... |
11(a) |
1 → many |
II(12694340-12725413) |
ENSEMBL Gene Tree for TBC1D3F (if available)
TreeFam Gene Tree for TBC1D3F (if available) |
Paralogs
for TBC1D3F gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TBC1D3F gene
- TBC1D31 2 TBC1D3G1 2 TBC1D3H1 2 TBC1D3C1 2 TBC1D3B1 2 SGSM32 TBC1D2B2 GRTP12
- TBC1D10C2 TBC1D10B2 TBC1D262 ENSG000002487512 TBC1D10A2 TBC1D22 USP6NL2 TBC1D282
16 SIMAP similar genes for TBC1D3F using alignment to 3 protein entries: TBC3F_HUMAN (see all proteins):TBC1D3B TBC1D3H TBC1D3 TBC1D3G TBC1D3C USP6-short
USP6 tre TRE17 CDH11/USP6 fusion oncogene LOC440419 TBC1D26
TBC1D28 TBC1D29 TBC1D10A TBC1D10C
TBC1D3F for paralogs About GeneDecksing
|
Genomic Variants
for TBC1D3F gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TBC1D3F (36283960 - 36294915 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 12 variations for TBC1D3F
11 CNVs: 77584 77586 88451 72914 5005 88450 77587 88449 88448 4034 77585
1 Inversion: 37189 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBC1D3F |
|
Disorders
/ Diseases
for TBC1D3F gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TBC1D3F for disorders About GeneDecksing
OMIM gene information: 610809
OMIM disorders: --
3  diseases for TBC1D3F: About MalaCardsprostate cancer prostatitis malaria
Export disorders for TBC1D3F gene to outside databases
|
Publications
for TBC1D3F gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TBC1D3F gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with TBC1D3F) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12. (PubMed id 16863688)1, 2, 3 Hodzic D....Stahl P.D. (2006)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (2006)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
- Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1 Ishibashi K.... Fukuda M. (2009)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling. (PubMed id 12612085)1 Masuda-Robens J.M....Chou M.M. (2003)
- PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer. (PubMed id 12359748)1 Pei L.... Li J. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TBC1D3F gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TBC1D3F gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBC1D3F gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TBC1D3F gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TBC1D3F | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TBC1D3F gene:
Search GeneIP for patents involving TBC1D3F
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TBC1D3F gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBC1D3F | | | OriGene Protein Over-expression Lysate for TBC1D3F | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TBC1D3F | | OriGene 3'-UTR Clone for TBC1D3F | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D3F | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D3F | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D3F |
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