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Aliases for TBC1D3F Gene

Aliases for TBC1D3F Gene

  • TBC1 Domain Family Member 3F 2 3 5
  • TBC1 Domain Family, Member 3F 2 3
  • Prostate Cancer Gene 17 Protein 3
  • TBC1 Domain Family Member 3 3
  • Protein TRE17-Alpha 3
  • TBC1D3E 4
  • TBC1D3 3

External Ids for TBC1D3F Gene

Previous GeneCards Identifiers for TBC1D3F Gene

  • GC17M031607
  • GC17U900818
  • GC17P033363
  • GC17M033595
  • GC17P036283
  • GC17M030678
  • GC17M036377

Summaries for TBC1D3F Gene

GeneCards Summary for TBC1D3F Gene

TBC1D3F (TBC1 Domain Family Member 3F) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is TBC1D10C.

UniProtKB/Swiss-Prot for TBC1D3F Gene

  • Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).

Gene Wiki entry for TBC1D3F Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D3F Gene

Genomics for TBC1D3F Gene

Regulatory Elements for TBC1D3F Gene

Enhancers for TBC1D3F Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TBC1D3F on UCSC Golden Path with GeneCards custom track

Genomic Location for TBC1D3F Gene

36,428,612 bp from pter
36,439,566 bp from pter
10,955 bases
Minus strand

Genomic View for TBC1D3F Gene

Genes around TBC1D3F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D3F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D3F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D3F Gene

Proteins for TBC1D3F Gene

  • Protein details for TBC1D3F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TBC1 domain family member 3F
    Protein Accession:

    Protein attributes for TBC1D3F Gene

    549 amino acids
    Molecular mass:
    62185 Da
    Quaternary structure:
    No Data Available
    • TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog, some human genomes encoding well over 50 copies depending on ethnic origin of the donor.

neXtProt entry for TBC1D3F Gene

Proteomics data for TBC1D3F Gene at MOPED

Post-translational modifications for TBC1D3F Gene

  • Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination.
  • Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBC1D3F Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TBC1D3F Gene

Domains & Families for TBC1D3F Gene

Protein Domains for TBC1D3F Gene


Suggested Antigen Peptide Sequences for TBC1D3F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Rab-GAP TBC domain.
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with TBC1D3F: view

No data available for Gene Families for TBC1D3F Gene

Function for TBC1D3F Gene

Molecular function for TBC1D3F Gene

UniProtKB/Swiss-Prot Function:
Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TBC1D3F Gene

Localization for TBC1D3F Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBC1D3F Gene

Cell membrane; Lipid-anchor. Note=Associated with lipid rafts. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for TBC1D3F Gene COMPARTMENTS Subcellular localization image for TBC1D3F gene
Compartment Confidence
plasma membrane 3
cytosol 2
nucleus 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for TBC1D3F Gene

Pathways & Interactions for TBC1D3F Gene

SuperPathways for TBC1D3F Gene

No Data Available

Interacting Proteins for TBC1D3F Gene

Selected Interacting proteins: A6NER0-TBC3F_HUMAN for TBC1D3F Gene via I2D

Gene Ontology (GO) - Biological Process for TBC1D3F Gene


No data available for Pathways by source and SIGNOR curated interactions for TBC1D3F Gene

Drugs & Compounds for TBC1D3F Gene

No Compound Related Data Available

Transcripts for TBC1D3F Gene

mRNA/cDNA for TBC1D3F Gene

(1) REFSEQ mRNAs :
(48) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D3F Gene

No ASD Table

Relevant External Links for TBC1D3F Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBC1D3F Gene

mRNA expression in normal human tissues for TBC1D3F Gene

mRNA Expression by UniProt/SwissProt for TBC1D3F Gene

Tissue specificity: Expressed in most tissues including pancreas, thymus and testis.
genes like me logo Genes that share expression patterns with TBC1D3F: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TBC1D3F Gene

Orthologs for TBC1D3F Gene

Evolution for TBC1D3F Gene

Gene Tree for TBC1D3F (if available)
Gene Tree for TBC1D3F (if available)

No data available for Orthologs for TBC1D3F Gene

Paralogs for TBC1D3F Gene

genes like me logo Genes that share paralogs with TBC1D3F: view

Variants for TBC1D3F Gene

Sequence variations from dbSNP and Humsavar for TBC1D3F Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs7221592 -- 36,428,797(+) TGAAT(C/G)TCTCT utr-variant-3-prime
rs78545873 -- 36,428,804(+) CTCTC(A/G)AGCTG utr-variant-3-prime
rs79095614 -- 36,428,828(+) TACAT(A/T)TTCAT utr-variant-3-prime
rs78351615 -- 36,441,419(+) AGGTT(C/G/T)CTCCC upstream-variant-2KB
rs112039081 -- 36,440,467(+) GTCAT(C/T)ATTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TBC1D3F Gene

Variant ID Type Subtype PubMed ID
dgv957e1 CNV Complex 17122850
nsv908172 CNV Loss 21882294
nsv471398 CNV Duplication 19718026
nsv820624 CNV Duplication 20802225
nsv833435 CNV Gain+Loss 17160897

Variation tolerance for TBC1D3F Gene

Gene Damage Index Score: 0.25; 5.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TBC1D3F Gene

Disorders for TBC1D3F Gene

Relevant External Links for TBC1D3F

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TBC1D3F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D3F Gene

Publications for TBC1D3F Gene

  1. TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12. (PMID: 16863688) Hodzic D. … Stahl P.D. (Genomics 2006) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PMID: 23535730) Pharoah P.D. … Sellers T.A. (Nat. Genet. 2013) 3
  4. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3
  5. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K. … Fukuda M. (Genes Cells 2009) 3

Products for TBC1D3F Gene

Sources for TBC1D3F Gene