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Aliases for TBC1D3B Gene

Aliases for TBC1D3B Gene

  • TBC1 Domain Family, Member 3B 2 3
  • TBC1 Domain Family, Member 3I 2 3
  • TBC1D3I 3 4
  • PRC17 3 6
  • Rab GTPase-Activating Protein PRC17 Duplicate 3
  • Prostate Cancer Gene 17 Duplicate 3
  • TBC1 Domain Family Member 3B/I 3
  • TBC1 Domain Family Member 3B 3
  • TBC1D3L 3

External Ids for TBC1D3B Gene

Previous HGNC Symbols for TBC1D3B Gene

  • TBC1D3I

Previous GeneCards Identifiers for TBC1D3B Gene

  • GC17M031519
  • GC17M034492

Summaries for TBC1D3B Gene

Entrez Gene Summary for TBC1D3B Gene

  • This gene encodes a protein that is similar to TBC1 domain family, member 3. This protein contains a TBC (Tre-2, Bub2p, and Cdc16p) domain, which is found in proteins involved in RAB GTPase signaling and vesicle trafficking. There are multiple copies of this gene located within a cluster of chemokine genes on chromosome 17q. [provided by RefSeq, Apr 2009]

GeneCards Summary for TBC1D3B Gene

TBC1D3B (TBC1 Domain Family, Member 3B) is a Protein Coding gene. Diseases associated with TBC1D3B include prostate cancer. An important paralog of this gene is LOC101060321.

UniProtKB/Swiss-Prot for TBC1D3B Gene

  • Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D3B Gene

Genomics for TBC1D3B Gene

Regulatory Elements for TBC1D3B Gene

Genomic Location for TBC1D3B Gene

Start:
36,165,624 bp from pter
End:
36,264,527 bp from pter
Size:
98,904 bases
Orientation:
Minus strand

Genomic View for TBC1D3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBC1D3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D3B Gene

Proteins for TBC1D3B Gene

  • Protein details for TBC1D3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NDS4-TBC3B_HUMAN
    Recommended name:
    TBC1 domain family member 3B
    Protein Accession:
    A6NDS4
    Secondary Accessions:
    • A8K892

    Protein attributes for TBC1D3B Gene

    Size:
    549 amino acids
    Molecular mass:
    62320 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • TBC1D3 is encoded by a collection of very similar paralogs with multiple copies of each paralog, some human genomes encoding well over 50 copies depending on ethnic origin of the donor

neXtProt entry for TBC1D3B Gene

Proteomics data for TBC1D3B Gene at MOPED

Post-translational modifications for TBC1D3B Gene

  • Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination.
  • Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBC1D3B Gene

No data available for DME Specific Peptides for TBC1D3B Gene

Domains for TBC1D3B Gene

Protein Domains for TBC1D3B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TBC1D3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NDS4

UniProtKB/Swiss-Prot:

TBC3B_HUMAN :
  • A6NDS4
Domain:
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with TBC1D3B: view

No data available for Gene Families for TBC1D3B Gene

Function for TBC1D3B Gene

Molecular function for TBC1D3B Gene

UniProtKB/Swiss-Prot Function: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).

Gene Ontology (GO) - Molecular Function for TBC1D3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with TBC1D3B: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TBC1D3B Gene

Localization for TBC1D3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBC1D3B Gene

Cell membrane; Lipid-anchor. Note=Associated with lipid rafts. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBC1D3B Gene COMPARTMENTS Subcellular localization image for TBC1D3B gene
Compartment Confidence
cytosol 2

Gene Ontology (GO) - Cellular Components for TBC1D3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with TBC1D3B: view

Pathways for TBC1D3B Gene

SuperPathways for TBC1D3B Gene

No Data Available

Interacting Proteins for TBC1D3B Gene

Gene Ontology (GO) - Biological Process for TBC1D3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with TBC1D3B: view

No data available for Pathways by source for TBC1D3B Gene

Transcripts for TBC1D3B Gene

Unigene Clusters for TBC1D3B Gene

TBC1 domain family, member 3B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D3B Gene

No ASD Table

Relevant External Links for TBC1D3B Gene

GeneLoc Exon Structure for
TBC1D3B
ECgene alternative splicing isoforms for
TBC1D3B

Expression for TBC1D3B Gene

mRNA expression in normal human tissues for TBC1D3B Gene

mRNA differential expression in normal tissues according to GTEx for TBC1D3B Gene

This gene is overexpressed in Testis (6.1).

SOURCE GeneReport for Unigene cluster for TBC1D3B Gene Hs.105891

genes like me logo Genes that share expressions with TBC1D3B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for TBC1D3B Gene

Orthologs for TBC1D3B Gene

Evolution for TBC1D3B Gene

ENSEMBL:
Gene Tree for TBC1D3B (if available)
TreeFam:
Gene Tree for TBC1D3B (if available)

No data available for Orthologs for TBC1D3B Gene

Paralogs for TBC1D3B Gene

Paralogs for TBC1D3B Gene

Selected SIMAP similar genes for TBC1D3B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TBC1D3B: view

Variants for TBC1D3B Gene

Structural Variations from Database of Genomic Variants (DGV) for TBC1D3B Gene

Variant ID Type Subtype PubMed ID
dgv945e1 CNV Complex 17122850
nsv428340 CNV Gain 18775914
dgv946e1 CNV Complex 17122850
dgv947e1 CNV Complex 17122850
dgv948e1 CNV Complex 17122850
nsv9540 CNV Gain+Loss 18304495
esv29264 CNV Gain+Loss 19812545
esv2664544 CNV Deletion 23128226
dgv3145n71 CNV Gain 21882294
nsv514836 CNV Gain 21397061
dgv122e55 CNV Gain 17911159
esv2715876 CNV Deletion 23290073
esv33107 CNV Loss 17666407
esv2751645 CNV Gain 17911159
dgv3147n71 CNV Gain 21882294
dgv3148n71 CNV Gain 21882294
dgv3150n71 CNV Gain 21882294
dgv3151n71 CNV Gain 21882294
nsv433448 CNV Gain 18776910
esv29998 CNV Loss 17803354
nsv526727 CNV Gain 19592680
dgv3155n71 CNV Gain 21882294
nsv2040 CNV Loss 18451855
dgv12n31 CNV Duplication 19718026
nsv514837 CNV Complex 21397061

Relevant External Links for TBC1D3B Gene

HapMap Linkage Disequilibrium report
TBC1D3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TBC1D3B Gene

Disorders for TBC1D3B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TBC1D3B Gene including...

Search for TBC1D3B Gene in MalaCards »
genes like me logo Genes that share disorders with TBC1D3B: view

No data available for UniProtKB/Swiss-Prot for TBC1D3B Gene

Publications for TBC1D3B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4
  3. TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12. (PMID: 16863688) Hodzic D. … Stahl P.D. (Genomics 2006) 2 3
  4. PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer. (PMID: 12359748) Pei L. … Li J. (Cancer Res. 2002) 2
  5. Diversity of human copy number variation and multicopy genes. (PMID: 21030649) Sudmant P.H. … Eichler E.E. (Science 2010) 4

Products for TBC1D3B Gene

  • antibodies-online proteins for TBC1D3B
  • antibodies-online antibodies for TBC1D3B
  • antibodies-online kits for TBC1D3B

Sources for TBC1D3B Gene

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