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Aliases for TBC1D31 Gene

Aliases for TBC1D31 Gene

  • TBC1 Domain Family, Member 31 2 3
  • WD Repeat-Containing Protein 67 3 4
  • WD Repeat Domain 67 2 3
  • WDR67 3 4
  • TBC1 Domain Family Member 31 3
  • Gm85 3

External Ids for TBC1D31 Gene

Previous HGNC Symbols for TBC1D31 Gene

  • WDR67

Previous GeneCards Identifiers for TBC1D31 Gene

  • GC08P124055

Summaries for TBC1D31 Gene

GeneCards Summary for TBC1D31 Gene

TBC1D31 (TBC1 Domain Family, Member 31) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D31 Gene

Genomics for TBC1D31 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TBC1D31 Gene

Start:
123,041,968 bp from pter
End:
123,152,153 bp from pter
Size:
110,186 bases
Orientation:
Plus strand

Genomic View for TBC1D31 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBC1D31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D31 Gene

No data available for Regulatory Elements for TBC1D31 Gene

Proteins for TBC1D31 Gene

  • Protein details for TBC1D31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DN5-TBC31_HUMAN
    Recommended name:
    TBC1 domain family member 31
    Protein Accession:
    Q96DN5
    Secondary Accessions:
    • B7ZL19
    • Q2M2J9
    • Q3MIR6
    • Q8TBP9

    Protein attributes for TBC1D31 Gene

    Size:
    1066 amino acids
    Molecular mass:
    124189 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH27237.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TBC1D31 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBC1D31 Gene

Proteomics data for TBC1D31 Gene at MOPED

Post-translational modifications for TBC1D31 Gene

  • Ubiquitination at Lys41, Lys682, Lys729, Lys782, Lys833, Lys844, Lys866, and Lys877
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TBC1D31 Gene

Domains for TBC1D31 Gene

Gene Families for TBC1D31 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for TBC1D31 Gene

Graphical View of Domain Structure for InterPro Entry

Q96DN5

UniProtKB/Swiss-Prot:

TBC31_HUMAN :
  • Q96DN5
Domain:
  • Contains 1 Rab-GAP TBC domain.
Similarity:
  • Contains 5 WD repeats.
genes like me logo Genes that share domains with TBC1D31: view

No data available for Suggested Antigen Peptide Sequences for TBC1D31 Gene

Function for TBC1D31 Gene

Gene Ontology (GO) - Molecular Function for TBC1D31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TBC1D31: view

Phenotypes for TBC1D31 Gene

GenomeRNAi human phenotypes for TBC1D31:
genes like me logo Genes that share phenotypes with TBC1D31: view

Animal Model Products

CRISPR Products

miRNA for TBC1D31 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TBC1D31 Gene

Localization for TBC1D31 Gene

Gene Ontology (GO) - Cellular Components for TBC1D31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with TBC1D31: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TBC1D31 Gene

Pathways for TBC1D31 Gene

SuperPathways for TBC1D31 Gene

No Data Available

Interacting Proteins for TBC1D31 Gene

Gene Ontology (GO) - Biological Process for TBC1D31 Gene

None

No data available for Pathways by source for TBC1D31 Gene

Transcripts for TBC1D31 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBC1D31

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D31 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4:
SP5: - - - -
SP6: - -
SP7: -
SP8: -
SP9: - - - - - - - - - - - - - -
SP10:
SP11: - -

ExUns: 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1:
SP2: -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TBC1D31 Gene

GeneLoc Exon Structure for
TBC1D31
ECgene alternative splicing isoforms for
TBC1D31

Expression for TBC1D31 Gene

mRNA expression in normal human tissues for TBC1D31 Gene

Protein differential expression in normal tissues for TBC1D31 Gene

This gene is overexpressed in Platelet (50.5), Plasma (8.6), and Fetal Brain (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TBC1D31 Gene

genes like me logo Genes that share expressions with TBC1D31: view

Expression partners for TBC1D31 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TBC1D31 Gene

Orthologs for TBC1D31 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBC1D31 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TBC1D31 35
  • 88.79 (n)
  • 86.06 (a)
TBC1D31 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBC1D31 35
  • 88.9 (n)
  • 87.9 (a)
TBC1D31 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbc1d31 35
  • 82.7 (n)
  • 82.13 (a)
Wdr67 16
Tbc1d31 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR67 35
  • 99.62 (n)
  • 99.81 (a)
WDR67 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbc1d31 35
  • 83.07 (n)
  • 81.62 (a)
oppossum
(Monodelphis domestica)
Mammalia TBC1D31 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves WDR67 35
  • 71.62 (n)
  • 68.59 (a)
TBC1D31 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBC1D31 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tbc1d31 35
  • 65.88 (n)
  • 64.4 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7579 35
zebrafish
(Danio rerio)
Actinopterygii tbc1d31 35
  • 60.9 (n)
  • 57.02 (a)
tbc1d31 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16896 36
  • 22 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4658 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for TBC1D31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBC1D31 Gene

ENSEMBL:
Gene Tree for TBC1D31 (if available)
TreeFam:
Gene Tree for TBC1D31 (if available)

Paralogs for TBC1D31 Gene

genes like me logo Genes that share paralogs with TBC1D31: view

No data available for Paralogs for TBC1D31 Gene

Variants for TBC1D31 Gene

Sequence variations from dbSNP and Humsavar for TBC1D31 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs952655 -- 123,115,253(+) GATGG(C/G)AACTC intron-variant
rs952656 -- 123,115,355(+) ATGAG(A/G)ATTTC intron-variant
rs952657 -- 123,115,307(+) TAGGA(G/T)AATAT intron-variant
rs1014943 -- 123,151,439(+) ATGGT(A/G)TATAT intron-variant
rs1878776 -- 123,091,155(-) GTCAT(A/C)TCTTG intron-variant

Relevant External Links for TBC1D31 Gene

HapMap Linkage Disequilibrium report
TBC1D31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TBC1D31 Gene

Disorders for TBC1D31 Gene

No disorders were found for TBC1D31 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TBC1D31 Gene

Publications for TBC1D31 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for TBC1D31 Gene

Sources for TBC1D31 Gene

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