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Aliases for TBC1D31 Gene

Aliases for TBC1D31 Gene

  • TBC1 Domain Family Member 31 2 3 5
  • WD Repeat-Containing Protein 67 3 4
  • WD Repeat Domain 67 2 3
  • WDR67 3 4
  • TBC1 Domain Family, Member 31 2
  • Gm85 3

External Ids for TBC1D31 Gene

Previous HGNC Symbols for TBC1D31 Gene

  • WDR67

Previous GeneCards Identifiers for TBC1D31 Gene

  • GC08P124055

Summaries for TBC1D31 Gene

GeneCards Summary for TBC1D31 Gene

TBC1D31 (TBC1 Domain Family Member 31) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D31 Gene

Genomics for TBC1D31 Gene

Regulatory Elements for TBC1D31 Gene

Enhancers for TBC1D31 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F123095 1 Ensembl ENCODE 20.2 +54.3 54325 2.1 ATF1 PKNOX1 L3MBTL2 CREB3L1 EBF1 OSR2 ZNF335 ZNF316 RAD51 PBX2 TBC1D31 DERL1 FAM83A-AS1 HMGB1P19 RNY4P5
GH08F123112 0.5 ENCODE 19.7 +70.8 70781 0.9 GATA3 GATA2 ZSCAN29 TBC1D31 DERL1 HMGB1P19 RNY4P5
GH08F123084 0.5 ENCODE 18.9 +43.6 43602 3.9 SOX13 ETV1 JUN GABPA PBX2 HMBOX1 NR2F6 ZNF18 TBC1D31 DERL1 FAM83A-AS1 FAM83A HMGB1P19 RNY4P5
GH08F123065 0.5 Ensembl ENCODE 13.2 +23.7 23733 0.6 HDGF PKNOX1 ARNT CREB3L1 ZNF133 FEZF1 ZNF2 ZNF121 ZNF143 KLF7 DERL1 TBC1D31 ENSG00000238901 ENSG00000253607 FAM83A-AS1 RNY4P5 HMGB1P19
GH08F123018 0.2 ENCODE 13.1 -23.0 -23010 1.4 CTCF ZNF146 ETV1 FEZF1 ZNF2 RAD21 ZBTB48 SCRT2 SMC3 PRDM10 DERL1 TBC1D31 ENSG00000238901 FAM83A-AS1 ENSG00000253607
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TBC1D31 on UCSC Golden Path with GeneCards custom track

Promoters for TBC1D31 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001400523 132 2201 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3

Genomic Location for TBC1D31 Gene

Chromosome:
8
Start:
123,041,968 bp from pter
End:
123,165,173 bp from pter
Size:
123,206 bases
Orientation:
Plus strand

Genomic View for TBC1D31 Gene

Genes around TBC1D31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D31 Gene

Proteins for TBC1D31 Gene

  • Protein details for TBC1D31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DN5-TBC31_HUMAN
    Recommended name:
    TBC1 domain family member 31
    Protein Accession:
    Q96DN5
    Secondary Accessions:
    • B7ZL19
    • Q2M2J9
    • Q3MIR6
    • Q8TBP9

    Protein attributes for TBC1D31 Gene

    Size:
    1066 amino acids
    Molecular mass:
    124189 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH27237.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TBC1D31 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBC1D31 Gene

Post-translational modifications for TBC1D31 Gene

  • Ubiquitination at Lys 41, Lys 682, Lys 729, Lys 782, Lys 833, Lys 844, Lys 866, and Lys 877
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TBC1D31 Gene

Domains & Families for TBC1D31 Gene

Gene Families for TBC1D31 Gene

Suggested Antigen Peptide Sequences for TBC1D31 Gene

Graphical View of Domain Structure for InterPro Entry

Q96DN5

UniProtKB/Swiss-Prot:

TBC31_HUMAN :
  • Contains 1 Rab-GAP TBC domain.
  • Contains 5 WD repeats.
Domain:
  • Contains 1 Rab-GAP TBC domain.
Similarity:
  • Contains 5 WD repeats.
genes like me logo Genes that share domains with TBC1D31: view

Function for TBC1D31 Gene

genes like me logo Genes that share phenotypes with TBC1D31: view

Animal Model Products

miRNA for TBC1D31 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBC1D31 Gene

Localization for TBC1D31 Gene

Gene Ontology (GO) - Cellular Components for TBC1D31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with TBC1D31: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TBC1D31 Gene

Pathways & Interactions for TBC1D31 Gene

SuperPathways for TBC1D31 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TBC1D31 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TBC1D31 Gene

Transcripts for TBC1D31 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D31 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4:
SP5: - - - -
SP6: - -
SP7: -
SP8: -
SP9: - - - - - - - - - - - - - -
SP10:
SP11: - -

ExUns: 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1:
SP2: -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TBC1D31 Gene

GeneLoc Exon Structure for
TBC1D31
ECgene alternative splicing isoforms for
TBC1D31

Expression for TBC1D31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TBC1D31 Gene

Protein differential expression in normal tissues from HIPED for TBC1D31 Gene

This gene is overexpressed in Platelet (50.5), Plasma (8.6), and Fetal Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TBC1D31 Gene



Protein tissue co-expression partners for TBC1D31 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TBC1D31 Gene:

TBC1D31
genes like me logo Genes that share expression patterns with TBC1D31: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TBC1D31 Gene

Orthologs for TBC1D31 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBC1D31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR67 34 35
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia TBC1D31 34 35
  • 88.9 (n)
cow
(Bos Taurus)
Mammalia TBC1D31 34 35
  • 88.79 (n)
rat
(Rattus norvegicus)
Mammalia Tbc1d31 34
  • 83.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 83 (a)
OneToMany
-- 35
  • 78 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tbc1d31 34 16 35
  • 82.7 (n)
oppossum
(Monodelphis domestica)
Mammalia TBC1D31 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR67 34
  • 71.62 (n)
TBC1D31 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBC1D31 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tbc1d31 34
  • 65.88 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7579 34
zebrafish
(Danio rerio)
Actinopterygii tbc1d31 34 35
  • 60.9 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG16896 35
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4658 34
Species where no ortholog for TBC1D31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBC1D31 Gene

ENSEMBL:
Gene Tree for TBC1D31 (if available)
TreeFam:
Gene Tree for TBC1D31 (if available)

Paralogs for TBC1D31 Gene

genes like me logo Genes that share paralogs with TBC1D31: view

No data available for Paralogs for TBC1D31 Gene

Variants for TBC1D31 Gene

Sequence variations from dbSNP and Humsavar for TBC1D31 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10087248 -- 123,088,752(+) TGTTA(C/T)GGATT intron-variant
rs10087912 -- 123,158,475(+) TCCCA(C/G)GGAAA intron-variant
rs10094426 -- 123,040,183(+) tatac(A/G)ctcca intron-variant, upstream-variant-2KB
rs10099669 -- 123,154,285(+) ctatg(A/T)tggga intron-variant
rs10101062 -- 123,112,091(+) gctca(A/G)gtgat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TBC1D31 Gene

Variant ID Type Subtype PubMed ID
esv3572973 CNV loss 25503493
nsv1015490 CNV loss 25217958
nsv1028933 CNV gain 25217958
nsv1032827 CNV gain 25217958

Variation tolerance for TBC1D31 Gene

Residual Variation Intolerance Score: 46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.73; 89.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBC1D31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TBC1D31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D31 Gene

Disorders for TBC1D31 Gene

Relevant External Links for TBC1D31

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TBC1D31

No disorders were found for TBC1D31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D31 Gene

Publications for TBC1D31 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for TBC1D31 Gene

Sources for TBC1D31 Gene

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