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Aliases for TBC1D31 Gene

Aliases for TBC1D31 Gene

  • TBC1 Domain Family Member 31 2 3 5
  • WD Repeat-Containing Protein 67 3 4
  • TBC1 Domain Family, Member 31 2 3
  • WD Repeat Domain 67 2 3
  • WDR67 3 4
  • Gm85 3

External Ids for TBC1D31 Gene

Previous HGNC Symbols for TBC1D31 Gene

  • WDR67

Previous GeneCards Identifiers for TBC1D31 Gene

  • GC08P124055

Summaries for TBC1D31 Gene

GeneCards Summary for TBC1D31 Gene

TBC1D31 (TBC1 Domain Family Member 31) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D31 Gene

Genomics for TBC1D31 Gene

Regulatory Elements for TBC1D31 Gene

Promoters for TBC1D31 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TBC1D31 on UCSC Golden Path with GeneCards custom track

Genomic Location for TBC1D31 Gene

Chromosome:
8
Start:
123,041,968 bp from pter
End:
123,165,173 bp from pter
Size:
123,206 bases
Orientation:
Plus strand

Genomic View for TBC1D31 Gene

Genes around TBC1D31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D31 Gene

Proteins for TBC1D31 Gene

  • Protein details for TBC1D31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DN5-TBC31_HUMAN
    Recommended name:
    TBC1 domain family member 31
    Protein Accession:
    Q96DN5
    Secondary Accessions:
    • B7ZL19
    • Q2M2J9
    • Q3MIR6
    • Q8TBP9

    Protein attributes for TBC1D31 Gene

    Size:
    1066 amino acids
    Molecular mass:
    124189 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH27237.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TBC1D31 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBC1D31 Gene

Proteomics data for TBC1D31 Gene at MOPED

Post-translational modifications for TBC1D31 Gene

  • Ubiquitination at Lys 41, Lys 682, Lys 729, Lys 782, Lys 833, Lys 844, Lys 866, and Lys 877
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TBC1D31 Gene

Domains & Families for TBC1D31 Gene

Gene Families for TBC1D31 Gene

Protein Domains for TBC1D31 Gene

Suggested Antigen Peptide Sequences for TBC1D31 Gene

Graphical View of Domain Structure for InterPro Entry

Q96DN5

UniProtKB/Swiss-Prot:

TBC31_HUMAN :
  • Contains 1 Rab-GAP TBC domain.
  • Contains 5 WD repeats.
Domain:
  • Contains 1 Rab-GAP TBC domain.
Similarity:
  • Contains 5 WD repeats.
genes like me logo Genes that share domains with TBC1D31: view

Function for TBC1D31 Gene

Phenotypes for TBC1D31 Gene

genes like me logo Genes that share phenotypes with TBC1D31: view

Animal Model Products

CRISPR Products

miRNA for TBC1D31 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBC1D31 Gene

Localization for TBC1D31 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TBC1D31 Gene

Pathways & Interactions for TBC1D31 Gene

SuperPathways for TBC1D31 Gene

No Data Available

Interacting Proteins for TBC1D31 Gene

Gene Ontology (GO) - Biological Process for TBC1D31 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TBC1D31 Gene

Drugs & Compounds for TBC1D31 Gene

No Compound Related Data Available

Transcripts for TBC1D31 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D31 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4:
SP5: - - - -
SP6: - -
SP7: -
SP8: -
SP9: - - - - - - - - - - - - - -
SP10:
SP11: - -

ExUns: 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1:
SP2: -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TBC1D31 Gene

GeneLoc Exon Structure for
TBC1D31
ECgene alternative splicing isoforms for
TBC1D31

Expression for TBC1D31 Gene

mRNA expression in normal human tissues for TBC1D31 Gene

Protein differential expression in normal tissues from HIPED for TBC1D31 Gene

This gene is overexpressed in Platelet (50.5), Plasma (8.6), and Fetal Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TBC1D31 Gene



genes like me logo Genes that share expression patterns with TBC1D31: view

Protein tissue co-expression partners for TBC1D31 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TBC1D31 Gene

Orthologs for TBC1D31 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBC1D31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR67 36
  • 100 (a)
OneToOne
WDR67 35
  • 99.62 (n)
  • 99.81 (a)
cow
(Bos Taurus)
Mammalia TBC1D31 36
  • 86 (a)
OneToOne
TBC1D31 35
  • 88.79 (n)
  • 86.06 (a)
dog
(Canis familiaris)
Mammalia TBC1D31 35
  • 88.9 (n)
  • 87.9 (a)
TBC1D31 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbc1d31 16
Tbc1d31 35
  • 82.7 (n)
  • 82.13 (a)
Tbc1d31 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TBC1D31 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tbc1d31 35
  • 83.07 (n)
  • 81.62 (a)
chicken
(Gallus gallus)
Aves WDR67 35
  • 71.62 (n)
  • 68.59 (a)
TBC1D31 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBC1D31 36
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7579 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tbc1d31 35
  • 65.88 (n)
  • 64.4 (a)
zebrafish
(Danio rerio)
Actinopterygii tbc1d31 36
  • 56 (a)
OneToOne
tbc1d31 35
  • 60.9 (n)
  • 57.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16896 36
  • 22 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4658 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for TBC1D31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBC1D31 Gene

ENSEMBL:
Gene Tree for TBC1D31 (if available)
TreeFam:
Gene Tree for TBC1D31 (if available)

Paralogs for TBC1D31 Gene

genes like me logo Genes that share paralogs with TBC1D31: view

No data available for Paralogs for TBC1D31 Gene

Variants for TBC1D31 Gene

Sequence variations from dbSNP and Humsavar for TBC1D31 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs16897967 - 123,109,348(+) AAAGC(A/G)TTTAC nc-transcript-variant, reference, missense
rs16898023 - 123,129,073(+) AGACA(G/T)TTGAA nc-transcript-variant, reference, missense
rs34994118 - 123,151,931(+) TTTTG(A/G)CTGCA intron-variant, nc-transcript-variant, reference, missense
rs1670178 -- 123,164,881(+) TATCT(A/G)TGTAA intron-variant
rs1670182 -- 123,163,181(-) gcact(C/T)tggga intron-variant

Variation tolerance for TBC1D31 Gene

Residual Variation Intolerance Score: 46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.73; 89.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBC1D31 Gene

HapMap Linkage Disequilibrium report
TBC1D31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TBC1D31 Gene

Disorders for TBC1D31 Gene

Relevant External Links for TBC1D31

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TBC1D31

No disorders were found for TBC1D31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D31 Gene

Publications for TBC1D31 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PMID: 21399614) Jakobsen L. … Andersen J.S. (EMBO J. 2011) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for TBC1D31 Gene

Sources for TBC1D31 Gene

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