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Aliases for TBC1D2B Gene

Aliases for TBC1D2B Gene

  • TBC1 Domain Family Member 2B 2 3 5
  • TBC1 Domain Family, Member 2B 2
  • KIAA1055 4

External Ids for TBC1D2B Gene

Previous GeneCards Identifiers for TBC1D2B Gene

  • GC15M076077
  • GC15M078276
  • GC15M055044

Summaries for TBC1D2B Gene

GeneCards Summary for TBC1D2B Gene

TBC1D2B (TBC1 Domain Family Member 2B) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is TBC1D30.

UniProtKB/Swiss-Prot for TBC1D2B Gene

  • May act as a GTPase-activating protein.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D2B Gene

Genomics for TBC1D2B Gene

Regulatory Elements for TBC1D2B Gene

Promoters for TBC1D2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TBC1D2B on UCSC Golden Path with GeneCards custom track

Genomic Location for TBC1D2B Gene

Chromosome:
15
Start:
77,984,036 bp from pter
End:
78,077,724 bp from pter
Size:
93,689 bases
Orientation:
Minus strand

Genomic View for TBC1D2B Gene

Genes around TBC1D2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D2B Gene

Proteins for TBC1D2B Gene

  • Protein details for TBC1D2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPU7-TBD2B_HUMAN
    Recommended name:
    TBC1 domain family member 2B
    Protein Accession:
    Q9UPU7
    Secondary Accessions:
    • A7MD42
    • Q8N1F9
    • Q9NXM0

    Protein attributes for TBC1D2B Gene

    Size:
    963 amino acids
    Molecular mass:
    109880 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH33712.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI52466.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW99190.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TBC1D2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBC1D2B Gene

Proteomics data for TBC1D2B Gene at MOPED

Post-translational modifications for TBC1D2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBC1D2B Gene

No data available for DME Specific Peptides for TBC1D2B Gene

Domains & Families for TBC1D2B Gene

Protein Domains for TBC1D2B Gene

Suggested Antigen Peptide Sequences for TBC1D2B Gene

Graphical View of Domain Structure for InterPro Entry

Q9UPU7

UniProtKB/Swiss-Prot:

TBD2B_HUMAN :
  • Contains 1 PH domain.
Domain:
  • Contains 1 PH domain.
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with TBC1D2B: view

No data available for Gene Families for TBC1D2B Gene

Function for TBC1D2B Gene

Molecular function for TBC1D2B Gene

UniProtKB/Swiss-Prot Function:
May act as a GTPase-activating protein.

Gene Ontology (GO) - Molecular Function for TBC1D2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0017137 Rab GTPase binding IBA --
genes like me logo Genes that share ontologies with TBC1D2B: view
genes like me logo Genes that share phenotypes with TBC1D2B: view

Animal Models for TBC1D2B Gene

MGI Knock Outs for TBC1D2B:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TBC1D2B Gene

Localization for TBC1D2B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBC1D2B Gene COMPARTMENTS Subcellular localization image for TBC1D2B gene
Compartment Confidence
cytosol 4
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TBC1D2B Gene

Pathways & Interactions for TBC1D2B Gene

SuperPathways for TBC1D2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TBC1D2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0090630 activation of GTPase activity IBA --
genes like me logo Genes that share ontologies with TBC1D2B: view

No data available for Pathways by source and SIGNOR curated interactions for TBC1D2B Gene

Drugs & Compounds for TBC1D2B Gene

No Compound Related Data Available

Transcripts for TBC1D2B Gene

Unigene Clusters for TBC1D2B Gene

TBC1 domain family, member 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D2B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15a · 15b · 15c · 15d
SP1: - - - - - - - -
SP2: - - - - - -
SP3:
SP4:
SP5: -
SP6: - - -
SP7:

Relevant External Links for TBC1D2B Gene

GeneLoc Exon Structure for
TBC1D2B
ECgene alternative splicing isoforms for
TBC1D2B

Expression for TBC1D2B Gene

mRNA expression in normal human tissues for TBC1D2B Gene

Protein differential expression in normal tissues from HIPED for TBC1D2B Gene

This gene is overexpressed in Lavage (34.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TBC1D2B Gene



SOURCE GeneReport for Unigene cluster for TBC1D2B Gene Hs.567426

genes like me logo Genes that share expression patterns with TBC1D2B: view

Protein tissue co-expression partners for TBC1D2B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TBC1D2B Gene

Orthologs for TBC1D2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TBC1D2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TBC1D2B 35
  • 87.97 (n)
  • 90.17 (a)
TBC1D2B 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBC1D2B 35
  • 83.73 (n)
  • 89.04 (a)
TBC1D2B 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbc1d2b 35
  • 87.05 (n)
  • 89.91 (a)
Tbc1d2b 16
Tbc1d2b 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TBC1D2B 35
  • 99.41 (n)
  • 99.67 (a)
TBC1D2B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbc1d2b 35
  • 86.7 (n)
  • 90.44 (a)
oppossum
(Monodelphis domestica)
Mammalia TBC1D2B 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TBC1D2B 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves TBC1D2B 35
  • 73.08 (n)
  • 77.72 (a)
TBC1D2B 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBC1D2B 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17641 35
tbc1d2b 35
  • 67 (n)
  • 69.8 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9850 35
zebrafish
(Danio rerio)
Actinopterygii tbc1d2b 35
  • 64.08 (n)
  • 64.71 (a)
tbc1d2b 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7324 36
  • 12 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tbc-2 35
  • 46.82 (n)
  • 37.27 (a)
tbc-2 36
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MDR1 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for TBC1D2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TBC1D2B Gene

ENSEMBL:
Gene Tree for TBC1D2B (if available)
TreeFam:
Gene Tree for TBC1D2B (if available)

Paralogs for TBC1D2B Gene

Paralogs for TBC1D2B Gene

(8) SIMAP similar genes for TBC1D2B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TBC1D2B: view

Variants for TBC1D2B Gene

Sequence variations from dbSNP and Humsavar for TBC1D2B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs894294 -- 78,058,909(+) TTACC(C/T)AGGCC intron-variant
rs894295 -- 78,059,517(+) CTACA(G/T)GACAG intron-variant
rs894296 -- 78,060,051(+) TGTTC(A/G/T)CATTC intron-variant
rs894301 -- 78,005,183(+) CGGAG(A/G)GCTGG intron-variant
rs894302 -- 78,005,966(+) GTTCT(A/G)AGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TBC1D2B Gene

Variant ID Type Subtype PubMed ID
nsv1626 CNV Insertion 18451855

Variation tolerance for TBC1D2B Gene

Residual Variation Intolerance Score: 29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.21; 84.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBC1D2B Gene

HapMap Linkage Disequilibrium report
TBC1D2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D2B Gene

Disorders for TBC1D2B Gene

Relevant External Links for TBC1D2B

Genetic Association Database (GAD)
TBC1D2B
Human Genome Epidemiology (HuGE) Navigator
TBC1D2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TBC1D2B

No disorders were found for TBC1D2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D2B Gene

Publications for TBC1D2B Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. (PMID: 22354992) Popovic D. … Dikic I. (Mol. Cell. Biol. 2012) 3
  4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for TBC1D2B Gene

Sources for TBC1D2B Gene

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