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TBC1D2B Gene

protein-coding   GIFtS: 50
GCID: GC15M078276

TBC1 Domain Family, Member 2B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TBC1 Domain Family, Member 2B1 2
TBC1 Domain Family Member 2B2
KIAA10553

External Ids:    HGNC: 291831   Entrez Gene: 231022   Ensembl: ENSG000001672027   UniProtKB: Q9UPU73   

Export aliases for TBC1D2B gene to outside databases

Previous GC identifers: GC15M076077 GC15M055044


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TBC1D2B Gene:
TBC1D2B (TBC1 domain family, member 2B) is a protein-coding gene. GO annotations related to this gene include Rab GTPase activator activity and phospholipid binding. An important paralog of this gene is TBC1D2.

UniProtKB/Swiss-Prot: TBD2B_HUMAN, Q9UPU7
Function: May act as a GTPase-activating protein (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TBC1D2B gene promoter:
         AML1a   HEN1   RORalpha1   CBF-A   CBF-B   HFH-1   ARP-1   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBC1D2B promoter sequence
   Search Chromatin IP Primers for TBC1D2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBC1D2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.3-q25.1   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q24.3-q25.1

TBC1D2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBC1D2B gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M078276:  view genomic region     (about GC identifiers)

Start:
78,276,378 bp from pter      End:
78,370,066 bp from pter
Size:
93,689 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TBD2B_HUMAN, Q9UPU7 (See protein sequence)
Recommended Name: TBC1 domain family member 2B  
Size: 963 amino acids; 109880 Da
Sequence caution: Sequence=AAH33712.1; Type=Erroneous initiation; Sequence=AAI52466.1; Type=Erroneous initiation;
Sequence=EAW99190.1; Type=Erroneous gene model prediction;
Secondary accessions: A7MD42 Q8N1F9 Q9NXM0
Alternative splicing: 3 isoforms:  Q9UPU7-1   Q9UPU7-2   Q9UPU7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TBC1D2B: NX_Q9UPU7

Explore proteomics data for TBC1D2B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TBC1D2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_055894.6  NP_653173.1  

    ENSEMBL proteins: 
     ENSP00000453114   ENSP00000300584   ENSP00000387165   ENSP00000413666  

    TBC1D2B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TBC1D2B

     
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    Novus Biologicals TBC1D2B Antibodies
    Abcam antibodies for TBC1D2B
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    LSBio Antibodies in human, mouse, rat for TBC1D2B

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    Search eBioscience for ELISAs for TBC1D2B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000195 Rab-GTPase-TBC_dom
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UPU7

    ProtoNet protein and cluster: Q9UPU7

    3 Blocks protein domains:
    IPB000195 RabGAP/TBC domain
    IPB001849 Pleckstrin-like
    IPB001909 KRAB box


    UniProtKB/Swiss-Prot: TBD2B_HUMAN, Q9UPU7
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Rab-GAP TBC domain


    Find genes that share domains with TBC1D2B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBD2B_HUMAN, Q9UPU7
    Function: May act as a GTPase-activating protein (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005097Rab GTPase activator activity IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with TBC1D2B           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tbc1d2b):
     behavior/neurological  cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism 
     skeleton 

    Find genes that share phenotypes with TBC1D2B           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBC1D2B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TBC1D2B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TBC1D2B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TBC1D2B

    miRNA
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    miRTarBase miRNAs that target TBC1D2B:
    hsa-mir-26b-5p (MIRT030132), hsa-mir-484 (MIRT042358), hsa-mir-7-5p (MIRT025936)

    Block miRNA regulation of human, mouse, rat TBC1D2B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TBC1D2B (see all 34):
    hsa-miR-15a hsa-miR-30d hsa-miR-548l hsa-miR-4267 hsa-miR-1273d hsa-miR-1244 hsa-miR-30a hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidTBC1D2B 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TBC1D2B
    Predesigned siRNA for gene silencing in human, mouse, rat TBC1D2B

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TBC1D2B (NM_015079)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBC1D2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D2B

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D2B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBC1D2B
    Interactions:

        Search GeneGlobe Interaction Network for TBC1D2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TBC1D2B (Q9UPU71, 2, 3 ENSP000003005844) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPL1Q9H0R81, 3, ENSP000002664584EBI-2947180,EBI-746969 I2D: score=3 STRING: ENSP00000266458
    MAP1LC3CQ9BXW41, 3, ENSP000003497854EBI-2947180,EBI-2603996 I2D: score=1 STRING: ENSP00000349785
    GABARAPL2P605201, 3EBI-2947180,EBI-720116 I2D: score=2 
    GABARAPO951661, 3EBI-2947180,EBI-712001 I2D: score=1 
    MAP1LC3BQ9GZQ81, 3EBI-2947180,EBI-373144 I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032313regulation of Rab GTPase activity ----

    Find genes that share ontologies with TBC1D2B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TBC1D2B (TBD2B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TBC1D2B gene (2 alternative transcripts): 
    NM_015079.5  NM_144572.1  

    Unigene Cluster for TBC1D2B:

    TBC1 domain family, member 2B
    Hs.567426  [show with all ESTs]
    Unigene Representative Sequence: NM_144572
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465531 ENST00000300584(uc002bcy.4 uc010bla.3) ENST00000409931
    ENST00000418039 ENST00000491479 ENST00000492078 ENST00000459715 ENST00000497942
    ENST00000472786(uc002bda.3) ENST00000486703 ENST00000435468 ENST00000482562

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TBC1D2B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TBC1D2B (see all 34):
    hsa-miR-15a hsa-miR-30d hsa-miR-548l hsa-miR-4267 hsa-miR-1273d hsa-miR-1244 hsa-miR-30a hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidTBC1D2B 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TBC1D2B
    Predesigned siRNA for gene silencing in human, mouse, rat TBC1D2B
    Clone
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    OriGene clones in human, mouse for TBC1D2B (see all 11)
    OriGene ORF clones in mouse, rat for TBC1D2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TBC1D2B (NM_015079)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TBC1D2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D2B
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TBC1D2B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBC1D2B
      QuantiTect SYBR Green Assays in human, mouse, rat TBC1D2B
      QuantiFast Probe-based Assays in human, mouse, rat TBC1D2B

    Additional mRNA sequence: 

    AB028978.1 AK074871.1 AL080229.1 AL109773.1 AL137303.1 BC015718.1 BC033712.1 BC140766.1 
    BC144482.1 BC152465.1 

    13 DOTS entries:

    DT.414650  DT.95164363  DT.91846103  DT.100703789  DT.121077250  DT.100835853  DT.87015339  DT.99937374 
    DT.121077545  DT.95081108  DT.97815531  DT.75116531  DT.95164364 

    Selected AceView cDNA sequences (see all 175):

    BE018143 AI679579 CN483854 BQ009040 CR590128 AW089595 AB028978 AW504893 
    AW135485 AI598196 CD367384 AI680016 BX509192 AW300664 BE504351 BE220729 
    AK000173 AI347503 AI697115 NM_015079 BG740652 BM904256 AI679570 BF195608 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D2B (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15a · 15b · 15c · 15d
    SP1:        -                                                     -                             -     -                 -     -     -     -                     
    SP2:                                                              -                             -     -                 -     -     -                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                    -                                       


    ECgene alternative splicing isoforms for TBC1D2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TBC1D2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTATTGC
    TBC1D2B Expression
    About this image

    TBC1D2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TBC1D2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567426
        Custom PCR Arrays for TBC1D2B
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    QuantiFast Probe-based Assays in human, mouse, rat TBC1D2B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TBC1D2B gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbc1d2b1 , 5 TBC1 domain family, member 2B1, 5 87.05(n)1
    89.91(a)1
      9 (47.48 cM)5
    670161  NM_194334.21  NP_919315.21 
     902020475 
    chicken
    (Gallus gallus)
    Aves TBC1D2B1 TBC1 domain family, member 2B 73.08(n)
    77.72(a)
      415364  XM_413750.4  XP_413750.4 
    lizard
    (Anolis carolinensis)
    Reptilia TBC1D2B6
    TBC1 domain family, member 2B
    74(a)
    1 ↔ 1
    GL343573.1(96304-121011)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.98502 Xenopus laevis transcribed sequence with weak similarity more 78.68(n)    BG814437.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tbc1d2b1 TBC1 domain family, member 2B 64.08(n)
    64.71(a)
      100330777  XM_002666866.3  XP_002666912.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73246
    --
    12(a)
    many ↔ many
    3L(21330781-21336816)
    worm
    (Caenorhabditis elegans)
    Secernentea tbc-21 tbc-2 46.82(n)
    37.27(a)
      173986  NM_062755.6  NP_495156.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MDR16
    Cytoplasmic GTPase-activating protein for Ypt/Rab ...
    13(a)
    1 → many
    VII(690245-693097) YGR100W


    ENSEMBL Gene Tree for TBC1D2B (if available)
    TreeFam Gene Tree for TBC1D2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TBC1D2B gene
    TBC1D22  TBC1D8B2  SGSM32  TBC1D302  TBC1D9B2  TBC1D82  TBC1D92  
    8 SIMAP similar genes for TBC1D2B using alignment to 6 protein entries:     TBD2B_HUMAN (see all proteins):
    DKFZp434O086    LOC646938    SGSM3    FLJ00006    TBC1D2    FLJ00288
    GRTP1    TBC1D6

    Find genes that share paralogs with TBC1D2B           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for TBC1D2B (see all 6)
    PGOHUM00000239564 PGOHUM00000262067 PGOHUM00000262069 PGOHUM00000262259 PGOHUM00000262113


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TBC1D2B (see all 1626)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs667131081,2
    C--55046350(+) GGGGT-/G/GG  
            
    GGGGG
    4 -- ut311CSA 2
    rs169693671,2
    C,F,H--78288662(+) CAGGGG/TCCATT 2 -- ut31 ese313Minor allele frequency- T:0.09NA NS WA CSA 1513
    rs763981341,2
    C,F--78288727(+) CAGCCG/ACCCCC 2 -- ut315Minor allele frequency- A:0.14NA CSA EA 245
    rs2008810241,2
    --78288769(+) GAGGG-/GTGGGGG 2 -- ut310--------
    rs562550851,2
    C--78288771(+) GGGGT-/GGGGGG 2 -- ut311Minor allele frequency- G:0.00NA 2
    rs572989701,2
    C--78288774(+) TGGGG-/TGG   
       
    /TGGG
    GGGGT
    4 -- cds1 ut310--------
    rs563673081,2
    C--78288778(+) GGGGGT/GTTCCA 2 -- ut312Minor allele frequency- G:0.25NA WA 4
    rs751808101,2
    C,F--78288799(+) CGAGCG/AGACTG 2 -- ut312Minor allele frequency- A:0.50NA CSA 4
    rs1922018081,2
    --78288841(+) TCAGAC/TCTCAA 2 -- ut310--------
    rs620114731,2
    C,F--78288848(+) TCAAAC/TTGCTG 2 -- ut312Minor allele frequency- T:0.08NA 122

    HapMap Linkage Disequilibrium report for TBC1D2B (78276378 - 78370066 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TBC1D2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1626CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TBC1D2B
    DNA2.0 Custom Variant and Variant Library Synthesis for TBC1D2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with TBC1D2B           About GenesLikeMe

    Genetic Association Database (GAD): TBC1D2B
    Human Genome Epidemiology (HuGE) Navigator: TBC1D2B (1 document)

    Export disorders for TBC1D2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TBC1D2B gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with TBC1D2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R.... Ohara O. (DNA Res. 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    4. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. (PubMed id 22354992)1 Popovic D....Dikic I. (Mol. Cell. Biol. 2012)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    8. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (Nature 2010)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23102 HGNC: 29183 AceView: KIAA1055 Ensembl:ENSG00000167202 euGenes: HUgn23102
    ECgene: TBC1D2B H-InvDB: TBC1D2B

    (According to HUGE)
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    HUGE: KIAA1055

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TBC1D2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TBC1D2B gene:
    Search GeneIP for patents involving TBC1D2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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