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Aliases for TBC1D28 Gene

Aliases for TBC1D28 Gene

  • TBC1 Domain Family, Member 28 2 3

External Ids for TBC1D28 Gene

Previous GeneCards Identifiers for TBC1D28 Gene

  • GC17M018480
  • GC17M018482
  • GC17M018538
  • GC17M018146
  • GC17M018635

Summaries for TBC1D28 Gene

GeneCards Summary for TBC1D28 Gene

TBC1D28 (TBC1 Domain Family, Member 28) is a Protein Coding gene. An important paralog of this gene is TBC1D10B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D28 Gene

Genomics for TBC1D28 Gene

Regulatory Elements for TBC1D28 Gene

Genomic Location for TBC1D28 Gene

Chromosome:
17
Start:
18,634,434 bp from pter
End:
18,661,950 bp from pter
Size:
27,517 bases
Orientation:
Minus strand

Genomic View for TBC1D28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBC1D28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D28 Gene

Proteins for TBC1D28 Gene

  • Protein details for TBC1D28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M2D7-TBC28_HUMAN
    Recommended name:
    TBC1 domain family member 28
    Protein Accession:
    Q2M2D7
    Secondary Accessions:
    • Q2M2E1

    Protein attributes for TBC1D28 Gene

    Size:
    210 amino acids
    Molecular mass:
    24072 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TBC1D28 Gene

Proteomics data for TBC1D28 Gene at MOPED

Post-translational modifications for TBC1D28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBC1D28 Gene

No data available for DME Specific Peptides for TBC1D28 Gene

Domains & Families for TBC1D28 Gene

Protein Domains for TBC1D28 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TBC1D28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2M2D7

UniProtKB/Swiss-Prot:

TBC28_HUMAN :
  • Contains 1 Rab-GAP TBC domain.
Domain:
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with TBC1D28: view

No data available for Gene Families for TBC1D28 Gene

Function for TBC1D28 Gene

Phenotypes for TBC1D28 Gene

GenomeRNAi human phenotypes for TBC1D28:
genes like me logo Genes that share phenotypes with TBC1D28: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBC1D28

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TBC1D28 Gene

Localization for TBC1D28 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TBC1D28 Gene

Pathways & Interactions for TBC1D28 Gene

SuperPathways for TBC1D28 Gene

No Data Available

Interacting Proteins for TBC1D28 Gene

Gene Ontology (GO) - Biological Process for TBC1D28 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TBC1D28 Gene

Drugs & Compounds for TBC1D28 Gene

No Compound Related Data Available

Transcripts for TBC1D28 Gene

mRNA/cDNA for TBC1D28 Gene

(6) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TBC1D28 Gene

TBC1 domain family, member 28:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBC1D28

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D28 Gene

No ASD Table

Relevant External Links for TBC1D28 Gene

GeneLoc Exon Structure for
TBC1D28
ECgene alternative splicing isoforms for
TBC1D28

Expression for TBC1D28 Gene

mRNA expression in normal human tissues for TBC1D28 Gene

mRNA differential expression in normal tissues according to GTEx for TBC1D28 Gene

This gene is overexpressed in Testis (x48.7).

Protein differential expression in normal tissues from HIPED for TBC1D28 Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TBC1D28 Gene



SOURCE GeneReport for Unigene cluster for TBC1D28 Gene Hs.434123

genes like me logo Genes that share expression patterns with TBC1D28: view

Protein tissue co-expression partners for TBC1D28 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TBC1D28 Gene

Orthologs for TBC1D28 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBC1D28 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 20 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 1 (a)
ManyToMany
-- 36
  • 12 (a)
ManyToMany
-- 36
  • 14 (a)
ManyToMany
-- 36
  • 16 (a)
ManyToMany
-- 36
  • 2 (a)
ManyToMany
-- 36
  • 14 (a)
ManyToMany
-- 36
  • 18 (a)
ManyToMany
-- 36
  • 15 (a)
ManyToMany
-- 36
  • 16 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 23 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 18 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TBC1D28 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 18 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 21 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TBC1D3G 36
  • 6 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta RN-tre 36
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tbc-17 36
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
OneToMany
Species with no ortholog for TBC1D28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TBC1D28 Gene

ENSEMBL:
Gene Tree for TBC1D28 (if available)
TreeFam:
Gene Tree for TBC1D28 (if available)

Paralogs for TBC1D28 Gene

Paralogs for TBC1D28 Gene

(8) SIMAP similar genes for TBC1D28 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TBC1D28: view

Variants for TBC1D28 Gene

Sequence variations from dbSNP and Humsavar for TBC1D28 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2386412 -- 18,637,983(-) GGCCC(C/T)GCCCT intron-variant
rs2529975 -- 18,637,286(+) TACAA(C/T)CAATC intron-variant
rs2529981 -- 18,639,401(+) CTTGG(A/T)GAAGA intron-variant
rs2529985 -- 18,640,789(+) GCTCT(A/G)GTCCC intron-variant
rs2530001 -- 18,644,573(+) tgaac(A/C)catgt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TBC1D28 Gene

Variant ID Type Subtype PubMed ID
nsv827913 CNV Gain 20364138
nsv9504 CNV Gain+Loss 18304495
nsv907782 CNV Gain 21882294
nsv499818 OTHER Inversion 21111241
esv29176 CNV Gain 19812545

Variation tolerance for TBC1D28 Gene

Residual Variation Intolerance Score: 77.97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBC1D28 Gene

HapMap Linkage Disequilibrium report
TBC1D28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D28 Gene

Disorders for TBC1D28 Gene

Relevant External Links for TBC1D28

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TBC1D28
genes like me logo Genes that share disorders with TBC1D28: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D28 Gene

Publications for TBC1D28 Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for TBC1D28 Gene

Sources for TBC1D28 Gene

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