Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TBC1D28 Gene

Aliases for TBC1D28 Gene

  • TBC1 Domain Family Member 28 2 3 5
  • TBC1 Domain Family, Member 28 2

External Ids for TBC1D28 Gene

Previous GeneCards Identifiers for TBC1D28 Gene

  • GC17M018480
  • GC17M018482
  • GC17M018538
  • GC17M018146
  • GC17M018635
  • GC17M018636
  • GC17M018687
  • GC17M018725
  • GC17M018764

Summaries for TBC1D28 Gene

GeneCards Summary for TBC1D28 Gene

TBC1D28 (TBC1 Domain Family Member 28) is a Protein Coding gene. An important paralog of this gene is TBC1D26.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D28 Gene

Genomics for TBC1D28 Gene

Regulatory Elements for TBC1D28 Gene


Genomic Location for TBC1D28 Gene

Chromosome:
17
Start:
18,634,434 bp from pter
End:
18,661,950 bp from pter
Size:
27,517 bases
Orientation:
Minus strand

Genomic View for TBC1D28 Gene

Genes around TBC1D28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D28 Gene

Proteins for TBC1D28 Gene

  • Protein details for TBC1D28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M2D7-TBC28_HUMAN
    Recommended name:
    TBC1 domain family member 28
    Protein Accession:
    Q2M2D7
    Secondary Accessions:
    • Q2M2E1

    Protein attributes for TBC1D28 Gene

    Size:
    210 amino acids
    Molecular mass:
    24072 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TBC1D28 Gene

Post-translational modifications for TBC1D28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TBC1D28 Gene

Domains & Families for TBC1D28 Gene

Protein Domains for TBC1D28 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TBC1D28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TBC1D28: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TBC1D28 Gene

Function for TBC1D28 Gene

Gene Ontology (GO) - Molecular Function for TBC1D28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0017137 Rab GTPase binding IBA --
genes like me logo Genes that share ontologies with TBC1D28: view

Phenotypes for TBC1D28 Gene

GenomeRNAi human phenotypes for TBC1D28:
genes like me logo Genes that share phenotypes with TBC1D28: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBC1D28 Gene

Localization for TBC1D28 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBC1D28 gene
Compartment Confidence
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TBC1D28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with TBC1D28: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TBC1D28 Gene

Pathways & Interactions for TBC1D28 Gene

SuperPathways for TBC1D28 Gene

No Data Available

Interacting Proteins for TBC1D28 Gene

Gene Ontology (GO) - Biological Process for TBC1D28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0031338 regulation of vesicle fusion IBA --
GO:0090630 activation of GTPase activity IBA --
genes like me logo Genes that share ontologies with TBC1D28: view

No data available for Pathways by source and SIGNOR curated interactions for TBC1D28 Gene

Drugs & Compounds for TBC1D28 Gene

No Compound Related Data Available

Transcripts for TBC1D28 Gene

mRNA/cDNA for TBC1D28 Gene

Unigene Clusters for TBC1D28 Gene

TBC1 domain family, member 28:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D28 Gene

No ASD Table

Relevant External Links for TBC1D28 Gene

GeneLoc Exon Structure for
TBC1D28
ECgene alternative splicing isoforms for
TBC1D28

Expression for TBC1D28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TBC1D28 Gene

mRNA differential expression in normal tissues according to GTEx for TBC1D28 Gene

This gene is overexpressed in Testis (x48.7).

Protein differential expression in normal tissues from HIPED for TBC1D28 Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TBC1D28 Gene



Protein tissue co-expression partners for TBC1D28 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TBC1D28 Gene:

TBC1D28

SOURCE GeneReport for Unigene cluster for TBC1D28 Gene:

Hs.434123

Evidence on tissue expression from TISSUES for TBC1D28 Gene

  • Kidney(3.2)
genes like me logo Genes that share expression patterns with TBC1D28: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TBC1D28 Gene

Orthologs for TBC1D28 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBC1D28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBC1D28 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 23 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 20 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 18 (a)
ManyToMany
-- 35
  • 16 (a)
ManyToMany
-- 35
  • 16 (a)
ManyToMany
-- 35
  • 15 (a)
ManyToMany
-- 35
  • 14 (a)
ManyToMany
-- 35
  • 14 (a)
ManyToMany
-- 35
  • 12 (a)
ManyToMany
-- 35
  • 2 (a)
ManyToMany
-- 35
  • 1 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 18 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 18 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 21 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TBC1D3G 35
  • 6 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta RN-tre 35
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tbc-17 35
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 16 (a)
OneToMany
Species where no ortholog for TBC1D28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TBC1D28 Gene

ENSEMBL:
Gene Tree for TBC1D28 (if available)
TreeFam:
Gene Tree for TBC1D28 (if available)

Paralogs for TBC1D28 Gene

(8) SIMAP similar genes for TBC1D28 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TBC1D28: view

Variants for TBC1D28 Gene

Sequence variations from dbSNP and Humsavar for TBC1D28 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000065631 -- 18,642,092(+) CAAAC(A/G)GAAGG intron-variant
rs1000416866 -- 18,642,416(+) CCAGA(A/C)CCTGC intron-variant
rs1001477783 -- 18,640,648(+) CCAGG(C/T)CAGGT intron-variant
rs1001703409 -- 18,634,869(+) GCCGC(C/G)TCAGC utr-variant-3-prime
rs1001757140 -- 18,634,193(+) ATGAT(-/A/AA)AAAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TBC1D28 Gene

Variant ID Type Subtype PubMed ID
dgv3111n100 CNV gain 25217958
dgv3115n100 CNV gain 25217958
esv29176 CNV gain 19812545
esv3640158 CNV loss 21293372
esv3640159 CNV gain 21293372
nsv1057803 CNV loss 25217958
nsv1060744 CNV gain 25217958
nsv499818 OTHER inversion 21111241
nsv827913 CNV gain 20364138
nsv9504 CNV gain+loss 18304495
nsv960070 CNV duplication 23825009
nsv978379 CNV duplication 23825009

Variation tolerance for TBC1D28 Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBC1D28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TBC1D28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D28 Gene

Disorders for TBC1D28 Gene

Relevant External Links for TBC1D28

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TBC1D28

No disorders were found for TBC1D28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D28 Gene

Publications for TBC1D28 Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TBC1D28 Gene

Sources for TBC1D28 Gene

Content
Loading form....