Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TBC1D26 Gene

Aliases for TBC1D26 Gene

  • TBC1 Domain Family, Member 26 2 3

External Ids for TBC1D26 Gene

Previous GeneCards Identifiers for TBC1D26 Gene

  • GC17P015577
  • GC17P015580
  • GC17P015635
  • GC17P015510

Summaries for TBC1D26 Gene

GeneCards Summary for TBC1D26 Gene

TBC1D26 (TBC1 Domain Family, Member 26) is a Protein Coding gene. An important paralog of this gene is TBC1D10B.

UniProtKB/Swiss-Prot for TBC1D26 Gene

  • May act as a GTPase-activating protein for Rab family protein(s).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D26 Gene

Genomics for TBC1D26 Gene

Regulatory Elements for TBC1D26 Gene

Genomic Location for TBC1D26 Gene

15,732,247 bp from pter
15,749,192 bp from pter
16,946 bases
Plus strand

Genomic View for TBC1D26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBC1D26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D26 Gene

Proteins for TBC1D26 Gene

  • Protein details for TBC1D26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TBC1 domain family member 26
    Protein Accession:
    Secondary Accessions:
    • A8K929
    • Q4G172

    Protein attributes for TBC1D26 Gene

    250 amino acids
    Molecular mass:
    28839 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TBC1D26 Gene


neXtProt entry for TBC1D26 Gene

Proteomics data for TBC1D26 Gene at MOPED

Post-translational modifications for TBC1D26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBC1D26 Gene

No data available for DME Specific Peptides for TBC1D26 Gene

Domains for TBC1D26 Gene

Protein Domains for TBC1D26 Gene


Suggested Antigen Peptide Sequences for TBC1D26 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Rab-GAP TBC domain.
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with TBC1D26: view

No data available for Gene Families for TBC1D26 Gene

Function for TBC1D26 Gene

Molecular function for TBC1D26 Gene

UniProtKB/Swiss-Prot Function:
May act as a GTPase-activating protein for Rab family protein(s).

Gene Ontology (GO) - Molecular Function for TBC1D26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with TBC1D26: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBC1D26

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TBC1D26 Gene

Localization for TBC1D26 Gene

Subcellular locations from

Jensen Localization Image for TBC1D26 Gene COMPARTMENTS Subcellular localization image for TBC1D26 gene
Compartment Confidence
cytosol 3
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TBC1D26 Gene

Pathways for TBC1D26 Gene

SuperPathways for TBC1D26 Gene

No Data Available

Interacting Proteins for TBC1D26 Gene

Gene Ontology (GO) - Biological Process for TBC1D26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with TBC1D26: view

No data available for Pathways by source for TBC1D26 Gene

Transcripts for TBC1D26 Gene

mRNA/cDNA for TBC1D26 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TBC1D26 Gene

TBC1 domain family, member 26:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBC1D26

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D26 Gene

No ASD Table

Relevant External Links for TBC1D26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBC1D26 Gene

mRNA expression in normal human tissues for TBC1D26 Gene

mRNA differential expression in normal tissues according to GTEx for TBC1D26 Gene

This gene is overexpressed in Testis (24.1) and Brain - Nucleus accumbens (basal ganglia) (6.2).

SOURCE GeneReport for Unigene cluster for TBC1D26 Gene Hs.567880

genes like me logo Genes that share expressions with TBC1D26: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for TBC1D26 Gene

Orthologs for TBC1D26 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBC1D26 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TBC1D26 35
  • 98 (n)
  • 96.4 (a)
-- 36
  • 24 (a)
(Bos Taurus)
Mammalia -- 36
  • 21 (a)
(Canis familiaris)
Mammalia -- 36
  • 2 (a)
-- 36
  • 17 (a)
-- 36
  • 19 (a)
-- 36
  • 21 (a)
-- 36
  • 15 (a)
-- 36
  • 19 (a)
-- 36
  • 22 (a)
-- 36
  • 22 (a)
-- 36
  • 21 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 29 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 25 (a)
(Gallus gallus)
Aves -- 36
  • 22 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
(Danio rerio)
Actinopterygii TBC1D3G 36
  • 8 (a)
fruit fly
(Drosophila melanogaster)
Insecta RN-tre 36
  • 13 (a)
(Caenorhabditis elegans)
Secernentea tbc-17 36
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
Species with no ortholog for TBC1D26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TBC1D26 Gene

Gene Tree for TBC1D26 (if available)
Gene Tree for TBC1D26 (if available)

Paralogs for TBC1D26 Gene

(8) SIMAP similar genes for TBC1D26 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TBC1D26: view

Variants for TBC1D26 Gene

Sequence variations from dbSNP and Humsavar for TBC1D26 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1057430 -- 15,744,581(+) CACCC(G/T)CTGGC utr-variant-3-prime
rs1465247 -- 15,738,503(-) TGTGC(A/G)TCTGA intron-variant
rs2003514 -- 15,742,538(+) CAGCT(C/T)CCTCA intron-variant
rs2003515 -- 15,742,398(+) CACGT(C/G)TGCTC intron-variant
rs2240593 -- 15,744,409(-) CCCTC(A/G)TTCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TBC1D26 Gene

Variant ID Type Subtype PubMed ID
nsv520426 CNV Loss 19592680
nsv907705 CNV Gain 21882294
nsv518765 CNV Loss 19592680
esv29820 CNV Gain+Loss 19812545
esv2715701 CNV Deletion 23290073
nsv436847 CNV Insertion 17901297
esv2421582 CNV Duplication 20811451
nsv516755 CNV Loss 19592680
nsv524553 CNV Loss 19592680

Relevant External Links for TBC1D26 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D26 Gene

Disorders for TBC1D26 Gene

No disorders were found for TBC1D26 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TBC1D26 Gene

Publications for TBC1D26 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K. … Fukuda M. (Genes Cells 2009) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for TBC1D26 Gene

Sources for TBC1D26 Gene

Back to Top