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Aliases for TBC1D26 Gene

Aliases for TBC1D26 Gene

  • TBC1 Domain Family Member 26 2 3 5
  • TBC1 Domain Family, Member 26 2

External Ids for TBC1D26 Gene

Previous GeneCards Identifiers for TBC1D26 Gene

  • GC17P015577
  • GC17P015580
  • GC17P015635
  • GC17P015510

Summaries for TBC1D26 Gene

GeneCards Summary for TBC1D26 Gene

TBC1D26 (TBC1 Domain Family Member 26) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is TBC1D28.

UniProtKB/Swiss-Prot for TBC1D26 Gene

  • May act as a GTPase-activating protein for Rab family protein(s).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D26 Gene

Genomics for TBC1D26 Gene

Regulatory Elements for TBC1D26 Gene

Enhancers for TBC1D26 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F016377 0.9 Ensembl ENCODE 11.2 +647.9 647854 4.6 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000266538 LOC649873 MPRIP-AS1 LOC644422 ENSG00000265519 MEIS3P1 TBC1D26 ACTG1P24 ZSWIM7 UPF3AP1
GH17F016476 0.9 Ensembl ENCODE 11.2 +746.0 746023 2.8 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000266538 ENSG00000264729 LRRC75A-AS1 ENSG00000264765 NOS2P4 COTL1P1 ENSG00000265853 LOC100418862 ZSWIM5P1 ENSG00000233193
GH17F016535 1.2 FANTOM5 Ensembl ENCODE 11.2 +804.0 803955 2.4 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 LRRC75A TBC1D26 UPF3AP1 ZNF287 KRT16P6 CCDC144A ZNF624 GC17M016532 LOC105371554
GH17F015892 1 Ensembl ENCODE 10.9 +160.8 160849 1.8 ZNF146 PKNOX1 ETV1 CEBPG ZNF7 GATA3 CTBP1 PRDM10 ZNF263 RFX1 ADORA2B TTC19 ZSWIM7 MEIS3P1 TBC1D26 UPF3AP1 GC17P015908 GC17P015909 GC17P015867
GH17F015894 0.5 Ensembl 10.9 +162.3 162254 0.2 EHMT2 TBC1D26 UPF3AP1 GC17P015908 GC17P015909 GC17P015867
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TBC1D26 on UCSC Golden Path with GeneCards custom track

Genomic Location for TBC1D26 Gene

Chromosome:
17
Start:
15,732,247 bp from pter
End:
15,749,192 bp from pter
Size:
16,946 bases
Orientation:
Plus strand

Genomic View for TBC1D26 Gene

Genes around TBC1D26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D26 Gene

Proteins for TBC1D26 Gene

  • Protein details for TBC1D26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UD7-TBC26_HUMAN
    Recommended name:
    TBC1 domain family member 26
    Protein Accession:
    Q86UD7
    Secondary Accessions:
    • A8K929
    • Q4G172

    Protein attributes for TBC1D26 Gene

    Size:
    250 amino acids
    Molecular mass:
    28839 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TBC1D26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBC1D26 Gene

Post-translational modifications for TBC1D26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBC1D26 Gene

No data available for DME Specific Peptides for TBC1D26 Gene

Domains & Families for TBC1D26 Gene

Protein Domains for TBC1D26 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TBC1D26 Gene

Graphical View of Domain Structure for InterPro Entry

Q86UD7

UniProtKB/Swiss-Prot:

TBC26_HUMAN :
  • Contains 1 Rab-GAP TBC domain.
Domain:
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with TBC1D26: view

No data available for Gene Families for TBC1D26 Gene

Function for TBC1D26 Gene

Molecular function for TBC1D26 Gene

UniProtKB/Swiss-Prot Function:
May act as a GTPase-activating protein for Rab family protein(s).

Gene Ontology (GO) - Molecular Function for TBC1D26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0017137 Rab GTPase binding IBA --
genes like me logo Genes that share ontologies with TBC1D26: view

Phenotypes for TBC1D26 Gene

GenomeRNAi human phenotypes for TBC1D26:
genes like me logo Genes that share phenotypes with TBC1D26: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TBC1D26 Gene

Localization for TBC1D26 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBC1D26 Gene COMPARTMENTS Subcellular localization image for TBC1D26 gene
Compartment Confidence
cytosol 3
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TBC1D26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with TBC1D26: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TBC1D26 Gene

Pathways & Interactions for TBC1D26 Gene

SuperPathways for TBC1D26 Gene

No Data Available

Interacting Proteins for TBC1D26 Gene

Selected Interacting proteins: Q86UD7-TBC26_HUMAN for TBC1D26 Gene via IID

Gene Ontology (GO) - Biological Process for TBC1D26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0031338 regulation of vesicle fusion IBA --
GO:0090630 activation of GTPase activity IBA --
genes like me logo Genes that share ontologies with TBC1D26: view

No data available for Pathways by source and SIGNOR curated interactions for TBC1D26 Gene

Transcripts for TBC1D26 Gene

mRNA/cDNA for TBC1D26 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TBC1D26 Gene

TBC1 domain family, member 26:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D26 Gene

No ASD Table

Relevant External Links for TBC1D26 Gene

GeneLoc Exon Structure for
TBC1D26
ECgene alternative splicing isoforms for
TBC1D26

Expression for TBC1D26 Gene

mRNA expression in normal human tissues for TBC1D26 Gene

mRNA differential expression in normal tissues according to GTEx for TBC1D26 Gene

This gene is overexpressed in Testis (x24.1) and Brain - Nucleus accumbens (basal ganglia) (x6.2).

NURSA nuclear receptor signaling pathways regulating expression of TBC1D26 Gene:

TBC1D26

SOURCE GeneReport for Unigene cluster for TBC1D26 Gene:

Hs.567880
genes like me logo Genes that share expression patterns with TBC1D26: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TBC1D26 Gene

Orthologs for TBC1D26 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBC1D26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBC1D26 34
  • 98 (n)
-- 35
  • 24 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 29 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 25 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 22 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
-- 35
  • 19 (a)
ManyToMany
-- 35
  • 19 (a)
ManyToMany
-- 35
  • 17 (a)
ManyToMany
-- 35
  • 15 (a)
ManyToMany
-- 35
  • 2 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 21 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 22 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 27 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TBC1D3G 35
  • 8 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta RN-tre 35
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tbc-17 35
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 20 (a)
OneToMany
Species where no ortholog for TBC1D26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TBC1D26 Gene

ENSEMBL:
Gene Tree for TBC1D26 (if available)
TreeFam:
Gene Tree for TBC1D26 (if available)

Paralogs for TBC1D26 Gene

(8) SIMAP similar genes for TBC1D26 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for TBC1D26 Gene

genes like me logo Genes that share paralogs with TBC1D26: view

Variants for TBC1D26 Gene

Sequence variations from dbSNP and Humsavar for TBC1D26 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1057430 -- 15,744,581(+) CACCC(G/T)CTGGC downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs111266641 -- 15,742,740(+) GATGA(A/G)TCCCT intron-variant
rs111945977 -- 15,743,936(+) CTGGG(C/T)GACAG intron-variant, upstream-variant-2KB
rs112042993 -- 15,740,069(+) ACACA(A/C)AAAAA intron-variant
rs112114630 -- 15,737,262(+) GTGTC(C/T)CCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TBC1D26 Gene

Variant ID Type Subtype PubMed ID
dgv3107n100 CNV gain 25217958
dgv562e214 CNV loss 21293372
esv2421582 CNV duplication 20811451
esv2715701 CNV deletion 23290073
esv29820 CNV gain+loss 19812545
esv3640083 CNV gain 21293372
esv3892969 CNV loss 25118596
esv3892972 CNV loss 25118596
nsv1149017 CNV duplication 26484159
nsv436847 CNV insertion 17901297
nsv516755 CNV loss 19592680
nsv518765 CNV loss 19592680
nsv520426 CNV loss 19592680
nsv524553 CNV loss 19592680
nsv960060 CNV duplication 23825009

Variation tolerance for TBC1D26 Gene

Residual Variation Intolerance Score: 92.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.46; 94.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBC1D26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TBC1D26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D26 Gene

Disorders for TBC1D26 Gene

Relevant External Links for TBC1D26

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TBC1D26

No disorders were found for TBC1D26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D26 Gene

Publications for TBC1D26 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 64
  2. Protein array based interactome analysis of amyloid-I^ indicates an inhibition of protein translation. (PMID: 21244100) Virok D.P. … FA1lAPp L. (J. Proteome Res. 2011) 3 64
  3. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K. … Fukuda M. (Genes Cells 2009) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64

Products for TBC1D26 Gene

Sources for TBC1D26 Gene

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