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TBC1D26 Gene

protein-coding   GIFtS: 39
GCID: GC17P015635

TBC1 Domain Family, Member 26

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TBC1 Domain Family, Member 261 2
TBC1 Domain Family Member 262

External Ids:    HGNC: 287451   Entrez Gene: 3531492   Ensembl: ENSG000002149467   UniProtKB: Q86UD73   

Export aliases for TBC1D26 gene to outside databases

Previous GC identifers: GC17P015577 GC17P015580 GC17P015510


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TBC1D26 Gene:
TBC1D26 (TBC1 domain family, member 26) is a protein-coding gene. GO annotations related to this gene include Rab GTPase activator activity. An important paralog of this gene is TBC1D3H.

UniProtKB/Swiss-Prot: TBC26_HUMAN, Q86UD7
Function: May act as a GTPase-activating protein for Rab family protein(s) (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TBC1D26 gene promoter:
         POU2F1   POU2F1a   POU3F2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBC1D26 promoter sequence
   Search Chromatin IP Primers for TBC1D26

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBC1D26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p12   HGNC cytogenetic band: 17p11.2

TBC1D26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBC1D26 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P015635:  view genomic region     (about GC identifiers)

Start:
15,635,561 bp from pter      End:
15,649,476 bp from pter
Size:
13,916 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TBC26_HUMAN, Q86UD7 (See protein sequence)
Recommended Name: TBC1 domain family member 26  
Size: 250 amino acids; 28839 Da
Secondary accessions: A8K929 Q4G172
Alternative splicing: 3 isoforms:  Q86UD7-1   Q86UD7-2   Q86UD7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TBC1D26: NX_Q86UD7

Explore proteomics data for TBC1D26 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TBC1D26 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_848666.2  
    ENSEMBL proteins: 
     ENSP00000464236   ENSP00000463606   ENSP00000463783   ENSP00000463097   ENSP00000434391  
     ENSP00000464068   ENSP00000410111  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000195 Rab-GTPase-TBC_dom

    Graphical View of Domain Structure for InterPro Entry Q86UD7

    ProtoNet protein and cluster: Q86UD7

    UniProtKB/Swiss-Prot: TBC26_HUMAN, Q86UD7
    Similarity: Contains 1 Rab-GAP TBC domain


    Find genes that share domains with TBC1D26           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBC26_HUMAN, Q86UD7
    Function: May act as a GTPase-activating protein for Rab family protein(s) (Potential)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005097Rab GTPase activator activity IEA--
         
    Find genes that share ontologies with TBC1D26           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular1
    lysosome1
    mitochondrion1
    nucleus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBC1D26
    Interactions:

        Search GeneGlobe Interaction Network for TBC1D26

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032313regulation of Rab GTPase activity ----

    Find genes that share ontologies with TBC1D26           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TBC1D26 (TBC26)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TBC1D26 gene: 
    NM_178571.4  

    Unigene Cluster for TBC1D26:

    TBC1 domain family, member 26
    Hs.567880  [show with all ESTs]
    Unigene Representative Sequence: BC028414
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000584301 ENST00000580596 ENST00000464963 ENST00000582140 ENST00000579428(uc010cou.1)
    ENST00000491819 ENST00000469477(uc002gpb.4) ENST00000582534 ENST00000578506
    ENST00000583620 ENST00000580970 ENST00000437605
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      QuantiFast Probe-based Assays in human, mouse, rat TBC1D26

    Additional mRNA sequence: 

    AB449913.1 AK315847.1 BC028414.1 BC047400.1 

    5 DOTS entries:

    DT.75173822  DT.70104658  DT.92038189  DT.120939474  DT.120974345 

    2 AceView cDNA sequences:

    BF591671 AV749688 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TBC1D26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGCCGGTG
    TBC1D26 Expression
    About this image

    TBC1D26 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TBC1D26 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567880
        Custom PCR Arrays for TBC1D26
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TBC1D26 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    --
    (see all 9)
    Uncharacterized protein
    (see all 9)
    22(a)
    22(a)
    (see all 9)
    many ↔ many
    many ↔ many
    (see all 9)
    4(35158703-35165770)
    38(23900814-23911859)
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    22(a)
    1 → many
    5(15411217-15475247)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    27(a)
    1 → many
    1(74862925-74883710)
    zebrafish
    (Danio rerio)
    Actinopterygii TBC1D3G6
    TBC1 domain family, member 3G
    8(a)
    1 → many
    25(16824916-16909191) ENSDARG00000086840
    fruit fly
    (Drosophila melanogaster)
    Insecta RN-tre6
    tre oncogene-related protein
    13(a)
    1 → many
    2R(9872320-9878215)
    worm
    (Caenorhabditis elegans)
    Secernentea tbc-176
    Protein TBC-17, isoform d (tbc-17) mRNA, complete ...
    7(a)
    1 → many
    II(12694412-12725483) WBGene00012894


    ENSEMBL Gene Tree for TBC1D26 (if available)
    TreeFam Gene Tree for TBC1D26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TBC1D26 gene
    TBC1D3H2  TBC1D3F2  TBC1D32  ENSG000002487512  TBC1D3C2  GRTP12  TBC1D10C2  TBC1D10A2  
    TBC1D3G2  TBC1D10B2  USP6NL2  TBC1D282  TBC1D3B2  
    8 SIMAP similar genes for TBC1D26 using alignment to 6 protein entries:     TBC26_HUMAN (see all proteins):
    TBC1D28    TBC1D3F    TBC1D3H    TBC1D3B    tre    TBC1D3
    TBC1D3G    TBC1D3C

    Find genes that share paralogs with TBC1D26           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for TBC1D26 (see all 8)
    PGOHUM00000248018 PGOHUM00000236942 PGOHUM00000244531 PGOHUM00000238988 PGOHUM00000246178


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TBC1D26 (see all 356)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1918733501,2
    --15634018(+) GTGTGC/TGCGCG 1 -- us2k10--------
    rs1918670001,2
    C--15634038(+) GCGCAC/TGTGAC 1 -- us2k10--------
    rs1997107151,2
    --15634085(+) GTGTG-/CACC  
            
    TGTGT
    1 -- us2k10--------
    rs562945031,2
    C--15634427(-) CGGTAC/GCTCAT 1 -- us2k10--------
    rs1837304991,2
    --15634710(+) AGAGGC/GCTTTT 1 -- us2k10--------
    rs1380936501,2
    C--15634832(+) TGATGC/TGGGGA 1 -- us2k10--------
    rs1142614961,2
    F--15634883(+) ATTGAG/TCACCG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs590977031,2
    --15634935(+) CAGTGA/GAGGCC 1 -- us2k10--------
    rs586928731,2
    --15634936(+) AGTGAA/GGGCCT 1 -- us2k10--------
    rs1431393891,2
    C--15634998(+) GTGGCA/GGCTAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TBC1D26 (15635561 - 15649476 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TBC1D26:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715701CNV Deletion23290073
    esv2421582CNV Duplication20811451
    nsv436847CNV Insertion17901297
    nsv524553CNV Loss19592680
    nsv518765CNV Loss19592680
    nsv520426CNV Loss19592680
    nsv516755CNV Loss19592680
    nsv907705CNV Gain21882294
    esv29820CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TBC1D26 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TBC1D26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    2. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1 Ishibashi K.... Fukuda M. (Genes Cells 2009)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 353149 HGNC: 28745 AceView: MGC51025 Ensembl:ENSG00000214946 euGenes: HUgn353149
    ECgene: TBC1D26 H-InvDB: TBC1D26

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TBC1D26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TBC1D26 gene:
    Search GeneIP for patents involving TBC1D26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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