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Aliases for TBC1D25 Gene

Aliases for TBC1D25 Gene

  • TBC1 Domain Family Member 25 2 3 5
  • Ornithine Aminotransferase-Like 1 2 3
  • TBC1 Domain Family, Member 25 2 3
  • OATL1 3 4
  • 5SN3 SnoRNA 3
  • MG81 3

External Ids for TBC1D25 Gene

Previous HGNC Symbols for TBC1D25 Gene

  • OATL1

Previous GeneCards Identifiers for TBC1D25 Gene

  • GC0XP048283
  • GC0XP048397
  • GC0XP046061

Summaries for TBC1D25 Gene

Entrez Gene Summary for TBC1D25 Gene

  • This gene encodes a protein with a TBC domain and may function as a Rab GTPase activating protein. This gene was previously known as ornithine aminotransferase-like 1, but has no similarity to ornithine aminotransferase. [provided by RefSeq, Jul 2008]

GeneCards Summary for TBC1D25 Gene

TBC1D25 (TBC1 Domain Family Member 25) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is SGSM2.

UniProtKB/Swiss-Prot for TBC1D25 Gene

  • Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D25 Gene

Genomics for TBC1D25 Gene

Regulatory Elements for TBC1D25 Gene

Enhancers for TBC1D25 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TBC1D25 on UCSC Golden Path with GeneCards custom track

Promoters for TBC1D25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TBC1D25 on UCSC Golden Path with GeneCards custom track

Genomic Location for TBC1D25 Gene

Chromosome:
X
Start:
48,539,457 bp from pter
End:
48,562,609 bp from pter
Size:
23,153 bases
Orientation:
Plus strand

Genomic View for TBC1D25 Gene

Genes around TBC1D25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D25 Gene

Proteins for TBC1D25 Gene

  • Protein details for TBC1D25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3MII6-TBC25_HUMAN
    Recommended name:
    TBC1 domain family member 25
    Protein Accession:
    Q3MII6
    Secondary Accessions:
    • Q08AN9
    • Q3MII4
    • Q8TAR9

    Protein attributes for TBC1D25 Gene

    Size:
    688 amino acids
    Molecular mass:
    76327 Da
    Quaternary structure:
    • Interacts (via N-terminus) with MAP1LC3B, GABARAP and GABARAPL2.

    Alternative splice isoforms for TBC1D25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBC1D25 Gene

Proteomics data for TBC1D25 Gene at MOPED

Post-translational modifications for TBC1D25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBC1D25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TBC1D25 Gene

Domains & Families for TBC1D25 Gene

Protein Domains for TBC1D25 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q3MII6

UniProtKB/Swiss-Prot:

TBC25_HUMAN :
  • Contains 1 Rab-GAP TBC domain.
Domain:
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with TBC1D25: view

No data available for Gene Families for TBC1D25 Gene

Function for TBC1D25 Gene

Molecular function for TBC1D25 Gene

UniProtKB/Swiss-Prot Function:
Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes.

Gene Ontology (GO) - Molecular Function for TBC1D25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017137 Rab GTPase binding IBA --
genes like me logo Genes that share ontologies with TBC1D25: view
genes like me logo Genes that share phenotypes with TBC1D25: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TBC1D25

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBC1D25 Gene

Localization for TBC1D25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBC1D25 Gene

Cytoplasm. Cytoplasmic vesicle, autophagosome. Note=It is dispersed in the cytoplasm under nutrient-rich conditions. Localizes at autophagosomes under cell starving conditions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBC1D25 Gene COMPARTMENTS Subcellular localization image for TBC1D25 gene
Compartment Confidence
vacuole 5
cytosol 2
nucleus 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for TBC1D25 Gene

Pathways & Interactions for TBC1D25 Gene

SuperPathways for TBC1D25 Gene

No Data Available

Interacting Proteins for TBC1D25 Gene

SIGNOR curated interactions for TBC1D25 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TBC1D25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0031338 regulation of vesicle fusion IBA --
GO:0090630 activation of GTPase activity IBA --
GO:1901096 regulation of autophagosome maturation IMP 21383079
genes like me logo Genes that share ontologies with TBC1D25: view

No data available for Pathways by source for TBC1D25 Gene

Drugs & Compounds for TBC1D25 Gene

No Compound Related Data Available

Transcripts for TBC1D25 Gene

Unigene Clusters for TBC1D25 Gene

TBC1 domain family, member 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D25 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - - - - - -
SP8: - - - - - -
SP9: - - -
SP10: - - - - - -
SP11: -

Relevant External Links for TBC1D25 Gene

GeneLoc Exon Structure for
TBC1D25
ECgene alternative splicing isoforms for
TBC1D25

Expression for TBC1D25 Gene

mRNA expression in normal human tissues for TBC1D25 Gene

Protein differential expression in normal tissues from HIPED for TBC1D25 Gene

This gene is overexpressed in CD8 Tcells (34.8), Ovary (13.6), Testis (6.8), NK cells (6.6), and Blymphocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TBC1D25 Gene



SOURCE GeneReport for Unigene cluster for TBC1D25 Gene Hs.694353

genes like me logo Genes that share expression patterns with TBC1D25: view

Protein tissue co-expression partners for TBC1D25 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TBC1D25 Gene

Orthologs for TBC1D25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TBC1D25 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TBC1D25 35
  • 88.16 (n)
  • 92.29 (a)
TBC1D25 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBC1D25 35
  • 89.91 (n)
  • 94.32 (a)
TBC1D25 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbc1d25 35
  • 87.16 (n)
  • 94.04 (a)
Tbc1d25 16
Tbc1d25 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TBC1D25 35
  • 98.35 (n)
  • 97.96 (a)
rat
(Rattus norvegicus)
Mammalia Tbc1d25 35
  • 86.63 (n)
  • 93.6 (a)
oppossum
(Monodelphis domestica)
Mammalia TBC1D25 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TBC1D25 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TBC1D25 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBC1D25 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495342 35
  • 67.54 (n)
  • 66.17 (a)
zebrafish
(Danio rerio)
Actinopterygii tbc1d25 35
  • 70.79 (n)
  • 80.35 (a)
tbc1d25 36
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8155 36
  • 26 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GYP7 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for TBC1D25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBC1D25 Gene

ENSEMBL:
Gene Tree for TBC1D25 (if available)
TreeFam:
Gene Tree for TBC1D25 (if available)

Paralogs for TBC1D25 Gene

Paralogs for TBC1D25 Gene

(3) SIMAP similar genes for TBC1D25 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TBC1D25 Gene

genes like me logo Genes that share paralogs with TBC1D25: view

Variants for TBC1D25 Gene

Sequence variations from dbSNP and Humsavar for TBC1D25 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs2293948 - 48,559,738(+) AGCGA(A/C/G)CCCTG reference, missense
rs235836 -- 48,560,271(-) ACCAG(C/T)GTCTG reference, missense
rs1043614 -- 48,562,320(+) CCCTT(C/T)TGCTG utr-variant-3-prime
rs1060807 -- 48,559,876(-) GGGTA(A/G)CGGCA reference, missense
rs1882931 -- 48,555,325(+) GCCTA(G/T)GGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TBC1D25 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680

Variation tolerance for TBC1D25 Gene

Residual Variation Intolerance Score: 9.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.47% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TBC1D25 Gene

Disorders for TBC1D25 Gene

Relevant External Links for TBC1D25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TBC1D25

No disorders were found for TBC1D25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D25 Gene

Publications for TBC1D25 Gene

  1. OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation. (PMID: 21383079) Itoh T. … Fukuda M. (J. Cell Biol. 2011) 2 3 4 67
  2. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. (PMID: 22354992) Popovic D. … Dikic I. (Mol. Cell. Biol. 2012) 3
  3. Association of polyaminergic loci with anxiety, mood disorders, and attempted suicide. (PMID: 21152090) Fiori L.M. … Turecki G. (PLoS ONE 2010) 3
  4. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K. … Fukuda M. (Genes Cells 2009) 3
  5. Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth. (PMID: 17558447) Tian H. … Sun D. (Acta Biochim. Biophys. Sin. (Shanghai) 2007) 3

Products for TBC1D25 Gene

Sources for TBC1D25 Gene

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