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TBC1D25 Gene

protein-coding   GIFtS: 45
GCID: GC0XP048397

TBC1 Domain Family, Member 25

(Previous name: ornithine aminotransferase-like 1)
(Previous symbol: OATL1)
  See TBC1D25-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TBC1 Domain Family, Member 251 2
OATL11 2 3 5
Ornithine Aminotransferase-Like 11 2
5SN3 SnoRNA2
MG812
TBC1 Domain Family Member 252

External Ids:    HGNC: 80921   Entrez Gene: 49432   Ensembl: ENSG000000683547   OMIM: 3112405   UniProtKB: Q3MII63   

Export aliases for TBC1D25 gene to outside databases

Previous GC identifers: GC0XP048283 GC0XP046061


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TBC1D25 Gene:
This gene encodes a protein with a TBC domain and may function as a Rab GTPase activating protein. This gene was
previously known as ornithine aminotransferase-like 1, but has no similarity to ornithine aminotransferase.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TBC1D25 Gene:
TBC1D25 (TBC1 domain family, member 25) is a protein-coding gene. Diseases associated with TBC1D25 include mood disorder. GO annotations related to this gene include Rab GTPase activator activity. An important paralog of this gene is SGSM1.

UniProtKB/Swiss-Prot: TBC25_HUMAN, Q3MII6
Function: Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome
maturation, the process in which autophagosomes fuse with endosomes and lysosomes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TBC1D25 gene promoter:
         HFH-3   AML1a   C/EBPalpha   FOXI1   PPAR-alpha   CREB   GATA-6   deltaCREB   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBC1D25 promoter sequence
   Search Chromatin IP Primers for TBC1D25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBC1D25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

TBC1D25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBC1D25 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP048397:  view genomic region     (about GC identifiers)

Start:
48,397,845 bp from pter      End:
48,420,997 bp from pter
Size:
23,153 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TBC25_HUMAN, Q3MII6 (See protein sequence)
Recommended Name: TBC1 domain family member 25  
Size: 688 amino acids; 76327 Da
Subunit: Interacts (via N-terminus) with MAP1LC3B, GABARAP and GABARAPL2
Secondary accessions: Q08AN9 Q3MII4 Q8TAR9
Alternative splicing: 2 isoforms:  Q3MII6-1   Q3MII6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TBC1D25: NX_Q3MII6

Explore proteomics data for TBC1D25 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TBC1D25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002527.1  
    ENSEMBL proteins: 
     ENSP00000365962   ENSP00000476787   ENSP00000402268   ENSP00000444091  

    TBC1D25 Human Recombinant Protein Products:

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    Novus Biologicals TBC1D25 Protein
    Novus Biologicals TBC1D25 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TBC1D25 

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    Search eBioscience for ELISAs for TBC1D25 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000195 Rab-GTPase-TBC_dom

    Graphical View of Domain Structure for InterPro Entry Q3MII6

    ProtoNet protein and cluster: Q3MII6

    1 Blocks protein domain: IPB000195 RabGAP/TBC domain

    UniProtKB/Swiss-Prot: TBC25_HUMAN, Q3MII6
    Similarity: Contains 1 Rab-GAP TBC domain


    Find genes that share domains with TBC1D25           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBC25_HUMAN, Q3MII6
    Function: Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome
    maturation, the process in which autophagosomes fuse with endosomes and lysosomes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005097Rab GTPase activator activity IDA--
    GO:0005515protein binding IPI--
    GO:0008483transaminase activity ----
         
    Find genes that share ontologies with TBC1D25           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TBC1D25:
     Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBC1D25
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TBC1D25
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TBC1D25

    miRNA
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    miRTarBase miRNAs that target TBC1D25:
    hsa-mir-1296-5p (MIRT036096), hsa-mir-19b-3p (MIRT031139)

    Block miRNA regulation of human, mouse, rat TBC1D25 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TBC1D25 (see all 20):
    hsa-miR-522 hsa-miR-449a hsa-miR-888* hsa-miR-3150a-3p hsa-miR-374a* hsa-miR-140-3p hsa-miR-34c-5p hsa-miR-449b
    SwitchGear 3'UTR luciferase reporter plasmidTBC1D25 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat TBC1D25

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TBC1D25 (NM_002536)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D25


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TBC25_HUMAN, Q3MII6: Cytoplasm. Cytoplasmic vesicle, autophagosome. Note=It is dispersed in the cytoplasm under
    nutrient-rich conditions. Localizes at autophagosomes under cell starving conditions
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    vacuole5
    cytosol2
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005776autophagic vacuole IDA--
    GO:0031410cytoplasmic vesicle IEA--

    Find genes that share ontologies with TBC1D25           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBC1D25
    Interactions:

        Search GeneGlobe Interaction Network for TBC1D25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for TBC1D25 (Q3MII63 ENSP000003659624) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FEZ1Q996893, ENSP000002789194I2D: score=2 STRING: ENSP00000278919
    FEZ2Q9UHY83, ENSP000003685474I2D: score=1 STRING: ENSP00000368547
    GABARAPENSP000003068664STRING: ENSP00000306866
    GABARAPL2ENSP000000372434STRING: ENSP00000037243
    MAP1LC3BENSP000002686074STRING: ENSP00000268607
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006914autophagy IEA--
    GO:0032313regulation of Rab GTPase activity ----
    GO:0032851positive regulation of Rab GTPase activity IDA--
    GO:1901096regulation of autophagic vacuole maturation IMP--

    Find genes that share ontologies with TBC1D25           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TBC1D25 (TBC25)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TBC1D25 gene (2 alternative transcripts): 
    NM_001006113.1  NM_002536.2  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376771(uc004dka.1 uc011mly.1 uc004dkb.1 uc011mlz.1 uc011mma.1 uc004dkc.1 uc011mmb.1 uc011mmc.1 uc011mmd.1)
    ENST00000481090 ENST00000494495 ENST00000476141 ENST00000418627 ENST00000537536

    miRNA
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    Block miRNA regulation of human, mouse, rat TBC1D25 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TBC1D25 (see all 20):
    hsa-miR-522 hsa-miR-449a hsa-miR-888* hsa-miR-3150a-3p hsa-miR-374a* hsa-miR-140-3p hsa-miR-34c-5p hsa-miR-449b
    SwitchGear 3'UTR luciferase reporter plasmidTBC1D25 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TBC1D25
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    OriGene ORF clones in mouse, rat for TBC1D25
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TBC1D25 (NM_002536)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D25
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TBC1D25
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TBC1D25
      QuantiTect SYBR Green Assays in human, mouse, rat TBC1D25
      QuantiFast Probe-based Assays in human, mouse, rat TBC1D25

    Selected AceView cDNA sequences (see all 155):

    BC041614 AW291613 BQ646486 AL550349 BQ673865 CK299092 BU726929 BC052609 
    AW089388 CA447032 AJ707405 BX280004 BQ669144 BQ651229 BU737793 BE279778 
    BQ643383 AW612031 CD519271 CB155002 CK300702 BE671227 BC064334 BQ648952 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D25 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
    SP1:                          -     -           -     -           -                                                         
    SP2:                          -     -           -     -     -     -                                                         
    SP3:                                -           -     -           -     -     -                                             
    SP4:                          -     -     -     -     -     -     -                                                         
    SP5:                          -     -           -     -           -     -     -                                             


    ECgene alternative splicing isoforms for TBC1D25

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TBC1D25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACCCCACC
    TBC1D25 Expression
    About this image

    TBC1D25 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TBC1D25 Protein Expression
        Custom PCR Arrays for TBC1D25
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D25

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TBC1D25 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbc1d251 , 5 TBC1 domain family, member 251, 5 87.16(n)1
    94.04(a)1
      X (3.69 cM)5
    2098151  NM_001166437.11  NP_001159909.11 
     81544725 
    chicken
    (Gallus gallus)
    Aves TBC1D256
    TBC1 domain family, member 25
    54(a)
    1 ↔ 1
    JH375710.1(21-1417)
    lizard
    (Anolis carolinensis)
    Reptilia TBC1D256
    TBC1 domain family, member 25
    66(a)
    1 ↔ 1
    2(69358195-69369500)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004953421 TBC1 domain family member 25-like 67.54(n)
    66.17(a)
      100495342  XM_002943776.2  XP_002943822.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tbc1d251 TBC1 domain family, member 25 70.79(n)
    80.35(a)
      556338  NM_001128236.1  NP_001121708.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG81556
    --
    26(a)
    1 ↔ 1
    2R(11205349-11209674)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GYP76
    GTPase-activating protein for yeast Rab family mem...
    15(a)
    1 → many
    IV(34237-36477) YDL234C


    ENSEMBL Gene Tree for TBC1D25 (if available)
    TreeFam Gene Tree for TBC1D25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TBC1D25 gene
    SGSM12  TBC1D172  TBC1D162  SGSM22  TBC1D152  
    3 SIMAP similar genes for TBC1D25 using alignment to 4 protein entries:     TBC25_HUMAN (see all proteins):
    OATL1    DKFZp761D0223    TBC1D16

    Find genes that share paralogs with TBC1D25           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TBC1D25
    PGOHUM00000237278


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TBC1D25 (see all 312)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs585792381,2
    C--48396502(+) TGGCCA/CCTTCT 1 -- us2k10--------
    rs734857341,2
    C,F--48396957(+) TTCATG/ACAGGA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1812818291,2
    --48397056(+) GGTATA/CAATTA 1 -- us2k10--------
    rs726190211,2
    C--48397094(+) TCTGTA/GGTGCA 1 -- us2k10--------
    rs556519281,2
    C--48397165(+) CTGCCA/GCTTCA 1 -- us2k10--------
    rs1867635201,2
    --48397201(+) GTGTGC/TGCCAC 1 -- us2k10--------
    rs1915540831,2
    --48397242(+) AGAGAC/TGGGGT 1 -- us2k10--------
    rs736323841,2
    C,F--48397838(+) TGGCGG/AACGAG 1 -- us2k11Minor allele frequency- A:0.00WA 2
    rs1838087191,2
    --48398021(+) GGCGAC/TCTCCA 1 -- us2k10--------
    rs1871176421,2
    --48398054(+) GGTGGC/GGGGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TBC1D25 (48397845 - 48420997 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TBC1D25:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv528292CNV Gain19592680
    esv32909CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TBC1D25
    DNA2.0 Custom Variant and Variant Library Synthesis for TBC1D25

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 311240    OMIM disorders: --

    1 disease for TBC1D25:    
    About MalaCards
    mood disorder


    Find genes that share disorders with TBC1D25           About GenesLikeMe


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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TBC1D25 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with TBC1D25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation. (PubMed id 21383079)1, 2, 3 Itoh T.... Fukuda M. (J. Cell Biol. 2011)
    2. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    3. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. (PubMed id 22354992)1 Popovic D....Dikic I. (Mol. Cell. Biol. 2012)
    4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    5. Association of polyaminergic loci with anxiety, mood disorders, and attempted suicide. (PubMed id 21152090)1 Fiori L.M....Turecki G. (PLoS ONE 2010)
    6. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    7. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1 Ishibashi K.... Fukuda M. (Genes Cells 2009)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. (PubMed id 16923123)1 Itoh T.... Fukuda M. (Genes Cells 2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4943 HGNC: 8092 AceView: OATL1 Ensembl:ENSG00000068354 euGenes: HUgn4943
    ECgene: TBC1D25 H-InvDB: TBC1D25

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TBC1D25 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TBC1D25 gene:
    Search GeneIP for patents involving TBC1D25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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