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Aliases for TBC1D25 Gene

Aliases for TBC1D25 Gene

  • TBC1 Domain Family, Member 25 2 3
  • OATL1 3 4 6
  • Ornithine Aminotransferase-Like 1 2 3
  • TBC1 Domain Family Member 25 3
  • 5SN3 SnoRNA 3
  • MG81 3

External Ids for TBC1D25 Gene

Previous HGNC Symbols for TBC1D25 Gene

  • OATL1

Previous GeneCards Identifiers for TBC1D25 Gene

  • GC0XP048283
  • GC0XP048397
  • GC0XP046061

Summaries for TBC1D25 Gene

Entrez Gene Summary for TBC1D25 Gene

  • This gene encodes a protein with a TBC domain and may function as a Rab GTPase activating protein. This gene was previously known as ornithine aminotransferase-like 1, but has no similarity to ornithine aminotransferase. [provided by RefSeq, Jul 2008]

GeneCards Summary for TBC1D25 Gene

TBC1D25 (TBC1 Domain Family, Member 25) is a Protein Coding gene. Diseases associated with TBC1D25 include mood disorder. An important paralog of this gene is SGSM2.

UniProtKB/Swiss-Prot for TBC1D25 Gene

  • Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D25 Gene

Genomics for TBC1D25 Gene

Regulatory Elements for TBC1D25 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TBC1D25 Gene

48,539,457 bp from pter
48,562,609 bp from pter
23,153 bases
Plus strand

Genomic View for TBC1D25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBC1D25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D25 Gene

Proteins for TBC1D25 Gene

  • Protein details for TBC1D25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TBC1 domain family member 25
    Protein Accession:
    Secondary Accessions:
    • Q08AN9
    • Q3MII4
    • Q8TAR9

    Protein attributes for TBC1D25 Gene

    688 amino acids
    Molecular mass:
    76327 Da
    Quaternary structure:
    • Interacts (via N-terminus) with MAP1LC3B, GABARAP and GABARAPL2.

    Alternative splice isoforms for TBC1D25 Gene


neXtProt entry for TBC1D25 Gene

Proteomics data for TBC1D25 Gene at MOPED

Post-translational modifications for TBC1D25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBC1D25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TBC1D25 Gene

Domains for TBC1D25 Gene

Protein Domains for TBC1D25 Gene


Suggested Antigen Peptide Sequences for TBC1D25 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q3MII6
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with TBC1D25: view

No data available for Gene Families for TBC1D25 Gene

Function for TBC1D25 Gene

Molecular function for TBC1D25 Gene

UniProtKB/Swiss-Prot Function: Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes.

Gene Ontology (GO) - Molecular Function for TBC1D25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 21383079
GO:0005515 protein binding IPI 21383079
genes like me logo Genes that share ontologies with TBC1D25: view

Phenotypes for TBC1D25 Gene

GenomeRNAi human phenotypes for TBC1D25:
genes like me logo Genes that share phenotypes with TBC1D25: view

Animal Model Products

CRISPR Products

miRNA for TBC1D25 Gene

miRTarBase miRNAs that target TBC1D25

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TBC1D25 Gene

Localization for TBC1D25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBC1D25 Gene

Cytoplasm. Cytoplasmic vesicle, autophagosome. Note=It is dispersed in the cytoplasm under nutrient-rich conditions. Localizes at autophagosomes under cell starving conditions.

Subcellular locations from

Jensen Localization Image for TBC1D25 Gene COMPARTMENTS Subcellular localization image for TBC1D25 gene
Compartment Confidence
vacuole 5
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TBC1D25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005776 autophagic vacuole IDA 21383079
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with TBC1D25: view

Pathways for TBC1D25 Gene

SuperPathways for TBC1D25 Gene

No Data Available

Interacting Proteins for TBC1D25 Gene

Gene Ontology (GO) - Biological Process for TBC1D25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:1901096 regulation of autophagic vacuole maturation IMP 21383079
genes like me logo Genes that share ontologies with TBC1D25: view

No data available for Pathways by source for TBC1D25 Gene

Transcripts for TBC1D25 Gene

Unigene Clusters for TBC1D25 Gene

TBC1 domain family, member 25:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBC1D25

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TBC1D25

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D25 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - - - - - -
SP8: - - - - - -
SP9: - - -
SP10: - - - - - -
SP11: -

Relevant External Links for TBC1D25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBC1D25 Gene

mRNA expression in normal human tissues for TBC1D25 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TBC1D25 Gene

SOURCE GeneReport for Unigene cluster for TBC1D25 Gene Hs.694353

genes like me logo Genes that share expressions with TBC1D25: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TBC1D25 Gene

Orthologs for TBC1D25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TBC1D25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TBC1D25 35
  • 98.35 (n)
  • 97.96 (a)
(Bos Taurus)
Mammalia TBC1D25 35
  • 88.16 (n)
  • 92.29 (a)
TBC1D25 36
  • 87 (a)
(Canis familiaris)
Mammalia TBC1D25 35
  • 89.91 (n)
  • 94.32 (a)
TBC1D25 36
  • 88 (a)
(Mus musculus)
Mammalia Tbc1d25 35
  • 87.16 (n)
  • 94.04 (a)
Tbc1d25 16
Tbc1d25 36
  • 87 (a)
(Monodelphis domestica)
Mammalia TBC1D25 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia TBC1D25 36
  • 68 (a)
(Rattus norvegicus)
Mammalia Tbc1d25 35
  • 86.63 (n)
  • 93.6 (a)
(Gallus gallus)
Aves TBC1D25 36
  • 54 (a)
(Anolis carolinensis)
Reptilia TBC1D25 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495342 35
  • 67.54 (n)
  • 66.17 (a)
(Danio rerio)
Actinopterygii tbc1d25 35
  • 70.79 (n)
  • 80.35 (a)
tbc1d25 36
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8155 36
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GYP7 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
Species with no ortholog for TBC1D25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBC1D25 Gene

Gene Tree for TBC1D25 (if available)
Gene Tree for TBC1D25 (if available)

Paralogs for TBC1D25 Gene

Paralogs for TBC1D25 Gene

Selected SIMAP similar genes for TBC1D25 Gene using alignment to 4 proteins: Pseudogenes for TBC1D25 Gene

genes like me logo Genes that share paralogs with TBC1D25: view

Variants for TBC1D25 Gene

Sequence variations from dbSNP and Humsavar for TBC1D25 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs235836 -- 48,560,271(-) ACCAG(C/T)GTCTG missense, reference
rs1043614 -- 48,562,320(+) CCCTT(C/T)TGCTG utr-variant-3-prime
rs1060807 -- 48,559,876(-) GGGTA(A/G)CGGCA missense, reference
rs1882931 -- 48,555,325(+) GCCTA(G/T)GGTTT intron-variant
rs2293948 - 48,559,738(+) AGCGA(A/C/G)CCCTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TBC1D25 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680

Relevant External Links for TBC1D25 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D25 Gene

Disorders for TBC1D25 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TBC1D25 Gene including...

Search for TBC1D25 Gene in MalaCards »
genes like me logo Genes that share disorders with TBC1D25: view

No data available for UniProtKB/Swiss-Prot for TBC1D25 Gene

Publications for TBC1D25 Gene

  1. OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation. (PMID: 21383079) Itoh T. … Fukuda M. (J. Cell Biol. 2011) 2 3 4
  2. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. (PMID: 22354992) Popovic D. … Dikic I. (Mol. Cell. Biol. 2012) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4
  5. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4

Products for TBC1D25 Gene

Sources for TBC1D25 Gene

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