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Aliases for TBC1D23 Gene

Aliases for TBC1D23 Gene

  • TBC1 Domain Family, Member 23 2 3
  • HCV Non-Structural Protein 4A-Transactivated Protein 1 3 4
  • NS4ATP1 3 4
  • HCV Nonstructural Protein 4A-Transactivated Protein 1 3
  • TBC1 Domain Family Member 23 3

External Ids for TBC1D23 Gene

Summaries for TBC1D23 Gene

GeneCards Summary for TBC1D23 Gene

TBC1D23 (TBC1 Domain Family, Member 23) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D23 Gene

Genomics for TBC1D23 Gene

Genomic Location for TBC1D23 Gene

Start:
100,260,817 bp from pter
End:
100,325,252 bp from pter
Size:
64,436 bases
Orientation:
Plus strand

Genomic View for TBC1D23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBC1D23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D23 Gene

Regulatory Elements for TBC1D23 Gene

Proteins for TBC1D23 Gene

  • Protein details for TBC1D23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUY8-TBC23_HUMAN
    Recommended name:
    TBC1 domain family member 23
    Protein Accession:
    Q9NUY8
    Secondary Accessions:
    • B9A6M5
    • Q8TCN8
    • Q8WUB7
    • Q96D90
    • Q9NV75

    Protein attributes for TBC1D23 Gene

    Size:
    699 amino acids
    Molecular mass:
    78322 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH10221.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH20955.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91881.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TBC1D23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBC1D23 Gene

Proteomics data for TBC1D23 Gene at MOPED

Post-translational modifications for TBC1D23 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys495

Other Protein References for TBC1D23 Gene

No data available for DME Specific Peptides for TBC1D23 Gene

Domains for TBC1D23 Gene

Protein Domains for TBC1D23 Gene

UniProtKB/Swiss-Prot:

TBC23_HUMAN
Domain:
  • Contains 1 Rab-GAP TBC domain.:
    • Q9NUY8
  • Contains 1 rhodanese domain.:
    • Q9NUY8
genes like me logo Genes that share domains with TBC1D23: view

No data available for Gene Families for TBC1D23 Gene

Function for TBC1D23 Gene

Gene Ontology (GO) - Molecular Function for TBC1D23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TBC1D23: view

Phenotypes for TBC1D23 Gene

genes like me logo Genes that share phenotypes with TBC1D23: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TBC1D23 Gene

Localization for TBC1D23 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBC1D23 Gene COMPARTMENTS Subcellular localization image for TBC1D23 gene
Compartment Confidence
cytosol 2
golgi apparatus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TBC1D23 Gene

Pathways for TBC1D23 Gene

SuperPathways for TBC1D23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TBC1D23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032680 regulation of tumor necrosis factor production IEA --
GO:0032755 positive regulation of interleukin-6 production IEA --
GO:0050727 regulation of inflammatory response IEA --
genes like me logo Genes that share ontologies with TBC1D23: view

No data available for Pathways by source for TBC1D23 Gene

Transcripts for TBC1D23 Gene

Unigene Clusters for TBC1D23 Gene

TBC1 domain family, member 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D23 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: - - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - -
SP8: - - - -
SP9: - - -
SP10:

ExUns: 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
SP1: -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TBC1D23 Gene

GeneLoc Exon Structure for
TBC1D23
ECgene alternative splicing isoforms for
TBC1D23

Expression for TBC1D23 Gene

mRNA expression in normal human tissues for TBC1D23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TBC1D23 Gene

SOURCE GeneReport for Unigene cluster for TBC1D23 Gene Hs.477003

genes like me logo Genes that share expressions with TBC1D23: view

Orthologs for TBC1D23 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBC1D23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBC1D23 36
  • 99.48 (n)
  • 99.28 (a)
TBC1D23 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TBC1D23 36
  • 93.13 (n)
  • 96.14 (a)
TBC1D23 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBC1D23 36
  • 94.71 (n)
  • 96.71 (a)
TBC1D23 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbc1d23 36
  • 88.6 (n)
  • 94.44 (a)
Tbc1d23 16
Tbc1d23 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TBC1D23 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TBC1D23 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbc1d23 36
  • 89.94 (n)
  • 94.99 (a)
chicken
(Gallus gallus)
Aves TBC1D23 36
  • 82.03 (n)
  • 89.96 (a)
TBC1D23 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBC1D23 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10381 36
tbc1d23 36
  • 74.92 (n)
  • 83.02 (a)
zebrafish
(Danio rerio)
Actinopterygii tbc1d23 36
  • 72.12 (n)
  • 78.68 (a)
tbc1d23 37
  • 77 (a)
OneToOne
zgc63756 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007749 36
  • 51.23 (n)
  • 47.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4552 36
  • 50.25 (n)
  • 46.55 (a)
CG4552 37
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tbc-1 36
  • 47.29 (n)
  • 34.04 (a)
tbc-1 37
  • 32 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4706 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
OneToOne
Species with no ortholog for TBC1D23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TBC1D23 Gene

ENSEMBL:
Gene Tree for TBC1D23 (if available)
TreeFam:
Gene Tree for TBC1D23 (if available)

Paralogs for TBC1D23 Gene

No data available for Paralogs for TBC1D23 Gene

Variants for TBC1D23 Gene

Sequence variations from dbSNP and Humsavar for TBC1D23 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs166748 -- 100,301,499(+) TTTTT(A/C)TATTT intron-variant
rs169357 -- 100,301,089(-) ttaca(C/G)aaata intron-variant
rs175822 -- 100,311,087(+) ATTGT(G/T)TCTTA intron-variant
rs183933 -- 100,301,061(+) tttta(C/T)acatt intron-variant
rs185723 -- 100,301,142(+) ATATA(C/T)ACATT intron-variant

Relevant External Links for TBC1D23 Gene

HapMap Linkage Disequilibrium report
TBC1D23
Human Gene Mutation Database (HGMD)
TBC1D23

No data available for Structural Variations from Database of Genomic Variants (DGV) for TBC1D23 Gene

Disorders for TBC1D23 Gene

No disorders were found for TBC1D23 Gene.

No data available for UniProtKB/Swiss-Prot for TBC1D23 Gene

Publications for TBC1D23 Gene

  1. Spatiotemporal inhibition of innate immunity signaling by the Tbc1d23 RAB-GAP. (PMID: 22312129) De Arras L. … Alper S. (J. Immunol. 2012) 2 3
  2. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K. … Fukuda M. (Genes Cells 2009) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TBC1D23 Gene

Sources for TBC1D23 Gene

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