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Aliases for TBC1D23 Gene

Aliases for TBC1D23 Gene

  • TBC1 Domain Family Member 23 2 3 5
  • HCV Non-Structural Protein 4A-Transactivated Protein 1 3 4
  • TBC1 Domain Family, Member 23 2 3
  • NS4ATP1 3 4
  • HCV Nonstructural Protein 4A-Transactivated Protein 1 3

External Ids for TBC1D23 Gene

Previous GeneCards Identifiers for TBC1D23 Gene

  • GC03P101463
  • GC03P099979
  • GC03P097347

Summaries for TBC1D23 Gene

GeneCards Summary for TBC1D23 Gene

TBC1D23 (TBC1 Domain Family Member 23) is a Protein Coding gene. Diseases associated with TBC1D23 include Pneumocystosis.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D23 Gene

Genomics for TBC1D23 Gene

Regulatory Elements for TBC1D23 Gene

Enhancers for TBC1D23 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TBC1D23 on UCSC Golden Path with GeneCards custom track

Promoters for TBC1D23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TBC1D23 on UCSC Golden Path with GeneCards custom track

Genomic Location for TBC1D23 Gene

Chromosome:
3
Start:
100,260,817 bp from pter
End:
100,325,252 bp from pter
Size:
64,436 bases
Orientation:
Plus strand

Genomic View for TBC1D23 Gene

Genes around TBC1D23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D23 Gene

Proteins for TBC1D23 Gene

  • Protein details for TBC1D23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUY8-TBC23_HUMAN
    Recommended name:
    TBC1 domain family member 23
    Protein Accession:
    Q9NUY8
    Secondary Accessions:
    • B9A6M5
    • Q8TCN8
    • Q8WUB7
    • Q96D90
    • Q9NV75

    Protein attributes for TBC1D23 Gene

    Size:
    699 amino acids
    Molecular mass:
    78322 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH10221.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH20955.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91881.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TBC1D23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBC1D23 Gene

Proteomics data for TBC1D23 Gene at MOPED

Post-translational modifications for TBC1D23 Gene

  • Ubiquitination at Lys 495
  • Modification sites at PhosphoSitePlus

Other Protein References for TBC1D23 Gene

No data available for DME Specific Peptides for TBC1D23 Gene

Domains & Families for TBC1D23 Gene

Protein Domains for TBC1D23 Gene

Suggested Antigen Peptide Sequences for TBC1D23 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NUY8

UniProtKB/Swiss-Prot:

TBC23_HUMAN :
  • Contains 1 Rab-GAP TBC domain.
Domain:
  • Contains 1 Rab-GAP TBC domain.
  • Contains 1 rhodanese domain.
genes like me logo Genes that share domains with TBC1D23: view

No data available for Gene Families for TBC1D23 Gene

Function for TBC1D23 Gene

genes like me logo Genes that share phenotypes with TBC1D23: view

Animal Model Products

CRISPR Products

miRNA for TBC1D23 Gene

miRTarBase miRNAs that target TBC1D23

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBC1D23 Gene

Localization for TBC1D23 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBC1D23 Gene COMPARTMENTS Subcellular localization image for TBC1D23 gene
Compartment Confidence
golgi apparatus 3
cytosol 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TBC1D23 Gene

Pathways & Interactions for TBC1D23 Gene

SuperPathways for TBC1D23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TBC1D23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032755 positive regulation of interleukin-6 production IEA --
genes like me logo Genes that share ontologies with TBC1D23: view

No data available for Pathways by source and SIGNOR curated interactions for TBC1D23 Gene

Drugs & Compounds for TBC1D23 Gene

No Compound Related Data Available

Transcripts for TBC1D23 Gene

Unigene Clusters for TBC1D23 Gene

TBC1 domain family, member 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D23 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: - - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - -
SP8: - - - -
SP9: - - -
SP10:

ExUns: 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
SP1: -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TBC1D23 Gene

GeneLoc Exon Structure for
TBC1D23
ECgene alternative splicing isoforms for
TBC1D23

Expression for TBC1D23 Gene

mRNA expression in normal human tissues for TBC1D23 Gene

Protein differential expression in normal tissues from HIPED for TBC1D23 Gene

This gene is overexpressed in Salivary gland (10.3) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TBC1D23 Gene



SOURCE GeneReport for Unigene cluster for TBC1D23 Gene Hs.477003

genes like me logo Genes that share expression patterns with TBC1D23: view

Protein tissue co-expression partners for TBC1D23 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TBC1D23 Gene

Orthologs for TBC1D23 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBC1D23 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TBC1D23 35
  • 93.13 (n)
  • 96.14 (a)
TBC1D23 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBC1D23 35
  • 94.71 (n)
  • 96.71 (a)
TBC1D23 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbc1d23 35
  • 88.6 (n)
  • 94.44 (a)
Tbc1d23 16
Tbc1d23 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TBC1D23 35
  • 99.48 (n)
  • 99.28 (a)
TBC1D23 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbc1d23 35
  • 89.94 (n)
  • 94.99 (a)
oppossum
(Monodelphis domestica)
Mammalia TBC1D23 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TBC1D23 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves TBC1D23 35
  • 82.03 (n)
  • 89.96 (a)
TBC1D23 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBC1D23 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10381 35
tbc1d23 35
  • 74.92 (n)
  • 83.02 (a)
zebrafish
(Danio rerio)
Actinopterygii tbc1d23 35
  • 72.12 (n)
  • 78.68 (a)
zgc63756 35
tbc1d23 36
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007749 35
  • 51.23 (n)
  • 47.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4552 35
  • 50.25 (n)
  • 46.55 (a)
CG4552 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tbc-1 35
  • 47.29 (n)
  • 34.04 (a)
tbc-1 36
  • 32 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4706 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for TBC1D23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TBC1D23 Gene

ENSEMBL:
Gene Tree for TBC1D23 (if available)
TreeFam:
Gene Tree for TBC1D23 (if available)

Paralogs for TBC1D23 Gene

No data available for Paralogs for TBC1D23 Gene

Variants for TBC1D23 Gene

Sequence variations from dbSNP and Humsavar for TBC1D23 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs166748 -- 100,301,499(+) TTTTT(A/C)TATTT intron-variant
rs169357 -- 100,301,089(-) ttaca(C/G)aaata intron-variant
rs175822 -- 100,311,087(+) ATTGT(G/T)TCTTA intron-variant
rs364854 -- 100,308,471(-) gagac(A/G)gagtc intron-variant
rs1036770 -- 100,299,871(+) ACTAT(C/T)GCTTA intron-variant

Variation tolerance for TBC1D23 Gene

Residual Variation Intolerance Score: 10.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBC1D23 Gene

Human Gene Mutation Database (HGMD)
TBC1D23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TBC1D23 Gene

Disorders for TBC1D23 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TBC1D23 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pneumocystosis
  • pneumocystis carinii pneumonia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TBC1D23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TBC1D23
genes like me logo Genes that share disorders with TBC1D23: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TBC1D23 Gene

Publications for TBC1D23 Gene

  1. Spatiotemporal inhibition of innate immunity signaling by the Tbc1d23 RAB-GAP. (PMID: 22312129) De Arras L. … Alper S. (J. Immunol. 2012) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PMID: 24144296) Cheng C.Y. … Baird P.N. (Am. J. Hum. Genet. 2013) 3

Products for TBC1D23 Gene

Sources for TBC1D23 Gene

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