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TBC1D22B Gene

protein-coding   GIFtS: 45
GCID: GC06P037225

TBC1 Domain Family, Member 22B

(Previous name: chromosome 6 open reading frame 197)
(Previous symbol: C6orf197)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TBC1 Domain Family, Member 22B1 2
C6orf1971 2 3
Chromosome 6 Open Reading Frame 1971
dJ744I24.22
TBC1 Domain Family Member 22B2

External Ids:    HGNC: 216021   Entrez Gene: 556332   Ensembl: ENSG000000654917   UniProtKB: Q9NU193   

Export aliases for TBC1D22B gene to outside databases

Previous GC identifers: GC06P037334 GC06P036944


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TBC1D22B Gene:
TBC1D22B (TBC1 domain family, member 22B) is a protein-coding gene. Diseases associated with TBC1D22B include malaria. GO annotations related to this gene include Rab GTPase activator activity. An important paralog of this gene is TBCK.

UniProtKB/Swiss-Prot: TB22B_HUMAN, Q9NU19
Function: May act as a GTPase-activating protein for Rab family protein(s) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for TBC1D22B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTBC1D22B promoter sequence
   Search Chromatin IP Primers for TBC1D22B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TBC1D22B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21.2

TBC1D22B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TBC1D22B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P037225:  view genomic region     (about GC identifiers)

Start:
37,225,548 bp from pter      End:
37,300,746 bp from pter
Size:
75,199 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TB22B_HUMAN, Q9NU19 (See protein sequence)
Recommended Name: TBC1 domain family member 22B  
Size: 505 amino acids; 59081 Da
Sequence caution: Sequence=BAA91099.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for TBC1D22B:
3DZX (3D)    
Secondary accessions: Q32MQ8 Q5VUK9 Q7Z6P7 Q9BPV6 Q9BUT5 Q9NXB6

Explore the universe of human proteins at neXtProt for TBC1D22B: NX_Q9NU19

Explore proteomics data for TBC1D22B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TBC1D22B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060242.2  
    ENSEMBL proteins: 
     ENSP00000362590  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000195 Rab-GTPase-TBC_dom

    Graphical View of Domain Structure for InterPro Entry Q9NU19

    ProtoNet protein and cluster: Q9NU19

    1 Blocks protein domain: IPB000195 RabGAP/TBC domain

    UniProtKB/Swiss-Prot: TB22B_HUMAN, Q9NU19
    Similarity: Contains 1 Rab-GAP TBC domain


    TBC1D22B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TB22B_HUMAN, Q9NU19
    Function: May act as a GTPase-activating protein for Rab family protein(s) (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005097Rab GTPase activator activity IEA--
         
    TBC1D22B for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TBC1D22B
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    miRNA
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    miRTarBase miRNAs that target TBC1D22B:
    hsa-mir-122-5p (MIRT023331), hsa-mir-215-5p (MIRT024727), hsa-mir-335-5p (MIRT017891), hsa-mir-192-5p (MIRT026519)

    Block miRNA regulation of human, mouse, rat TBC1D22B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TBC1D22B (see all 67):
    hsa-miR-140-5p hsa-miR-631 hsa-miR-218-1* hsa-miR-128 hsa-miR-149 hsa-miR-208b hsa-miR-383 hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidTBC1D22B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TBC1D22B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D22B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    mitochondrion1
    nucleus1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TBC1D22B
    Interactions:

        Search GeneGlobe Interaction Network for TBC1D22B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TBC1D22B (Q9NU193 ENSP000003625904) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DYMQ7RTS93, ENSP000002694454I2D: score=2 STRING: ENSP00000269445
    COG6ENSP000003974414STRING: ENSP00000397441
    COG8ENSP000003054594STRING: ENSP00000305459
    SYS1ENSP000002439184STRING: ENSP00000243918
    ARFRP1ENSP000003268844STRING: ENSP00000326884
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032313regulation of Rab GTPase activity ----

    TBC1D22B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TBC1D22B (TB22B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TBC1D22B gene: 
    NM_017772.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000373491(uc003onn.3 uc010jwt.3 uc003ono.1 uc003onp.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat TBC1D22B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TBC1D22B (see all 67):
    hsa-miR-140-5p hsa-miR-631 hsa-miR-218-1* hsa-miR-128 hsa-miR-149 hsa-miR-208b hsa-miR-383 hsa-miR-3909
    SwitchGear 3'UTR luciferase reporter plasmidTBC1D22B 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TBC1D22B
    Predesigned siRNA for gene silencing in human, mouse, rat TBC1D22B
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    OriGene clones in human, mouse for TBC1D22B (see all 6)
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    GenScript: all cDNA clones in your preferred vector: TBC1D22B (NM_017772)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D22B
    Primer
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    OriGene qPCR primer pairs and template standards for TBC1D22B
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TBC1D22B
      QuantiTect SYBR Green Assays in human, mouse, rat TBC1D22B
      QuantiFast Probe-based Assays in human, mouse, rat TBC1D22B

    Selected AceView cDNA sequences (see all 133):

    CD674134 AL521025 BC002720 BQ438303 BQ707954 NM_017772 BM750148 BM725980 
    AA335499 AW629346 AY313781 AA948606 BI333073 BC063523 AA723807 AI279972 
    BQ637987 BM053100 AI278672 AI246672 CB159422 CK904001 AI366854 BC047658 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D22B (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                    -                                         -                                                         
    SP2:                    -                                                                                                   
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for TBC1D22B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TBC1D22B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATGTGTGA
    TBC1D22B Expression
    About this image


    TBC1D22B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Ovary (Reproductive System)
             Oviduct
    TBC1D22B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TBC1D22B Protein Expression
        Custom PCR Arrays for TBC1D22B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D22B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TBC1D22B gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tbc1d22b1 , 5 TBC1 domain family, member 22B1, 5 89.5(n)1
    98.81(a)1
      17 (15.43 cM)5
    3810851  NM_198647.11  NP_941049.11 
     295497885 
    chicken
    (Gallus gallus)
    Aves TBC1D22B1 TBC1 domain family, member 22B 81.65(n)
    93.27(a)
      421181  XM_419261.4  XP_419261.3 
    lizard
    (Anolis carolinensis)
    Reptilia TBC1D22B6
    TBC1 domain family, member 22B
    93(a)
    1 ↔ 1
    GL343382.1(268058-338850)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL865124.22   -- 79.13(n)    AL865124.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tbc1d22b6
    TBC1 domain family, member 22B
    63(a)
    1 ↔ 1
    8(10803415-10879501) ENSDARG00000026988
    fruit fly
    (Drosophila melanogaster)
    Insecta CG57451 CG5745 55.51(n)
    52.03(a)
      42498  NM_142684.3  NP_650941.3 
    worm
    (Caenorhabditis elegans)
    Secernentea tbc-31 tbc-3 56.56(n)
    54.29(a)
      177845  NM_001027994.2  NP_001023165.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GYP1(YOR070C)4 Cis-golgi GTPase-activating protein (GAP) for the Rab more   --   15(457820-455907) 854236  NP_014713.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G307101 AT2G30710 56.15(n)
    50.62(a)
      817622  NM_128624.1  NP_565706.1 
    rice
    (Oryza sativa)
    Liliopsida AK066076.12   -- 76.34(n)    AK066076.1 


    ENSEMBL Gene Tree for TBC1D22B (if available)
    TreeFam Gene Tree for TBC1D22B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TBC1D22B gene
    TBCK2  TBC1D22A2  
    2 SIMAP similar genes for TBC1D22B using alignment to 3 protein entries:     TB22B_HUMAN (see all proteins):
    DKFZp762J0110    TBC1D22A

    TBC1D22B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TBC1D22B (see all 1538)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1141075331,2
    C,F--37227976(+) GAATAG/TAACTT 1 -- int11Minor allele frequency- T:0.09WA 118
    rs1852484591,2
    --37228000(+) CTTTCA/GGTCTT 1 -- int10--------
    rs1441194601,2
    --37228007(+) TCTTAA/GAGAAG 1 -- int10--------
    rs1897004361,2
    --37228156(+) CTGATC/TATGAT 1 -- int10--------
    rs771722311,2
    --37228186(+) CAAATA/CGAAAT 1 -- int10--------
    rs1408993071,2
    --37228215(+) TTGCAA/GATGAA 1 -- int10--------
    rs1500841491,2
    C--37228289(+) TCTTTA/TAAAGT 1 -- int10--------
    rs1812995011,2
    C--37228298(+) GTGTAC/TAATTC 1 -- int10--------
    rs1848803901,2
    --37228356(+) CATCAC/TCACTA 1 -- int10--------
    rs117571321,2
    C,F,H--37228381(+) TCATCA/GTCCTG 1 -- int19Minor allele frequency- G:0.03NS EA NA 908

    HapMap Linkage Disequilibrium report for TBC1D22B (37225548 - 37300746 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TBC1D22B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731932CNV Deletion23290073
    esv2669404CNV Deletion23128226
    esv2068563CNV Deletion18987734
    nsv521807CNV Loss19592680
    esv987594CNV Gain20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TBC1D22B
    DNA2.0 Custom Variant and Variant Library Synthesis for TBC1D22B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for TBC1D22B:    
    About MalaCards
    malaria


    TBC1D22B for disorders           About GeneDecksing

    Genetic Association Database (GAD): TBC1D22B
    Human Genome Epidemiology (HuGE) Navigator: TBC1D22B (1 document)

    Export disorders for TBC1D22B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TBC1D22B gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with TBC1D22B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. (PubMed id 23572552)1 Greninger A.L....DeRisi J.L. (MBio 2013)
    6. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    9. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1 Ishibashi K.... Fukuda M. (Genes Cells 2009)
    10. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55633 HGNC: 21602 AceView: C6orf197 Ensembl:ENSG00000065491 euGenes: HUgn55633
    ECgene: TBC1D22B H-InvDB: TBC1D22B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TBC1D22B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TBC1D22B gene:
    Search GeneIP for patents involving TBC1D22B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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