TBC1D22B Gene
protein-coding GIFtS: 47
GCID: GC06P037225
|
|
TBC1 domain family, member 22B(Previous name: chromosome 6 open reading frame 197 )
(Previous symbol: C6orf197)
| |
Aliases
for TBC1D22B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TBC1 Domain Family, Member 22B1 2 | | Chromosome 6 Open Reading Frame 1971 | | C6orf1971 2 3 | | RP4-744I24.22 | | DJ744I24.21 | | TBC1 Domain Family Member 22B2 | | FLJ203371 | | |
Export aliases for TBC1D22B gene to outside databasesPrevious GC identifers: GC06P037334 GC06P036944 |
Summaries
for TBC1D22B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TB22B_HUMAN, Q9NU19Function: May act as a GTPase-activating protein for Rab family protein(s) (By similarity)
|
Genomic Views
for TBC1D22B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TBC1D22B
Other transcription factors
Search SABiosciences Chromatin IP Primers for TBC1D22B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBC1D22B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.2 Ensembl cytogenetic band: 6p21.2 HGNC cytogenetic band: 6p21.2TBC1D22B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P037225: view genomic region
(about GC identifiers)
Start:
|
37,225,548 bp from pter |
End:
|
37,300,746 bp from pter |
Size:
|
75,199 bases |
Orientation:
|
plus strand |
|
Proteins
for TBC1D22B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TB22B_HUMAN, Q9NU19 (See
protein sequence)Recommended Name: TBC1 domain family member 22B Size: 505 amino acids; 59081 Da
Sequence caution: Sequence=BAA91099.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for TBC1D22B:3DZX (3D)
Secondary accessions: Q32MQ8 Q5VUK9 Q7Z6P7 Q9BPV6 Q9BUT5 Q9NXB6Explore the universe of human proteins at neXtProt for TBC1D22B: NX_Q9NU19
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NU19
TBC1D22B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060242.2
ENSEMBL proteins: ENSP00000362590
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
TBC1D22B for ontologies About GeneDecksing
TBC1D22B Antibody Products:
Assay Products for TBC1D22B: |
Protein
Domains /
Families
for TBC1D22B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TBC1D22B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NU19ProtoNet protein and cluster: Q9NU19 1 Blocks protein family: IPB000195 RabGAP/TBC domain
UniProtKB/Swiss-Prot: TB22B_HUMAN, Q9NU19Similarity: Contains 1 Rab-GAP TBC domain |
Function
for TBC1D22B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TB22B_HUMAN, Q9NU19Function: May act as a GTPase-activating protein for Rab family protein(s) (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D22B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D22B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TBC1D22B (NM_017772) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBC1D22B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D22B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D22B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005097 | Rab GTPase activator activity |
IEA | -- |
TBC1D22B for ontologies About GeneDecksing
|
Pathways & Interactions
for TBC1D22B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBC1D22B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/8 Interacting proteins for TBC1D22B (Q9NU193 ENSP000003625904) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
|
Drugs & Compounds
for TBC1D22B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TBC1D22B
Search CenterWatch for drugs/clinical trials and news about TBC1D22B / TB22B
|
Transcripts
for TBC1D22B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TBC1D22B gene: NM_017772.2 Unigene Cluster for TBC1D22B: TBC1 domain family, member 22B Hs.731702 [show with all ESTs]Unigene Representative Sequence: BC0476581 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000373491(uc003onn.3 uc010jwt.3 uc003ono.1 uc003onp.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D22B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D22B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TBC1D22B (NM_017772) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBC1D22B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D22B |
Additional cDNA sequence: AB449909.1 AK000344.1 AK021840.1 AK096340.1 AK292893.1 AY313781.1 AY927466.1 AY927467.1 BC000291.2 BC000743.2 BC001927.1 BC002720.2 BC047658.1 BC063523.1 BC109026.1 BC109027.1 BX648317.1 CR749710.1 11 DOTS entries: DT.453005 DT.101982439 DT.121353515 DT.75144988 DT.427275 DT.100780068 DT.121353553 DT.422189 DT.91697826 DT.92064882 DT.95258077 24/133 AceView cDNA sequences (see all 133): AL521025 CD674134 CB159422 CK904001 AI366854 BC047658 BC002720 BQ707954 BQ438303 AY313781 AI246672 NM_017772 BM725980 AI278672 BM053100 BQ637987 BC063523 AA948606 AI279972 AA723807 AW629346 BI333073 AA335499 BM750148
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D22B (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TBC1D22B
|
Expression
for TBC1D22B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TBC1D22B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGATGTGTGA
About this image
See TBC1D22B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TBC1D22B
SOURCE GeneReport for Unigene cluster: Hs.731702
SABiosciences Custom PCR Arrays for TBC1D22B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBC1D22B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TBC1D22B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBC1D22B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBC1D22B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D22B |
Orthologs
for TBC1D22B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TBC1D22B gene from 8/30 species (see all 30) About this table
ENSEMBL Gene Tree for TBC1D22B (if available)
TreeFam Gene Tree for TBC1D22B (if available) |
Paralogs
for TBC1D22B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TBC1D22B gene
- TBC1D132 TBC1D22A2 TBC1D52
2 SIMAP similar genes for TBC1D22B using alignment to 3 protein entries: TB22B_HUMAN (see all proteins):DKFZp762J0110 TBC1D22A
TBC1D22B for paralogs About GeneDecksing
|
Genomic Variants
for TBC1D22B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TBC1D22B (37225548 - 37300746 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TBC1D22B
1 Indel: 47115 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBC1D22B |
|
Disorders
/ Diseases
for TBC1D22B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TBC1D22B for disorders About GeneDecksing
1  disease for TBC1D22B: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: TBC1D22B (1 document)
Export disorders for TBC1D22B gene to outside databases
|
Publications
for TBC1D22B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TBC1D22B gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TBC1D22B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1 Ishibashi K.... Fukuda M. (2009)
- Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays. (PubMed id 15998911)1 Kapranov P....Gingeras T.R. (2005)
- Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. (PubMed id 15790807)1 Cheng J....Gingeras T.R. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TBC1D22B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TBC1D22B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBC1D22B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TBC1D22B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TBC1D22B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TBC1D22B gene:
Search GeneIP for patents involving TBC1D22B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TBC1D22B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TBC1D22B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TBC1D22B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBC1D22B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TBC1D22B | | OriGene 3'-UTR Clone for TBC1D22B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D22B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D22B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TBC1D22B | | OriGene Custom Protein Services for TBC1D22B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TBC1D22B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBC1D22B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBC1D22B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBC1D22B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBC1D22B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBC1D22B |
| |
 |  |  |  | |
| | | |  |  |  |  | | | | |
 |
 |
 |
 | | | TBC1D22B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D22B |
|  |  |  | | | | Search ThermoFisher Antibodies for TBC1D22B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D22B |
|
|
|
|
