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Aliases for TBC1D22B Gene

Aliases for TBC1D22B Gene

  • TBC1 Domain Family, Member 22B 2 3
  • C6orf197 3 4
  • Chromosome 6 Open Reading Frame 197 2
  • TBC1 Domain Family Member 22B 3

External Ids for TBC1D22B Gene

Previous HGNC Symbols for TBC1D22B Gene

  • C6orf197

Previous GeneCards Identifiers for TBC1D22B Gene

  • GC06P037334
  • GC06P036944

Summaries for TBC1D22B Gene

GeneCards Summary for TBC1D22B Gene

TBC1D22B (TBC1 Domain Family, Member 22B) is a Protein Coding gene. An important paralog of this gene is TBC1D22A.

UniProtKB/Swiss-Prot for TBC1D22B Gene

  • May act as a GTPase-activating protein for Rab family protein(s).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D22B Gene

Genomics for TBC1D22B Gene

Genomic Location for TBC1D22B Gene

37,257,752 bp from pter
37,332,970 bp from pter
75,219 bases
Plus strand

Genomic View for TBC1D22B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBC1D22B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D22B Gene

No data available for Regulatory Elements for TBC1D22B Gene

Proteins for TBC1D22B Gene

  • Protein details for TBC1D22B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TBC1 domain family member 22B
    Protein Accession:
    Secondary Accessions:
    • A8KA28
    • Q32MQ8
    • Q5VUK9
    • Q6P4C3
    • Q7Z6P7
    • Q9BPV6
    • Q9BUT5
    • Q9NXB6

    Protein attributes for TBC1D22B Gene

    505 amino acids
    Molecular mass:
    59081 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91099.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TBC1D22B Gene

neXtProt entry for TBC1D22B Gene

Proteomics data for TBC1D22B Gene at MOPED

Post-translational modifications for TBC1D22B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBC1D22B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TBC1D22B Gene

Domains for TBC1D22B Gene

Protein Domains for TBC1D22B Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Rab-GAP TBC domain.
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with TBC1D22B: view

No data available for Gene Families for TBC1D22B Gene

Function for TBC1D22B Gene

Molecular function for TBC1D22B Gene

UniProtKB/Swiss-Prot Function:
May act as a GTPase-activating protein for Rab family protein(s).

Gene Ontology (GO) - Molecular Function for TBC1D22B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TBC1D22B: view

Animal Model Products

CRISPR Products

miRNA for TBC1D22B Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBC1D22B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for TBC1D22B Gene

Localization for TBC1D22B Gene

Subcellular locations from

Jensen Localization Image for TBC1D22B Gene COMPARTMENTS Subcellular localization image for TBC1D22B gene
Compartment Confidence
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TBC1D22B Gene

Pathways for TBC1D22B Gene

SuperPathways for TBC1D22B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TBC1D22B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
GO:1902017 NOT regulation of cilium assembly IMP 17646400
genes like me logo Genes that share ontologies with TBC1D22B: view

No data available for Pathways by source for TBC1D22B Gene

Transcripts for TBC1D22B Gene

Unigene Clusters for TBC1D22B Gene

TBC1 domain family, member 22B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBC1D22B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D22B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - -
SP2: -
SP6: - -

Relevant External Links for TBC1D22B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBC1D22B Gene

mRNA expression in normal human tissues for TBC1D22B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TBC1D22B Gene

This gene is overexpressed in Bone (27.3), Pancreatic juice (25.3), and Testis (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TBC1D22B Gene

SOURCE GeneReport for Unigene cluster for TBC1D22B Gene Hs.731702

genes like me logo Genes that share expressions with TBC1D22B: view

Expression partners for TBC1D22B Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TBC1D22B Gene

Orthologs for TBC1D22B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TBC1D22B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TBC1D22B 35
  • 93.14 (n)
  • 98.61 (a)
TBC1D22B 36
  • 99 (a)
(Canis familiaris)
Mammalia TBC1D22B 35
  • 93.7 (n)
  • 98.77 (a)
TBC1D22B 36
  • 98 (a)
(Mus musculus)
Mammalia Tbc1d22b 35
  • 89.5 (n)
  • 98.81 (a)
Tbc1d22b 16
Tbc1d22b 36
  • 99 (a)
(Pan troglodytes)
Mammalia TBC1D22B 35
  • 99.8 (n)
  • 99.6 (a)
TBC1D22B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tbc1d22b 35
  • 90.43 (n)
  • 98.42 (a)
(Monodelphis domestica)
Mammalia TBC1D22B 36
  • 27 (a)
(Ornithorhynchus anatinus)
Mammalia TBC1D22B 36
  • 92 (a)
(Gallus gallus)
Aves TBC1D22B 35
  • 81.65 (n)
  • 93.27 (a)
TBC1D22B 36
  • 93 (a)
(Anolis carolinensis)
Reptilia TBC1D22B 36
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tbc1d22b 35
  • 74.32 (n)
  • 85.37 (a)
(Danio rerio)
Actinopterygii tbc1d22b 36
  • 63 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004522 35
  • 53.39 (n)
  • 48.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5745 35
  • 55.51 (n)
  • 52.03 (a)
CG5745 36
  • 42 (a)
(Caenorhabditis elegans)
Secernentea tbc-3 35
  • 56.56 (n)
  • 54.29 (a)
tbc-3 36
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GYP1 36
  • 29 (a)
GYP1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G30710 35
  • 56.15 (n)
  • 50.62 (a)
(Oryza sativa)
Liliopsida Os09g0515800 35
  • 56.15 (n)
  • 49.69 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3104 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04241 35
  • 51.85 (n)
  • 44.68 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gyp1 35
  • 52.12 (n)
  • 48.51 (a)
Species with no ortholog for TBC1D22B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TBC1D22B Gene

Gene Tree for TBC1D22B (if available)
Gene Tree for TBC1D22B (if available)

Paralogs for TBC1D22B Gene

Paralogs for TBC1D22B Gene

(2) SIMAP similar genes for TBC1D22B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TBC1D22B: view

Variants for TBC1D22B Gene

Sequence variations from dbSNP and Humsavar for TBC1D22B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1447 -- 37,294,888(-) tgact(C/T)cttga intron-variant
rs1449 -- 37,294,847(-) gcagg(C/T)atgaa intron-variant
rs149701 -- 37,315,171(-) GTATT(C/T)GTAAG intron-variant
rs149702 -- 37,314,880(-) AAATG(C/T)TAAGT intron-variant
rs149703 -- 37,314,765(-) AGGTA(A/G)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TBC1D22B Gene

Variant ID Type Subtype PubMed ID
esv2068563 CNV Deletion 18987734
esv2731932 CNV Deletion 23290073
esv2669404 CNV Deletion 23128226
nsv521807 CNV Loss 19592680
esv987594 CNV Gain 20482838

Relevant External Links for TBC1D22B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D22B Gene

Disorders for TBC1D22B Gene

Relevant External Links for TBC1D22B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for TBC1D22B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TBC1D22B Gene

Publications for TBC1D22B Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K. … Fukuda M. (Genes Cells 2009) 3 4

Products for TBC1D22B Gene

Sources for TBC1D22B Gene

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