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Aliases for TBC1D21 Gene

Aliases for TBC1D21 Gene

  • TBC1 Domain Family Member 21 2 3 5
  • TBC1 Domain Family, Member 21 2 3
  • Male Germ Cell-Specific Expressed, Containing A RabGAP Domain 3
  • Male Germ Cell-Specific Expressed 2
  • Containing A RabGAP Domain 2
  • MgcRabGAP 3

External Ids for TBC1D21 Gene

Previous GeneCards Identifiers for TBC1D21 Gene

  • GC15P071954
  • GC15P074165
  • GC15P050997

Summaries for TBC1D21 Gene

GeneCards Summary for TBC1D21 Gene

TBC1D21 (TBC1 Domain Family Member 21) is a Protein Coding gene. GO annotations related to this gene include actin binding and Rab GTPase binding.

UniProtKB/Swiss-Prot for TBC1D21 Gene

  • May act as a GTPase-activating protein for Rab family protein(s).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D21 Gene

Genomics for TBC1D21 Gene

Regulatory Elements for TBC1D21 Gene

Genomic Location for TBC1D21 Gene

Chromosome:
15
Start:
73,873,575 bp from pter
End:
73,909,783 bp from pter
Size:
36,209 bases
Orientation:
Plus strand

Genomic View for TBC1D21 Gene

Genes around TBC1D21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D21 Gene

Proteins for TBC1D21 Gene

  • Protein details for TBC1D21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYX1-TBC21_HUMAN
    Recommended name:
    TBC1 domain family member 21
    Protein Accession:
    Q8IYX1
    Secondary Accessions:
    • B9A6M2

    Protein attributes for TBC1D21 Gene

    Size:
    336 amino acids
    Molecular mass:
    39221 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TBC1D21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBC1D21 Gene

Proteomics data for TBC1D21 Gene at MOPED

Post-translational modifications for TBC1D21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBC1D21 Gene

No data available for DME Specific Peptides for TBC1D21 Gene

Domains & Families for TBC1D21 Gene

Protein Domains for TBC1D21 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TBC1D21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYX1

UniProtKB/Swiss-Prot:

TBC21_HUMAN :
  • The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rabs switch 2 glutamine and insert in Rabs active site.
Domain:
  • The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rabs switch 2 glutamine and insert in Rabs active site.
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with TBC1D21: view

No data available for Gene Families for TBC1D21 Gene

Function for TBC1D21 Gene

Molecular function for TBC1D21 Gene

UniProtKB/Swiss-Prot Function:
May act as a GTPase-activating protein for Rab family protein(s).

Gene Ontology (GO) - Molecular Function for TBC1D21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0017137 NOT Rab GTPase binding IMP 16923123
genes like me logo Genes that share ontologies with TBC1D21: view

Phenotypes for TBC1D21 Gene

genes like me logo Genes that share phenotypes with TBC1D21: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBC1D21 Gene

Localization for TBC1D21 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBC1D21 Gene COMPARTMENTS Subcellular localization image for TBC1D21 gene
Compartment Confidence
extracellular 5
cytosol 2
mitochondrion 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for TBC1D21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0012505 endomembrane system IBA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TBC1D21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TBC1D21 Gene

Pathways & Interactions for TBC1D21 Gene

SuperPathways for TBC1D21 Gene

No Data Available

Interacting Proteins for TBC1D21 Gene

Gene Ontology (GO) - Biological Process for TBC1D21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0090630 activation of GTPase activity IBA --
genes like me logo Genes that share ontologies with TBC1D21: view

No data available for Pathways by source and SIGNOR curated interactions for TBC1D21 Gene

Drugs & Compounds for TBC1D21 Gene

No Compound Related Data Available

Transcripts for TBC1D21 Gene

mRNA/cDNA for TBC1D21 Gene

Unigene Clusters for TBC1D21 Gene

TBC1 domain family, member 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D21 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -

Relevant External Links for TBC1D21 Gene

GeneLoc Exon Structure for
TBC1D21
ECgene alternative splicing isoforms for
TBC1D21

Expression for TBC1D21 Gene

mRNA expression in normal human tissues for TBC1D21 Gene

mRNA differential expression in normal tissues according to GTEx for TBC1D21 Gene

This gene is overexpressed in Testis (x52.5).

Protein differential expression in normal tissues from HIPED for TBC1D21 Gene

This gene is overexpressed in Testis (44.5), Ovary (13.9), and Heart (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TBC1D21 Gene



SOURCE GeneReport for Unigene cluster for TBC1D21 Gene Hs.124512

genes like me logo Genes that share expression patterns with TBC1D21: view

Protein tissue co-expression partners for TBC1D21 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TBC1D21 Gene

Orthologs for TBC1D21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TBC1D21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBC1D21 35
  • 99.6 (n)
  • 99.11 (a)
TBC1D21 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TBC1D21 36
  • 93 (a)
OneToOne
TBC1D21 35
  • 89.97 (n)
  • 92.31 (a)
dog
(Canis familiaris)
Mammalia TBC1D21 35
  • 89.98 (n)
  • 90.18 (a)
TBC1D21 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbc1d21 16
Tbc1d21 36
  • 87 (a)
OneToOne
Tbc1d21 35
  • 87.1 (n)
  • 87.2 (a)
oppossum
(Monodelphis domestica)
Mammalia TBC1D21 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TBC1D21 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbc1d21 35
  • 86.41 (n)
  • 86.9 (a)
lizard
(Anolis carolinensis)
Reptilia TBC1D21 36
  • 59 (a)
OneToOne
Species with no ortholog for TBC1D21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TBC1D21 Gene

ENSEMBL:
Gene Tree for TBC1D21 (if available)
TreeFam:
Gene Tree for TBC1D21 (if available)

Paralogs for TBC1D21 Gene

(1) SIMAP similar genes for TBC1D21 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TBC1D21: view

No data available for Paralogs for TBC1D21 Gene

Variants for TBC1D21 Gene

Sequence variations from dbSNP and Humsavar for TBC1D21 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs16958445 - 73,884,216(+) GCACC(A/G)GAACT reference, missense, utr-variant-5-prime
rs13638 -- 73,889,197(-) ACTGT(C/T)TATAT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs2084851 -- 73,879,027(-) AATCT(C/T)GGTGT intron-variant
rs2053959 -- 73,884,858(+) AGATC(C/T)TGCTC reference, synonymous-codon, utr-variant-5-prime
rs4257159 -- 73,892,325(+) gagct(A/G)taaca intron-variant

Variation tolerance for TBC1D21 Gene

Residual Variation Intolerance Score: 63.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBC1D21 Gene

HapMap Linkage Disequilibrium report
TBC1D21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TBC1D21 Gene

Disorders for TBC1D21 Gene

Relevant External Links for TBC1D21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TBC1D21

No disorders were found for TBC1D21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D21 Gene

Publications for TBC1D21 Gene

  1. Identification and characterization of a novel Rab GTPase-activating protein in spermatids. (PMID: 21128978) Lin Y.H. … Kuo P.L. (Int. J. Androl. 2011) 2 3 67
  2. Novel common variants and susceptible haplotype for exfoliation glaucoma specific to Asian population. (PMID: 24938310) Nakano M. … Tashiro K. (Sci Rep 2014) 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  5. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K. … Fukuda M. (Genes Cells 2009) 3

Products for TBC1D21 Gene

Sources for TBC1D21 Gene

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