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Aliases for TBC1D21 Gene

Aliases for TBC1D21 Gene

  • TBC1 Domain Family, Member 21 2 3
  • Male Germ Cell-Specific Expressed, Containing A RabGAP Domain 3
  • Male Germ Cell-Specific Expressed 2
  • TBC1 Domain Family Member 21 3
  • Containing A RabGAP Domain 2
  • MgcRabGAP 3

External Ids for TBC1D21 Gene

Previous GeneCards Identifiers for TBC1D21 Gene

  • GC15P071954
  • GC15P074165
  • GC15P050997

Summaries for TBC1D21 Gene

GeneCards Summary for TBC1D21 Gene

TBC1D21 (TBC1 Domain Family, Member 21) is a Protein Coding gene. GO annotations related to this gene include actin binding.

UniProtKB/Swiss-Prot for TBC1D21 Gene

  • May act as a GTPase-activating protein for Rab family protein(s)

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D21 Gene

Genomics for TBC1D21 Gene

Regulatory Elements for TBC1D21 Gene

Genomic Location for TBC1D21 Gene

73,873,581 bp from pter
73,889,214 bp from pter
15,634 bases
Plus strand

Genomic View for TBC1D21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBC1D21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D21 Gene

Proteins for TBC1D21 Gene

  • Protein details for TBC1D21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TBC1 domain family member 21
    Protein Accession:
    Secondary Accessions:
    • B9A6M2

    Protein attributes for TBC1D21 Gene

    336 amino acids
    Molecular mass:
    39221 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TBC1D21 Gene


neXtProt entry for TBC1D21 Gene

Proteomics data for TBC1D21 Gene at MOPED

Post-translational modifications for TBC1D21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBC1D21 Gene

No data available for DME Specific Peptides for TBC1D21 Gene

Domains for TBC1D21 Gene

Protein Domains for TBC1D21 Gene


Suggested Antigen Peptide Sequences for TBC1D21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8IYX1
  • The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rabs switch 2 glutamine and insert in Rabs active site.
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with TBC1D21: view

No data available for Gene Families for TBC1D21 Gene

Function for TBC1D21 Gene

Molecular function for TBC1D21 Gene

UniProtKB/Swiss-Prot Function: May act as a GTPase-activating protein for Rab family protein(s)

Gene Ontology (GO) - Molecular Function for TBC1D21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005096 GTPase activator activity IEA --
GO:0017137 NOT Rab GTPase binding IMP 16923123
genes like me logo Genes that share ontologies with TBC1D21: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TBC1D21 Gene

Localization for TBC1D21 Gene

Subcellular locations from

Jensen Localization Image for TBC1D21 Gene COMPARTMENTS Subcellular localization image for TBC1D21 gene
Compartment Confidence
cytosol 2
mitochondrion 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for TBC1D21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TBC1D21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TBC1D21 Gene

Pathways for TBC1D21 Gene

SuperPathways for TBC1D21 Gene

No Data Available

Interacting Proteins for TBC1D21 Gene

Gene Ontology (GO) - Biological Process for TBC1D21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
GO:1902017 NOT regulation of cilium assembly IMP 17646400
genes like me logo Genes that share ontologies with TBC1D21: view

No data available for Pathways by source for TBC1D21 Gene

Transcripts for TBC1D21 Gene

mRNA/cDNA for TBC1D21 Gene

Unigene Clusters for TBC1D21 Gene

TBC1 domain family, member 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D21 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP2: -

Relevant External Links for TBC1D21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBC1D21 Gene

mRNA expression in normal human tissues for TBC1D21 Gene

mRNA differential expression in normal tissues according to GTEx for TBC1D21 Gene

This gene is overexpressed in Testis (52.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TBC1D21 Gene

SOURCE GeneReport for Unigene cluster for TBC1D21 Gene Hs.124512

genes like me logo Genes that share expressions with TBC1D21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TBC1D21 Gene

Orthologs for TBC1D21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TBC1D21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TBC1D21 35
  • 99.6 (n)
  • 99.11 (a)
TBC1D21 36
  • 99 (a)
(Bos Taurus)
Mammalia TBC1D21 35
  • 89.97 (n)
  • 92.31 (a)
TBC1D21 36
  • 93 (a)
(Canis familiaris)
Mammalia TBC1D21 35
  • 89.98 (n)
  • 90.18 (a)
TBC1D21 36
  • 90 (a)
(Mus musculus)
Mammalia Tbc1d21 35
  • 87.1 (n)
  • 87.2 (a)
Tbc1d21 16
Tbc1d21 36
  • 87 (a)
(Monodelphis domestica)
Mammalia TBC1D21 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia TBC1D21 36
  • 83 (a)
(Rattus norvegicus)
Mammalia Tbc1d21 35
  • 86.41 (n)
  • 86.9 (a)
(Anolis carolinensis)
Reptilia TBC1D21 36
  • 59 (a)
Species with no ortholog for TBC1D21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TBC1D21 Gene

Gene Tree for TBC1D21 (if available)
Gene Tree for TBC1D21 (if available)

Paralogs for TBC1D21 Gene

Selected SIMAP similar genes for TBC1D21 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TBC1D21: view

No data available for Paralogs for TBC1D21 Gene

Variants for TBC1D21 Gene

Sequence variations from dbSNP and Humsavar for TBC1D21 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs13638 -- 73,889,197(-) ACTGT(C/T)TATAT utr-variant-3-prime, downstream-variant-500B, nc-transcript-variant
rs896590 -- 73,885,212(+) TCCAG(C/G)CTTCT intron-variant
rs2053959 -- 73,884,858(+) AGATC(C/T)TGCTC reference, synonymous-codon, utr-variant-5-prime, nc-transcript-variant
rs2069320 -- 73,887,066(-) CTGCT(C/G)ATGGC intron-variant
rs2084851 -- 73,879,027(-) AATCT(C/T)GGTGT intron-variant

Relevant External Links for TBC1D21 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TBC1D21 Gene

Disorders for TBC1D21 Gene

No disorders were found for TBC1D21 Gene.

No data available for UniProtKB/Swiss-Prot for TBC1D21 Gene

Publications for TBC1D21 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K. … Fukuda M. (Genes Cells 2009) 3 4
  3. Identification and characterization of a novel Rab GTPase-activating protein in spermatids. (PMID: 21128978) Lin Y.H. … Kuo P.L. (Int. J. Androl. 2011) 2 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Novel common variants and susceptible haplotype for exfoliation glaucoma specific to Asian population. (PMID: 24938310) Nakano M. … Tashiro K. (Sci Rep 2014) 3

Products for TBC1D21 Gene

Sources for TBC1D21 Gene

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