TBC1D20 Gene
protein-coding GIFtS: 45
GCID: GC20M000416
|
|
TBC1 domain family, member 20(Previous name: chromosome 20 open reading frame 140 )
(Previous symbol: C20orf140)
| |
Aliases
for TBC1D20 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TBC1 Domain Family, Member 201 2 | | C20orf1401 2 3 5 | | Chromosome 20 Open Reading Frame 1401 | | DJ852M4.21 | | TBC1 Domain Family Member 202 |
Export aliases for TBC1D20 gene to outside databasesPrevious GC identifer: GC20M000367 |
Summaries
for TBC1D20 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TBC20_HUMAN, Q96BZ9Function: May act as a GTPase-activating protein for Rab family protein(s)
|
Genomic Views
for TBC1D20 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TBC1D20 gene promoter:
STAT5B Sox5 GATA-3 AML1a C/EBPalpha POU2F1 POU2F1a Sox9 STAT3 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for TBC1D20
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBC1D20 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13TBC1D20 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M000416: view genomic region
(about GC identifiers)
Start:
|
416,124 bp from pter |
End:
|
443,197 bp from pter |
Size:
|
27,074 bases |
Orientation:
|
minus strand |
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Proteins
for TBC1D20 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TBC20_HUMAN, Q96BZ9 (See
protein sequence)Recommended Name: TBC1 domain family member 20 Size: 403 amino acids; 45855 Da
Subunit: Directly interacts with the N-terminal amphipathic helix of hepatitis C virus (HCV) NS5A
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
2 PDB 3D structures from  and Proteopedia  for TBC1D20:4HL4 (3D)
4HLQ (3D)
Secondary accessions: A8K6I3 Q5JWQ7 Q6ZSY8 Q96NE1 Q9BYM7 Q9H140Alternative splicing: 3 isoforms: Q96BZ9-1 Q96BZ9-2 Q96BZ9-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TBC1D20: NX_Q96BZ9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96BZ9
TBC1D20 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653229.1
ENSEMBL proteins: ENSP00000432280 ENSP00000346139
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TBC1D20 for ontologies About GeneDecksing
TBC1D20 Antibody Products:
Assay Products for TBC1D20: |
Protein
Domains /
Families
for TBC1D20 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TBC1D20 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96BZ9ProtoNet protein and cluster: Q96BZ9 1 Blocks protein family: IPB000195 RabGAP/TBC domain
UniProtKB/Swiss-Prot: TBC20_HUMAN, Q96BZ9Similarity: Contains 1 Rab-GAP TBC domain |
Function
for TBC1D20 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TBC20_HUMAN, Q96BZ9Function: May act as a GTPase-activating protein for Rab family protein(s)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D20 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D20
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D20 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005097 | Rab GTPase activator activity |
IEA | -- |
TBC1D20 for ontologies About GeneDecksing
|
Pathways & Interactions
for TBC1D20 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBC1D20
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for TBC1D20 (Q96BZ93 ENSP000003461394) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019048 | virus-host interaction |
IEA | -- | | GO:0044419 | interspecies interaction between organisms |
-- | -- |
TBC1D20 for ontologies About GeneDecksing
|
Drugs & Compounds
for TBC1D20 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TBC1D20
Search CenterWatch for drugs/clinical trials and news about TBC1D20 / TBC20
|
Transcripts
for TBC1D20 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TBC1D20 gene: NM_144628.2 Unigene Cluster for TBC1D20: TBC1 domain family, member 20 Hs.590876 [show with all ESTs]Unigene Representative Sequence: BX6473704 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000461188 ENST00000461304 ENST00000354200(uc002wds.3 uc002wdt.3 uc002wdv.3)
ENST00000494633
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D20 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D20
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TBC1D20 (NM_144628) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBC1D20 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D20 |
Additional cDNA sequence: AB449906.1 AF116909.1 AK055488.1 AK055573.1 AK092063.1 AK095110.1 AK291648.1 BC014648.1 BC047616.1 BX647370.1 14 DOTS entries: DT.101984765 DT.101984764 DT.100027958 DT.449727 DT.100650382 DT.95254074 DT.100001328 DT.100816828 DT.102830204 DT.75188690 DT.100816830 DT.407716 DT.407717 DT.95263804 24/226 AceView cDNA sequences (see all 226): BM928614 BX369519 AI242835 W77983 CR611379 BM918467 BQ643538 BC047616 BC014648 BM354028 AW074047 BE276163 BQ650018 BE349614 BQ956553 CR622506 AI206491 AA857033 BM480403 BM676962 AA182783 AI299608 AI560940 AI287660
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D20 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 |
|---|
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| SP1: | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | - | | | | - | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TBC1D20
|
Expression
for TBC1D20 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TBC1D20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGACCAGGGT
About this image
See TBC1D20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TBC1D20
SOURCE GeneReport for Unigene cluster: Hs.590876
SABiosciences Custom PCR Arrays for TBC1D20
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBC1D20
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TBC1D20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBC1D20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBC1D20 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D20 |
Orthologs
for TBC1D20 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TBC1D20 gene from 7/28 species (see all 28) About this table
ENSEMBL Gene Tree for TBC1D20 (if available)
TreeFam Gene Tree for TBC1D20 (if available) |
Paralogs
for TBC1D20 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TBC1D20 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TBC1D20 (416124 - 443197 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for TBC1D20
4 CNVs: 2250 5120 31028 102894
1 Indel: 26824 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBC1D20 |
|
Disorders
/ Diseases
for TBC1D20 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TBC1D20 for disorders About GeneDecksing
OMIM gene information: 611663
OMIM disorders: --
2  diseases for TBC1D20: About MalaCardshepatitis c hepatitis
Export disorders for TBC1D20 gene to outside databases
|
Publications
for TBC1D20 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TBC1D20 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with TBC1D20) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A Rab-GAP TBC domain protein binds hepatitis C virus NS5A and mediates viral replication. (PubMed id 17686842)1, 2 Sklan E.H.... Glenn J.S. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Role for TBC1D20 and Rab1 in hepatitis C virus replica tion via interaction with lipid droplet-bound nonstructural protein 5A. (PubMed id 22491470)1 Nevo-Yassaf I....Sklan E.H. (2012)
- Human immunodeficiency virus type 1 envelope proteins traffic toward virion assembly sites via a TBC1D20/Rab1-regulated pathway. (PubMed id 22260459)1 Nachmias D....Bacharach E. (2012)
- Catalytic mechanism of a mammalian Rab^RabGAP complex in atomic detail. (PubMed id 23236136)1 Gavriljuk K....Gerwert K. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
|
External Searches for TBC1D20 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TBC1D20 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBC1D20 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TBC1D20 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TBC1D20 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TBC1D20 gene:
Search GeneIP for patents involving TBC1D20
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TBC1D20 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TBC1D20 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBC1D20 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for TBC1D20 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D20 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D20 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TBC1D20 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TBC1D20 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBC1D20 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBC1D20 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBC1D20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBC1D20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBC1D20 |
| |
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| |  |  |  |  | | | | |
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 | | | TBC1D20 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D20 |
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