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Aliases for TBC1D19 Gene

Aliases for TBC1D19 Gene

  • TBC1 Domain Family, Member 19 2 3

External Ids for TBC1D19 Gene

Previous GeneCards Identifiers for TBC1D19 Gene

  • GC04P026262
  • GC04P025923

Summaries for TBC1D19 Gene

GeneCards Summary for TBC1D19 Gene

TBC1D19 (TBC1 Domain Family, Member 19) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TBC1D19 Gene

  • May act as a GTPase-activating protein for Rab family protein(s)

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D19 Gene

Genomics for TBC1D19 Gene

Regulatory Elements for TBC1D19 Gene

Genomic Location for TBC1D19 Gene

26,576,437 bp from pter
26,756,610 bp from pter
180,174 bases
Plus strand

Genomic View for TBC1D19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBC1D19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D19 Gene

Proteins for TBC1D19 Gene

  • Protein details for TBC1D19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TBC1 domain family member 19
    Protein Accession:
    Secondary Accessions:
    • B9A6M0
    • Q9NUX1

    Protein attributes for TBC1D19 Gene

    526 amino acids
    Molecular mass:
    60208 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TBC1D19 Gene


neXtProt entry for TBC1D19 Gene

Proteomics data for TBC1D19 Gene at MOPED

Post-translational modifications for TBC1D19 Gene

  • Ubiquitination at Lys234
  • Modification sites at PhosphoSitePlus

Other Protein References for TBC1D19 Gene

Antibody Products

No data available for DME Specific Peptides for TBC1D19 Gene

Domains for TBC1D19 Gene

Protein Domains for TBC1D19 Gene


Suggested Antigen Peptide Sequences for TBC1D19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Rab-GAP TBC domain.
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with TBC1D19: view

No data available for Gene Families for TBC1D19 Gene

Function for TBC1D19 Gene

Molecular function for TBC1D19 Gene

UniProtKB/Swiss-Prot Function:
May act as a GTPase-activating protein for Rab family protein(s)

Gene Ontology (GO) - Molecular Function for TBC1D19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 22354992
genes like me logo Genes that share ontologies with TBC1D19: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBC1D19

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TBC1D19 Gene

Localization for TBC1D19 Gene

Subcellular locations from

Jensen Localization Image for TBC1D19 Gene COMPARTMENTS Subcellular localization image for TBC1D19 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TBC1D19 Gene

Pathways for TBC1D19 Gene

SuperPathways for TBC1D19 Gene

No Data Available

Interacting Proteins for TBC1D19 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000264866 Q8N5T2-TBC19_HUMAN for TBC1D19 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for TBC1D19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
GO:1902017 NOT regulation of cilium assembly IMP 17646400
genes like me logo Genes that share ontologies with TBC1D19: view

No data available for Pathways by source for TBC1D19 Gene

Transcripts for TBC1D19 Gene

Unigene Clusters for TBC1D19 Gene

TBC1 domain family, member 19:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBC1D19

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D19 Gene

No ASD Table

Relevant External Links for TBC1D19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBC1D19 Gene

mRNA expression in normal human tissues for TBC1D19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TBC1D19 Gene

This gene is overexpressed in Breast (52.6) and NK cells (16.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TBC1D19 Gene

SOURCE GeneReport for Unigene cluster for TBC1D19 Gene Hs.479403

genes like me logo Genes that share expressions with TBC1D19: view

Expression partners for TBC1D19 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TBC1D19 Gene

Orthologs for TBC1D19 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBC1D19 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TBC1D19 35
  • 95.69 (n)
  • 98.1 (a)
TBC1D19 36
  • 98 (a)
(Canis familiaris)
Mammalia TBC1D19 35
  • 95.74 (n)
  • 98.78 (a)
TBC1D19 36
  • 99 (a)
(Mus musculus)
Mammalia Tbc1d19 35
  • 91.7 (n)
  • 97.34 (a)
Tbc1d19 16
Tbc1d19 36
  • 97 (a)
(Pan troglodytes)
Mammalia TBC1D19 35
  • 99.81 (n)
  • 99.81 (a)
TBC1D19 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tbc1d19 35
  • 92.65 (n)
  • 97.72 (a)
(Monodelphis domestica)
Mammalia TBC1D19 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia TBC1D19 36
  • 94 (a)
(Gallus gallus)
Aves TBC1D19 35
  • 83.84 (n)
  • 91.44 (a)
TBC1D19 36
  • 91 (a)
(Anolis carolinensis)
Reptilia TBC1D19 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tbc1d19 35
  • 74.97 (n)
  • 82.18 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.34245 35
(Danio rerio)
Actinopterygii tbc1d19 35
  • 70.87 (n)
  • 77.86 (a)
zgc63795 35
tbc1d19 36
  • 77 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008377 35
  • 48.12 (n)
  • 43.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7742 35
  • 49.36 (n)
  • 42.36 (a)
CG7742 36
  • 41 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12660 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6389 36
  • 59 (a)
Species with no ortholog for TBC1D19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBC1D19 Gene

Gene Tree for TBC1D19 (if available)
Gene Tree for TBC1D19 (if available)

Paralogs for TBC1D19 Gene

No data available for Paralogs for TBC1D19 Gene

Variants for TBC1D19 Gene

Sequence variations from dbSNP and Humsavar for TBC1D19 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs15666 -- 26,755,218(-) GATTA(C/T)ATATA utr-variant-3-prime
rs166353 -- 26,611,833(+) atTCT(C/T)CTTTT intron-variant
rs260934 -- 26,658,840(+) ccttc(A/G)tggca intron-variant
rs260935 -- 26,658,790(+) tgaag(A/C/G/T)ggttc intron-variant
rs260936 -- 26,656,869(+) ttttt(A/G)aaaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TBC1D19 Gene

Variant ID Type Subtype PubMed ID
nsv522423 CNV Gain 19592680
nsv878768 CNV Loss 21882294
nsv524115 CNV Loss 19592680
esv2678106 CNV Deletion 23128226
nsv470021 CNV Loss 18288195

Relevant External Links for TBC1D19 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D19 Gene

Disorders for TBC1D19 Gene

No disorders were found for TBC1D19 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TBC1D19 Gene

Publications for TBC1D19 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K. … Fukuda M. (Genes Cells 2009) 3 4
  4. Identification of the human testis protein phosphatase 1 interactome. (PMID: 21382349) Fardilha M. … da Cruz e Silva E.F. (Biochem. Pharmacol. 2011) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for TBC1D19 Gene

Sources for TBC1D19 Gene

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