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Aliases for TBC1D16 Gene

Aliases for TBC1D16 Gene

  • TBC1 Domain Family, Member 16 2 3

External Ids for TBC1D16 Gene

Previous GeneCards Identifiers for TBC1D16 Gene

  • GC17M078609
  • GC17M078611
  • GC17M075513
  • GC17M077913
  • GC17M073354
  • GC17M077907

Summaries for TBC1D16 Gene

GeneCards Summary for TBC1D16 Gene

TBC1D16 (TBC1 Domain Family, Member 16) is a Protein Coding gene. An important paralog of this gene is SGSM2.

UniProtKB/Swiss-Prot for TBC1D16 Gene

  • May act as a GTPase-activating protein for Rab family protein(s)

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D16 Gene

Genomics for TBC1D16 Gene

Regulatory Elements for TBC1D16 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TBC1D16 Gene

Start:
79,932,343 bp from pter
End:
80,035,858 bp from pter
Size:
103,516 bases
Orientation:
Minus strand

Genomic View for TBC1D16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBC1D16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D16 Gene

Proteins for TBC1D16 Gene

  • Protein details for TBC1D16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBP0-TBC16_HUMAN
    Recommended name:
    TBC1 domain family member 16
    Protein Accession:
    Q8TBP0
    Secondary Accessions:
    • B9A6L7
    • I3L1E0
    • I3L4U2
    • Q8N3Z4
    • Q96DH7

    Protein attributes for TBC1D16 Gene

    Size:
    767 amino acids
    Molecular mass:
    86372 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH01525.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TBC1D16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBC1D16 Gene

Proteomics data for TBC1D16 Gene at MOPED

Post-translational modifications for TBC1D16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TBC1D16 Gene

Domains for TBC1D16 Gene

Protein Domains for TBC1D16 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TBC1D16 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TBP0

UniProtKB/Swiss-Prot:

TBC16_HUMAN :
  • Q8TBP0
Domain:
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with TBC1D16: view

No data available for Gene Families for TBC1D16 Gene

Function for TBC1D16 Gene

Molecular function for TBC1D16 Gene

UniProtKB/Swiss-Prot Function: May act as a GTPase-activating protein for Rab family protein(s)

Gene Ontology (GO) - Molecular Function for TBC1D16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 22354992
genes like me logo Genes that share ontologies with TBC1D16: view

Animal Model Products

CRISPR Products

miRNA for TBC1D16 Gene

miRTarBase miRNAs that target TBC1D16

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TBC1D16 Gene

Localization for TBC1D16 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBC1D16 Gene COMPARTMENTS Subcellular localization image for TBC1D16 gene
Compartment Confidence
nucleus 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TBC1D16 Gene

Pathways for TBC1D16 Gene

SuperPathways for TBC1D16 Gene

No Data Available

Interacting Proteins for TBC1D16 Gene

Gene Ontology (GO) - Biological Process for TBC1D16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
GO:1902017 NOT regulation of cilium assembly IMP 17646400
genes like me logo Genes that share ontologies with TBC1D16: view

No data available for Pathways by source for TBC1D16 Gene

Transcripts for TBC1D16 Gene

Unigene Clusters for TBC1D16 Gene

TBC1 domain family, member 16:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TBC1D16

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D16 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - -
SP2: - -
SP3: -
SP4: -
SP5:
SP6: -
SP7:
SP8:

Relevant External Links for TBC1D16 Gene

GeneLoc Exon Structure for
TBC1D16
ECgene alternative splicing isoforms for
TBC1D16

Expression for TBC1D16 Gene

mRNA expression in normal human tissues for TBC1D16 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TBC1D16 Gene

SOURCE GeneReport for Unigene cluster for TBC1D16 Gene Hs.369819

genes like me logo Genes that share expressions with TBC1D16: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TBC1D16 Gene

Orthologs for TBC1D16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TBC1D16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBC1D16 35
  • 99.35 (n)
  • 99.74 (a)
TBC1D16 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TBC1D16 35
  • 86.74 (n)
  • 89.31 (a)
TBC1D16 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TBC1D16 35
  • 88.39 (n)
  • 89.22 (a)
TBC1D16 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tbc1d16 35
  • 84.73 (n)
  • 88.77 (a)
Tbc1d16 16
Tbc1d16 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TBC1D16 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TBC1D16 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbc1d16 35
  • 84.64 (n)
  • 88.38 (a)
chicken
(Gallus gallus)
Aves TBC1D16 35
  • 77.41 (n)
  • 78.95 (a)
TBC1D16 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBC1D16 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68883 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5438 35
tbc1d16 35
  • 68.62 (n)
  • 70.13 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2556 35
zebrafish
(Danio rerio)
Actinopterygii tbc1d16 35
  • 72.37 (n)
  • 74.89 (a)
tbc1d16 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011218 35
  • 64.13 (n)
  • 57.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5337 35
  • 56.51 (n)
  • 48.35 (a)
CG5337 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tbc-16 35
  • 50.03 (n)
  • 46.52 (a)
tbc-16 36
  • 37 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GYP7 36
  • 17 (a)
OneToMany
Species with no ortholog for TBC1D16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TBC1D16 Gene

ENSEMBL:
Gene Tree for TBC1D16 (if available)
TreeFam:
Gene Tree for TBC1D16 (if available)

Paralogs for TBC1D16 Gene

Paralogs for TBC1D16 Gene

genes like me logo Genes that share paralogs with TBC1D16: view

Variants for TBC1D16 Gene

Sequence variations from dbSNP and Humsavar for TBC1D16 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs3742 -- 79,935,759(+) CCAAA(A/C)CAAAA utr-variant-3-prime
rs3743 -- 79,935,827(+) TGGTG(A/G)AAATT utr-variant-3-prime
rs9799 -- 79,936,357(-) CAGCC(A/G)TGTGC utr-variant-3-prime
rs11213 -- 79,932,541(+) TTGCC(C/T)ATTGC utr-variant-3-prime
rs15776 -- 79,932,777(+) GCGTC(A/G)TTGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TBC1D16 Gene

Variant ID Type Subtype PubMed ID
nsv469865 CNV Loss 16826518
nsv908961 CNV Loss 21882294
dgv3295n71 CNV Loss 21882294
dgv3296n71 CNV Loss 21882294
nsv520743 CNV Gain 19592680
esv2210925 CNV Deletion 18987734
esv2716353 CNV Deletion 23290073
nsv833561 CNV Loss 17160897
nsv908971 CNV Loss 21882294
nsv527410 CNV Loss 19592680
nsv517686 CNV Loss 19592680
dgv572e199 CNV Deletion 23128226
esv2716354 CNV Deletion 23290073
esv2666144 CNV Deletion 23128226
esv29117 CNV Loss 19812545
nsv828121 CNV Loss 20364138
esv2716355 CNV Deletion 23290073
esv2642422 CNV Insertion 19546169
esv2671544 CNV Deletion 23128226

Relevant External Links for TBC1D16 Gene

HapMap Linkage Disequilibrium report
TBC1D16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D16 Gene

Disorders for TBC1D16 Gene

Relevant External Links for TBC1D16

Genetic Association Database (GAD)
TBC1D16
genes like me logo Genes that share disorders with TBC1D16: view

No data available for UniProtKB/Swiss-Prot for TBC1D16 Gene

Publications for TBC1D16 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K. … Fukuda M. (Genes Cells 2009) 3 4
  3. TBC1D16 is a Rab4A GTPase activating protein that regulates receptor recycling and EGF receptor signaling. (PMID: 23019362) Goueli B.S. … Pfeffer S.R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 2 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4

Products for TBC1D16 Gene

Sources for TBC1D16 Gene

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