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Aliases for TBC1D16 Gene

Aliases for TBC1D16 Gene

  • TBC1 Domain Family Member 16 2 3 5
  • TBC1 Domain Family, Member 16 2

External Ids for TBC1D16 Gene

Previous GeneCards Identifiers for TBC1D16 Gene

  • GC17M078609
  • GC17M078611
  • GC17M075513
  • GC17M077913
  • GC17M073354
  • GC17M077907

Summaries for TBC1D16 Gene

GeneCards Summary for TBC1D16 Gene

TBC1D16 (TBC1 Domain Family Member 16) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is SGSM2.

UniProtKB/Swiss-Prot for TBC1D16 Gene

  • May act as a GTPase-activating protein for Rab family protein(s).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D16 Gene

Genomics for TBC1D16 Gene

Regulatory Elements for TBC1D16 Gene

Enhancers for TBC1D16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TBC1D16 on UCSC Golden Path with GeneCards custom track

Genomic Location for TBC1D16 Gene

79,932,343 bp from pter
80,035,867 bp from pter
103,525 bases
Minus strand

Genomic View for TBC1D16 Gene

Genes around TBC1D16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D16 Gene

Proteins for TBC1D16 Gene

  • Protein details for TBC1D16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TBC1 domain family member 16
    Protein Accession:
    Secondary Accessions:
    • B9A6L7
    • I3L1E0
    • I3L4U2
    • Q8N3Z4
    • Q96DH7

    Protein attributes for TBC1D16 Gene

    767 amino acids
    Molecular mass:
    86372 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH01525.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TBC1D16 Gene


neXtProt entry for TBC1D16 Gene

Proteomics data for TBC1D16 Gene at MOPED

Post-translational modifications for TBC1D16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TBC1D16 Gene

Domains & Families for TBC1D16 Gene

Protein Domains for TBC1D16 Gene


Suggested Antigen Peptide Sequences for TBC1D16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Rab-GAP TBC domain.
  • Contains 1 Rab-GAP TBC domain.
genes like me logo Genes that share domains with TBC1D16: view

No data available for Gene Families for TBC1D16 Gene

Function for TBC1D16 Gene

Molecular function for TBC1D16 Gene

UniProtKB/Swiss-Prot Function:
May act as a GTPase-activating protein for Rab family protein(s).

Gene Ontology (GO) - Molecular Function for TBC1D16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 23019362
GO:0017137 Rab GTPase binding IBA --
genes like me logo Genes that share ontologies with TBC1D16: view
genes like me logo Genes that share phenotypes with TBC1D16: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBC1D16 Gene

Localization for TBC1D16 Gene

Subcellular locations from

Jensen Localization Image for TBC1D16 Gene COMPARTMENTS Subcellular localization image for TBC1D16 gene
Compartment Confidence
cytosol 5
endosome 5
mitochondrion 2
nucleus 2
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TBC1D16 Gene

Pathways & Interactions for TBC1D16 Gene

SuperPathways for TBC1D16 Gene

No Data Available

Interacting Proteins for TBC1D16 Gene

Gene Ontology (GO) - Biological Process for TBC1D16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001919 regulation of receptor recycling IDA 23019362
GO:0006886 intracellular protein transport IBA --
GO:0090630 activation of GTPase activity IBA --
genes like me logo Genes that share ontologies with TBC1D16: view

No data available for Pathways by source and SIGNOR curated interactions for TBC1D16 Gene

Drugs & Compounds for TBC1D16 Gene

No Compound Related Data Available

Transcripts for TBC1D16 Gene

Unigene Clusters for TBC1D16 Gene

TBC1 domain family, member 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D16 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - -
SP2: - -
SP3: -
SP4: -
SP6: -

Relevant External Links for TBC1D16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBC1D16 Gene

mRNA expression in normal human tissues for TBC1D16 Gene

Protein differential expression in normal tissues from HIPED for TBC1D16 Gene

This gene is overexpressed in Adipocyte (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TBC1D16 Gene

SOURCE GeneReport for Unigene cluster for TBC1D16 Gene Hs.369819

genes like me logo Genes that share expression patterns with TBC1D16: view

Protein tissue co-expression partners for TBC1D16 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TBC1D16 Gene

Orthologs for TBC1D16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TBC1D16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TBC1D16 35
  • 86.74 (n)
  • 89.31 (a)
TBC1D16 36
  • 90 (a)
(Canis familiaris)
Mammalia TBC1D16 35
  • 88.39 (n)
  • 89.22 (a)
TBC1D16 36
  • 89 (a)
(Mus musculus)
Mammalia Tbc1d16 35
  • 84.73 (n)
  • 88.77 (a)
Tbc1d16 16
Tbc1d16 36
  • 89 (a)
(Pan troglodytes)
Mammalia TBC1D16 35
  • 99.35 (n)
  • 99.74 (a)
TBC1D16 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tbc1d16 35
  • 84.64 (n)
  • 88.38 (a)
(Monodelphis domestica)
Mammalia TBC1D16 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia TBC1D16 36
  • 65 (a)
(Gallus gallus)
Aves TBC1D16 35
  • 77.41 (n)
  • 78.95 (a)
TBC1D16 36
  • 78 (a)
(Anolis carolinensis)
Reptilia TBC1D16 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5438 35
tbc1d16 35
  • 68.62 (n)
  • 70.13 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68883 35
(Danio rerio)
Actinopterygii tbc1d16 35
  • 72.37 (n)
  • 74.89 (a)
tbc1d16 36
  • 73 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2556 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011218 35
  • 64.13 (n)
  • 57.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5337 35
  • 56.51 (n)
  • 48.35 (a)
CG5337 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea tbc-16 35
  • 50.03 (n)
  • 46.52 (a)
tbc-16 36
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GYP7 36
  • 17 (a)
Species with no ortholog for TBC1D16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TBC1D16 Gene

Gene Tree for TBC1D16 (if available)
Gene Tree for TBC1D16 (if available)

Paralogs for TBC1D16 Gene

Paralogs for TBC1D16 Gene

genes like me logo Genes that share paralogs with TBC1D16: view

Variants for TBC1D16 Gene

Sequence variations from dbSNP and Humsavar for TBC1D16 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs34845477 - 79,948,987(+) GTGCT(C/T)CTCGG reference, missense
rs3742 -- 79,935,759(+) CCAAA(A/C)CAAAA utr-variant-3-prime
rs3743 -- 79,935,827(+) TGGTG(A/G)AAATT utr-variant-3-prime
rs9799 -- 79,936,357(-) CAGCC(A/G)TGTGC utr-variant-3-prime
rs11213 -- 79,932,541(+) TTGCC(C/T)ATTGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TBC1D16 Gene

Variant ID Type Subtype PubMed ID
nsv469865 CNV Loss 16826518
nsv908961 CNV Loss 21882294
dgv3295n71 CNV Loss 21882294
dgv3296n71 CNV Loss 21882294
nsv520743 CNV Gain 19592680
esv2210925 CNV Deletion 18987734
esv2716353 CNV Deletion 23290073
nsv833561 CNV Loss 17160897
nsv908971 CNV Loss 21882294
nsv527410 CNV Loss 19592680
nsv517686 CNV Loss 19592680
dgv572e199 CNV Deletion 23128226
esv2716354 CNV Deletion 23290073
esv2666144 CNV Deletion 23128226
esv29117 CNV Loss 19812545
nsv828121 CNV Loss 20364138
esv2716355 CNV Deletion 23290073
esv2642422 CNV Insertion 19546169
esv2671544 CNV Deletion 23128226

Variation tolerance for TBC1D16 Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.26; 52.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TBC1D16 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D16 Gene

Disorders for TBC1D16 Gene

Relevant External Links for TBC1D16

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TBC1D16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D16 Gene

Publications for TBC1D16 Gene

  1. TBC1D16 is a Rab4A GTPase activating protein that regulates receptor recycling and EGF receptor signaling. (PMID: 23019362) Goueli B.S. … Pfeffer S.R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 2 3 67
  2. Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR. (PMID: 26030178) Vizoso M. … Esteller M. (Nat. Med. 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. (PMID: 22354992) Popovic D. … Dikic I. (Mol. Cell. Biol. 2012) 3

Products for TBC1D16 Gene

Sources for TBC1D16 Gene