TBC1D16 Gene
protein-coding GIFtS: 43
GCID: GC17M077907
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TBC1 domain family, member 16
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Aliases for TBC1D16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| TBC1 Domain Family, Member 161 2 | | FLJ207481 | | MGC250621 | | TBC1 Domain Family Member 162 |
Export aliases for TBC1D16 gene to outside databasesPrevious GC identifers: GC17M078609 GC17M078611 GC17M075513 GC17M077913 GC17M073354 |
Summaries for TBC1D16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: TBC16_HUMAN, Q8TBP0Function: May act as a GTPase-activating protein for Rab family protein(s)
|
Genomic Views for TBC1D16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TBC1D16 gene promoter: SREBP-1c AP-2gamma GATA-1 SREBP-1b RORalpha1 SREBP-1a AP-2beta AP-2alpha MRF-2 AP-2alphaA Other transcription factors
Search SABiosciences Chromatin IP Primers for TBC1D16
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBC1D16 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3TBC1D16 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M077907: view genomic region
(about GC identifiers)
Start:
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77,906,142 bp from pter |
End:
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78,009,647 bp from pter |
Size:
|
103,506 bases |
Orientation:
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minus strand |
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Proteins for TBC1D16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: TBC16_HUMAN, Q8TBP0 (See
protein sequence)Recommended Name: TBC1 domain family member 16 Size: 767 amino acids; 86372 DaExplore the universe of human proteins at neXtProt for TBC1D16: NX_Q8TBP0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TBP0 TBC1D16 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins (4 alternative transcripts):
NP_001258773.1 NP_001258774.1 NP_001258775.1 NP_061893.2 ENSEMBL proteins: ENSP00000309794 ENSP00000461522 ENSP00000341517 ENSP00000458766 ENSP00000458377 ENSP00000461531 ENSP00000461509 ENSP00000458356 ENSP00000459342 Human Recombinant Protein Products for TBC1D16:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
TBC1D16 for ontologies About GeneDecksing
TBC1D16 Antibody Products: Assay Products for TBC1D16: |
Protein
Domains / Families for TBC1D16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TBC1D16 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TBP0ProtoNet protein and cluster: Q8TBP0 1 Blocks protein family: IPB000195 RabGAP/TBC domain
UniProtKB/Swiss-Prot: TBC16_HUMAN, Q8TBP0Similarity: Contains 1 Rab-GAP TBC domain |
Function for TBC1D16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: TBC16_HUMAN, Q8TBP0Function: May act as a GTPase-activating protein for Rab family protein(s) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005097 | Rab GTPase activator activity |
IEA | -- |
TBC1D16 for ontologies About GeneDecksing
Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D16 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D16 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TBC1D16 (NM_019020) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D16 |
|
Pathways & Interactions for TBC1D16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBC1D16
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
 2 Interacting proteins for TBC1D16 (ENSP000003097944) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds for TBC1D16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for TBC1D16 Search CenterWatch for drugs/clinical trials and news about TBC1D16 / TBC16 
|
Transcripts for TBC1D16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for TBC1D16 gene (4 alternative transcripts): NM_001271844.1 NM_001271845.1 NM_001271846.1 NM_019020.3 Unigene Cluster for TBC1D16: TBC1 domain family, member 16 Hs.369819 [show with all ESTs]Unigene Representative Sequence: NM_01902010 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000310924(uc002jxj.3) ENST00000576768(uc002jxi.3) ENST00000340848(uc002jxh.3) ENST00000573334 ENST00000572862(uc002jxk.1) ENST00000570373 ENST00000574241 ENST00000573782 ENST00000574427 ENST00000571872
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D16 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TBC1D16 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TBC1D16 (NM_019020) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TBC1D16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TBC1D16  |
Additional cDNA sequence: AB449902.1 AK000755.1 AK091923.1 AK097283.1 AL157485.1 AL512709.1 BC001525.2 BC028290.1 BC036947.1 BC062601.1 BC080571.1 CR936670.1 18 DOTS entries: DT.211671 DT.437983 DT.91923186 DT.115081 DT.92421069 DT.100786813 DT.95282864 DT.95342182 DT.40122379 DT.100786818 DT.120978682 DT.120978692 DT.120978698 DT.120978700 DT.75140612 DT.91879936 DT.95099692 DT.99941161 24/306 AceView cDNA sequences (see all 306): CF594241 BE277141 BM671267 BG760498 BG768769 BQ685538 BQ182969 BC062601 AI990892 BQ899284 AI905060 NM_019020 BG762541 AW665539 BQ009514 BC000248 BG820848 AI264271 BU185533 BC028290 BI862132 BQ689412 BG576098 AW501834 GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D16 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for TBC1D16
|
Expression for TBC1D16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TBC1D16 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GATTCCACAG
 About this image See TBC1D16 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TBC1D16
SOURCE GeneReport for Unigene cluster: Hs.369819 SABiosciences Custom PCR Arrays for TBC1D16
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TBC1D16 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TBC1D16 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBC1D16 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBC1D16 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D16 |
Orthologs for TBC1D16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TBC1D16 gene from 6/22 species (see all 22) About this table
ENSEMBL Gene Tree for TBC1D16 (if available) TreeFam Gene Tree for TBC1D16 (if available)  |
Paralogs for TBC1D16 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for TBC1D16 gene
- SGSM12 TBC1D172 TBC1D212 SGSM22 TBC1D152 TBC1D252
5 SIMAP similar genes for TBC1D16 using alignment to 11 protein entries: TBC16_HUMAN (see all proteins):DKFZp761D0223 TBC1D15 OATL1 TBC1D25 TBC1D17
TBC1D16 for paralogs About GeneDecksing
|
Genomic Variants for TBC1D16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 17 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for TBC1D16 (77906142 - 78009647 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 12 variations for TBC1D16 12 CNVs: 77750 49943 77751 88645 88642 2234 77752 67278 49942 88644 88643 102552  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBC1D16 |
|
Disorders
/ Diseases for TBC1D16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications for TBC1D16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TBC1D16 gene integrated from 9 sources: (articles sorted by number of sources associating them with TBC1D16) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- TBC1D16 is a Rab4A GTPase activating protein that regu lates receptor recycling and EGF receptor signaling. (PubMed id 23019362)1 Goueli B.S....Pfeffer S.R. (2012)
- Rab GTPase-activating proteins in autophagy: regulatio n of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. (PubMed id 22354992)1 Popovic D....Dikic I. (2012)
- An integrated approach to uncover drivers of cancer. (PubMed id 21129771)1 Akavia U.D....Pe'er D. (2010)
- Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1 Ishibashi K.... Fukuda M. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
|
External Searches for TBC1D16 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TBC1D16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBC1D16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TBC1D16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for TBC1D16 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TBC1D16 gene: Search GeneIP for patents involving TBC1D16
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for TBC1D16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TBC1D16 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TBC1D16 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TBC1D16 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TBC1D16 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TBC1D16 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TBC1D16 |
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 | | TBC1D16 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TBC1D16 |
|  |  |  |  | | | Search ThermoFisher Antibodies for TBC1D16 |
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